Troponin As Marker For Intermittent Atrial Fibrillation - EP3088900

The patent EP3088900 was granted to F Hoffmann LA Roche on Aug 12, 2020. The application was originally filed on Oct 17, 2012 under application number EP16175468A. The patent is currently recorded with a legal status of "Revoked".

EP3088900

F HOFFMANN LA ROCHE
Application Number
EP16175468A
Filing Date
Oct 17, 2012
Status
Revoked
Feb 23, 2024
Publication Date
Aug 12, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MATHYS & SQUIREMay 12, 2021GRIFFIN -

Patent Citations (6) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONEP0648228
DESCRIPTIONUS5744305
DESCRIPTIONWO02083913
DESCRIPTIONWO02089657
OPPOSITIONWO2010007041
OPPOSITIONWO2012025355

Non-Patent Literature (NPL) Citations (73) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ADAMS H.P. ET AL., STROKE, (1993), vol. 24, pages 35 - 41
DESCRIPTION- ANDERSON, CIRCULATION RESEARCH, (1995), vol. 76, no. 4, pages 681 - 686
DESCRIPTION- ANDERSON JL, "ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction.", J AM COLL CARDIOL., (2007), vol. 50, no. 7
DESCRIPTION- "An introduction to stroke", Stroke Genetics, OXFORD UNIVERSITY PRESS, INCORPORATED
DESCRIPTION- BONOW, CIRCULATION, (1996), vol. 93, pages 1946 - 1950
DESCRIPTION- CAIRNS J.A. ET AL., CANADIAN J OF CARDIOLOGY, (2011), vol. 27, pages 74 - 90
DESCRIPTION- CAMM A.J. ET AL., EUR HEART JOURNAL, (2010), vol. 31, pages 2369 - 429
DESCRIPTION- "Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment", STROKE, vol. 24, no. 1, pages 35 - 41
DESCRIPTION- CONNOLLY S.J. ET AL., NEJM, (2010), vol. 261, pages 1139 - 51
DESCRIPTION- DONNAN GA; FISHER M; MACLEOD M; DAVIS SM, "Stroke", LANCET, (200805), vol. 371, no. 9624, pages 1612 - 23
DESCRIPTION- FERRIERES, CLINICAL CHEMISTRY, (1998), vol. 44, pages 487 - 493
DESCRIPTION- FUSTER ET AL., J AM COLL CARDIOL, (2001), vol. 38, page 1231
DESCRIPTION- FUSTER V. ET AL., CIRCULATION, (2006), pages 114 - 257
DESCRIPTION- FUSTER V; RY-DEN LE; ASINGER RW ET AL., "ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation", CIRCULATION, (20011023), vol. 104, no. 17, pages 2118 - 50
DESCRIPTION- "Guidelines for the Early Management of Adults With Ischemic Stroke", ADAMS ET AL., A Guideline From the American Heart Association, AMERICAN STROKE ASSOCIATION STROKE COUNCIL, (2007), vol. 38, page 1655
DESCRIPTION- KAMEL H. ET AL., CURR ATHEROSCLER REP, (2011), vol. 13, pages 338 - 343
DESCRIPTION- KARL, SCAND J CLIN LAB INVEST, (1999), vol. 230, pages 177 - 181
DESCRIPTION- MASSON ET AL., CURR HEART FAIL REP, (2010), vol. 7, pages 15 - 21
DESCRIPTION- MOSES ET AL., PNAS USA, (1999), vol. 96, no. 6, pages 2645 - 2650
DESCRIPTION- MUELLER, CLIN CHEM LAB MED, (2004), vol. 42, pages 942 - 4
DESCRIPTION- NEEDLEMAN; WUNSCH, J. MOL. BIOL., (1970), vol. 48, page 443
DESCRIPTION- NOLAN, TRENDS BIOTECH-NOL, (2002), vol. 20, no. 1, pages 9 - 12
DESCRIPTION- OMLAND ET AL., N ENGL J MED, (2009), vol. 361, no. 26, pages 2538 - 2547
DESCRIPTION- PATEL M.R. ET AL., NEJM, (2011), vol. 365, pages 883 - 91
DESCRIPTION- PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. (USA, (1988), vol. 85, page 2444
DESCRIPTION- RIZOS T., CEREBROVASC. DIS, (2011), vol. 32, pages 276 - 282
DESCRIPTION- RODRIGUEZ-YANEZ ET AL., DISEASE MARKERS, (2009), vol. 26, pages 189 - 195
DESCRIPTION- SMITH, J ENDOCRINOL, (2000), vol. 167, pages 239 - 46
DESCRIPTION- SMITH; WATERMAN, ADD. APL. MATH., (1981), vol. 2, page 482
DESCRIPTION- SONG ET AL., JOURNAL OF CLINICAL NEUROLOGY, (2006), vol. 4, pages 75 - 83
DESCRIPTION- VAN DER WORP B; VAN GIJN J., NEJM, (2007), vol. 357, pages 572 - 578
DESCRIPTION- WALLACE ET AL., "Prevalence and determinants of troponin T elevation in the general population.", CIRCULATION, (2006), vol. 113, no. 16, pages 1958 - 1965
DESCRIPTION- WU, CLIN CHEM, (2004), vol. 50, pages 867 - 73
DESCRIPTION- YEO, CLINICA CHIMICA ACTA, (2003), vol. 338, pages 107 - 115
DESCRIPTION- ZWEIG, CLIN. CHEM., (1993), vol. 39, pages 561 - 577
OPPOSITION- Mcclatchey Kenneth D., Ami, "Unstable Angina and AMI", Clinical Laboratory Medicine, 2nd Edition C, Lippincott Williams & Wilkins, (20020101), XP055959995
OPPOSITION- Michael J Conrad, Petr Jarolim, "Cardiac Troponins and High­ sensitivity Cardiac Troponin Assays", Clin Lab Med, (20140101), vol. 34, pages 59 - 73, XP055625696
OPPOSITION- Michiel Rienstra, Steven A. Lubitz, Saagar Mahida, Jared W. Magnani, João D. Fontes, Moritz F. Sinner, Isabelle C. Van Gelder, Patrick T. Ellinor, And Emelia J. Benjamin, "Symptoms and Functional Status of Patients With Atrial Fibrillation State of the Art and Future Research Opportunities", CIRCULATION, (20120101), vol. 125, pages 2933 - 2943, XP055740424
OPPOSITION- Shave, R. ; Baggish, A. ; George, K. ; Wood, M. ; Scharhag, J. ; Whyte, G. ; Gaze, D. ; Thompson, P.D., "Exercise-Induced Cardiac Troponin Elevation", Journal of the American College of Cardiology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20100713), vol. 56, no. 3, ISSN 0735-1097, pages 169 - 176, XP027182013
OPPOSITION- James A De Lemos, Mark H. Drazner, Md, Msc; Torbjorn Omland, Md, Phd; Colby R. Ayers, Ms; Amit Khera, Md, Msc; Anand Rohatgi, Md; Ibrahim Hashim, Phd, Msc; Jarett D. Berry, Md, Ms; Sandeep R. Das, Md, Mph; David A. Morrow, Md, Mph; Darren K. Mcguire, Md, Mhsc , "Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population", JAMA, (20101208), vol. 304, no. 22, pages 2503 - 2512, XP055059960
OPPOSITION- Masson Serge, Latini Roberto, Anand Inder S., "An Update on Cardiac Troponins as Circulating Biomarkers in Heart Failure", CURRENT HEART FAILURE REPORTS, CURRENT SCIENCE INC., PHILADELPHIA, PA,, US, US , (20100301), vol. 7, no. 1, doi:10.1007/s11897-010-0001-0, ISSN 1546-9530, pages 15 - 21, XP055959986
OPPOSITION- Gahlmann, R. ; Wade, R. ; Gunning, P. ; Kedes, L., "Differential expression of slow and fast skeletal muscle troponin C - Slow skeletal muscle troponin C is expressed in human fibroblasts", Journal of Molecular Biology, Academic Press, United Kingdom, United Kingdom , (19880520), vol. 201, no. 2, doi:10.1016/0022-2836(88)90145-3, ISSN 0022-2836, pages 379 - 391, XP024009812
OPPOSITION- A.K. Saenger; R. Beyrau; S. Braun; R. Cooray; A. Dolci; H. Freidank; E. Giannitsis; S. Gustafson; B. Handy; H. Katus; S.E. Melanson; M. Panteghini; P. Venge; M. Zorn; P. Jarolim; D. Bruton; J. Jarausch; A.S. Jaffe;, "Multicenter analytical evaluation of a high-sensitivity troponin T assay", CLINICA CHIMICA ACTA, Elsevier BV, AMSTERDAM, NL, AMSTERDAM, NL , (20101227), vol. 412, no. 9, doi:10.1016/j.cca.2010.12.034, ISSN 0009-8981, pages 748 - 754, XP028148110
OPPOSITION- Omland Torbjørn, Pfeffer Marc A., Solomon Scott D., De Lemos James A., Røsjø Helge, Šaltytė Benth Jūratė, Maggioni Aldo, Domanski Michael J., Rouleau Jean L., Sabatine Marc S., Braunwald Eugene, "Prognostic Value of Cardiac Troponin I Measured With a Highly Sensitive Assay in Patients With Stable Coronary Artery Disease", Journal of the American College of Cardiology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20130326), vol. 61, no. 12, doi:10.1016/j.jacc.2012.12.026, ISSN 0735-1097, pages 1240 - 1249, XP055959980
OPPOSITION- Lowbeer, C. Seeberger, A. Gustafsson, S.A. Bouvier, F. Hulting, J., "Serum cardiac troponin T, troponin I, plasma BNP and left ventricular mass index in professional football players", Journal of Science and Medicine in Sport, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20070824), vol. 10, no. 5, doi:10.1016/j.jsams.2006.10.002, ISSN 1440-2440, pages 291 - 296, XP022211854
OPPOSITION- Beaulieu-Boire Isabelle, Leblanc Nancy, Berger Léo, Boulanger Jean-Martin, "Troponin Elevation Predicts Atrial Fibrillation in Patients with Stroke or Transient Ischemic Attack", JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES, DEMOS PUBLICATIONS, NEW YORK, NY, US, US , (20131001), vol. 22, no. 7, doi:10.1016/j.jstrokecerebrovasdis.2012.01.008, ISSN 1052-3057, pages 978 - 983, XP055959963
OPPOSITION- Mallamaci Francesca; Zoccali Carmine; Parlongo Saverio; Tripepi Giovanni; Benedetto Francesco A.; Cutrupi Sebastiano; Bonanno Graziella; Fatuzzo Pasquale; Rapisarda Francesco; Seminara Giuseppe; Stancanelli Benedetta; Bellanuova Ignazio; Cataliotti Alessando; Malatino Lorenzo S., "Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients", American Journal of Kidney Diseases, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (19000101), vol. 40, no. 1, doi:10.1053/ajkd.2002.33914, ISSN 0272-6386, pages 68 - 75, XP028836442
OPPOSITION- Torbjørn Omland, James A. De Lemos, Marc S. Sabatine,M.P.H., Costas A. Christophi, Madeline Murguia Rice, Kathleen A. Jablonski, Solve Tjora, Michael J. Domanski, Bernard J. Gersh, M.B., Ch.B., D.Phil., Jean L. Rouleau, "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease", N. Engl. J. Med., (20090101), vol. 361, doi:10.1056/NEJMoa0805299, pages 2538 - 2547, XP055740301
OPPOSITION- J. Sundstrom, E. Ingelsson, L. Berglund, B. Zethelius, L. Lind, P. Venge, J. Arnlov, "Cardiac troponin-I and risk of heart failure: a community-based cohort study", European Heart Journal, No longer published by Elsevier, (20080101), vol. 30, no. 7, doi:10.1093/eurheartj/ehp047, ISSN 0195668X, pages 773 - 781, XP055051011
OPPOSITION- K. Thygesen, J. Mair, H. Katus, M. Plebani, P. Venge, P. Collinson, B. Lindahl, E. Giannitsis, Y. Hasin, M. Galvani, M. Tubaro, J. S. Alpert, L. M. Biasucci, W. Koenig, C. Mueller, K. Huber, C. Hamm, A. S. Jaffe, "Recommendations for the use of cardiac troponin measurement in acute cardiac care", European Heart Journal, Oxford University Press, GB, GB , (20100902), vol. 31, no. 18, doi:10.1093/eurheartj/ehq251, ISSN 0195-668X, pages 2197 - 2204, XP055413063
