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IP Verse

A Rapamycin Derivative For Treating Lung Cancer - EP3143995

The patent EP3143995 was granted to Novartis on Jan 15, 2025. The application was filed on Feb 18, 2002 under application number EP16186041A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3143995

NOVARTIS
Application Number
EP16186041A
Filing Date
Feb 18, 2002
Status
Patent Maintained As Amended
Dec 13, 2024
Publication Date
Jan 15, 2025
External Links
Slate, Register, Google Patents

Patent Summary

A compound, 40-O-(2-hydroxyethyl)-rapamycin, for treating solid tumors, particularly lung cancer, by inhibiting angiogenesis and tumor growth. The compound, a derivative of the macrolide antibiotic rapamycin, selectively targets endothelial cells and suppresses their proliferation, particularly in response to vascular endothelial growth factor (VEGF). It exhibits antitumor activity in preclinical models, including human lung and epidermoid tumor xenografts, and shows potential for combination therapy with conventional anticancer agents.

Patent Family

Patent Family

Patent Oppositions (7)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status
ACCORD HEALTHCARESep 5, 2019PLOUGMANN VINGTOFTADMISSIBLE
GENERICS UKSep 5, 2019ELKINGTON AND FIFEWITHDRAWN
STADA ARZNEIMITTELSep 5, 2019HAMM & WITTKOPPWITHDRAWN
ZENTIVA KSSep 3, 2019BIRD & BIRDADMISSIBLE
TEVA PHARMACEUTICALSAug 30, 2019GREINERADMISSIBLE
SYNTHONAug 27, 2019BENNEKERADMISSIBLE
ETHYPHARMJun 12, 2019LLRADMISSIBLE

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
OPPOSITIONEP1064942
OPPOSITIONEP2793686
OPPOSITIONEP3143995
OPPOSITIONGB104072
OPPOSITIONGB124957
OPPOSITIONUS4885171
OPPOSITIONUS5206018
OPPOSITIONUS5672605
OPPOSITIONUS5985325
OPPOSITIONWO0151049
OPPOSITIONWO02066019
OPPOSITIONWO9409010
OPPOSITIONWO9725977
OPPOSITIONWO9747317
SEARCHWO0151049
SEARCHWO9747317

Dossier Documents

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