Cns Delivery Of Therapeutic Agents - EP3103469

The patent EP3103469 was granted to Shire Human Genetic Therapies on Dec 9, 2020. The application was originally filed on Jun 25, 2011 under application number EP16179150A. The patent is currently recorded with a legal status of "Revoked".

EP3103469

SHIRE HUMAN GENETIC THERAPIES
Application Number
EP16179150A
Filing Date
Jun 25, 2011
Status
Revoked
Jun 6, 2025
Grant Date
Dec 9, 2020
External Links
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GREEN CROSSSep 9, 2021HGF -

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS6217552
DESCRIPTIONUS6534300
DESCRIPTIONUS6537785
OPPOSITIONEP3626258
SEARCHUS2009017005

Non-Patent Literature (NPL) Citations (86) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALTSCHUL ET AL., METHODS IN ENZYMOLOGY-
DESCRIPTION- ALTSCHUL ET AL., NUCLEIC ACIDS RES., (1997), vol. 25, pages 3389 - 3402-
DESCRIPTION- BASKIN G. ET AL., LAB ANIM. SCI., (1998), vol. 48, pages 476 - 82-
DESCRIPTION- BASKIN G. ET AL., LAB ANIM. SCI.,, (1998), vol. 48, pages 476 - 82-
DESCRIPTION- BEGLEY ET AL., CURR PHARM DES, (2008), vol. 14, pages 1566 - 1580-
DESCRIPTION- BENIAMINOVITZ ET AL., N. ENGL J. MED., (2000), vol. 342, pages 613 - 619-
DESCRIPTION- BERARD ET AL., PHARMACOTHERAPY, (1999), vol. 19, pages 1127 - 1137-
DESCRIPTION- Bioinformatics Methods and Protocols (Methods in Molecular Biology, HUMANA PRESS, (1999), vol. 132-
DESCRIPTION- BISWAS S. ET AL., NEUROSCI. LETT., (2003), page 347-
DESCRIPTION- BOBO ET AL., PROC. NATL. ACAD. SCI. U.S.A, (1994), vol. 91, pages 2076 - 2080-
DESCRIPTION- BRANCO ET AL., TRANSPLANTATION, (1999), vol. 68, pages 1588 - 1596-
DESCRIPTION- BUTT MT, TOXICOL. PATHOL., (2011), vol. 39, pages 213 - 219-
DESCRIPTION- CHIRMULE ET AL., J. VIROL., (2000), vol. 74, pages 3345 - 3352-
DESCRIPTION- DEKABAN AS, "Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights", ANN NEUROL, (1978), vol. 4, pages 345 - 56-
DESCRIPTION- DESNICK, R.J., J. INHERIT. METAB. DIS., (2004), vol. 27, no. 3, pages 385 - 410-
DESCRIPTION- DICHIRO ET AL., NEUROLOGY, (1976), vol. 26, pages 1 - 8-
DESCRIPTION- ECKHOFF ET AL., TRANSPLANTATION, (2000), vol. 69, pages 1867 - 1872-
DESCRIPTION- EKBERG ET AL., TRANSPL. INT., (2000), vol. 13, pages 151 - 159-
DESCRIPTION- FENSTERMACHER ET AL., ANN N Y ACAD SCI, (1988), vol. 531, pages 29 - 39-
DESCRIPTION- FISHWILD ET AL., CLIN. IMMUNOL., (1999), vol. 92, pages 138 - 152-
DESCRIPTION- "Galactosylceramide Lipidosis: Globoid Cell Leukodystrophy (Krabbe Disease)", WENGER , D.A ET AL., The Metabolic and Molecular Bases of Inherited Disease, MCGRAW-HILL, (2001), pages 3669 - 3687-
DESCRIPTION- "Galactosylceramide Lipidosis: Globoid Cell Leukodystrophy (Krabbe Disease)", WENGER, D.A ET AL., The Metabolic and Molecular Bases of Inherited Disease, MCGRAW-HILL, (2001), pages 3669 - 3687-