OPPOSITION- A. J. Camm, P. Kirchhof, G. Y. H. Lip, U. Schotten, I. Savelieva, S. Ernst, I. C. Van Gelder, N. Al-Attar, G. Hindricks, B. Prendergast, H. Heidbuchel, O. Alfieri, A. Angelini, D. Atar, P. Colonna, R. De Caterina, J. De Sutter, A. Goette, B. Gorenek, M. Heldal, S. H. Hohloser, P. Kolh, J.-Y. Le Heuzey, P. Ponikowski, F. H. Rutten, A. Vahanian, A. Auricchio, J. Bax, C. Ceconi, V. Dean, G. Filippatos, C. Funck-Brentano, R. Hobbs, P. Kearney, T. Mcdonagh, B. A. Popescu, Z. Reiner, U. Sechtem, P. A. Sirnes, M. Tendera, P. E. Vardas, P. Widimsky, V. Agladze, E. Aliot, T. Balabanski, C. Blomstrom-Lundqvist, A. Capucci, H. Crijns, B. Dahlof, T. Folliguet, M. Glikson, M. Goethals, D. C. Gulba, S. Y. Ho, R. J. M. Klautz, S. Kose, J. Mcmurray, P. Perrone Filardi, P. Raatikainen, M. J. Salvador, M. J. Schalij, A. Shpektor, J. Sousa, J. Stepinska, H. Uuetoa, J. L. Zamorano, I. Zupan, "Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)", European Heart Journal, No longer published by Elsevier, (20101001), vol. 31, no. 19, doi:10.1093/eurheartj/ehq278, ISSN 0195668X, pages 2369 - 2429, XP055124167
OPPOSITION- E. J. Van Den Bos, Constantinescu A. A., Van Domburg R. T., Akin S., Jordaens L. J., Kofflard M. J. M., "Minor elevations in troponin I are associated with mortality and adverse cardiac events in patients with atrial fibrillation", European Heart Journal, No longer published by Elsevier, (20110301), vol. 32, no. 5, doi:10.1093/eurheartj/ehq491, ISSN 0195668X, pages 611 - 617, XP055029203
OPPOSITION- Kristian Thygesen, Johannes Mair, Evangelos Giannitsis, Christian Mueller, Bertil Lindahl, Stefan Blankenberg, Kurt Huber, Mario Plebani, Luigi M. Biasucci, Marco Tubaro, Paul Collinson, Per Venge, Yonathan Hasin, Marcello Galvani, Wolfgang Koenig, Christian Hamm, Joseph S. Alpert, Hugo Katus, Allan S. Jaffe, "How to use high-sensitivity cardiac troponins in acute cardiac care", EUROPEAN HEART JOURNAL, (20120101), vol. 33, doi:10.1093/eurheartj/ehs154, pages 2252 - 2257, XP055740123
OPPOSITION- Kirchhof Paulus, Gregory Y H Lip, Isabelle C Van Gelder, Jeroen Bax, Elaine Hylek, Stefan Kaab, Ulrich Schotten, Karl Wegscheider, Giuseppe Boriani, Axel Brandes, Michael Ezekowitz, Hans Diener, Laurent Haegeli, Hein Heidbuchel, Deirdre Lane, Luis Mont, Stephan Willems, Paul Dorian, Maria Aunes-Jansson, Carina Blomstrom-Lundqvist, Maria Borentain, Stefanie Breitenstein, Martina Brueckmann, Nilo Cater, Andreas Clemens, Dobromir Dobrev, Sergio Dubner, Nils G Edvardsson, Leif Friberg, Andreas Goette, Michele Gulizia, Robert Hatala, Jenny Horwood, Lukas Szumowski, Lukas Kappenberger, Josef Kautzner, Angelika Leute, Trudie Lobban, Ralf Meyer, Jay Millerhagen, John Morgan, Felix Muenzel, Michael Nabauer, Christoph Baertels, Michael Oeff, Dieter Paar, Juergen Polifka, Ursula Ravens, Ludger Rosin, W Stegink, Gerhard Steinbeck, Panos Vardas, Alphons Vincent, Maureen Walter, Günter Breithardt, A John Camm, "Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference", EUROSPACE, (20120101), vol. 14, doi:10.1093/europace/eur241, pages 8 - 27, XP055740416
OPPOSITION- Brugts Jasper J; Akin Sakir; Helming Anne-Mijntje; Loonstra Simone; van den Bos Ewout J; Kofflard Marcel J M, "The predictive value of cardiac biomarkers in prognosis and risk stratification of patients with atrial fibrillation", CURRENT OPINION IN CARDIOLOGY., GOWER ACADEMIC JOURNALS, LONDON., GB, GB , (20110901), vol. 26, no. 5, doi:10.1097/HCO.0b013e3283499ed3, ISSN 0268-4705, pages 449 - 456, XP008152363
OPPOSITION- R. Latini, S. Masson, S. Pirelli, S. Barlera, G. Pulitano, E. Carbonieri, M. Gulizia, T. Vago, C. Favero, D. Zdunek, J. Struck, L. Staszewsky, A. P. Maggioni, M. G. Franzosi, M. Disertori, "Circulating cardiovascular biomarkers in recurrent atrial fibrillation: data from the GISSI-Atrial Fibrillation Trial", Journal of Internal Medicine, Blackwell Scientific Publications, (20110201), vol. 269, no. 2, doi:10.1111/j.1365-2796.2010.02287.x, ISSN 09546820, pages 160 - 171, XP055048526
OPPOSITION- Schotten Ulrich, Verheule Sander, Kirchhof Paulus, Goette Andreas, "Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal", PHYSIOLOGICAL REVIEWS, AMERICAN PHYSIOLOGICAL SOCIETY, US, US , (20110101), vol. 91, no. 1, doi:10.1152/physrev.00031.2009, ISSN 0031-9333, pages 265 - 325, XP055959974
OPPOSITION- Kerr Gillian; Ray Gautamananda; Wu Olivia; Stott David J; Langhorne Peter, "Elevated troponin after stroke: a systematic review.", CEREBROVASCULAR DISEASES, KARGER, BASEL,, CH, CH , (20090801), vol. 28, no. 3, doi:10.1159/000226773, ISSN 1015-9770, pages 220 - 226, XP008150080
OPPOSITION- Bugnicourt Jean-Marc; Rogez Vincent; Guillaumont Marie-Pierre; Rogez Jean-Claude; Canaple Sandrine; Godefroy Olivier, "Troponin levels help predict new-onset atrial fibrillation in ischaemic stroke patients: a retrospective study.", European Neurology, S. Karger AG, Switzerland, Switzerland , (20100101), vol. 63, no. 1, doi:10.11591000258679, ISSN 0014-3022, pages 24 - 28, XP008152374
OPPOSITION- Tilson M. David, "The Polymorphonuclear Leukocyte and the Abdominal Aortic Aneurysm : A Neglected Cell Type and a Neglected Disease", Circulation, American Heart Association, US, US , (20050712), vol. 112, no. 2, doi:10.1161/CIRCULATIONAHA.105.553370, ISSN 0009-7322, pages 154 - 156, XP055959967
OPPOSITION- ZETHELIUS BJÖRN ET AL, "Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study.", CIRCULATION, American Heart Association, Inc., US, US , (20060228), vol. 113, no. 8, doi:10.1161/CIRCULATIONAHA.105.570762, ISSN 1524-4539, pages 1071 - 1078, XP002399990
OPPOSITION- Benjamin Emelia J., Chen Peng-Sheng, Bild Diane E., Mascette Alice M., Albert Christine M., Alonso Alvaro, Calkins Hugh, Connolly Stuart J., Curtis Anne B., Darbar Dawood, Ellinor Patrick T., Go Alan S., Goldschlager Nora F., Heckbert Susan R., Jalife José, Kerr Charles R., Levy Daniel, Lloyd-Jones Donald M., Massie Barry M., Nattel Stanley, Olgin Jeffrey E., Packer Douglas L., Po Sunny S., Tsang Teresa S.M., Van Wagoner David R., Waldo Albert L., Wyse D. George, "Prevention of Atrial Fibrillation : Report From a National Heart, Lung, and Blood Institute Workshop", Circulation, American Heart Association, US, US , (20090203), vol. 119, no. 4, doi:10.1161/CIRCULATIONAHA.108.825380, ISSN 0009-7322, pages 606 - 618, XP055959971
OPPOSITION- Hijazi Ziad, Jonas Oldgren, Ulrika Andersson, Stuart J. Connolly, Michael D. Ezekowitz, Stefan H. Hohnloser, Paul A. Reilly, Dragos Vinereanu, Agneta Siegbahn, Salim Yusuf, And Lars Wallentin, "Cardiac Biomarkers Are Associated With an Increased Risk of Stroke and Death in Patients With Atrial Fibrillation A Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Substudy", Circulation, (20120101), vol. 125, doi:10.1161/CIRCULATIONAHA.112.133546, pages 1605 - 1616, XP055740237
OPPOSITION- Jan F Scheitz;Hans-Christian Mochmann;Christian H Nolte;Karl G Haeusler;Heinrich J Audebert;Peter U Heuschmann;Ulrich Laufs;Bernhard Witzenbichler;Heinz-Peter Schultheiss;Matthias Endres, "Troponin elevation in acute ischemic stroke (TRELAS) - protocol of a prospective observational trial", BMC NEUROLOGY, BIOMED CENTRAL LTD., LONDON, GB, GB , (20110808), vol. 11, no. 1, doi:10.1186/1471-2377-11-98, ISSN 1471-2377, page 98, XP021091996
OPPOSITION- Cadamuro, Et Al., "Cardiac troponins T and I: reproducible discrepancies in the clinical setting", CLIN. CHEM., (20110101), vol. 57, no. 1, doi:10.1373/clinchem.2010.151241, pages 134 - 140, XP055740219
OPPOSITION- Lieke J J Klinkenberg, Karin Wildi, Noreen Van Der Linden, Lmre W.K. Kouw, Marijke Niens, Raphael Twerenbold, Maria Rubini Gimenez, Christian Puelacher, Jean Daniel Neuhaus, Petra Hillinger, Thomas Nestelberger, Jasper Boeddingaus, Karin Grimm, Zaid Sabti, Judith A.P. Bons, Jeroen D.E. Van Suijlen, Frans E.S. Tan, Joop Ten Kate, Otto Bekers, Luc J.C. Van Loon, Marja P. Van Dieijen -Visser, Christian Mueller, And Steven J.R. Meex, "Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction", Clnical Chemistry, (20160101), vol. 62, no. 12, doi:10.1373/clinchem.2016.257485, pages 1602 - 1611, XP055625693
SEARCH- JOSEF FINSTERER ET AL, "Positive troponin-T in noncompaction is associated with neuromuscular disorders and poor outcome", CLINICAL RESEARCH IN CARDIOLOGY, STEINKOPFF-VERLAG, DA, (20061208), vol. 96, no. 2, ISSN 1861-0692, pages 109 - 113, XP019490963 [A] 1-13 * page 110, column 1 - column 2; tables 1,2 *
SEARCH- A. GOETTE ET AL, "Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles", EUROPEAN HEART JOURNAL, GB, (20090305), vol. 30, no. 11, doi:10.1093/eurheartj/ehp046, ISSN 0195-668X, pages 1411 - 1420, XP055300688 [Y] 1-13 * abstract *
SEARCH- E. J. VAN DEN BOS ET AL, "Minor elevations in troponin I are associated with mortality and adverse cardiac events in patients with atrial fibrillation", EUROPEAN HEART JOURNAL, (20110120), vol. 32, no. 5, doi:10.1093/eurheartj/ehq491, ISSN 0195-668X, pages 611 - 617, XP055029203 [X] 1,2,6,12 * abstract * * page 612, column 2, paragraph 1 * [I] 1-13
SEARCH- BRUGTS JASPER J ET AL, "The predictive value of cardiac biomarkers in prognosis and risk stratification of patients with atrial fibrillation", CURRENT OPINION IN CARDIOLOGY, GOWER ACADEMIC JOURNALS, LONDON, GB, (20110901), vol. 26, no. 5, doi:10.1097/HCO.0B013E3283499ED3, ISSN 0268-4705, pages 449 - 456, XP008152363 [Y] 1-13 * abstract * * table 1 * * page 449, column 1, paragraph l - page 451 * * reference 47; pages 453,456 *
SEARCH- R. LATINI ET AL, "Circulating cardiovascular biomarkers in recurrent atrial fibrillation: data from the GISSI-Atrial Fibrillation Trial", JOURNAL OF INTERNAL MEDICINE, (20110201), vol. 269, no. 2, doi:10.1111/j.1365-2796.2010.02287.x, ISSN 0954-6820, pages 160 - 171, XP055048526 [A] 1-13 * abstract * * page 161, column 1, paragraph 1 *
SEARCH- FOREMAN J H ET AL, "Cardiac troponin-1 plasma concentration in normal horses and in horses with arrhythmias and toxicities", JOURNAL OF VETERINARY INTERNAL MEDICINE, LIPPINCOTT, PHILADELPHIA, US, vol. 19, no. 3, doi:10.1111/J.1939-1676.2005.TB00640.X, ISSN 0891-6640, (20050501), page 478, (20080910), XP008152372 [A] 1-13 * abstract *
SEARCH- BUGNICOURT JEAN-MARC ET AL, "Troponin levels help predict new-onset atrial fibrillation in ischaemic stroke patients: a retrospective study", EUROPEAN NEUROLOGY, S. KARGER AG, SWITZERLAND, vol. 63, no. 1, doi:10.11591000258679, ISSN 0014-3022, (20100101), pages 24 - 28, (20091117), XP008152374 [A] 1-13 * abstract *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents