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Il-15 Heterogeneous Dimer Protein And Uses Thereof - EP3093295

The patent EP3093295 was granted to Jiangsu Hengrui Medicine on May 27, 2020. The application was originally filed on Dec 25, 2014 under application number EP14878154A. The patent is currently recorded with a legal status of "Revoked".

EP3093295

JIANGSU HENGRUI MEDICINE
Application Number
EP14878154A
Filing Date
Dec 25, 2014
Status
Revoked
Jun 2, 2023
Grant Date
May 27, 2020
External Links
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MARGARET DIXONMar 1, 2021MEWBURN ELLISADMISSIBLE

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONCN100334112C
DESCRIPTIONCN101360827B
DESCRIPTIONCN1942481
DESCRIPTIONUS2010286374
DESCRIPTIONUS4683195
INTERNATIONAL-SEARCH-REPORTCN1760209
INTERNATIONAL-SEARCH-REPORTWO2012040323
OPPOSITIONUS2006257361
OPPOSITIONUS2009238791
OPPOSITIONWO2005085282
OPPOSITIONWO2009002562
OPPOSITIONWO2012146628
OPPOSITIONWO9627011
SEARCHUS2006257361
SEARCHWO2012146628

Non-Patent Literature (NPL) Citations (29) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- DUBOIS, SIGRID et al., "Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8(+)/CD44(high) T cells and its antitumor action", The Journal of Immunology, US , (20080201), vol. 180, no. 4, ISSN 0022-1767, pages 2099 - 2106, XP002582129-
OPPOSITION- Landolfi N.F., "A chimeric IL-2/Ig molecule possesses the functional activity of both proteins", Journal of Immunology, (19910201), vol. 146, no. 3, pages 915 - 919, XP055982867-
OPPOSITION- RIDGWAY ET AL, "'KNOBS-INTO-HOLES' ENGINEERING OF ANTIBODY CH3 DOMAINS FOR HEAVY CHAIN HETERODIMERIZATION", PROTEIN ENGINEERING, GB , (19960101), vol. 9, no. 7, ISSN 0269-2139, pages 617 - 621, XP002084766-
OPPOSITION- STOKLASEK T A, SCHLUNS K S, LEFRANCOIS L, "Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo", The Journal of Immunology, US , (20061101), vol. 177, no. 9, ISSN 0022-1767, pages 6072 - 6080, XP002521797-
OPPOSITION- Xia Zong-Jing, Kong Xiang-Li, Zhang Ping, "In vivo Effect of Recombined IL-15/Fc Fusion Protein on EAU", J Sichuan Univ (Med Sci Edi), (20080101), vol. 39, no. 6, pages 944 - 949, XP055982845-
OPPOSITION- YON SU KIM ET AL, "Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fcgamma2a protein blocks delayed-type hypersensitivity.", The Journal of Immunology, US , (19980615), vol. 160, no. 12, ISSN 0022-1767, pages 5742 - 5748, XP002185136-
OPPOSITION- ZHENG X. X. et al., "ADMINISTRATION OF NONCYTOLYTIC IL-10/FC IN MURINE MODELS OF LIPOPOLYSACCHARIDE-INDUCED SEPTIC SHOCK AND ALLOGENEIC ISLET TRANSPLANTATION.", The Journal of Immunology, US , (19950101), vol. 154, ISSN 0022-1767, pages 5590 - 5600, XP002061428-
OPPOSITION- Ashlesha Deshpande, Balananda-Dhurjati Kumar Putcha, Srilalitha Kuruganti, Mark R. Walter, "Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers", Protein Science, US , (20130801), vol. 22, no. 8, doi:10.1002/pro.2285, ISSN 0961-8368, pages 1100 - 1108, XP002745726
OPPOSITION- Shane Atwell , John B.B Ridgway ,James A Wells , Paul Carter, "Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library", Journal of Molecular Biology, United Kingdom , (19970701), vol. 270, no. 1, doi:10.1006/jmbi.1997.1116, ISSN 0022-2836, pages 26 - 35, XP000885572
OPPOSITION- James W. Larrick, Andrew Mendelsohn, Vik Sharma, Jianming Wang, Jeff Fang, Manley Huang, John M. Wages, Susan C.Wright, "Chapter 28 - Trophokines: Novel Therapy for Senescence- Related Fibrosis", Inflammation, Advancing Age and Nutrition, (20140101), doi:10.1016/B978-0-12-397803-5.00028-9, pages 333 - 344, XP055982875
OPPOSITION- Kai-ping Han; Xiaoyun Zhu; Bai Liu; Emily Jeng; Lin Kong; Jason L. Yovandich; Vinay V. Vyas; Warren D. Marcus; Pierre-Andre Chavaillaz; Christian A. Romero; Peter R. Rhode; Hing C. Wong;, "IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization", Cytokine, US , (20110928), vol. 56, no. 3, doi:10.1016/j.cyto.2011.09.028, ISSN 1043-4666, pages 804 - 810, XP028115119
OPPOSITION- CARTER PAUL, "Bispecific human IgG by design", Journal of Immunological Methods, NL , (20010101), vol. 248, no. 1-2, doi:10.1016/S0022-1759(00)00339-2, ISSN 0022-1759, pages 7 - 15, XP002974199
OPPOSITION- MERCHANT A MARGARET ET AL., "An efficient route to human bispecific IgG", Nature Biotechnology, New York, (19980701), vol. 16, no. 7, doi:10.1038/nbt0798-677, ISSN 1087-0156, pages 677 - 681, XP002141015
OPPOSITION- RUBINSTEIN MARK P ET AL, "Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}", Proceedings of the National Academy of Sciences, (20060613), vol. 103, no. 24, doi:10.1073/pnas.0600240103, ISSN 0027-8424, pages 9166 - 9171, XP002521796
OPPOSITION- MORTIER ERWAN, ET AL, "Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.", Journal of Biological Chemistry, US , (20060120), vol. 281, no. 3, doi:10.1074/jbc.M508624200, ISSN 0021-9258, pages 1612 - 1619, XP002394330
OPPOSITION- Maria Laura Belladonna, Ursula Grohmann, "Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents", BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, GB , (20131001), vol. 29, no. 2, doi:10.1080/02648725.2013.801228, ISSN 0264-8725, pages 149 - 174, XP055236875
OPPOSITION- LOW S C ET AL, "Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis", Human Reproduction, GB , (20050701), vol. 20, no. 7, doi:10.1093/humrep/deh896, ISSN 0268-1161, pages 1805 - 1813, XP002455704
OPPOSITION- Z. Wu, Y. Xu, "IL-15R -IgG1-Fc Enhances IL-2 and IL-15 Anti-tumor Action through NK and CD8+ T Cells Proliferation and Activation", Journal of Molecular Cell Biology, (20100801), vol. 2, no. 4, doi:10.1093/jmcb/mjq012, ISSN 16742788, pages 217 - 222, XP055153506
OPPOSITION- Hinrichs Christian S., "Can interleukin-15 keep its therapeutic promise? ", Science Translational Medicine, (20180307), vol. 10, no. 431, doi:10.1126/scitranslmed.aar7532, XP055982862
OPPOSITION- Xu Wenxin, Jones Monica, Liu Bai, Zhu Xiaoyun, Johnson Christopher B., Edwards Ana C., Kong Lin, Jeng Emily K., Han Kaiping, Marcus Warren D., Rubinstein Mark P., Rhode Peter R., Wong Hing C., "Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor αSu/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma", Cancer research, 2019 San Antonio Breast Cancer Symposium, San Antonio, Texas , (20130515), vol. 73, no. 10, doi:10.1158/0008-5472.CAN-12-2357, ISSN 0008-5472, pages 3075 - 3086, XP055982853
OPPOSITION- DUMONT JENNIFER A; LOW SUSAN C; PETERS ROBERT T; BITONTI ALAN J, "MONOMERIC FC FUSIONS: IMPACT ON PHARMACOKINETIC AND BIOLOGICAL ACTIVITY OF PROTEIN THERAPEUTICS.", BIODRUGS, NZ , (20060101), vol. 20, no. 3, doi:10.2165/00063030-200620030-00002, ISSN 1173-8804, pages 151 - 160, XP009082835
OPPOSITION- Klein Christian; Sustmann Claudio; Thomas Markus; Stubenrauch Kay; Croasdale Rebecca; Schanzer Juergen; Brinkmann Ulrich; Kettenberger Hubert; Regula Joerg T; Schaefer Wolfgang, "Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies", mAbs, US , (20121101), vol. 4, no. 6, doi:10.4161/mabs.21379, ISSN 1942-0862, pages 653 - 663, XP009170958
OPPOSITION- Jennifer Wu, "IL-15 Agonists: The Cancer Cure Cytokine", Journal of Molecular and Genetic Medicine, vol. 7, no. 4, doi:10.4172/1747-0862.1000085, XP055329945
SEARCH- DUBOIS SIGRID ET AL, "Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8(+)/CD44(high) T cells and its antitumor action", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (20080201), vol. 180, no. 4, ISSN 0022-1767, pages 2099 - 2106, XP002582129 [X] 1,4,5,12-18 * page 2100 - page 2101; figure 1E * [Y] 1-3,7-22-
SEARCH[ ] - SICHUAN DA XUE XUE BAO. YI XUE BAN = JOURNAL OF SICHUAN UNIVERSITY. MEDICAL SCIENCE EDITION NOV 2008, (200811), vol. 39, no. 6, ISSN 1672-173X, pages 944 - 949-
SEARCH- XIA ZONG-JING ET AL, "[In vivo effect of recombined IL-15/Fc fusion protein on EAU].", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (200811), Database accession no. NLM19253832, XP002770942 [Y] 1-3,7-22 * abstract *-
SEARCH- KAI-PING HAN ET AL, "IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 56, no. 3, doi:10.1016/J.CYTO.2011.09.028, ISSN 1043-4666, (20110928), pages 804 - 810, (20111003), XP028115119 [Y] 1,2,4-22 * page 805 *
SEARCH- Z. WU ET AL, "IL-15R -IgG1-Fc Enhances IL-2 and IL-15 Anti-tumor Action through NK and CD8+ T Cells Proliferation and Activation", JOURNAL OF MOLECULAR CELL BIOLOGY, (20100729), vol. 2, no. 4, doi:10.1093/jmcb/mjq012, ISSN 1674-2788, pages 217 - 222, XP055153506 [Y] 1,2,4-22 * page 218 *
SEARCH- W. XU ET AL, "Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor Su/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma", CANCER RESEARCH, (20130503), vol. 73, no. 10, doi:10.1158/0008-5472.CAN-12-2357, ISSN 0008-5472, pages 3075 - 3086, XP055151674 [Y] 1,2,4-22 * page 3077 *

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