IP Verse

Improved Methods For Manufacturing Adoptive Cell Therapies - EP3134095

The patent EP3134095 was granted to Bluebird BIO on Apr 22, 2020. The application was originally filed on Apr 24, 2015 under application number EP15783117A. The patent is currently recorded with a legal status of "Revoked".

EP3134095

BLUEBIRD BIO
Application Number
EP15783117A
Filing Date
Apr 24, 2015
Status
Revoked
Jul 18, 2025
Grant Date
Apr 22, 2020
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (3)

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BOULT WADE TENNANTJan 22, 2021BOULT WADE TENNANTADMISSIBLE
GLAXOSMITHKLINEJan 21, 2021CHIAPPINELLIWITHDRAWN
DEHNSJan 19, 2021DEHNSADMISSIBLE

Patent Citations (12) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTUS7754482
INTERNATIONAL-SEARCH-REPORTUS7977095
OPPOSITIONUS2008274091
OPPOSITIONUS2012301447
OPPOSITIONUS2013280220
OPPOSITIONWO2012079000
OPPOSITIONWO2013126712
OPPOSITIONWO2014048920
OPPOSITIONWO2014099671
SEARCHWO2012140130
SEARCHWO2013126712
SEARCHWO2014039523

Non-Patent Literature (NPL) Citations (25) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
INTERNATIONAL-SEARCH-REPORT- ZHONG et al., "Retroviral Transduction of T- cell Receptors in Mouse T-cells", Journal of Visualized Experiments, (20101022), vol. 44, page 2307, XP055232196 [A] 1-8 * . Entire document *
OPPOSITION- Anonymous 1, 2, "Dynabeads® CD3/CD28", Invitrogen DYNAL, (20080101), pages 1 - 2, Invitrogen DYNAL, URL: https://www.veritastk.co.jp/products/pdf/111.41D_Dynabeads_CD3CD28.(rev003).pdf, (20220715), XP055943079-
OPPOSITION- Anonymous, "Dynabeads CD3/CD28 product leaflet", Invitrogen Dynal, (20080000), pages 1 - 2, XP055780719-
OPPOSITION- Anonymous, "RosetteSepâ„¢ Human CD4+ T Cell Enrichment Cocktail ", STEMCELL, (20180101), pages 1 - 3, STEMCELL, URL: https://cdn.stemcell.com/media/files/pis/28571-PIS_1_3_1.pdf?_ga=2.104061380.579582491.1657874924-1978280207.1657874924, (20220715), XP055943095-
OPPOSITION- Ge Healthcare, "Isolation of mononuclear cells Methodology and applications", (19830101), URL: http://www.gelifesciences.com/file_source/GELS/Service and Support/Documents and Downloads/Handbooks/pdfs/Isolation of Mononuclear Cells.pdf, (20160923), XP055305056-
OPPOSITION- M Di Ianni, B Del Papa, D Cecchini, E Bonifacio, L Moretti, T Zei, R Iacucci Ostini, F Falzetti, L Fontana, G Tagliapietra, C Maldini, M F Martelli, and A Tabilio*, "Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications", Clinical and Experimental Immunology, (20090000), vol. 156, pages 246 - 253, XP055780761-
OPPOSITION- Patrick J Schuler , Malgorzata Harasymczuk, Bastian Schilling, Stephan Lang, Theresa L Whiteside, "Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets", J Immunol. Method, (20110000), vol. 369, no. 1-2, pages 59 - 68, XP055780770-
OPPOSITION- Sara Bobisse 1, Maria Rondina, Anna Merlo, Veronica Tisato, Susanna Mandruzzato, Mario Amendola, Luigi Naldini, Ralph A Willemsen, Reno Debets, Paola Zanovello, Antonio Rosato, "Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors", Cancer Research, (20090000), vol. 69, pages 9385 - 9394, XP055780732-
OPPOSITION- "T-cell surface glycoprotein CD8 alpha chain", UniprotKB, (20090120), Database accession no. P01732, URL: Uniprot, XP055780784-
OPPOSITION- Verhoeyen Els; Costa Caroline; Cosset Francois-Loic, "Lentiviral vector gene transfer into human T cells.", Antibody-drug conjugates; IN: Methods in Molecular Biology; ISSN 1064-3745; Vol. 263, Humana Press, US, US , (20090101), vol. 506, ISBN 978-1-62703-541-5, pages 97 - 114, XP009131783-
OPPOSITION- Guest Ryan D., Kirillova Natalia, Mowbray Sam, Gornall Hannah, Rothwell Dominic G., Cheadle Eleanor J., Austin Eric, Smith Keith, Watt Suzanne M., Kühlcke Klaus, Westwood Nigel, Thistlethwaite Fiona, Hawkins Robert E., Gilham David E., "Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial", Cancer immunology immunotherapy, Springer, Berlin/Heidelberg, Berlin/Heidelberg , (20140201), vol. 63, no. 2, doi:10.1007/s00262-013-1492-9, ISSN 0340-7004, pages 133 - 145, XP055980885
OPPOSITION- Pouw Nadine, Treffers-Westerlaken Elike, Mondino Anna, Lamers Cor, Debets Reno, "TCR gene-engineered T cell: Limited T cell activation and combined use of IL-15 and IL-21 ensure minimal differentiation and maximal antigen-specificity", Molecular Immunology, PERGAMON, GB, GB , (20100401), vol. 47, no. 7-8, doi:10.1016/j.molimm.2010.02.022, ISSN 0161-5890, pages 1411 - 1420, XP055980887
OPPOSITION- Michael C. Milone, Jonathan D. Fish, Carmine Carpenito, Richard G. Carroll, Gwendolyn K. Binder, David Teachey, Minu Samanta, Mehdi Lakhal, Brian Gloss, Gwenn Danet-Desnoyers, Dario Campana, James L. Riley, Stephan A. Grupp, Carl H. June, "Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo.", Molecular Therapy, Elsevier Inc., US, US , (20090801), vol. 17, no. 8, doi:10.1038/MT.2009.83, ISSN 1525-0016, pages 1453 - 1464, XP002732433
OPPOSITION- Ge Zhang, Lei Wang, Honglian Cui, Xiaomin Wang, Ganlin Zhang, Juan Ma, Huamin Han, Wen He, Wei Wang, Yunfeng Zhao, Changzhen Liu, Meiyi Sun & Bin Gao, Scientific Reports, (20140000), vol. 4, no. 3571, pages 1 - 8, XP055511393
OPPOSITION- Q. Han et al, "Polyfunctional responses by human T cells result from sequential release of cytokines", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20120131), vol. 109, no. 5, doi:10.1073/pnas.1117194109, ISSN 0027-8424, pages 1607 - 1612, XP055413889
OPPOSITION- Dai Jihong, Et Al, "Human Immunodeficiency Virus Integrates Directly into Naïve Resting CD4 + T Cells but Enters Naïve Cells Less Efficiently than Memory Cells", Journal of Virology, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, US , (20090501), vol. 83, no. 9, doi:10.1128/JVI.01910-08, ISSN 0022-538X, pages 4528 - 4537, XP055943099
OPPOSITION- Eleni G. Iliopoulou,Michalis V. Karamouzis, Ioannis Missitzis, Alexandros Ardavanis, Nectaria N. Sotiriadou, Constantin N. Baxevanis, Gerasimos Rigatos, Michael Papamichail, and Sonia A. Perez, Clin Cancer Res, (20060000), vol. 12, no. 23, pages 6901 - 6909, XP002500705
OPPOSITION- Berger Carolina, Blau C. Anthony, Clackson Tim, Riddell Stanley R., Heimfeld Shelly, "CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy", Blood, American Society of Hematology, US, US , (20030115), vol. 101, no. 2, doi:10.1182/blood-2002-07-2142, ISSN 0006-4971, pages 476 - 484, XP055980882
OPPOSITION- Victoria Hillerdal et al, "Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice", BMC CANCER, BIOMED CENTRAL, LONDON, GB, LONDON, GB , (20140118), vol. 14, no. 1, doi:10.1186/1471-2407-14-30, ISSN 1471-2407, page 30, XP021174267
OPPOSITION- Adam P Cribbs; Alan Kennedy; Bernard Gregory; Fionula M Brennan, "Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells", BMC Biotechnology, (20130000), vol. 13, no. 1, page 98, XP021167925
OPPOSITION- Adam P Cribbs;Alan Kennedy;Bernard Gregory;Fionula M Brennan, "Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells", BMC Biotechnology, BioMed Central Ltd, (20131112), vol. 13, no. 1, doi:10.1186/1472-6750-13-98, ISSN 1472-6750, page 98, XP021167925
OPPOSITION- Adam P Cribbs et al, "Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells", BMC Biotechnology, BioMed Central Ltd, (20131112), vol. 13, no. 1, doi:10.1186/1472-6750-13-98, ISSN 1472-6750, page 98, XP021167925
OPPOSITION- Robert PT Somerville;Laura Devillier;Maria R Parkhurst;Steven A Rosenberg;Mark E Dudley, "Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor ", Journal of Translational Medicine, BioMed Central, (20120404), vol. 10, no. 1, doi:10.1186/1479-5876-10-69, ISSN 1479-5876, page 69, XP021126773
SEARCH- DAWN MAIER, "Development of a Simple and Robust Closed System Manufacturing Platform for T Cells Engineered With Chimeric Antigen Receptor (CAR) for Adoptive Immunotherapy", MOLECULAR THERAPY -SUPPLEMENT 1, (20140501), vol. 22, page S284, XP055396203 [T] * the whole document *-
SEARCH- ADAM P CRIBBS ET AL, "Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD. LONDON, GB, (20131112), vol. 13, no. 1, doi:10.1186/1472-6750-13-98, ISSN 1472-6750, page 98, XP021167925 [X] 1-15 * the whole document * [Y] 1-15

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