Method Of Producing Recombinant High Molecular Weight Vwf In Cell Culture - EP3064508

The patent EP3064508 was granted to Baxalta on Mar 15, 2023. The application was originally filed on Jul 8, 2011 under application number EP16153131A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3064508

BAXALTA
Application Number
EP16153131A
Filing Date
Jul 8, 2011
Status
Patent Maintained As Amended
Feb 10, 2023
Grant Date
Mar 15, 2023
External Links
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JAMES POOLEMay 28, 2020CARPMAELS & RANSFORDADMISSIBLE

Patent Citations (24) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0481791
DESCRIPTIONUS2007212770
DESCRIPTIONUS5804420
DESCRIPTIONUS5994136
DESCRIPTIONUS6013516
DESCRIPTIONUS6100061
DESCRIPTIONWO0003000
DESCRIPTIONWO0123527
DESCRIPTIONWO2009086309
DESCRIPTIONWO8606096
DESCRIPTIONWO9615231
DESCRIPTIONWO9626266
DESCRIPTIONWO9808934
DESCRIPTIONWO9815614
OPPOSITIONEP1096017
OPPOSITIONUS4767704
OPPOSITIONWO2008082669
OPPOSITIONWO2008109410
OPPOSITIONWO2009086309
SEARCHEP1096017
SEARCHUS4767704
SEARCHWO2008082669
SEARCHWO2008109410
SEARCHWO2009086309

Non-Patent Literature (NPL) Citations (72) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ANDREINI ET AL., J. PROTEOME RES., (2005), vol. 4, no. 3, pages 881 - 888-
DESCRIPTION- APTE S.S., J BIOL CHEM., (20091113), vol. 284, no. 46, pages 31493 - 31497-
DESCRIPTION- BLOMER ET AL., J VIROL., (1997), vol. 71, no. 9, pages 6641 - 6649-
DESCRIPTION- BUTLER, Animal Cell Biotechnology, (1988), vol. 3, pages 283 - 303-
DESCRIPTION- CASTAMAN, DISORDERS OF HEMOSTASIS, (2003), vol. 88, no. 1, pages 94 - 108-
DESCRIPTION- CHANG ET AL., PHARM RES., (1996), vol. 13, pages 243 - 249-
DESCRIPTION- CHAUHAN, J EXP MED., (20080901), vol. 205, no. 9, pages 2065 - 2074-
DESCRIPTION- CHEN, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, (1992), vol. 18, pages 1311 - 1354-
DESCRIPTION- COTTEN ET AL., PROC NATL ACAD SCI USA, (1992), vol. 89, no. 13, pages 6094 - 6098-
DESCRIPTION- CURIEL, NAT IMMUN, (1994), vol. 13, no. 2-3, pages 141 - 164-
DESCRIPTION- EIKENBOOM ET AL., HAEMOPHILIA, (1995), vol. 1, pages 77 - 90-
DESCRIPTION- FLANNERY C.R., FRONT BIOSCI., (20060101), vol. 11, pages 544 - 569-
DESCRIPTION- FRANEK ET AL., BIOTECHNOLOGY PROGRESS, (2000), vol. 16, pages 688 - 692-
DESCRIPTION- FUJIKAWA, BLOOD, (2001), vol. 98, pages 1662 - 1666-
DESCRIPTION- GERRITSEN, "Assay of von Willebrand factor (vWF)-cleaving protease based on decreased collagen binding affinity of degraded vWF: a tool for the diagnosis of thrombotic thrombocytopenic purpura (TTP", THROMB HAEMOST, (1999), vol. 82, pages 1386 - 1389-
DESCRIPTION- GERRITSEN ET AL., BLOOD, (2001), vol. 98, pages 1654 - 1661-
DESCRIPTION- GRUNHAUS ET AL., SEMINAR IN VIROLOGY, (1992), vol. 200, no. 2, pages 535 - 546-
DESCRIPTION- "Hemophilia A, Hemophilia B, and von Willebrand's Disease", J. E. SADLER; E. W. DAVIE ET AL., The molecular basis of blood diseases, W.B. SAUNDERS CO., (1987), pages 576 - 602-
DESCRIPTION- JONES GC, CURR PHARM BIOTECHNOL., (200602), vol. 7, no. 1, pages 25 - 31-
DESCRIPTION- KAUFMAN, MOL CELL BIOL., (198903), vol. 9, no. 3, pages 1233 - 1242-
DESCRIPTION- KELLEHER; VOS, BIOTECHNIQUES, (1994), vol. 17, no. 6, pages 1110 - 1117-
DESCRIPTION- K. G. MANN ET AL., BLOOD, (1990), vol. 76, pages 1 - 16-
DESCRIPTION- KOKAME ET AL., BR J HAEMATOL., (200504), vol. 129, no. 1, pages 93 - 100-
DESCRIPTION- LARKIN ET AL., PLOS PATHOG., (200903), vol. 5, no. 3, page E1000349-
DESCRIPTION- LARKIN ET AL., PLOS PATHOG., (200903), vol. 5, no. 3, page EL000349-
DESCRIPTION- LEVY ET AL., NATURE, (2001), vol. 413, pages 488 - 494-
DESCRIPTION- LIN; LIU, OPEN ACCESS RHEUMATOLOGY RESEARCH AND REVIEWS, (2009), vol. 1, pages 121 - 131-
DESCRIPTION- MACFARLANE ET AL., THROMB. DIATH. HAEMORRH., (1975), vol. 34, pages 306 - 308-
DESCRIPTION- MANN ET AL., CELL, (1983), vol. 33, pages 153 - 159-
DESCRIPTION- MATHER, BIOL. REPROD, (1980), vol. 23, pages 243 - 251-
DESCRIPTION- MATHER ET AL., Annals N. Y. Acad. Sci., (1982), vol. 383, pages 44 - 68-
DESCRIPTION- MAYADAS ET AL., J. BIOL. CHEM., (1989), vol. 264, no. 23, pages 13497 - 13503-
DESCRIPTION- MOAKE JL, SEMIN HEMATOL., (200401), vol. 41, no. 1, pages 4 - 14-
DESCRIPTION- MUZYCZKA, CURR TOP MICROBIOL IMMUNOL, (1992), vol. 158, pages 97 - 129-
DESCRIPTION- NALDINI ET AL., SCIENCE, (1996), vol. 272, no. 5259, pages 263 - 267-
DESCRIPTION- NICHOLSON ET AL., BMC EVOL BIOL., (20050204), vol. 5, no. 1, page 11-
DESCRIPTION- NICOLAS; RUBINSTEIN, Vectors: A survey of molecular cloning vectors and their uses, BUTTERWORTH, (1988), pages 494 - 513-
DESCRIPTION- PLAIMAUER, BLOOD, (20020712), vol. 100, no. 10, pages 3626 - 3632-
DESCRIPTION- PLAIMAUER B; SCHEIFLINGER F., SEMIN HEMATOL., (200401), vol. 41, no. 1, pages 24 - 33-
DESCRIPTION- PLAIMAUER ET AL., BLOOD, (20011215), vol. 100, no. 10, pages 3626 - 3632-
DESCRIPTION- REITER ET AL., LMMUNO AKTIENGESELLSCHAFT-
DESCRIPTION- Remington's Pharmaceutical Sciences, MACK PUBLISHING CO., (1990), pages 1435 - 1712-
DESCRIPTION- RIEGER ET AL., THROMB HAEMOST. 2006, (2006), vol. 95, no. 2, pages 212 - 220-
DESCRIPTION- SOEJIMA ET AL., J BIOCHEM (TOKYO, (2001), vol. 130, pages 475 - 480-
DESCRIPTION- TANG ET AL., PHARM RES., (2004), vol. 21, pages 191 - 200-
DESCRIPTION- TEMIN, Gene Transfer, PLENUM PRESS, (1986), pages 149 - 188-
DESCRIPTION- TRIPODI ET AL., J THROMB HAEMOST., (200809), vol. 6, no. 9, pages 1534 - 1541-
DESCRIPTION- URIAUB; CHASIN, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, page 4216-
DESCRIPTION- VAN WEZEL, A.L., NATURE, (1967), vol. 216, pages 64 - 65-
DESCRIPTION- WEISS ET AL., J. CLIN. INVEST., (1973), vol. 52, pages 2708 - 2716-
DESCRIPTION- ZHENG, J BIOL CHEM., (2001), vol. 276, pages 41059 - 41063-
DESCRIPTION- ZUFFEREY, NAT BIOTECHNOL, (1997), vol. 15, no. 9, pages 871 - 875-
