IP Verse

Crispr-Based Genome Modification And Regulation - EP3138910

The patent EP3138910 was granted to Sigma Aldrich on Sep 20, 2017. The application was originally filed on Dec 5, 2013 under application number EP16183723A. The patent is currently recorded with a legal status of "Revoked".

EP3138910

SIGMA ALDRICH
Application Number
EP16183723A
Filing Date
Dec 5, 2013
Status
Revoked
Jul 8, 2022
Grant Date
Sep 20, 2017
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (10)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MATHYS & SQUIREJun 20, 2018WILDINGADMISSIBLE
POHLMANJun 20, 2018POHLMANADMISSIBLE
RAHMSTORFJun 20, 2018GRUNDADMISSIBLE
SCHLICHJun 20, 2018SCHLICHADMISSIBLE
MURPHYJun 20, 2018COOLEY UKWITHDRAWN
BASFJun 19, 2018EISENFUHR SPEISERADMISSIBLE
HGFJun 13, 2018HGFWITHDRAWN
CARIBOU BIOSCIENCESApr 12, 2018GRUNDWITHDRAWN
COHAUSZ & FLORACK PATENT UND RECHTSANWALTE PARTNERSCHAFTSGESELLSCHAFT MBBMar 29, 2018COHAUSZ & FLORACKADMISSIBLE
VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBDec 22, 2017VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONEP2800811
OPPOSITIONEP3138910
OPPOSITIONUS2005220796
OPPOSITIONUS201261734256P
OPPOSITIONUS2013073307
OPPOSITIONUS201361758624P
OPPOSITIONUS201361761046P
OPPOSITIONUS201361794422P
OPPOSITIONWO2013176772
OPPOSITIONWO2014065596
OPPOSITIONWO2014089290
SEARCHUS2010076057
SEARCHWO2013176772
SEARCHWO2014065596
SEARCHWO2014093655
SEARCHWO2014099744

Non-Patent Literature (NPL) Citations (242) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BEERLI ET AL., NAT. BIOTECHNOL., (2002), vol. 20, pages 135 - 141-
DESCRIPTION- BELFORT ET AL., NUCLEIC ACIDS RES., (1997), vol. 25, pages 3379 - 3388-
DESCRIPTION- CHOO ET AL., CURR. OPIN. STRUCT. BIOL., (2000), vol. 10, pages 411 - 416-
DESCRIPTION- CONG ET AL., SCIENCE, vol. 339, pages 819 - 823-
DESCRIPTION- DAYHOFF, Atlas of Protein Sequences and Structure, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, vol. 5, pages 353 - 358-
DESCRIPTION- DOYON ET AL., NAT. BIOTECHNOL., (2008), vol. 26, pages 702 - 708-
DESCRIPTION- DOYON ET AL., NAT. METHODS, (2011), vol. 8, pages 74 - 81-
DESCRIPTION- GRIBSKOV, NUCL. ACIDS RES., (1986), vol. 14, no. 6, pages 6745 - 6763-
DESCRIPTION- ISALAN ET AL., NAT. BIOTECHNOL, (2001), vol. 19, pages 656 - 660-
DESCRIPTION- ISELI ET AL., PLOS ONE, vol. 2, no. 6, page E579-
DESCRIPTION- JINEK ET AL., SCIENCE, vol. 337, pages 816 - 821-
DESCRIPTION- LANGE ET AL., J. BIOL. CHEM., (2007), vol. 282, pages 5101 - 5105-
DESCRIPTION- LOMBARDO ET AL., NAT. BIOTECHNOLOGY, (2007), vol. 25, pages 1298 - 1306-
DESCRIPTION- MILLER ET AL., NAT. BIOTECHNOL, vol. 25, pages 778 - 785-
DESCRIPTION- MOEHLE ET AL., PNAS, (2007), vol. 104, pages 3055 - 3060-
DESCRIPTION- PABO ET AL., ANN. REV. BIOCHEM, (2001), vol. 70, pages 313 - 340-
DESCRIPTION- SANTIAGO ET AL., PNAS, (2008), vol. 105, pages 5809 - 5814-
DESCRIPTION- SANTIAGO ET AL., PROC. NATL. ACAD. SCI. USA, (2008), vol. 105, pages 5809 - 5814-
DESCRIPTION- SEGAL ET AL., CURR. OPIN. BIOTECHNOL, (2001), vol. 12, pages 632 - 637-
DESCRIPTION- SMITH; WATERMAN, ADVANCES IN APPLIED MATHEMATICS, (1981), vol. 2, pages 482 - 489-
DESCRIPTION- SZCZPEK ET AL., NAT. BIOTECHNOL, (2007), vol. 25, pages 786 - 793-
DESCRIPTION- URNOV ET AL., NATURE, (2005), vol. 435, pages 646 - 651-
DESCRIPTION- ZHANG ET AL., J. BIOL. CHEM., (2000), vol. 275, no. 43, pages 33850 - 33860-
OPPOSITION- Alberts Bruce, Et Al, Molecular Biology of the Cell. Third Edition. Excerpts, Garland Publishers, (19940101), pages cover, 563 - 564, XP055819121-
OPPOSITION- ALBERTS, "Chapter 12 Intracellular compartments and protein sorting", Molecular Biology of the Cell, (20020101), pages 671 - 676, XP055486976-
OPPOSITION- Anonymous, "cNLS Mapper Result - report of predicted NLSs in the S. pyogenes Cas9 sequence generated using the online cNLS mapper algorithm", (20160425), URL: www.nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_y.cgi-
OPPOSITION- Anonymous, "Plasmid: pSVK3", addgene, URL: http://www.addgene.org/vector-database/4288-
OPPOSITION- Anonymous, "Scientific Background on the Nobel Prize in chemistry 2020", Kungliga Vetenskapsakademien, pages 1 - 14, XP055773900-
OPPOSITION- Benda Christina, Et Al, "Urine as a Source of Stem Cells. Excerpt from Mesenchymal Stem Cells: Basics and Clinical Application I", Advances in Biochemical Engineering/Biotechnology, Springer Verlag, (20120101), vol. 129, pages 19 - 32, XP055819225-
OPPOSITION- cNLS mapper report for S. pyogenes Cas9-
OPPOSITION- DAVIS, G.D. et al., "Zinc Finger Nucleases for Genome Editing", Genetic Engineering & Biotechnology News, (20100000), vol. 30, no. 12, XP055340181-
OPPOSITION- "Enabling Science to Improve the Quality of Life", Sigma-Aldrich Annual Report, (20120000), pages 1 - 92-
OPPOSITION- FIECK, "Modifications of the E. coli Lac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear acumulation", Nucleic Acids Res, (19920000), vol. 20, pages 1785 - 1791, XP002095852-
OPPOSITION- FREITAS, "Mechanisms and Signals for the Nuclear Import of Proteins", Current Genomics, (20090000), vol. 10, pages 550 - 557, XP055502464-
OPPOSITION- "Genome editing", Wikipedia, (20120906), page 7pp, Wikipedia, URL: https://en.wikipedia/wfinder.php?title=Genome_editing&oldid=511115185, XP055604306-
OPPOSITION- Kempken Frank, Jung Christian, "Genetic Modification of Plants. Agriculture, Horticulture and Forestry. Excerpt", Springer, (20100101), pages cover, 9 - 10, XP055819230-
OPPOSITION- LEWIN et al., "Nuclear localization sequences target proteins to the nucleus", Cells, (20070000), page 224, XP055254866-
OPPOSITION- MUSSOLINO, C. et al., "TALE nucleases: tailored genome engineering made easy", Current Opinion Biotechnology, (20120000), vol. 23, no. 5, pages 644 - 650-
OPPOSITION- Nandakumar, Et Al, "DNA delivery system", Plant Transformation Technology Revolution in Last Three Decades Volume Title: Historical Technology Developments, (20110101), page 3,5, XP055764686-
OPPOSITION- NLS mapper-
OPPOSITION- NLS Mapper analysis of S. pyogenes Cas9-
OPPOSITION- Psort data-
OPPOSITION- SCHRAMM, Genes Dev, (20020000), vol. 16, pages 2593 - 2620, XP055183585-
OPPOSITION- URL: http://www.addgene.org/vector- database/4288-
OPPOSITION- WATSON, J.D. et al., "12 Transferring Genes into Mammalian Cells", Recombinant DNA Second edition, (19920000), pages 213 - 234, XP055502977-
OPPOSITION- XU, "The Next Generation Biotechnology for Apple Improvement and Beyond: The CRISPR/Cas9 Story", New York Fruit Quarterly, (20130000), vol. 21, pages 19 - 22, XP055340191-
OPPOSITION- CRISTEA et al., "In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration", Biotechnology and Bioengineering, (20130000), vol. 110, no. 3, pages 871 - 880, XP055076901
OPPOSITION- CRISTEA, "In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration", Biotechnology and Bioengineering, (20130000), vol. 110, pages 871 - 880, XP055076901
OPPOSITION- SOUILHOL, "Nas transgenic mouse line allows visualization of Notch pathway activity in vivo", Genesis, (20060600), vol. 44, no. 6, pages 277 - 286, XP055502571
OPPOSITION- CHUGH et al., "Cell -penetrating peptides: Nanocarrier for macromolecule delivery in living cells", IUBMB life, (20100000), vol. 62.3, doi:10.1002/iub.297, pages 183 - 193, XP055071760
OPPOSITION- FURUTAMA, "Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum", J Neurosci Res, (20100000), vol. 88, pages 2810 - 2825, XP055502574
OPPOSITION- ZHIBAO et al., "Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo", Molecular Therapy, (20000000), vol. 2.4, pages 339 - 347, XP000998662
OPPOSITION- ZOLKIEWSKA A., "ADAM Proteases: Ligand Processing and Modulation of the Notch Pathway", NIH Public Access Author Manuscript, (20080000), vol. 65, no. 13, pages 1 - 19, XP055502966
OPPOSITION- BIZZARRI, "Fluorescence recovery after photobleaching reveals the biochemistry of nucleocytoplasmic exchange", Anal Bioanal Chem, (20120000), vol. 403, pages 2339 - 2351, XP035069015
OPPOSITION- MOJICA, F.J. et al., "Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements .", J. Mol. Evol., (20050000), vol. 60, pages 174 - 182, XP019363173
OPPOSITION- PATTERSON, "Codon optimization of bacterial luciferase (lux) for expression in mammalian cells", J Ind Microbiol. Biotechnol, (20050000), vol. 32, pages 115 - 123, XP002503994
OPPOSITION- REMY, "Zinc-finger nucleases: a powerful tool for genetic engineering of animals", Transgenic Res, (20100000), vol. 19, page 363, XP019831645
OPPOSITION- Je Chul Lee, Et Al, "Prediction of Bacterial Proteins Carrying A Nuclear Localization Signal and Nuclear Targeting of HsdM from Klebsiella pneumoniae", The Journal of Microbiology, (20091001), vol. 47, no. 5, pages 641 - 645, XP055710954
OPPOSITION- FOECKING, "Powerful and versatile enhancer-promoter unit for mammalian expression vectors", Gene, (19860000), pages 101 - 105, XP025688566
OPPOSITION- PEREZ-PINERA, "Advances in Targeted Genome Editing", Curr Opin Chem Biol, (20120000), vol. 16, pages 268 - 77, XP055501592
OPPOSITION- PEREZ-PINERA, P., "Advances in Targeted Genome Editing.", NIH Public Access Author Manuscript, (20120000), vol. 16, no. 3-4, pages 1 - 18, XP055501592
OPPOSITION- PEREZ-PINERA, P. et al., "Advances in targeted genome editing", Current Opinion in Chemical Biology, (20120000), vol. 16, pages 267 - 277, XP055065262
OPPOSITION- WANE, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", Cell, (20130000), vol. 153, pages 910 - 918, XP028538358
OPPOSITION- WANG et al., "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", Cell, (20130000), vol. 153, pages 910 - 918, XP028538358
OPPOSITION- WANG et al., "One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas- mediated genome engineering", Cell, (20130502), vol. 153, no. 4, pages 910 - 918, XP028538358
OPPOSITION- NISHIMASU et al., "Crystal structure of Cas9 in complex with Guide RNA and Target DNA", Cell, (20140000), vol. 156, no. 5, pages 935 - 949, XP028622533
OPPOSITION- MUSSOLINI, "TALE nucleases: tailored genome engineering made easy", Curr Opinion Biotechnol, (20120000), vol. 23, pages 644 - 650, XP055071668
OPPOSITION- MEI, YUE et al., "Recent Progress in CRISPR/Cas9 Technology", Genomics, (20160000), vol. 43, pages 63 - 72, XP029434259
OPPOSITION- CHAPMAN, "Playing the End Game: DNA Double-Strand Break Repair Pathway Choice", Molecular Cell, (20120000), vol. 47, pages 497 - 510, XP055502422
OPPOSITION- GOLDFARB, "Importin α: a multipurpose nuclear-transport receptor", Trends in Cell Biology, (20040000), vol. 14, no. 3, pages 505 - 514, XP004552656
OPPOSITION- LE PROVOST et al., "Zinc finger nuclease technology heralds a new era in mammalian transgenesis", Trends in Biotechnology, (20090000), vol. 28, no. 3, pages 134 - 141, XP026906787
OPPOSITION- WARD et al., "Targeted integration of a rAAV vector into the AAVS1 region", Virology, (20120913), vol. 433, pages 356 - 366, XP055502331
OPPOSITION- WARD, "Targeted integration of a rAAV vector into the AAVS1 region", Virology, (20120000), vol. 433, pages 356 - 366, XP055502331
OPPOSITION- YANG, "HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, pages 36 - 44, XP004395339
OPPOSITION- KARRAN, "DNA double strand break repair in mammalian cells", Current Opinion in Genetics & Development (2000, (20000401), vol. 10, no. 2, pages 144 - 150, XP001206008
OPPOSITION- CHIU, "Engineered GFP as a vital reporter in plants", Curr Biol, (19960000), vol. 6, pages 325 - 330, XP000571865
OPPOSITION- VILLION, "The double-edged sword of CRISPR-Cas systems", Cell Research, (20120000), vol. 23, pages 15 - 17, XP055086684
OPPOSITION- CHANG et al., "Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos", Cell Research, (20130000), vol. 23, pages 465 - 472, XP055251146
OPPOSITION- CHANG et al., "Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos", Cell Research, (20130326), vol. 23, no. 4, pages 465 - 472, XP055251146
OPPOSITION- Chang et al., "Supplementary Information ( tables S1-S6) to Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos", Cell Research, (20130401), page 10pp, XP055604261
OPPOSITION- CHANG, "Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos", Cell Research, (20130000), vol. 23, pages 465 - 472, XP055251146
OPPOSITION- CHANG, N. et al., "Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos", Cell Res., (20130400), vol. 23, no. 4, pages 465 - 472, XP055251146
OPPOSITION- SHEN et al., "Generation of gene -modified mice via Cas9/RNA-mediated gene targeting", Cell Research, (20130402), vol. 23, pages 720 - 723, XP055141533
OPPOSITION- Liu Pengpeng, Et Al, "Heritable/conditional genome editing in C. elegans using a CRISPR/Cas9 feeding system", Cell Research, (20140530), vol. 24, doi:10.1038/cr.2014.73, pages 886 - 889, XP055819130
OPPOSITION- CARROLL, D. et al., "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Ther., (20080911), vol. 15, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, D., "Progress and prospects: zinc-finger nucleases as gene therapy agents", Gene Therapy, (20080000), vol. 15, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, D., "Review Progress and prospects: Zinc-Finger nucleases as gene therapy agents", Gene therapy, (20080000), vol. 15, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Therapy, (20080000), vol. 15, no. 12, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Therapy, (20080000), vol. 15, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, D. A, "CRISPR Approach to Gene Targeting", Molecular Therapy, (20120000), vol. 20, no. 9, pages 1658 - 1660, XP055106489
OPPOSITION- CARROLL, D., "A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120000), vol. 20, no. 9, pages 1658 - 1660, XP055106489
OPPOSITION- CARROLL, D., "A CRISPR approach to gene targeting", Molecular Therapy, (20120900), vol. 20, no. 9, pages 1658 - 1660, XP055106489
OPPOSITION- URNOV, F.D. et al., "Highly efficient endogenous human gene correction using zinc-finger nucleases", Nature, (20050000), vol. 435, pages 646 - 651, XP002467423
OPPOSITION- URNOV, "Highly efficient endogenous human gene correction using designed zinc-finger nucleases", Nature, (20050000), vol. 435, pages 646 - 651, XP002411069
OPPOSITION- DELTCHEVA, E., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110000), vol. 471, pages 602 - 607, XP055068535
OPPOSITION- LI, "In vivo genome editing restores haemostasis in a mouse model of haemophilia", HHS Public Access Author Manuscript, (20110000), vol. 475, pages 1 - 20, XP055502541
OPPOSITION- BEDELL, "In vivo genome editing using a high-efficiency TALEN system", Nature, (20120000), vol. 491, pages 114 - 118, XP055048281
OPPOSITION- BEDELL, V.M. et al., "In vivo genome editing using a high-efficiency TALEN system", Nature, (20120000), vol. 491, pages 114 - 118, XP055048281
OPPOSITION- PORTEUS, M.H. et al., "Gene targeting using zinc finger nucleases", Nature Biotechnology, (20050000), vol. 23, no. 8, pages 967 - 973, XP002467422
OPPOSITION- IRION et al., "Identification and targeting of the ROSA26 locus in human embryonic stem cells", Nat Biotech, (20071125), vol. 25, no. 12, pages 1477 - 1482, XP008111005
OPPOSITION- IRION, "Identification and targeting of the ROSA26 locus in human embryonic stem cells", Nature Biotechnology, (20070000), vol. 25, pages 1477 - 1482, XP008111005
OPPOSITION- CUI, "Targeted integration in rat and mouse embryos with zinc-finger nucleases", Nat Biotechnol, (20110000), vol. 29, pages 64 - 67, XP055065200
OPPOSITION- MILLER, "A Tale nuclease architecture for efficient genome editing (includes Online Methods)", Nature Biotechnology, (20110000), vol. 29, pages 143 - 148+2PP, XP055285157
OPPOSITION- MILLER et al., "A TALE nuclease architecture for efficient genome editing (includes Online Methods)", Nature Biotechnology, (20110000), vol. 29, pages 143 - 148+2pp, XP002685898
OPPOSITION- MILLER, J. C. et al., "A TALE nuclease architecture for efficient genome editing", Nat. Biotechnol., (20111222), vol. 29, pages 143 - 148, XP055458374
OPPOSITION- MILLER, J.C. et al., "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, (20110000), vol. 29, no. 2, pages 143 - 148, XP002685898
OPPOSITION- HOCKEMEVER, "Genetic engineering of human pluripotent cells using TALE nucleases", Nature Biotechnology, (20110000), vol. 29, pages 731 - 734, XP055265362
OPPOSITION- TESSON, "Knockout rats generated by embryo microinjection of TALENS", Nat Biotechnol, (20110000), vol. 29, pages 695 - 696, XP002681970
OPPOSITION- REYON, D. et al., "FLASH Assembly of TALENS Enables High-Throughput Genome Editing", HHS Public Access Author Manuscript, (20120000), vol. 30, no. 5, pages 1 - 23, XP055501683
OPPOSITION- BARRANGOU, "RNA-mediated programmable DNA cleavage", Nature Biotechnology, (20120000), vol. 30, no. 9, pages 836 - 838, XP055118675
OPPOSITION- BARRANGOU, R., "RNA-mediated programmable DNA cleavage", Nat. Biotechnology, (20120000), vol. 30, no. 9, pages 836 - 838, XP055118675
OPPOSITION- BARRANGOU, R., "RNA-mediated programmable DNA cleavage", Nature Biotech ., (20120910), vol. 30, no. 9, pages 836 - 838, XP055118675
OPPOSITION- HWANG, "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (20130000), vol. 31, pages 227 - 229, XP055086625
OPPOSITION- HWANG, W. et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (20130000), vol. 31, pages 227 - 229, XP055086625
OPPOSITION- CHO, S. et al., "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (including supplementary information)", Nature Biotechnology, (20130129), vol. 31, pages 230 - 232, 1-11, XP002699850
OPPOSITION- CHO, S. W., "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nature Biotech., (20130000), vol. 31, no. 3, pages 230 - 232, 1-11, XP002699850
OPPOSITION- CHO, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nature Biotechnology, (20130000), vol. 31, pages 230 - 232,1-11, XP002699850
OPPOSITION- HSU et al., "DNA targeting specificity of RNA-guided Cas9 nucleases", Nature Biotech, (20130721), vol. 31, no. 9, pages 827 - 834, XP055382777
OPPOSITION- Hsu et al., "Supplementary Information to DNA targeting specificity of RNA-guided Cas9 nuclease", Nature Biotechnology, vol. 31, no. 9, (20130901), pages 1 - 26, XP002718605
OPPOSITION- HSU, P. S., "DNA targeting specificity of RNA-guided Cas9 nucleases", Nature Biotechnology, (20130000), vol. 31, no. 9, pages 827 - 832, XP055382777
OPPOSITION- LI et al., "Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9", NIH Public Access Author Manuscript, (20130000), vol. 31, no. 8, pages 1 - 8, XP055438438
OPPOSITION- Li et al., "Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 - Supplementary Information", Nature Biotechnology, vol. 31, no. 8, (20130801), pages 1 - 15, XP055337097
OPPOSITION- LI, J.F. et al., "Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9", nature biotechnology, (20130000), vol. 31, no. 8, pages 688 - 691, XP055129103
OPPOSITION- REBAR et al., "Induction of angiogenesis in a mouse model using engineered transcription factors", Nature Medicine, (20020000), vol. 8, no. 12, pages 1427 - 1432, XP002993087
OPPOSITION- REBAR et al., "Induction of angiogenesis in a mouse model using engineered transcription factors", Nature Medicine, (20020000), vol. 8, pages 1427 - 1432, XP002993087
OPPOSITION- REBAR, "Induction of angiogenesis in a mouse model using engineered transcription factors", Nature Medicine, (20020000), vol. 8, pages 1427 - 32, XP002993087
OPPOSITION- CARROLL, "Design, construction and in vitro testing of zinc finger nucleases", Nature Protocols, (20060000), vol. 1, pages 1329 - 1341, XP001539641
OPPOSITION- SANJANA, N., "A Transcription Activator-Like Effector (TALE) Toolbox for Genome Engineering", NIH Public Author Manuscript, (20120105), pages 171 - 192, XP055502289
OPPOSITION- URNOV et al., "Genome editing with engineered zinc finger nucleases", Nature Reviews Genetics, (20100000), vol. 11, no. 9, pages 636 - 646, XP055198280
OPPOSITION- URNOV, F.D. et al., "Genome editing with engineered zinc finger nucleases.", Nature Reviews Genetics, (20100000), vol. 11, pages 636 - 646, XP008150557
OPPOSITION- URNOV, F. et al., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Gene, (20100900), vol. 11, pages 636 - 646, XP055198280
OPPOSITION- URNOV, "Genome editing with engineered zinc finger nucleases", Nat. Rev. Gene, (20100000), vol. 11, pages 636 - 646, XP055198280
OPPOSITION- JOUNG et al., "TALENs: a widely applicable technology for targeted genome editing", Nature Reviews Molecular Cell Biology, (20130000), vol. 14, no. 1, pages 49 - 55, XP055282847
OPPOSITION- JOUNG, J. et al., "TALENS: a widely applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., (20121121), vol. 14, pages 49 - 55, XP055282847
OPPOSITION- JOUNG, "TALENs: a widely applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., (20130000), vol. 14, pages 49 - 55, XP055282847
OPPOSITION- MAKAROVA et al., "Evolution and classification of the CRISPR-Cas systems", Nature Reviews Microbiology, (20110509), vol. 9, pages 467 - 477, XP055502950
OPPOSITION- MAKAROVA, K.S. et al., "An Updated Evolutionary Classification of CRISPR-Cas Systems", Nature, (20150000), vol. 13, pages 722 - 736, XP055271841
OPPOSITION- LAUMONIER, "Lentivirus mediated HO-1 gene transfer enhances myogenic precursor cell survival after autologous transplantation in pig", Mol Ther, (20080000), vol. 16, pages 404 - 410, XP008159717
OPPOSITION- MOEHLE, "Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases (plus Corrections)", PNAS, (20070403), vol. 104, no. 14, pages 3055 - 3060+6090, XP002518477
OPPOSITION- BEUMER, "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases", PNAS, (20080000), vol. 105, pages 19821 - 19826, XP002782686
OPPOSITION- MAHFOUZ, "De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks", PNAS, (20110000), vol. 108, pages 2623 - 2628, XP055007615
OPPOSITION- MAHFOUZ, M.M. et al., "De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double- strand breaks", PNAS, (20110000), vol. 108, no. 6, pages 2623 - 2628, XP055007615
OPPOSITION- GASIUAS, G. et al., "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", Proc. Nat. Acad. Sci., (20120904), pages E2579 - E2586, XP055068588
OPPOSITION- GASIUNAS, G., "Cas9- crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", proc. nat. acad. sci., (20120000), vol. 109, no. 39, pages E2579 - E2586, XP055068588
OPPOSITION- LIANG, "Homology-directed repair is a major double-strand break repair pathway in mammalian cells.", PNAS, (19980000), vol. 95, pages 5172 - 5177, XP055502633
OPPOSITION- DEROSSI, "Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent", The Journal of Biological Biochemistry, (19960000), vol. 271, pages 18188 - 18193, XP002024485
OPPOSITION- DAI, "The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism", J Biol Chem, (20020000), vol. 277, pages 24390 - 24398, XP055251716
OPPOSITION- PLANEV, "Inhibition of Glucocorticoid-induced Apoptosis in 697 Pre-B Lymphocytes by the Mineralocorticoid Receptor N-terminal Domain", J Biol Chem, (20020000), vol. 277, pages 42188 - 42196, XP055251719
OPPOSITION- HODEL, "Nuclear Localization Signal Receptor Affinity Correlates with in Vivo Localization in Saccharomyces cerevisiae", JBC, (20060000), vol. 281, pages 23545 - 23556, XP055502581
OPPOSITION- P. Li, "Efficiency and Specificity of Targeted Integration Mediated by the Adeno-Associated Virus Serotype 2 Rep 78 Protein", Human Gene Therapy Methods, (20180101), vol. 29, no. 3, XP055710960
OPPOSITION- "Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases With Adeno-Associated Viral Vectors", Human Gene Therapy, (20120000), vol. 23, pages 321 - 329, XP002730956
OPPOSITION- KOURANOVA et al., "CRISPRs for Optimal Targeting: Delivery of CRISPR Components as DNA, RNA, and Protein into Cultured Cells and Single-Cell Embryos", Human Gene Therapy, (20160000), vol. 27, no. 6, pages 464 - 475, XP055465083
OPPOSITION- SALOMON et al., "Capture of genomic and T-DNA sequences during double-strand break repair in somatic plant cells", The EMBO Journal, (19980000), vol. 17, pages 6086 - 6095, XP002259898
OPPOSITION- PUCHTA, "The repair of double-strand breaks in plants: mechanisms and consequences for genome evolution", Journal of Experimental Botany, (20050000), vol. 56, no. 1, pages 1 - 14, XP002394840
OPPOSITION- ORLANDO, "Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology", Nucleic Acid Res, (20100000), vol. 38, pages 1 - 15, XP055076783
OPPOSITION- LI et al., "Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes", Nucleic Acids Research, (20110000), vol. 39, no. 14, pages 6315 - 6325, XP002680499
OPPOSITION- LI, T. et al., "Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes", Nucleic Acids Research, (20110000), vol. 39, no. 14, pages 6315 - 6325, XP002680499
OPPOSITION- CERMAK, "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Res, (20110000), vol. 39, pages 1 - 11, XP002659530
OPPOSITION- CERMAK et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Res, (20110000), vol. 39, pages 1 - 11, XP055130093
OPPOSITION- CERMAK et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Research, (20110000), vol. 39, no. 12, pages 1 - 11, XP055130093
OPPOSITION- CERMAK, T. et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Research, (20110000), vol. 39, no. 12, pages 1 - 11, XP002659530
OPPOSITION- SAPRANAUSKAS, R., "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli -useful background", Nucleic Acids Research, (20110000), vol. 39, no. 21, pages 9275 - 9282, XP055011535
OPPOSITION- FONFARA et al., "Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-cas systems", Nucleic Acids Research, (20140000), vol. 42, no. 4, pages 2577 - 2590, XP055399937
OPPOSITION- DICARLO et al., "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems", Nucleic Acids Research, (20130000), vol. 41, no. 7, pages 4336 - 4343, XP055086617
OPPOSITION- DiCarlo et al., "Supplemental Data to Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems", (20130401), vol. 41, no. 7, pages 1 - 5, XP055604254
OPPOSITION- DICARLO, J. et al., "Genome engineering in Saccharomyces cerevisiae using CRISPR/Cas systems", Nucl Acid Res., (20130304), vol. 41, no. 7, pages 4336 - 4343, XP055086617
OPPOSITION- DICARLO, Nucleic Acids Res, (20130000), vol. 41, pages 4336 - 4343, XP055086617
OPPOSITION- POURCEL, C. et al., "CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies", Microbiology, (20050000), vol. 151, pages 653 - 663, XP002460396
OPPOSITION- BOLOTIN, A. et al., "Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin", Microbiology, (20050000), vol. 151, pages 2551 - 2561, XP002424872
OPPOSITION- MARESCA, "Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining", Genome Research, (20130000), vol. 23, pages 539 - 546, XP055077484
OPPOSITION- HOCKEMEYER et al., "Gene Targeting in Human Pluripotent Cells", Cold Spring Harb Symp Quant Biol, (20100000), pages 201 - 209, URL: http://symposium.cshlp.org/content/75/201.full.pdf, (20180620), XP055604347
OPPOSITION- H. Bierne, Et Al, "When bacteria target the nucleus: the emerging family of nucleomodulins", Cellular Microbiology, (20120101), vol. 14, no. 5, pages 622 - 633, XP055710953
OPPOSITION- H Bierne, Et Al, "When bacteria target the nucleus: the emerging family of nucleomodulins", Cellular Microbiology, (20120223), vol. 145, pages 622 - 633, XP055710968
OPPOSITION- PORTEUS et al., "Chimeric nucleases stimulate gene targeting in human cells", Science, (20030000), vol. 300, page 763, XP002974231
OPPOSITION- BIBIKOVA, "Enhancing gene targeting with designed zinc finger nucleases", Science, (20030000), vol. 300, page 764, XP002974267
OPPOSITION- BARRANGOU, R. et al., "CRISPR provides acquired resistance against viruses in prokaryotes", Science, (20070000), vol. 315, pages 1709 - 1712, XP002428071
OPPOSITION- BROUNS, S. J. J. et al., "Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes", Science, (20080000), vol. 321, pages 960 - 964, XP002559962
OPPOSITION- MARRAFFINI, L.A. et al., "CRISPR interference limits horizontal gene transfer in Staphylococci by targeting DNA", NIH Public Access Author Manuscript, (20080000), vol. 322, pages 1 - 7, XP055463182
OPPOSITION- GEURTS, "Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases", Science, (20090000), vol. 325, page 433, XP002580718
OPPOSITION- Jinek et al., "Supplementary Materials for A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (08171220), vol. 337, pages 1 - 37, XP055067747
OPPOSITION- Jinek et al., "Supplementary Materials for A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, vol. 337, (20120817), pages 1 - 37, XP055067747
OPPOSITION- JINEK, M. et al., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", Science, (20120000), vol. 337, pages 816 - 821, XP055299674
OPPOSITION- JINEK, M et al., "A Programmable Dual-RNA- Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120000), vol. 337, pages 816 - 821, XP055299674
OPPOSITION- JINEK, M. et al., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", Science, (20120628), vol. 337, pages 816 - 821, XP055299674
OPPOSITION- JINEK, Science, (20120000), vol. 337, pages 816 - 820, XP055299674
OPPOSITION- BROUNS, "A Swiss Army Knife of Immunity", Science, (20120000), vol. 337, pages 808 - 809, XP055113718
OPPOSITION- BROUNS, S., "A Swiss army knife of immunity", Science, (20120817), vol. 337, no. 6096, pages 808 - 809, XP055113718
OPPOSITION- CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, pages 819 - 823, XP055067741
OPPOSITION- Cong et al., "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (01031320), vol. 339, no. 6121, pages 1 - 28, XP002730884
OPPOSITION- Cong et al., "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, vol. 339, pages 1 - 28, XP002730884
OPPOSITION- CONG, L. et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, pages 819 - 823, XP055067741
OPPOSITION- CONG, L. et al., "Multiplex genome engineering using CRISPR/Cas systems", Science, (20130103), vol. 339, pages 819 - 823, XP055067741
OPPOSITION- CONG, L. et al., "Multiplex Genome Engineering Using CRISPR Cas Systems", Science, (20130215), vol. 339, no. 6121, pages 819 - 23, XP055067741
OPPOSITION- Mali et al., "RNA Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055469277
OPPOSITION- Mali et al., "Supplementary information for RNA-Guided Human Genome Engineering via Cas9", Science, (02151520), vol. 336, no. 6121, pages 1 - 36, XP002723674
OPPOSITION- Mali et al., "Supplementary Materials for RNA-Guided Human Genome Engineering via Cas9", Science, (20130215), vol. 339, pages 1 - 36, XP002723674
OPPOSITION- MALI, P. et al., "RNA-guided human genome engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055111247
OPPOSITION- MALI, P. et al., "RNA Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055469277
OPPOSITION- MALI, P. et al., "RNA-guided human genome engineering via Cas9", Science, (20130103), vol. 339, pages 823 - 826, XP055111247
OPPOSITION- MALI, "RNA Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055469277
OPPOSITION- ISHINO Y et al., "Nucleotide sequence of the iap gene , responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product", Journal of Bacteriology, (19870000), vol. 169, no. 12, pages 5429 - 5433, XP055463130
OPPOSITION- V. J. Mcalister, Et Al, "Preferential Integration of Adeno-Associated Virus Type 2 into a Polypyrimidine/Polypurine-Rich Region within AAVS1", Journal of Virology, (20070901), pages 9718 - 9726, XP055710963
OPPOSITION- R. Surosky, Et Al, "Adeno-Associated Virus Rep Proteins Target DNA Sequences to a Unique Locus in the Human Genome", Journal of Virology, (19970101), vol. 71, no. 10, pages 7951 - 7959, XP055710956
OPPOSITION- BAIKER, "The Immediate-Early 63 Protein of Varicella-Zoster Virus; Analysis of Functional Domains Required for Replication In Vitro and for T- cell an Skin Tropism in the SCIDhu Model In Vivo", Journal of Viriology, (20040000), vol. 78, no. 3, pages 1181 - 1194, XP055268139
OPPOSITION- ROUET, "Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease.", Molecular and Cellular Biology, (19940000), vol. 14, pages 8096 - 8106, XP000572018
OPPOSITION- MILLER, "Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks", Mol Cell Biol, (20030000), vol. 23, pages 3550 - 3557, XP055502623
OPPOSITION- FISCHER-FANTUZZI, "Cell-dependent efficiency of reiterated nuclear signals in a mutant simian virus 40 oncoprotein targeted to the nucleus", Mol Cell Biol, (19880000), vol. 8, pages 5495 - 5503, XP009140368
OPPOSITION- RUDIN et al., "Efficient repair of HO-induced chromosomal breaks in Saccharomyces cerevisiae by recombination between flanking homologous sequences.", Molecular and Cellular Biology, (19880900), vol. 8, pages 3918 - 3928, XP055502440
OPPOSITION- LIEBER, "The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway", NIH Public Access Author Manuscript, (20100000), vol. 79, pages 1 - 34, XP055502406
OPPOSITION- MINAMI et al., "Ets Motifs Are Necessary for Endothelial Cell -Specific Expression of a 723-bp Tie-2 Promoter/Enhancer in Hprt Targeted Transgenic Mice", Arterioscler Thromb Vasc Biol, (20031100), pages 2041 - 2047, XP055502336
OPPOSITION- MINAMI, "Ets Motifs Are Necessary for Endothelial Cell -Specific Expression of a 723-bp Tie-2 Promoter/Enhancer in Hprt Targeted Transgenic Mice", Arterioscler Thromb Vasc Biol, (20030000), vol. 23, pages 2041 - 2047, XP055502336
OPPOSITION- MCCONNELL, "Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression", Molecular Cancer, (20110000), vol. 10, page 75, XP021103688
OPPOSITION- ZHANG, "Applications of mRNA injections for analyzing cell lineage and asymmetric cell divisions during segmentation in the leech Helobdella robusta", Development, (20050000), vol. 132, pages 2103 - 2113, XP055502340
OPPOSITION- ZHANG et al., "Applications of mRNA injections for analyzing cell lineage and asymmetric cell divisions during segmentation in the leech Helobdella robusta", Development, (20050000), vol. 132, pages 2103 - 2013, XP055502340
OPPOSITION- CHANG, "Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans", Development, (20110000), vol. 138, pages 3509 - 3518, XP055502632
OPPOSITION- CAMPEAU, "A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells", Plos One, (20090000), vol. 4, pages 1 - 18, XP055251120
OPPOSITION- GANTZ et al., "Targeted Genomic Integration of a Selectable Floxed Dual Fluorescence Reporter in Human Embryonic Stem Cells", PLOS One, (20120000), vol. 7, no. 10, pages 1 - 9, XP055514936
OPPOSITION- CHRISTIAN et al., "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", Genetics, (20100000), vol. 186, no. 2, pages 757 - 761+1SI-8SI, XP002632806
OPPOSITION- CHRISTIAN, M. et al., "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases", Genetics, (20100000), vol. 186, pages 757 - 761,1SI-8SI, XP002632806
OPPOSITION- CHRISTIAN, M. et al., "Targeting DNA double-strand breaks with TAL effector nucleases", Genetics, (20100726), vol. 186, pages 757 - 761, 1SI-8SI, XP002632806
OPPOSITION- CHRISTIAN, "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", Genetics, (20100000), vol. 186, pages 757 - 761,1SI-8SI, XP002632806
OPPOSITION- CARROLL, D., "Genome Engineering with Zinc-Finger Nucleases", Genetics, (20110000), vol. 188, pages 773 - 782, XP055036700
OPPOSITION- CARROLL, "Genome Engineering With Zinc-Finger Nucleases", Genetics, (20110000), vol. 188, pages 773 - 782, XP055036700
OPPOSITION- GRATZ et al., "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, (08011320), vol. 194, pages 1029 - 1035, XP055102690
OPPOSITION- GRATZ et al., "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, (20130000), vol. 194, pages 1029 - 1035, XP055102690
OPPOSITION- GRATZ, "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, (20130000), vol. 194, pages 1029 - 1035, XP055102690
OPPOSITION- YU et al., "Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila", Genetics, (20130705), vol. 95, no. 1, pages 289 - 291, XP055242275
OPPOSITION- GOLIC, "RNA-Guided Nucleases: A New Era for Engineering the Genomes of Model and Nonmodel Organisms", Genetics, (20130000), vol. 195, pages 303 - 308, XP055340188
OPPOSITION- LVSSENKO, "Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans", BioTechniques, (20070000), vol. 43, pages 596 - 600, XP055268137
OPPOSITION- NOGUCHI, "PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells", Diabetes, (20030000), vol. 52, pages 1732 - 37, XP002354481
OPPOSITION- Levi Lowder, Malzahn Aimee, Qi Yiping, "Rapid Evolution of Manifold CRISPR Systems for Plant Genome Editing", Frontiers in Plant Science, vol. 7, doi:10.3389/fpls.2016.01683, pages 1 - 12, XP055764684
OPPOSITION- RICHTER, C., "Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems", Viruses, (20120000), vol. 4, pages 2291 - 2311, XP055299758
OPPOSITION- JINEK, M. et al., "RNA-programmed genome editing in human cells", eLife, (20130000), pages 1 - 9, XP002699851
OPPOSITION- JINEK, M. et al., "RNA-programmed genome editing in human cells", eLife, (20130129), pages 1 - 9+3pp, XP055285239
OPPOSITION- JINEK, M., "RNA-programmed genome editing in human cells", eLife 2013, (20130000), vol. 2, pages 1 - 9, XP055245475
OPPOSITION- JINEK, "RNA-programmed genome editing in human cells (includes supplementary information)", Science, (20130000), vol. 337, pages 1 - 9+4PP, XP055285239
SEARCH- LEI S. QI ET AL, "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", CELL, US, (20130201), vol. 152, no. 5, doi:10.1016/j.cell.2013.02.022, ISSN 0092-8674, pages 1173 - 1183, XP055299671 [AP] 1-16 * the whole document *
SEARCH- DANA CARROLL, "A CRISPR Approach to Gene Targeting", MOLECULAR THERAPY, (20120901), vol. 20, no. 9, doi:10.1038/mt.2012.171, ISSN 1525-0016, pages 1658 - 1660, XP055106489 [A] 1-16 * the whole document *
SEARCH- R. SAPRANAUSKAS ET AL, "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", NUCLEIC ACIDS RESEARCH, GB, (20110803), vol. 39, no. 21, doi:10.1093/nar/gkr606, ISSN 0305-1048, pages 9275 - 9282, XP055265024 [A] 1-16 * the whole document *
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055229606 [A] 1-16
SEARCH[ ] - M. JINEK ET AL, "Supplementary Materials for A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 1 - 37, XP055067747
SEARCH- MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", ELIFE, GB, (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - 1, XP055245475 [AP] 1-16

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents