Producing Hybrid Antibodies Containing Human Variable Regions And Rodent Constant Regions - EP3085780

The patent EP3085780 was granted to Regeneron Pharmaceuticals on Jun 28, 2023. The application was originally filed on Feb 15, 2002 under application number EP16171561A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3085780

REGENERON PHARMACEUTICALS
Application Number
EP16171561A
Filing Date
Feb 15, 2002
Status
Patent Maintained As Amended
May 26, 2023
Grant Date
Jun 28, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

KYMABJun 28, 2019CMS CAMERON MCKENNA NABARRO OLSWANGWITHDRAWN

Patent Citations (10) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS5350689
DESCRIPTIONUS5436149
DESCRIPTIONUS5508189
DESCRIPTIONUS5770429
DESCRIPTIONUS5789215
OPPOSITIONEP1399575
OPPOSITIONWO2012148873
OPPOSITIONWO2015088643
SEARCHUS5939598
SEARCHWO9945962

Non-Patent Literature (NPL) Citations (105) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ABREMSKI; HOESS, J BIOL CHEM, (1984), vol. 259, pages 1509 - 14-
DESCRIPTION- ADRA ET AL., GENE, (1987), vol. 60, pages 65 - 74-
DESCRIPTION- ANAL BIOCHEM, (20010315), vol. 290, no. 2, pages 260 - 71-
DESCRIPTION- ANDREWS ET AL., CELL, (1985), vol. 40, pages 795 - 803-
DESCRIPTION- ANGRAND ET AL., NUCLEIC ACIDS RES, (1999), vol. 27, page E16-
DESCRIPTION- ANGRAND ET AL., NUCLEIC ACIDS RES, vol. 27, page E16,1999-
DESCRIPTION- AUSUBEL ET AL.,, Current Protocols in Molecular Biology, GREENE PUBL. ASSOC., WILEY INTERSCIENCE-
DESCRIPTION- BAGUISI ET AL., NAT BIOTECHNOL, (1999), vol. 17, pages 456 - 61-
DESCRIPTION- BECKER; GOLD, PROC NATL ACAD SCI USA, (1978), vol. 75, pages 4199 - 203-
DESCRIPTION- BECK ET AL., GENE, (1982), vol. 19, pages 327 - 36-
DESCRIPTION- BERNARD ET AL., EXP CELL RES, (1985), vol. 158, pages 237 - 43-
DESCRIPTION- BETHKE,B.; SAUER,B., NUCLEIC ACIDS RES., (1997), vol. 25, pages 2828 - 2834-
DESCRIPTION- BOER ET AL., BIOCHEM GENET, (1990), vol. 28, pages 299 - 308-
DESCRIPTION- CAMPBELL ET AL., NATURE, (1996), vol. 380, pages 64 - 6-
DESCRIPTION- CANTOR ET AL., ANNU REV BIOPHYS BIOPHYS CHEM, (1988), vol. 17, pages 287 - 304-
DESCRIPTION- CHENG ET AL., NATURE, (1994), vol. 369, pages 684 - 5-
DESCRIPTION- CLARK ET AL., COLD SPRING HARB SYMP QUANT BIOL, (1984), vol. 49, pages 453 - 62-
DESCRIPTION- COX, PROC NATL ACAD SCI USA, vol. 80, pages 4223 - 7,1983-
DESCRIPTION- DECHIARA ET AL., NATURE, (1990), vol. 345, pages 78 - 80-
DESCRIPTION- DENG; CAPECCHI, MOL CELL BIOL, (1992), vol. 12, pages 3365 - 71-
DESCRIPTION- DHAR ET AL., PROC NATL ACAD SCI USA, (1974), vol. 71, pages 371 - 5-
DESCRIPTION- DOETSCHMAN ET AL., NATURE, (1987), vol. 330, pages 576 - 578-
DESCRIPTION- FOORD; ROSE, PCR METHODS APPL, (1994), vol. 3, pages 149 - 61-
DESCRIPTION- FOROZAN ET AL., TRENDS GENET, (1997), vol. 13, pages 405 - 9-
DESCRIPTION- FUJIEDA, S.; LIN, Y. Q.; SAXON, A.; ZHANG, K., J IMMUNOL, (1996), vol. 157, pages 3450 - 3459-
DESCRIPTION- GIORDANO; MCALLISTER, GENE, (1990), vol. 88, pages 285 - 8-
DESCRIPTION- HAINES, B. B.; BRODEUR, P. H., EUR J IMMUNOL, (1998), vol. 28, pages 4228 - 4235-
DESCRIPTION- HALL ET AL., J BACTERIOL, (1993), vol. 175, pages 277 - 87-
DESCRIPTION- HALL; KOLODNER, PROC NATL ACAD SCI USA, (1994), vol. 91, pages 3205 - 9-
DESCRIPTION- HERAULT,Y.; RASSOULZADEGAN, M.; CUZIN, F.; DUBOULE, D., NATURE GENETICS, (1998), vol. 20, pages 381 - 384-
DESCRIPTION- HILL ET AL., GENOMICS, (2000), vol. 64, pages 111 - 3-
DESCRIPTION- HOESS, R.H.; WIERZBICKI,A.; ABREMSKI,K., NUCLEIC ACIDS RES., (1986), vol. 14, pages 2287 - 2300-
DESCRIPTION- HOULDSWORTH; CHAGANTI, AM J PATHOL, (1994), vol. 145, pages 1253 - 60-
DESCRIPTION- IZUMI ET AL., EXP CELL RES, (1991), vol. 197, pages 229 - 33-
DESCRIPTION- JOYNER, THE PRACTICAL APPROACH SERIES, (1999), vol. 293-
DESCRIPTION- KAFATOS FC; JONES CW; EFSTRATIADIS A, NUCLEIC ACIDS RES, (1979), vol. 7, no. 6, pages 1541 - 52-
DESCRIPTION- KOHLER; MILSTEIN, EUR. J. IMMUNOL., (1976), vol. 6, pages 511 - 519-
DESCRIPTION- KOLLER ET AL., PROC NATL ACAD SCI USA, (1989), vol. 86, pages 8927 - 8931-
DESCRIPTION- KOLODNER ET AL., MOL MICROBIOL, (1994), vol. 11, pages 23 - 30-
DESCRIPTION- KOVALL; MATTHEWS, SCIENCE, (1997), vol. 277, pages 1824 - 7-
DESCRIPTION- KUHN ET AL., SCIENCE, (1991), vol. 254, pages 707 - 710-
DESCRIPTION- KUROIWA ET AL., NAT BIOTECHNOL, (2000), vol. 18, pages 1086 - 1090-
DESCRIPTION- KUSANO ET AL., GENE, (1994), vol. 138, pages 17 - 25-
DESCRIPTION- LAAN ET AL., HUM GENET, (1995), vol. 96, pages 275 - 80-
DESCRIPTION- LIE; PETROPOULOS, CURR OPIN BIOTECHNOL, (1998), vol. 9, pages 43 - 8-
DESCRIPTION- LIZARDI ET AL., NAT GENET, (1998), vol. 19, pages 225 - 32-
DESCRIPTION- MEYER-LEON ET AL., COLD SPRING HARB SYMP QUANT BIOL, (1984), vol. 49, pages 797 - 804-
DESCRIPTION- MITRA; CHURCH, NUCLEIC ACIDS RES, (1999), vol. 27, page E34-
DESCRIPTION- MURPHY, J BACTERIOL, (1991), vol. 173, pages 5808 - 21-
DESCRIPTION- MUYRERS ET AL., NUCLEIC ACIDS RES, (1999), vol. 27, pages 1555 - 7-
DESCRIPTION- MYERS; STAHL, ANNU REV GENET, (1994), vol. 28, pages 49 - 70-
DESCRIPTION- NARAYANAN ET AL., GENE THER, (1999), vol. 6, pages 442 - 7-
DESCRIPTION- NOIROT; KOLODNER, J BIOL CHEM, (1998), vol. 273, pages 12274 - 80-
DESCRIPTION- ONG, J.; STEVENS, S.; ROEDER, R. G.; ECKHARDT, L. A., J IMMUNOL, (1998), vol. 160, pages 4896 - 4903-
DESCRIPTION- PAIN ET AL., DEVELOPMENT, (1996), vol. 122, pages 2339 - 48-
DESCRIPTION- PAN, Q.; PETIT-FRERE, C.; STAVNEZER, J.; HAMMARSTROM, L., EUR J IMMUNOL, (2000), vol. 30, pages 1019 - 1029-
DESCRIPTION- PONCE; MICOL, NUCLEIC ACIDS RES, (1992), vol. 20, page 623-
DESCRIPTION- POTEETE ET AL., J BACTERIOL, (1988), vol. 170, pages 2012 - 21-
DESCRIPTION- RACKWITZ ET AL., GENE, (1985), vol. 40, pages 259 - 66-
DESCRIPTION- REDDY ET AL., SCIENCE, (1978), vol. 200, pages 494 - 502-
DESCRIPTION- RIDEOUT ET AL., NAT GENET, (2000), vol. 24, pages 109 - 10-
DESCRIPTION- ROBERTSON, PRACTICAL APPROACH SERIES, (1987), vol. 254-
DESCRIPTION- RONAI, D.; BERRU, M.; SHULMAN, M., J. MOL CELL BIOL, (1999), vol. 19, pages 7031 - 7040-
DESCRIPTION- SAMBROOK, J.; E. F. FRITSCH; T. MANIATIS, MOLECULAR CLONING: A LABORATORY MANUAL, (1989), vol. 1, 2, 3-
DESCRIPTION- SAMBROOK, J.; E. F. FRITSCH; T. MANIATIS, Molecular Cloning: A Laboratory Manual, Second Edition,, (1989), page 1,2,3-
DESCRIPTION- SAMBROOK, J.; E. F. FRITSCH; T. MANIATIS, Molecular Cloning: A Laboratory Manual, Second Edition,, (1989), vol. 1, 2, 3-
DESCRIPTION- SAMBROOK; SAMBROOK, J.; E. F. FRITSCH; T. MANIATIS ET AL., Molecular Cloning: A Laboratory Manual, Second Edition,, (1989), vol. 1, 2, 3-
DESCRIPTION- SANTERRE ET AL., GENE, (1984), vol. 30, pages 147 - 56-
DESCRIPTION- SCHOONJANS ET AL., MOL REPROD DEV, (1996), vol. 45, pages 439 - 43-
DESCRIPTION- SCHWARTZBERG ET AL., SCIENCE, (1989), vol. 246, pages 799 - 803-
DESCRIPTION- SCHWARTZ; CANTOR, CELL, (1984), vol. 37, pages 67 - 75-
DESCRIPTION- SHIZUYA ET AL., PROC NATL ACAD SCI USA, (1992), vol. 89, pages 8794 - 7-
DESCRIPTION- SMITHIES ET AL., NATURE, (1985), vol. 317, pages 230 - 234-
DESCRIPTION- SOUTHERN, J., MOL. BIOL., (1975), vol. 98, page 503-
DESCRIPTION- SUBRAMANIAN ET AL., PROG NUCLEIC ACID RES MOL BIOL, (1976), vol. 19, pages 157 - 64-
DESCRIPTION- TAN ET AL., CHEMISTRY, (2000), vol. 6, pages 1107 - 11-
DESCRIPTION- THIMMAPPAYA ET AL., J BIOL CHEM, (1978), vol. 253, pages 1613 - 8-
DESCRIPTION- THOMAS ET AL., CELL, (1987), vol. 51, pages 503 - 512-
DESCRIPTION- THOMAS ET AL., NATURE, (1990), vol. 346, pages 847 - 850-
DESCRIPTION- THOMPSON; GRAY, J CELL BIOCHEM SUPPL, (1993), pages 139 - 43-
DESCRIPTION- THOMSON ET AL., CELL, (1989), vol. 5, pages 313 - 321-
DESCRIPTION- THRESHER ET AL., J MOL BIOL, (1995), vol. 254, pages 364 - 71-
DESCRIPTION- TILLETT; NEILAN, BIOTECHNIQUES, (1998), vol. 24, no. 572, pages 568 - 70-
DESCRIPTION- TILLETT; NEILAN, BIOTECHNIQUES, (1998), vol. 24, pages 568 - 70-
DESCRIPTION- TOMIZUKA, K.; SHINOHARA, T.; YOSHIDA, H.; UEJIMA, H.; OHGUMA, A.; TANAKA, S.; SATO, K.; OSHIMURA, M.; ISHIDA, I., PROC NATL ACAD SCI (USA, (2000), vol. 97, pages 722 - 727-
DESCRIPTION- WAKAYAMA ET AL., NAT GENET, (2000), vol. 24, pages 108 - 9-
DESCRIPTION- WAKAYAMA ET AL., NATURE, (1998), vol. 394, pages 369 - 74-
DESCRIPTION- WAKAYAMA ET AL., PROC NATL ACAD SCI USA, (1999), vol. 96, pages 14984 - 9-
DESCRIPTION- WANG ET AL., MECH DEV, (1997), vol. 62, pages 137 - 45-
DESCRIPTION- WILLERS, J.; KOLB, C.; WEILER, E., IMMUNOBIOLOGY, (2000), vol. 200, pages 150 - 164-
DESCRIPTION- WILMUT ET AL., NATURE, (1997), vol. 385, pages 810 - 3-
DESCRIPTION- WILMUT ET AL., REPROD FERTIL DEV, (1998), vol. 10, pages 639 - 43-
DESCRIPTION- WOOD ET AL., NATURE, (1993), vol. 365, pages 87 - 9-
DESCRIPTION- W WURST; A. GOSSLER, JOYNER, THE PRACTICAL APPROACH SERIES, (1999), vol. 293-
DESCRIPTION- YANG ET AL., NAT BIOTECHNOL, (1997), vol. 15, pages 859 - 65-
DESCRIPTION- YU ET AL., PROC NATL ACAD SCI USA, (2000), vol. 97, pages 5978 - 83-
DESCRIPTION- ZHANG ET AL., NAT GENET, (1998), vol. 20, pages 123 - 8-
OPPOSITION- Storb: Immunoglobulin.Genes (2nd.edition)-
OPPOSITION- Taki et al, Science,262(19) 1268-1.271-
OPPOSITION- Wei Shen, Yue Huang, Yi Tang, De-Pei Liu, Chih-Chuan Liang, "A General Method to Modify BACs to Generate Large Recombinant DNA Fragments", MOLECULAR BIOTECHNOLOGY, vol. 31, (20050101), pages 181 - 186, MOLECULAR BIOTECHNOLOGY, XP055765621-
OPPOSITION- WU et al., Nature protocols, (20080000), vol. 3, no. 6, pages 1056 - 1076-
OPPOSITION- WALLACE HELEN A C ET AL, "Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence", Cell, Elsevier, Amsterdam NL, Amsterdam NL, (20070101), vol. 128, no. 1, doi:10.1016/j.cell.2006.11.044, ISSN 0092-8674, pages 197 - 209, XP002481713
OPPOSITION- Brian B. Haines et al, "Germline diversity of the expressed BALB/c VhJ558 gene family", Molecular immunology, Pergamon, (20010101), vol. 38, no. 1, doi:10.1016/S0161-5890(01)00049-9, ISSN 01615890, pages 9 - 18, XP055100351
OPPOSITION- VALENZUELA D M ET AL, "High-throughput engineering of the mouse genome coupled with high-resolution expression analysis", Nature Biotechnology, Gale Group Inc., New York, us, us, (20030601), vol. 21, no. 6, doi:10.1038/NBT822, ISSN 1087-0156, pages 652 - 659, XP002615215
OPPOSITION- Z. H. Lu, Books Jason T, Kaufman Richard M, Ley Timothy J, "Long targeting arms do not increase the efficiency of homologous recombination in the �-globin locus of murine embryonic stem cells", Blood, American Society of Hematology, US, US, (20030101), vol. 102, no. 4, doi:10.1182/blood-2003-03-0708, ISSN 0006-4971, pages 1531 - 1533, XP055303531

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents