Small Molecule Biochemical Profiling Of Individual Subjects For Disease Diagnosis And Health Assessment - EP3129909

The patent EP3129909 was granted to Metabolon on Sep 16, 2020. The application was originally filed on Apr 8, 2015 under application number EP15721065A. The patent is currently recorded with a legal status of "Revoked".

EP3129909

METABOLON
Application Number
EP15721065A
Filing Date
Apr 8, 2015
Status
Revoked
Oct 14, 2022
Grant Date
Sep 16, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BOHMANNJun 16, 2021BOHMANNADMISSIBLE

Patent Citations (18) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS4863873
DESCRIPTIONUS5104639
DESCRIPTIONUS5284567
DESCRIPTIONUS5290420
DESCRIPTIONUS7561975
DESCRIPTIONUS7884318
DESCRIPTIONUS7949475
DESCRIPTIONUSRE32920E
DESCRIPTIONWO9213273
DESCRIPTIONWO9927361
EXAMINATIONUS7567870
INTERNATIONAL-SEARCH-REPORTUS2010174505
INTERNATIONAL-SEARCH-REPORTWO2004038381
OPPOSITIONUS2010174505
OPPOSITIONUS7567870
OPPOSITIONUS8849577
OPPOSITIONWO2004003831
OPPOSITIONWO2015157407

Non-Patent Literature (NPL) Citations (24) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BARNES, S.; GALLO, G.A.; TRASH, D.B.; MORRIS, J.S., "Diagnositic value of serum bile acid estimations in liver disease", J CLIN PATHOL, (1975), vol. 28, pages 506 - 509-
DESCRIPTION- KRISTAL ET AL., ANAL. BIOCHEM., (1998), vol. 263, pages 18 - 25-
DESCRIPTION- PERSEGHIN, G.; GHOSH, S.; GEROW, K.; SHULMAN, G.I., "Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study", DIABETES, (1997), vol. 46, pages 1001 - 1009-
DESCRIPTION- NEWGARD, C.B. ET AL., "A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance", CELL METAB, (2009), vol. 9, doi:doi:10.1016/j.cmet.2009.02.002, pages 311 - 326, XP055059282
DESCRIPTION- YAMAZAKI, M. ET AL., "Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats", TOXICOL APPL PHARMACOL, (2013), vol. 268, doi:doi:10.1016/j.taap.2013.01.018, pages 79 - 89, XP028994277
DESCRIPTION- YAMANOUCHI, T. ET AL., "Clinical usefulness of serum 1,5-anhydroglucitol in monitoring glycaemic control", LANCET, (1996), vol. 347, doi:doi:10.1016/S0140-6736(96)90672-8, pages 1514 - 1518, XP003010272
DESCRIPTION- SUHRE, K. ET AL., "Human metabolic individuality in biomedical and pharmaceutical research", NATURE, (2011), vol. 477, doi:doi:10.1038/nature10354, pages 54 - 60, XP055454517
DESCRIPTION- SUHRE, K.; GIEGER, C., "Genetic variation in metabolic phenotypes: study designs and applications", NAT REV GENET, (2012), vol. 13, doi:doi:10.1038/nrg3314, pages 759 - 769, XP055194348
DESCRIPTION- MILBURN, M.V.; LAWTON, K.A., "Application of metabolomics to diagnosis of insulin resistance", ANNU REV MED, (2013), vol. 64, doi:doi:10.1146/annurev-med-061511-134747, pages 291 - 305, XP055136395
DESCRIPTION- FERRANNINI, E. ET AL., "Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance", DIABETES, (2013), vol. 62, doi:doi:10.2337/db12-0707, pages 1730 - 1737, XP009176876
EXAMINATION- Warwick B Dunn ET AL, "Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry", Nature Protocols, GB, (20110630), vol. 6, no. 7, doi:10.1038/nprot.2011.335, ISSN 1754-2189, pages 1060 - 1083, XP055491419
OPPOSITION- VUCKOVIC D., "Current trends and challenges in sample preparation for global metabolomics using liquid chromatography-mass spectrometry", Anal Bioanal Chem, (20120000), vol. 403, doi:10.1007/s00216-012-6039-y, pages 1523 - 1548, XP035057315
OPPOSITION- GUCCIARDI A et al., "A rapid UPLC-MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening", Anal Bioanal Chem, (20120000), vol. 404, doi:10.1007/s00216-012-6194-1, pages 741 - 751, XP035091543
OPPOSITION- Kirwan J. A.; Broadhurst D. I.; Davidson R. L.; Viant M. R., "Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow", Analytical and Bioanalytical Chemistry, Springer Berlin Heidelberg, DE, DE, (20130301), vol. 405, no. 15, doi:10.1007/s00216-013-6856-7, ISSN 1618-2642, pages 5147 - 5157, XP036896647
OPPOSITION- GIKA HG et al., "Evaluation of the repeatability of ultra- performance liquid chromatography-TOF_MS for global metabolic profiling of human urine samples", J. Chromatogr. B, (20080000), vol. 871, doi:10.1016/j.jchromb.2008.05.048, pages 299 - 305, XP023782706
OPPOSITION- SIMON-MANSO Y et al., "Metabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950): GC-MS, LC-MS, NMR, and Clinical Laboratory Analyses, Libraries, and Web-based Resources", Anal. Chem., (20130000), vol. 85, doi:10.1021/ac402503m, pages 11725 - 11731, XP055382594
OPPOSITION- Loftus Neil, Et Al, "Metabonomic Investigation of Liver Profiles of Nonpolar Metabolites Obtained from Alcohol-Dosed Rats and Mice Using High Mass Accuracy MS n Analysis", JOURNAL OF PROTEOME RESEARCH, American Chemical Society, (20110204), vol. 10, no. 2, doi:10.1021/pr100885w, ISSN 1535-3893, pages 705 - 713, XP055818543
OPPOSITION- Hsu Ping-Ching, Et Al, "Feasibility of Identifying the Tobacco-related Global Metabolome in Blood by UPLC-QTOF-MS", JOURNAL OF PROTEOME RESEARCH, American Chemical Society, (20130201), vol. 12, no. 2, doi:10.1021/pr3007705, ISSN 1535-3893, pages 679 - 691, XP055818544
OPPOSITION- Want Elizabeth J, Et Al, "Global metabolic profiling procedures for urine using UPLC-MS", Nature Protocols, Nature Publishing Group, GB, GB, (20100601), vol. 5, no. 6, doi:10.1038/nprot.2010.50, ISSN 1754-2189, pages 1005 - 1018, XP055818549
OPPOSITION- DUNN WB et al., "Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry", Nature protocol s, (20110000), vol. 6, no. 7, doi:10.1038/nprot.2011.335, pages 1060 - 1083, XP055491419
OPPOSITION- SANGSTER T et al., "A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis", Analyst, (20060000), vol. 131, doi:10.1039/b604498k, pages 1075 - 1078, XP055782532
OPPOSITION- BARAN R et al., "MathDAMP: a package for differential analysis of metabolite profiles", BMC Bioinformatics, (20060000), vol. 7, doi:10.1186/1471-2105-7-530, page 530, XP021021670
OPPOSITION- CHACE DH et al., "Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns", Clinical Chemistry, (20030000), vol. 49, no. 11, doi:10.1373/clinchem.2003.022178, pages 1797 - 1817, XP001181755
OPPOSITION- Dunn Warwick B, Wilson Ian D, Nicholls Andrew W, Broadhurst David, "The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans", Bioanalysis, Future Science, London, UK, London, UK, (20120901), vol. 4, no. 18, doi:10.4155/bio.12.204, ISSN 1757-6180, pages 2249 - 2264, XP055818545

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents