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Methods Of Cancer Treatment With Antagonists Against Pd-1 And Pd-L1 In Combination With Radiation Therapy - EP3157629

The patent EP3157629 was granted to Medimmune on Oct 5, 2022. The application was originally filed on Jun 17, 2015 under application number EP15733375A. The patent is currently recorded with a legal status of "Opposition Rejected".

EP3157629

MEDIMMUNE
Application Number
EP15733375A
Filing Date
Jun 17, 2015
Status
Opposition Rejected
Mar 21, 2025
Grant Date
Oct 5, 2022
External Links
Slate, Register, Google Patents

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TESAROJul 4, 2023DRURYADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2010028330
EXAMINATIONWO2013079174
INTERNATIONAL-SEARCH-REPORTWO2012177624
INTERNATIONAL-SEARCH-REPORTWO2013190555
OPPOSITIONCN102935228
OPPOSITIONWO2012177624
OPPOSITIONWO2013079174
OPPOSITIONWO2014107873
OTHERWO2013079174

Non-Patent Literature (NPL) Citations (12) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- FILATENKOV ALEXANDER ET AL, "Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 AUG 2015, (20150815), vol. 21, no. 16, ISSN 1078-0432, pages 3727 - 3739-
EXAMINATION- K. Pilones ET AL, "Abstract 5020: Cooperative effects of programmed cell death-1 blockade and radiation in a model of a poorly immunogenic breast carcinoma", Proceedings of the 105th Annual Meeting of the American Association of Cancer Research, (20141001), vol. 74, no. 19 Suppl, XP055659598
EXAMINATION- LEE YOUJIN ET AL, "Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.", BLOOD 16 JUL 2009, (20090716), vol. 114, no. 3, doi:10.1182/blood-2009-02-206870, ISSN 1528-0020, pages 589 - 595, XP055978014
OPPOSITION- Barrett Ann et al, Practical Radiotherapy Planning: Fourth Edition, (20090000), pages 1 - 477-
OPPOSITION- Sagiv-Barfi Idit, Et Al, "Local tumor irradiation combined with alpha-PDL-1 immune checkpoint inhibition results in local and systemic anti-tumor responses: Successful translation of a mouse model to a human case series", Presentation Abstract 2941 AACR Annual Meeting 2014, (20140407), pages 1 - 1, XP093064089-
OPPOSITION- HALLETT et al., "Immunosuppressive Effects of Multiple Myeloma Are Overcome by PD-L1 Blockade", Biol Blood Marrow Transplant, (20110413), vol. 17, doi:10.1016/j.bbmt.2011.03.011, pages 1133 - 1145, XP028380126
OPPOSITION- ZENG et al., "Combining Anti-PD-1 (B7-H1) Immunotherapy with Stereotactic Radiosurgery in a Mouse Orthotopic Glioblastoma Model", Int. J. Radiat. Oncol. Biol. Phys., vol. 81, no. 2, doi:10.1016/j.ijrobp.2011.06.167, (20111001), XP055064459
OPPOSITION- VERBRUGGE et al., "Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies", Cancer Res, (20120508), vol. 72, no. 13, doi:10.1158/0008-5472.CAN-12-0210, pages 3163 - 74, XP002745807
OPPOSITION- DENG et al., "Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice", J Clin Invest, (20140102), vol. 124, no. 2, doi:10.1172/JCI67313, pages 687 - 695, XP002743472
OPPOSITION- Lee Youjin, Auh Sogyong L., Wang Yugang, Burnette Byron, Wang Yang, Meng Yuru, Beckett Michael, Sharma Rohit, Chin Robert, Tu Tony, Weichselbaum Ralph R., Fu Yang-Xin, "Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment", Blood, American Society of Hematology, US, US , (20090716), vol. 114, no. 3, doi:10.1182/blood-2009-02-206870, ISSN 0006-4971, pages 589 - 595, XP055978014
OPPOSITION- PILON-THOMAS et al., "Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of Combination Immunotherapy against Melanoma", J Immunol, (20100401), vol. 184, no. 7, doi:10.4049/jimmunol.0904114, pages 3442 - 3449, XP002767914
OPPOSITION- Lugade Amit A. et al, "Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor", Journal of Immunology, Williams & Wilkins, (20050615), vol. 174, no. 12, doi:10.4049/jimmunol.174.12.7516, ISSN 0022-1767, pages 7516 - 7523, XP093244187

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