Compositions And Methods For Treating Cytokine-Related Disorders - EP3134120

The patent EP3134120 was granted to The Childrens Hospital OF Philadelphia on Jan 24, 2024. The application was originally filed on Apr 21, 2015 under application number EP15782489A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3134120

THE CHILDRENS HOSPITAL OF PHILADELPHIA
Application Number
EP15782489A
Filing Date
Apr 21, 2015
Status
Granted And Under Opposition
Dec 22, 2023
Grant Date
Jan 24, 2024
External Links
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Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2013287777
DESCRIPTIONUS2013336980
DESCRIPTIONUS2014004107
DESCRIPTIONUS2014271658
DESCRIPTIONUS7087396
DESCRIPTIONUS7452980
DESCRIPTIONUS8444987
DESCRIPTIONWO2013165894
DESCRIPTIONWO2013173761
DESCRIPTIONWO2014152195
DESCRIPTIONWO2014164959
DESCRIPTIONWO9934217
INTERNATIONAL-SEARCH-REPORTUS2010260770
INTERNATIONAL-SEARCH-REPORTWO2014011984
OPPOSITIONWO2005079844
OPPOSITIONWO2014011984

Non-Patent Literature (NPL) Citations (41) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Cytokine storm", Wikipedia, (20240624), Wikipedia, URL: https://en.wikipedia.org/w/index.php?title=Cytokine_storm&oldid=1230675521, XP093233820-
OPPOSITION- Anonymous, "Cytokine", Wikipedia, (20240927), Wikipedia, URL: https://en.wikipedia.org/w/index.php?title=Cytokine&oldid=1248094648, XP093233817-
OPPOSITION- Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Iaria C, Cascio Antonio, "Haemophagocytic syndrome in rheumatic patients. A systematic review", European Review for Medical and Pharmacological Sciences, (20121001), vol. 16, no. 10, pages 1414 - 1424, XP093233831-
OPPOSITION- D29 - FRA U.S. FOOD AND DRUG ADMINISTRATION: "Ziv-Aflibercept", Retrieved from the Internet <URL:https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm314438.html> [retrieved on 20241003]-
OPPOSITION- Martine Szyper-Kravitz null, "The Hemophagocytic Syndrome/Macrophage Activation Syndrome: A Final Common Pathway of a Cytokine Storm", Israel Medical Association Journal (IMAJ), (200910), vol. 11, XP055763019-
OPPOSITION- Tristano Antonio G., "Macrophage activation syndrome: A frequent but under-diagnosed complication associated with rheumatic diseases", Medical Science Monitor, Warsaw, Poland : Medical Science International, PL, PL , (20080301), vol. 14, no. 3, ISSN 1234-1010, pages RA27 - RA36, XP093233856-
OPPOSITION- Gaby Palmer et al., "Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis", Arthritis & Rheumatism, (20090303), vol. 60, doi:10.1002/art.24305, XP055016952
OPPOSITION- Strippoli Raffaele, Carvello Francesco, Scianaro Roberta, De Pasquale Loredana, Vivarelli Marina, Petrini Stefania, Bracci‐laudiero Luisa, De Benedetti Fabrizio, "Amplification of the response to Toll‐like receptor ligands by prolonged exposure to interleukin‐6 in mice: Implication for the pathogenesis of macrophage activation syndrome", Arthritis & Rheumatism, Wiley InterScience, US, US , (20120501), vol. 64, no. 5, doi:10.1002/art.33496, ISSN 0004-3591, pages 1680 - 1688, XP093233898
OPPOSITION- Henderson Lauren A., Cron Randy Q., "Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management", PAEDIATRIC DRUGS, ADIS INTERNATIONAL, AUCKLAND, NZ, NZ , (20200201), vol. 22, no. 1, doi:10.1007/s40272-019-00367-1, ISSN 1174-5878, pages 29 - 44, XP093233892
OPPOSITION- Janka, G.E., "Hemophagocytic syndromes", Blood Reviews, Churchill Livingstone, AMSTERDAM, NL, AMSTERDAM, NL , (20070810), vol. 21, no. 5, doi:10.1016/j.blre.2007.05.001, ISSN 0268-960X, pages 245 - 253, XP022187287
OPPOSITION- Janka Gritta E., Lehmberg Kai, "Hemophagocytic syndromes — An update", Blood Reviews, Churchill Livingstone, AMSTERDAM, NL, AMSTERDAM, NL , (20140701), vol. 28, no. 4, doi:10.1016/j.blre.2014.03.002, ISSN 0268-960X, pages 135 - 142, XP093233848
OPPOSITION- Coca, A. ; Bundy, K.W. ; Marston, B. ; Huggins, J. ; Looney, R.J., "Macrophage activation syndrome: Serological markers and treatment with anti-thymocyte globulin", CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20090701), vol. 132, no. 1, doi:10.1016/j.clim.2009.02.005, ISSN 1521-6616, pages 10 - 18, XP026152813
OPPOSITION- Palmer, G. ; Lipsky, B.P. ; Smithgall, M.D. ; Meininger, D. ; Siu, S. ; Talabot-Ayer, D. ; Gabay, C. ; Smith, D.E., "The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33", Cytokine, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, US , (20080601), vol. 42, no. 3, doi:10.1016/j.cyto.2008.03.008, ISSN 1043-4666, pages 358 - 364, XP022696634
OPPOSITION- Ishikawa Sayaka, Shimizu Masaki, Ueno Kazuyuki, Sugimoto Naotoshi, Yachie Akihiro, "Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis", Cytokine, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, US , (20130501), vol. 62, no. 2, doi:10.1016/j.cyto.2013.03.007, ISSN 1043-4666, pages 272 - 277, XP093233839
OPPOSITION- Jin Guangxu, Wong Stephen T.C., "Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines", Drug Discovery Today, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20140501), vol. 19, no. 5, doi:10.1016/j.drudis.2013.11.005, ISSN 1359-6446, pages 637 - 644, XP093233891
OPPOSITION- Cecilia Garlanda null, "THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE", Immunity, (20131212), vol. 39, doi:10.1016/j.immuni.2013.11.010, XP055160331
OPPOSITION- Scott W. Canna, Edward M. Behrens, "Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes", PEDIATRIC CLINICS OF NORTH AMERICA., SAUNDERS CO., LONDON., GB, GB , (20120401), vol. 59, no. 2, doi:10.1016/j.pcl.2012.03.002, ISSN 0031-3955, pages 329 - 344, XP055393343
OPPOSITION- Grom A.A., M. Passo, " Macrophage activation syndrome in systemic juvenile rheumatoid arthritis", J Pediatr ., (19961101), vol. 129, no. 5, doi:10.1016/s0022-3476(96)70140-3, pages 630 - 632, XP093233853
OPPOSITION- Rahul Kakkar et al., "The IL-33/ST2 pathway: therapeutic target and novel biomarker", Nat Rev Drug Discov., (200810), vol. 7, doi:10.1038/NRD2660, XP002530680
OPPOSITION- Janka, G., "Hemophagocytic Lymphohistiocytosis: When the Immune System Runs Amok [Hämophagozytierende Lymphohistiozytose: Wenn das Immunsystem Amok läuft]", Klinische Paediatrie, Georg Thieme Verlag, DE, DE , (20090901), vol. 221, no. 5, doi:10.1055/s-0029-1237386, ISSN 1439-3824, pages 278 - 285, XP009558856
OPPOSITION- Hiroko Hayakawa et al., "Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation", The Journal of Biological Chemistry;, (20070907), vol. 282, doi:10.1074/jbc.M704916200, XP055030354
OPPOSITION- T. Horiuchi, Mitoma H., Harashima S.-I., Tsukamoto H., Shimoda T., "Transmembrane TNF-alpha : structure, function and interaction with anti-TNF agents", Rheumatology, Oxford University Press, (20100701), vol. 49, no. 7, doi:10.1093/rheumatology/keq031, ISSN 14620324, pages 1215 - 1228, XP055077475
OPPOSITION- Gupta Abha A., Tyrrell Pascal, Valani Rahim, Benseler Susanne, Abdelhaleem Mohamed, Weitzman Sheila, "Experience With Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome at a Single Institution", JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY, NEW YORK, US, US , (20090201), vol. 31, no. 2, doi:10.1097/MPH.0b013e3181923cb4, ISSN 1077-4114, pages 81 - 84, XP093233886
OPPOSITION- Tang Yong-Min, Xu Xiao-Jun, "Advances in Hemophagocytic Lymphohistiocytosis: Pathogenesis, Early Diagnosis/Differential Diagnosis, and Treatment", THE SCIENTIFIC WORLD JOURNAL, The ScientificWorld Ltd, GB, NL, GB, NL , (20110101), vol. 11, doi:10.1100/tsw.2011.62, ISSN 1537-744X, pages 697 - 708, XP093233837
OPPOSITION- Aronson Iris K., Worobec Sophie M., "Cytophagic histiocytic panniculitis and hemophagocytic lymphohistiocytosis: an overview ", Dermatologic therapy, Wiley-Blackwell Publishing, Inc., US, US , (20100701), vol. 23, no. 4, doi:10.1111/j.1529-8019.2010.01339.x, ISSN 1396-0296, pages 389 - 402, XP093233834
OPPOSITION- Cron R.Q., M. Zhang, "OP0017 Blurring of the Distinction Between Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome", Oral Presentations - Pathogenetic insights in autoimmunity from genetic diseases, BMJ Publishing Group Ltd and European League Against Rheumatism, (20130612), vol. 72, no. Suppl 3, doi:10.1136/annrheumdis-2013-eular.220, pages A53 - A54, XP093233871
OPPOSITION- Jennifer Kearley et al., "Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway", Am J Respir Crit Care Med, (2009), vol. 179, doi:10.1164/rccm.200805-666OC, XP002647399
OPPOSITION- Behrens Edward M., Canna Scott W., Slade Katharine, Rao Sheila, Kreiger Portia A., Paessler Michele, Kambayashi Taku, Koretzky Gary A., "Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice", Journal of Clinical Investigation, American Society for Clinical Investigation, (20110601), vol. 121, no. 6, doi:10.1172/JCI43157, ISSN 0021-9738, pages 2264 - 2277, XP093233896
OPPOSITION- Sato Kei, Misawa Naoko, Nie Chuanyi, Satou Yorifumi, Iwakiri Dai, Matsuoka Masao, Takahashi Rei, Kuzushima Kiyotaka, Ito Mamoru, Takada Kenzo, Koyanagi Yoshio, "A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice", Blood, issue 832, American Society of Hematology, US, US , (20110526), vol. 117, no. 21, doi:10.1182/blood-2010-09-305979, ISSN 0006-4971, pages 5663 - 5673, XP093233900
OPPOSITION- M. B. Jordan, C. E. Allen, S. Weitzman, A. H. Filipovich, K. L. Mcclain, "How I treat hemophagocytic lymphohistiocytosis", Blood, issue 832, American Society of Hematology, US, US , (20111013), vol. 118, no. 15, doi:10.1182/blood-2011-03-278127, ISSN 0006-4971, pages 4041 - 4052, XP055288710
OPPOSITION- Dinarello Charles A, "Proinflammatory Cytokines", Chest, (20000801), vol. 118, no. 2, doi:10.1378/chest.118.2.503, pages 503 - 508, XP093233862
OPPOSITION- Martin H Cohen et al., "FDA Drug Approval Summary: Bevacizumab Plus FOLFOX4 as Second-Line Treatment of Colorectal Cancer", The Oncologist, (2007), vol. 12, doi:10.1634/theoncologist.12-3-356, XP002712135
OPPOSITION- Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, Hirohisa Saito, Susumu Nakae, "IL-33 and IL-33 Receptors in Host Defense and Diseases", Allergology International, Blackwell Pub., (20100601), vol. 59, no. 2, doi:10.2332/allergolint.10-RAI-0186, ISSN 13238930, pages 143 - 160, XP055016756
OPPOSITION- Kurowska-Stolarska Mariola, Stolarski Bartosz, Kewin Peter, Murphy Grace, Corrigan Christopher J., Ying Sun, Pitman Nick, Mirchandani Ananda, Rana Batika, Van Rooijen Nico, Shepherd Malcolm, Mcsharry Charlie, Mcinnes Iain B., Xu Damo, Liew Foo Y., "IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation", Journal of Immunology, Williams & Wilkins Co., (20091115), vol. 183, no. 10, doi:10.4049/jimmunol.0901575, ISSN 0022-1767, pages 6469 - 6477, XP093233887
OPPOSITION- Bernard P Leung et al., "A novel therapy of murine collagen-induced arthritis with soluble T1/ST2", Journal of Immunoly, (2004), vol. 173, doi:10.4049/jimmunol.173.1.145, XP009167840
OPPOSITION- Machaczka Maciej, Sydor Wojciech, Rucinska Magorzata, Szostek Marta, Musia Jacek, "Autoimmune-Associated Hemophagocytic Syndrome/Macrophage Activation Syndrome", Autoimmune Disorders - Current Concepts and Advances from Bedside to Mechanistic Insights, InTech , (20111114), doi:10.5772/20126, ISBN 978-953-30-7653-9, XP093233881
SEARCH- JULIA ROOD ET AL, "Blockade of Interleukin-33 Signaling Prevents Death in a Mouse Model of Familial Hemophagocytic Lymphohistiocytosis", 78TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-RHEUMATOLOGY (ACR) / 49TH MEETING OF THE ASSOCIATION-; BOSTON, MA, USA; NOVEMBER 14 -19, 2014, (20141114), vol. 66, pages S835 - S836, XP055393906 [IP] 1-8 * abstract *-
SEARCH- SCOTT W. CANNA ET AL, "Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes", PEDIATRIC CLINICS OF NORTH AMERICA., GB, (20120401), vol. 59, no. 2, doi:10.1016/j.pcl.2012.03.002, ISSN 0031-3955, pages 329 - 344, XP055393343 [A] 1-8 * Synopsis, section on fHLH (on 3rd page) *
SEARCH- LUKE O'NEILL, "The interleukin-1 receptor/ Toll-like receptor superfamily: 10 years of progress", IMMUNOLOGICAL REVIEWS, (20081201), vol. 226, pages 10 - 18, XP055393676 [A] 1-8 * p.12, Fig.1, 2 *
SEARCH- P. KREBS ET AL, "Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice", BLOOD, (20110616), vol. 117, no. 24, doi:10.1182/blood-2011-01-329607, ISSN 0006-4971, pages 6582 - 6588, XP055393351 [A] 1-8 * Whole doc., in particular p.6584, col.2; Discussion *
SEARCH- Julia E Rood ET AL, "ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice", doi:10.1182/blood-2015-07-, (20151030), pages 6582 - 6588, URL: http://www.bloodjournal.org/content/bloodjournal/127/4/426.full.pdf?sso-checked=true, (20170724), XP055393347 [T] * Whole doc. (Appl. publ. of invention). *

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