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Method For Automated Generation Of Genetically Modified T Cells - EP3134512

The patent EP3134512 was granted to Miltenyi Biotec on Jan 2, 2019. The application was originally filed on Apr 23, 2015 under application number EP15721601A. The patent is currently recorded with a legal status of "Revoked".

EP3134512

MILTENYI BIOTEC
Application Number
EP15721601A
Filing Date
Apr 23, 2015
Status
Revoked
May 19, 2025
Grant Date
Jan 2, 2019
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (3)

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JAMES POOLEOct 2, 2019CARPMAELS & RANSFORDADMISSIBLE
D YOUNGOct 1, 2019D YOUNGADMISSIBLE
GE HEALTHCARE BIO SCIENCESSep 30, 2019KILBURN & STRODEADMISSIBLE

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2009072003
DESCRIPTIONWO2014048920
INTERNATIONAL-SEARCH-REPORTEP2594632
INTERNATIONAL-SEARCH-REPORTWO2005108589
INTERNATIONAL-SEARCH-REPORTWO2009072003
OPPOSITIONEP2594632
OPPOSITIONEP2711418
OPPOSITIONUS7572631
OPPOSITIONWO2005108589
OPPOSITIONWO2009072003
OPPOSITIONWO2013072288
OPPOSITIONWO2015162211
OTHEREP2594632
OTHEREP2711418
OTHERUS7572631
OTHERWO2009072003

Non-Patent Literature (NPL) Citations (22) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Bpi Contributor, "Expansion of T-cells using the Xuri Cell Expansion System W25 and WAVE Bioreactor 2/10 System", (20131024), URL: https://bioprocessintl.com/manufacturing/cell-therapies/expansion-of-t-cells-using-the-xuri-cell-expansion-system-w25-and-wave-bioreactor-210-system-abstract-347603/, XP055730465-
OPPOSITION- CASATI, A. et al., MACS & more, (20130000), vol. 15, no. 2, pages 20 - 24, XP055647710-
OPPOSITION- LEHMANN, C. et al., "Automated Magnetic Isolation and Lentiviral Vector Modification of Human CD34+ Cells in a Functionally Closed System", Molecular Therapy, (20140000), vol. 22, no. 1, pages S283 - S284, XP055653435-
OPPOSITION- MACS & more, (20130200), vol. 15-
OPPOSITION- ROBINET et al., "A CLOSED CULTURE SYSTEM FOR THE EX VIVO TRANSDUCTION AND EXPANSION OF HUMAN T LYMPHOCYTES", Journal of Hematotherapy, (19980000), vol. 7, no. 3, pages 205 - 215, XP009052788-
OPPOSITION- APEL et al., "Integrated Clinical Scale Manufacturing System for Cellular Products Derived by Magnetic Cell Separation, Centrifugation and Cell Culture", Chemie Ingenieur Technik, (20130000), vol. 85, no. 1-2, pages 103 - 110, XP055211907
OPPOSITION- APEL, M. et al., Chemie Ingenieur Technik, (20130000), vol. 85, no. 1-2, pages 103 - 110, XP055211907
OPPOSITION- CASATI et al., "Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients", Cancer Immunol Immunother., (20131000), vol. 62, no. 10, pages 1563 - 1573, XP055547685
OPPOSITION- TUMAINI, B. et al., Cytotherapy, (20130000), vol. 15, no. 11, pages 1406 - 1415, XP055211897
OPPOSITION- TUMAINI et al., "Simplified process for the production of anti-CD19-CAR-engineered T cells", Cytotherapy, (20130000), vol. 15, no. 11, pages 1406 - 1415, XP055211897
OPPOSITION- MAUER, D. et al., Cytotherapy, (20140000), vol. 16, no. 4, page S36, XP055647726
OPPOSITION- BUCHS, "Introduction to advantages and problems of shaken cultures", BIOCHEMICAL ENGINEERING JOURNAL, (20010000), vol. 7, pages 91 - 98, XP055730472
OPPOSITION- KAISER et al., "Towards a commercial process for the manufacture of genetically modified T cells for therapy", Cancer Gene Therapy, (20150000), vol. 22, no. 2, pages 72 - 78, XP055211554
OPPOSITION- WANG et al., "Manufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapies", Cancer Gene Therapy, (20150000), vol. 22, no. 2, pages 85 - 94, XP055211914
OPPOSITION- WANG, X. et al., Cancer gene therapy, (20150000), vol. 22, no. 2, pages 85 - 94, XP055211914
OPPOSITION- FELDMAN, S.A. et al., "Rapid Production of Clinical-Grade Gammaretroviral Vectors in Expanded Surface Roller Bottles Using a Modified Step-Filtration Process for Clearance of Packaging Cells", Human gene therapy, (20100000), vol. 22, no. 1, pages 107 - 115, XP055653446
OPPOSITION- WANG et al., "Phenotypic and Functional Attributes of Lentivirus-modified CD19-specific Human CD8+ Central Memory T Cells Manufactured at Clinical Scale", Journal of Immunotherapy, (20120000), vol. 35, no. 9, pages 689 - 701, XP055211902
OPPOSITION- MA et al., "Cell density plays a critical role in ex vivo expansion of T cells for adoptive immunotherapy", BioMed Research International, (20100000), page 386545, XP055517219
OPPOSITION- MA, Q. et al., BioMed Research International, (20100000), XP055517219
OPPOSITION- DRECHSEL, K. et al., Molecular Therapy, (20140000), vol. 22, no. 1, page S286, XP021202476
OPPOSITION- ZHAN et al., "Production and First-in-Man Use of T Cells Engineered to Express a HSVTK-CD34 Sort-Suicide Gene", PLOS One, (20130000), vol. 8, no. 10, page e77106, XP055211894
OPPOSITION- CARTELLIERI, M. et al., PLoS One, (20140000), vol. 9, no. 4, page e93745, XP002767236

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