DESCRIPTION- "Galactosylceramide Lipidosis: Globoid Cell Leukodystrophy (Krabbe Disease)", WENGER, D.A. ET AL., The Metabolic and Molecular Bases of Inherited Disease, MCGRAW-HILL, (2001), pages 3669 - 3687-
DESCRIPTION- GAZIEV ET AL., BONE MARROW TRANSPLANT, (1999), vol. 25, pages 689 - 696-
DESCRIPTION- GRAHAM ET AL., J. GEN VIROL., (1977), vol. 36, page 59-
DESCRIPTION- GUMMERT ET AL., J. AM. SOC. NEPHROL., (1999), vol. 10, pages 1366 - 1380-
DESCRIPTION- HENRY, CLIN. TRANSPLANT, (1999), vol. 13, pages 209 - 220-
DESCRIPTION- HONG ET AL., SEMIN. NEPHROL., (2000), vol. 20, pages 108 - 125-
DESCRIPTION- HOOD RD, DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, (2006), page 276-
DESCRIPTION- HOVLAND DN ET AL., TOXICOL. PATHOL., (2007), vol. 35, pages 1013 - 1029-
DESCRIPTION- IDEGUCHI ET AL., NEUROSCIENCE, (2000), vol. 95, pages 217 - 226-
DESCRIPTION- ITO ET AL., J. IMMUNOL., (2000), vol. 164, pages 1230 - 1235-
DESCRIPTION- JOHANSON CE ET AL., "Multiplicity of cerebrospinal fluid functions: New challenges in health and disease", CEREBROSPINAL FLUID RES, (20080514), vol. 5, page 10, XP021038488-
DESCRIPTION- JOHNSON K., J. AM. VET. MED. ASSOC., (1970), vol. 157, pages 2057 - 64-
DESCRIPTION- KOBAYASHI T. ET AL., BRAIN RES., (1980), vol. 202, pages 479 - 83-
DESCRIPTION- KURLBERG ET AL., SCAND. J. IMMUNOL., (2000), vol. 51, pages 224 - 230-
DESCRIPTION- LANCET, (1963), vol. 2, pages 983 - 84-
DESCRIPTION- LAZORTHES ET AL., ADVANCES IN DRUG DELIVERY SYSTEMS AND APPLICATIONS IN NEUROSURGERY, pages 143 - 192-
DESCRIPTION- LEVINE S. ET AL., J. NEUROSCI. RES., (2000), vol. 60, pages 231 - 6-
DESCRIPTION- LI HH ET AL., PNAS, (1999), vol. 96, no. 25, pages 14505 - 14510-
DESCRIPTION- LIN, D ET AL., MOL. THER., (2007), vol. 15, no. 1, pages 44 - 52-
DESCRIPTION- LIN, D. ET AL., MOL. THER., (2007), vol. 15, no. 1, pages 44 - 52-
DESCRIPTION- MARINOVA-MUTAFCHIEVA ET AL., ARTHRITIS RHEUM., (2000), vol. 43, pages 638 - 644-
DESCRIPTION- MATHER, BIOL. REPROD., (1980), vol. 23, pages 243 - 251-
DESCRIPTION- MATHER ET AL., ANNALS N.Y. ACAD. SCI., (1982), vol. 383, pages 44 - 68-
DESCRIPTION- MATHEUS, MG ET AL., NEURORADIOLOGY, (2004), vol. 46, pages 666 - 672-
DESCRIPTION- MEIKLE ET AL., DIN CHEM., (1997), vol. 43, pages 1325 - 1335-
DESCRIPTION- MIDDAUGH ET AL., J. BIOL. CHEM., (1979), vol. 254, pages 367 - 370-
DESCRIPTION- MODER, ANN. ALLERGY ASTHMA IMMUNOL., (2000), vol. 84, pages 280 - 284-
DESCRIPTION- NEUFELD, E.F., Enzyme Replacement therapy. Lysosomal disorders of the Brain, OXFORD UNIVERSITY PRESS, (2004), pages 327 - 338-
DESCRIPTION- NEUFELD EF ET AL., THE METABOLIC AND MOLECULAR BASES OF INHERITED DISEASE, (2001), pages 3421 - 3452-
DESCRIPTION- NEVINS, CURR. OPIN. PEDIATR., (2000), vol. 12, pages 146 - 150-
DESCRIPTION- NGUYEN ET AL., J. NEUROSURG, (2003), vol. 98, pages 584 - 590-
DESCRIPTION- OMAYA ET AL., CANCER DRUG DELIVERY, vol. 1, pages 169 - 179-
DESCRIPTION- OOGERBRUGGE, P.M. ET AL., J. CLIN. INVEST.,, (1998), vol. 81, no. 6, pages 1790 - 4-
DESCRIPTION- PONCE RP ET AL., REGUL. TOXICOL. PHARMACOL., (2009), vol. 54, pages 164 - 182-
DESCRIPTION- PONTICELLI ET AL., DRUGS R. D., (1999), vol. 1, pages 55 - 60-
DESCRIPTION- POTTER ET AL., ANN. N.Y. ACAD. SCI, (1999), vol. 875, pages 159 - 174-
DESCRIPTION- PRITCHARD D. ET AL., VET. PATHOL., (1980), vol. 17, pages 399 - 405-
DESCRIPTION- PRZEPIORKA ET AL., BLOOD, (1998), vol. 92, pages 4066 - 4071-
DESCRIPTION- QI ET AL., TRANSPLANTATION, (2000), vol. 69, pages 1275 - 1283-
DESCRIPTION- SIMARD JM ET AL., LANCET NEUROL., (2007), vol. 6, pages 258 - 268-
DESCRIPTION- SLAVIK ET AL., IMMUNOL. RES., (1999), vol. 19, pages 1 - 24-
DESCRIPTION- STAMATOVIC SM ET AL., CURR. NEUROPHARMACOL., (2008), vol. 6, pages 179 - 192-
DESCRIPTION- The Metabolic and Molecular Basis of Inherited Disease, MCGRAW HILL, (1995), vol. II-
DESCRIPTION- TOYOSHIMA, E. ET AL., J. NEUROL. SCI., (1986), vol. 74, no. 2-3, pages 307 - 18-
DESCRIPTION- URLAUB; CHASIN, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, page 4216-
DESCRIPTION- VEDOLIN, L. ET AL., AJNR AM J NEURORADIOL, (2007), vol. 28, pages 1029 - 1033-
DESCRIPTION- WENGER, D.A., MOL. MED. TODAY, (2000), vol. 6, no. 11, pages 449 - 451-
DESCRIPTION- WISEMAN ET AL., DRUGS, (1999), vol. 58, pages 1029 - 1042-
DESCRIPTION- YEAGER A. ET AL., SCIENCE, (1984), vol. 225, pages 1052 - 4-
DESCRIPTION- ALTSCHUL ET AL., "Basic local alignment search tool", J. MOL. BIOL., (1990), vol. 215, no. 3, doi:doi:10.1006/jmbi.1990.9999, pages 403 - 410, XP002949123
DESCRIPTION- ALTSCHUL ET AL., "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", NUCLEIC ACIDS RES., (1997), vol. 25, doi:doi:10.1093/nar/25.17.3389, pages 3389 - 3402, XP002905950
OPPOSITION- Alam, M.I. ; Beg, S. ; Samad, A. ; Baboota, S. ; Kohli, K. ; Ali, J. ; Ahuja, A. ; Akbar, M., "Strategy for effective brain drug delivery", European Journal of Pharmaceutical Sciences, Elsevier Amsterdam, NL, NL, (20100811), vol. 40, no. 5, ISSN 0928-0987, pages 385 - 403, XP027093081-
OPPOSITION- Anonymous, "A Controlled, Randomized, Two-arm, Open-label, Assessor-blinded, Multicenter Study of Intrathecal Idursulfase- IT Administered in Conjunction with Elaprase® in Pediatric Patients with Hunter Syndrome and Early Cognitive Impairment", Clinical Trial Protocol: HGT-HIT-094, (20130404), pages 1 - 100, XP093041059-
OPPOSITION- Anonymous, "A Study of Intrathecal SHP611 in Children With Metachromatic Leukodystrophy", ClinicalTrials.gov Identifier: NCT03771898, (20181211), pages 1 - 11, XP093041062-
OPPOSITION- anonymous, "History of Changes for Study: NCT00920647. A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®", ClinicalTrials.gov, (20190430), XP055844650-
OPPOSITION- Lukare Medical, LLC, "Elliotts B® Solution (buffered intrathecal electrolyte/dextrose injection)", Lukare Medical, LLC - Prescribing Information, (201510), pages 1 - 2, URL: http://www.elliottsbsolution.com/images/EBS_PI.pdf, XP055844648-
OPPOSITION- Zahra Shahrokh, Perry Callas, Lawrence Charnas, "INTRATHECAL DELIVERY OF PROTEIN THERAPEUTICS TO TREAT GENETIC DISEASES INVOLVING THE CNS", Ondrugdelivery, Frederick Furness Publishing, (20100101), pages 16 - 20, Ondrugdelivery, URL: http://www.ondrugdelivery.com/publications/Injectable%20Formulations%202010/Shire.pdf, (20130809), XP055074790-
OPPOSITION- Shih-Yen Tsai ; Tiffanie M. Markus ; Ellen M. Andrews ; Joseph L. Cheatwood ; April J. Emerick ; Anis K. Mir ; Martin E. Schwab ; Gwendolyn L. Kartje, "Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke", Experimental Brain Research, Springer, Berlin, DE, Berlin, DE, (20070824), vol. 182, no. 2, doi:10.1007/s00221-007-1067-0, ISSN 1432-1106, pages 261 - 266, XP019537874
OPPOSITION- DALI C. et al., "Safety of intrathecal delivery of recombinant human arylsulfatase A in children with metachromatic leukodystrophy: Results from a phase 1/2 clinical trial", Molecular Genetics and Metabolism, (20200900), vol. 131, no. 1-2, pages 235 - 244, XP086409849
OPPOSITION- Daniele, A. Tomanin, R. Villani, G.R.D. Zacchello, F. Scarpa, M. Di Natale, P., "Uptake of recombinant iduronate-2-sulfatase into neuronal and glial cells in vitro", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., AMSTERDAM, NL, NL, (20021212), vol. 1588, no. 3, doi:10.1016/S0925-4439(02)00166-7, ISSN 0925-4439, pages 203 - 209, XP004389111
SEARCH- Shire, "Elaprase 2 mg/ml", (20070101), URL: http://www.shire.de/-/media/shire/shireglobal/shiregermany/pdffiles/product information/fi-elaprase.pdf, (20160908), XP055301000 [I] 1-15 * the whole document *-
SEARCH- Zahra Shahrokh ET AL, "INTRATHECAL DELIVERY OF PROTEIN THERAPEUTICS TO TREAT GENETIC DISEASES INVOLVING THE CNS", Ondrugdelivery, (20100702), pages 16 - 20, URL: http://www.ondrugdelivery.com/publications/Injectable%20Formulations%202010/Shire.pdf, (20130809), XP055074790 [IP] 1-15 * the whole document *-
SEARCH- BELICHENKO P V ET AL, "Penetration, diffusion, and uptake of recombinant human alpha-l-iduronidase after intraventricular injection into the rat brain", MOLECULAR GENETICS AND METABOLISM, ACADEMIC PRESS, AMSTERDAM, NL, vol. 86, no. 1-2, doi:10.1016/J.YMGME.2005.04.013, ISSN 1096-7192, (20050901), pages 141 - 149, (20051001), XP027518224 [I] 1-15 * the whole document *
SEARCH- W. C. LEE ET AL, "Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy", THE FASEB JOURNAL, (20070801), vol. 21, no. 10, doi:10.1096/fj.06-6169com, ISSN 0892-6638, pages 2520 - 2527, XP055074782 [I] 1-15 * the whole document *

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