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Gastrin Antagonists (Eg Yf476, Netazepide) For Treatment And Prevention Of Osteoporosis - EP3071206

The patent EP3071206 was granted to CL Biosciences on Feb 17, 2021. The application was originally filed on Nov 21, 2014 under application number EP14815149A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3071206

CL BIOSCIENCES
Application Number
EP14815149A
Filing Date
Nov 21, 2014
Status
Granted And Under Opposition
Jan 15, 2021
Grant Date
Feb 17, 2021
External Links
Slate, Register, Google Patents

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TRIO MEDICINESNov 17, 2021HARRISWITHDRAWN

Patent Citations (7) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTWO2005007107
INTERNATIONAL-SEARCH-REPORTWO9312817
OPPOSITIONUS2003119896
OPPOSITIONUS5952511
OPPOSITIONWO2005007107
OPPOSITIONWO9312817
OPPOSITIONWO9419322

Non-Patent Literature (NPL) Citations (28) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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OPPOSITION- A R Moore, Et Al.,, "ABSTRACT OC-097 - THE NOVEL GASTRIN/CCK2 RECEPTOR ANTAGONIST YF476 INDUCES CLINICAL RESPONSES AND IS WELL TOLERATED IN PATIENTS WITH TYPE I GASTRIC NEUROENDOCRINE TUMOURS", GUT, (20120701), vol. 61, no. 2, pages A42 - A43, XP055870767-
OPPOSITION- "Chapter 11 - Rheumatology and bone disease", Parveen Kumar, Michael Clark, KUMAR & CLARKS Clinical Medicine Eighth Edition, Elsevier Ltd.,, (20120101), pages 3pp, 552 - 553, XP055870717-
OPPOSITION- Corley, D.A. ; Kubo, A. ; Zhao, W. ; Quesenberry, C., "Proton Pump Inhibitors and Histamine-2 Receptor Antagonists Are Associated With Hip Fractures Among At-Risk Patients", Gastroenterology, Elsevier Inc., US, US , (20100701), vol. 139, no. 1, ISSN 0016-5085, pages 93 - 101, XP027106459-
OPPOSITION- Duan Chen, Chun-Mei Zhao, Rolf Håkanson, Jens F Rehfeld, "Gastric Phenotypic Abnormality in Cholecystokinin 2 Receptor Null Mice", Pharmacology & Toxicology, (20021201), vol. 91, no. 6, pages 375 - 381, XP055870747-
OPPOSITION- Fossmark Reidar, Astrid K Stunes, Christiane Petzold, Helge L Waldum, Marina Rubert, Aina-Mari Lian, Janne E Reseland, Unni Syversen, "Decreased bone mineral density and reduced bone quality in H(+) /K(+) ATPase beta-subunit deficient mice", Journal of Cellular Biochemistry, (20120101), vol. 113, no. 1, pages 141 - 147, XP055871037-
OPPOSITION- G.-L. Cui, U. Syversen, C.-M. Zhao, D. Chen, H. L. Waldum, "Long-term Omeprazole Treatment Suppresses Body Weight Gain and Bone Mineralization in Young Male Rats", Scandinavian Journal of Gastroenterology, (20010101), vol. 36, no. 10, pages 1011 - 1015, XP055871076-
OPPOSITION- Kristin Matre Aasarød Et Al., "Abstract OC3.6- Skeletal effects of the gastrin receptor antagonist netazepide in H+/K+ ATPase beta-subunit deficient mice", Bone Abstracts, (20140501), vol. 3, XP055870980-
OPPOSITION- L. Grimelius, H. Johansson, G. Lundqvist, A. Olazabalj. H. Polak & A. G. E. Pearse, "The Parathyroid Glands in Experimentally Induced Hypergastrinemia in the Rat", Scandinavian Journal of Gastroenterology, (19770101), vol. 12, no. 6, pages 739 - 744, XP055871061-
OPPOSITION- Marc J. Berna, Robert T. Jensen, "Role of CCK/Gastrin Receptors in Gastrointestinal/Metabolic Diseases and Results of Human Studies Using Gastrin/CCK Receptor Agonists/Antagonists in these Diseases", Current Topics in Medicinal Chemistry, (20070101), vol. 7, no. 12, pages 1211 - 1231, XP055870735-
OPPOSITION- Merriman, N.A. ; Putt, M.E. ; Metz, D.C. ; Yang, Y., "Hip Fracture Risk in Patients With a Diagnosis of Pernicious Anemia", Gastroenterology, Elsevier Inc., US, US , (20100401), vol. 138, no. 4, ISSN 0016-5085, pages 1330 - 1337, XP026984992-
OPPOSITION- M Kidd, Z-L Siddique, I. Drozdov, B.I. Gustafsson, R.L Camp, J.W. Black, M. Boyce, I.M. Modlin, "The CCK receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development", Regulatory Peptides, (20100206), vol. 162, pages 52 - 60, XP055870962-
OPPOSITION- P Garnero, E Sornay-Rendu, M C Chapuy, P D Delmas, "Increased Bone Turnover in Late Postmenopausal Women Is a Major Determinant of Osteoporosis", Journal of Bone and Mineral Research, (19960301), vol. 11, no. 3, pages 337 - 349, XP055871081-
OPPOSITION- R. Gagnemo-Persson, R. Hakanson, F. Sundler & P. Persson, "Growth of the Parathyroid Glands in Omeprazole Treated Chickens", Scandinavian Journal of Gastroenterology, (19940101), vol. 29, no. 6, pages 493 - 497, XP055871064-
OPPOSITION- Wang Zhi, Wu Ren, "EFFECT OF ESTROGEN OR PROGESTOGEN INJECTION ON SERUM GASTRIN LEVELS AND GASTRIC ACID SECRETION OF OVARJECTOMIZED RATS", Acta Physiologica Sinica, (19870101), vol. 39, no. 3, pages 269 - 274, XP055870704-
OPPOSITION- Yu-Xiao Yang, "Proton Pump Inhibitor Therapy and Osteoporosis", Current Drug Safety, (20080901), vol. 3, no. 3, pages 204 - 209, XP055871085-
OPPOSITION- Gagnemo-Persson R., Samuelsson A., Håkanson R., Persson P., "Chicken Parathyroid Hormone Gene Expression in Response to Gastrin, Omeprazole, Ergocalciferol, and Restricted Food Intake", CALCIFIED TISSUE INTERNATIONAL, NEW YORK, NY, US, US , (19970901), vol. 61, no. 3, doi:10.1007/s002239900325, ISSN 0171-967X, pages 210 - 215, XP055871069
OPPOSITION- Yu-Xiao Yang, "Chronic Proton Pump Inihibitor Therapy and Calcium Metabolism", Current Gastroenterology Reports, Current Science Inc., New York, New York , (20121002), vol. 14, no. 6, doi:10.1007/s11894-012-0290-4, ISSN 1534-312X, pages 473 - 479, XP035129758
OPPOSITION- G Semple, H Ryder, D P Rooker, A R Batt, D A Kendrick, M Szelke, M Ohta, M Satoh, A Nishida, S Akuzawa, K Miyata, "(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist", Journal of medicinal chemistry, UNITED STATES, UNITED STATES , doi:10.1021/jm960669+, (19970131), pages 331 - 341, Journal of medicinal chemistry, URL: http://www.ncbi.nlm.nih.gov/pubmed/9022799, XP055211245
OPPOSITION- Thorsten Schinke, Arndt F Schilling, Anke Baranowsky, Sebastian Seitz, Robert P Marshall, Tilman Linn, Michael Blaeker, Antje K Huebner, Ansgar Schulz, Ronald Simon, Matthias Gebauer, Matthias Priemel, Uwe Kornak, Sandra Perkovic, Florian Barvencik, F Timo Beil, Andrea Del Fattore, Annalisa Frattini, Thomas Streichert, Klaus Pueschel, Anna Villa, Klaus-Michael Debatin, Johannes M Rueger, Anna Teti, Jozef Zustin, Guido Sauter, Michael Amling, "Impaired gastric acidification negatively affects calcium homeostasis and bone mass", Nature Medicine, Nature Pub. Co., (20090601), vol. 15, no. 6, doi:10.1038/nm.1963, ISSN 10788956, pages 674 - 681, XP055171204
OPPOSITION- Masayuki Kitano; Per Norlén; Xi‐Qin Ding; Sanae Nakamura; Rolf Håkanson, "Long‐lasting cholecystokinin2 receptor blockade after a single subcutaneous injection of YF476 or YM022", BRITISH JOURNAL OF PHARMACOLOGY, Wiley-Blackwell, UK, UK , (20000000), vol. 130, no. 3, doi:10.1038/sj.bjp.0703342, ISSN 0007-1188, pages 699 - 705, XP071122968
OPPOSITION- Fossmark R., Sørdal Ø., Jianu C. S., Qvigstad G., Nordrum I. S., Boyce M., Waldum H. L., "Treatment of gastric carcinoids type 1 with the gastrin receptor antagonist netazepide (YF476) results in regression of tumours and normalisation of serum chromogranin A", ALIMENTARY PHARMACOLOGY & THERAPEUTICS., BLACKWELL SCIENTIFIC PUBLICATIONS LTD., CAMBRIDGE., GB, GB , (20121201), vol. 36, no. 11-12, doi:10.1111/apt.12090, ISSN 0269-2813, pages 1067 - 1075, XP055870759
OPPOSITION- Boyce Malcolm, Warrington Steve, Black James, "Netazepide, a gastrin/CCK 2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects : Netazepide inhibits pentagastrin", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY., BLACKWELL SCIENTIFIC PUBL., GB, GB , (20131101), vol. 76, no. 5, doi:10.1111/bcp.12099, ISSN 0306-5251, pages 689 - 698, XP055870729
OPPOSITION- Boyce M., David O., Darwin K., Mitchell T., Johnston A., Warrington S., "Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects", ALIMENTARY PHARMACOLOGY & THERAPEUTICS., BLACKWELL SCIENTIFIC PUBLICATIONS LTD., CAMBRIDGE., GB, GB , (20120701), vol. 36, no. 2, doi:10.1111/j.1365-2036.2012.05143.x, ISSN 0269-2813, pages 181 - 189, XP055870727
OPPOSITION- Sharma B K, Walt R P, Pounder R E, Gomes M D, Wood E C, Logan L H, "Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity.", Gut microbiota, British medical association , London, UK, UK , (19840901), vol. 25, no. 9, doi:10.1136/gut.25.9.957, ISSN 0017-5749, pages 957 - 964, XP055871049
OPPOSITION- Zhao Chun-Mei, Håkanson Rolf, Chen Duan, "Secretory organelles in ECL cells: Effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting", INFLAMMOPHARMACOLOGY, KLUWER ACADEMIC PUBLISHERS, DORDRECHT., NL, NL , (20050801), vol. 13, no. 1-3, doi:10.1163/156856005774423818, ISSN 0925-4692, pages 75 - 82, XP055870754
OPPOSITION- RAISZ L G, "Pathogenesis of osteoporosis: concepts, conflicts and prospects", The Journal of Clinical Investigation, B M J Group, GB, GB , (20051201), vol. 115, no. 12, doi:10.1172/JCI27071, ISSN 0021-9738, pages 3318 - 3325, XP003003622
OPPOSITION- Kim Hye Won, Kim Yang-Hyun, Han Kyungdo, Nam Ga Eun, Kim Gwang Seon, Han Byoung-Duck, Lee Anna, Ahn Ji Yong, Ko Byung Joon, "Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women", PLoS ONE, (20140708), vol. 9, no. 7, doi:10.1371/journal.pone.0101852, pages e101852-1 - e101852-5, XP055870985

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