OPPOSITION- Claudia Altamirano, Et Al, "Advances in improving mammalian cells metabolism for recombinant protein production", EJB ELECTRONIC JOURNAL OF BIOTECHNOLOGY, CONICYT, SANTIAGO, CL, CL, vol. 16, no. 3, doi:10.2225/vol16-issue3-fulltext-2, ISSN 0717-3458, pages 1 - 14-
OPPOSITION- D D Wagner, T Mayadas, V J Marder, "Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.", The journal of cell biology, The Rockefeller University Press, US, US, (19860401), vol. 102, no. 4, doi:10.1083/jcb.102.4.1320, ISSN 0021-9525, pages 1320 - 1324-
OPPOSITION- DMEM/F-12 media components-
OPPOSITION- Fatemeh Davami, Farnaz Eghbalpour, Leila Nematollahi, Farzaneh Barkhordari, Fereidoun Mahboudi, "Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles", Iranian biomedical journal, Pasteur Institute of Iran, Iran, Iran, doi:10.7508/ibj.2015.04.002, (20150101), pages 194 - 205, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649854/pdf/ibj-19-194.pdf-
OPPOSITION- J E Sadler, "von Willebrand factor assembly and secretion", Journal of Thrombosis and Haemostasis, (20090101), vol. 7, no. 1, pages 24 - 27-
OPPOSITION- KAUFMAN, R.J. ET AL., "Effect of von Willebrand factor coexpression on the synthesis and secretion of Factor VIII in Chinese Hamster Ovary cells", MOLECULAR AND CELLULAR BIOLOGY, (19890301), vol. 9, no. 3, pages 1233 - 1242-
OPPOSITION- MAYADAS T.N., WAGNER D.D., "IN VITRO MULTIMERIZATION OF VON WILLEBRAND FACTOR IS TRIGGERED BY LOW PH.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19890101), vol. 264., no. 23., ISSN 0021-9258, page 13497 + 503.-
OPPOSITION- MAYADAS T.N., WAGNER D.D., "IN VITRO MULTIMERIZATION OF VON WILLEBRAND FACTOR IS TRIGGERED BY LOW PH.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19890101), vol. 264., no. 23., ISSN 0021-9258, page 13497 + 503., XP000885940-
OPPOSITION- M.-S. Lao, D. Toth, "Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture", Biotechnology Progress, American Chemical Society, (19971007), vol. 13, no. 5, doi:10.1021/bp9602360, ISSN 87567938, pages 688 - 691-
OPPOSITION- VOORBERG J , FONTIJN R, MOURIK VAN J A, PANNEKOEK H, "DOMAINS INVOLVED IN MULTIMER ASSEMBLY OF VON WILLEBRAND FACTOR VWF MULTIMERIZATION IS INDEPENDENT OF DIMERIZATION", The EMBO Journal, European Molecular Biology Organization, (19900101), vol. 9, no. 3, ISSN 0261-4189, pages 797 - 803-
OPPOSITION- VOORBERG J , FONTIJN R, MOURIK VAN J A, PANNEKOEK H, "DOMAINS INVOLVED IN MULTIMER ASSEMBLY OF VON WILLEBRAND FACTOR VWF MULTIMERIZATION IS INDEPENDENT OF DIMERIZATION", The EMBO Journal, European Molecular Biology Organization, (19900101), vol. 9, no. 3, ISSN 0261-4189, pages 797 - 803, XP002674469-
OPPOSITION- Y Sakai, Et Al, "GROWTH INHIBITION AND HEAVY METAL ACCUMULATION IN CHO CELLS", Animal Cell Technology: Developments towards the 21st Century, Kluwer, (19950101), pages 1111 - 1115-
OPPOSITION- Y Sakai, Et Al, "GROWTH INHIBITION AND HEAVY METAL ACCUMULATION IN CHO CELLS", Animal Cell Technology: Developments towards the 21st Century, Kluwer, (19950101), pages 1111 - 1115, XP055750458
OPPOSITION- M.-S. Lao, D. Toth, "Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture", Biotechnology Progress, American Chemical Society, (19971007), vol. 13, no. 5, doi:10.1021/bp9602360, ISSN 87567938, pages 688 - 691, XP055115728
OPPOSITION- D D Wagner, T Mayadas, V J Marder, "Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.", The journal of cell biology, The Rockefeller University Press, US, US, (19860401), vol. 102, no. 4, doi:10.1083/jcb.102.4.1320, ISSN 0021-9525, pages 1320 - 1324, XP055750915
OPPOSITION- J E Sadler, "von Willebrand factor assembly and secretion", Journal of Thrombosis and Haemostasis, (20090101), vol. 7, no. 1, pages 24 - 27, XP055750907
OPPOSITION- KAUFMAN, R.J. ET AL., "Effect of von Willebrand factor coexpression on the synthesis and secretion of Factor VIII in Chinese Hamster Ovary cells", MOLECULAR AND CELLULAR BIOLOGY, (19890301), vol. 9, no. 3, pages 1233 - 1242, XP002440263
OPPOSITION- Claudia Altamirano, Et Al, "Advances in improving mammalian cells metabolism for recombinant protein production", EJB ELECTRONIC JOURNAL OF BIOTECHNOLOGY, CONICYT, SANTIAGO, CL, CL, vol. 16, no. 3, doi:10.2225/vol16-issue3-fulltext-2, ISSN 0717-3458, pages 1 - 14, XP055750886
OPPOSITION- Fatemeh Davami, Farnaz Eghbalpour, Leila Nematollahi, Farzaneh Barkhordari, Fereidoun Mahboudi, "Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles", Iranian biomedical journal, Pasteur Institute of Iran, Iran, Iran, doi:10.7508/ibj.2015.04.002, (20150101), pages 194 - 205, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649854/pdf/ibj-19-194.pdf, XP055750435
SEARCH- M.-S. LAO ET AL, "Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture", BIOTECHNOLOGY PROGRESS, (19971007), vol. 13, no. 5, doi:10.1021/bp9602360, ISSN 8756-7938, pages 688 - 691, XP055115728 [Y] 1-3,5-7 * Pg.689 Col.1 Par.3 *

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