Variants Of C-Type Natriuretic Peptide - EP3175863

The patent EP3175863 was granted to Biomarin Pharmaceutical on Dec 1, 2021. The application was originally filed on May 20, 2010 under application number EP16192229A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3175863

BIOMARIN PHARMACEUTICAL
Application Number
EP16192229A
Filing Date
May 20, 2010
Status
Granted And Under Opposition
Oct 29, 2021
Grant Date
Dec 1, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

ASCENDIS PHARMAApr 10, 2025CARPMAELS & RANSFORDINTERVENTION
ASCENDIS PHARMA GROWTH DISORDERSSep 1, 2022CARPMAELS & RANSFORDADMISSIBLE

Patent Citations (53) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2008US84270-
DESCRIPTIONEP0466174
DESCRIPTIONEP0497368
DESCRIPTIONUS2004138134
DESCRIPTIONUS2007197434
DESCRIPTIONUS5252714
DESCRIPTIONUS5352770
DESCRIPTIONUS5434133
DESCRIPTIONUS5824784
DESCRIPTIONUS5846932
DESCRIPTIONUS6020168
DESCRIPTIONUS6034231
DESCRIPTIONUS6136040
DESCRIPTIONUS6265632
DESCRIPTIONUS6329375
DESCRIPTIONUS6344459
DESCRIPTIONUS6743425
DESCRIPTIONUS7276481
DESCRIPTIONWO0061631
DESCRIPTIONWO0247871
DESCRIPTIONWO2004047871
DESCRIPTIONWO2005098490
DESCRIPTIONWO9420534
EXAMINATIONEP2277890
EXAMINATIONUS6743425
EXAMINATIONWO02074234
EXAMINATIONWO03079979
EXAMINATIONWO2005099768
EXAMINATIONWO2006005140
EXAMINATIONWO2009046861
OPPOSITIONEP0477971
OPPOSITIONEP0769554
OPPOSITIONEP1333036
OPPOSITIONUS2007197434
OPPOSITIONUS2008312142
OPPOSITIONUS5252714
OPPOSITIONUS5340920
OPPOSITIONUS5824784
OPPOSITIONUS6743425
OPPOSITIONWO02098446
OPPOSITIONWO2004043396
OPPOSITIONWO2006005140
OPPOSITIONWO2009067639
OPPOSITIONWO2009086166
OTHEREP1743653
OTHERUS6743425
OTHERWO03079979
OTHERWO2005099768
OTHERWO2009046861
SEARCHEP1743653
SEARCHUS2008194682
SEARCHWO2009015011
SEARCHWO2009067639

Non-Patent Literature (NPL) Citations (160) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AGOSTON ET AL., BMC DEV. BIOL., (2007), vol. 7, page 18-
DESCRIPTION- ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 410-
DESCRIPTION- AMINO ACIDS, (2006), vol. 30, pages 351 - 367-
DESCRIPTION- AM. J. PHYSIOL., (1998), vol. 275, pages H1826 - 1833-
DESCRIPTION- AM. J. PHYSIOL., (1998), vol. 275, pages L645 - L652-
DESCRIPTION- AM. J. PHYSIOL., (2000), vol. 278, pages G974 - 980-
DESCRIPTION- AM. J. RESPIR. CRIT. CARE MED., (2004), vol. 170, pages 1204 - 1211-
DESCRIPTION- ANN. N.Y. ACAD. SCI., (1996), vol. 785, pages 182 - 187-
DESCRIPTION- ARTH. RHEUM., (2002), vol. 46, no. 8, pages 1986 - 1996-
DESCRIPTION- BARTELS ET AL., AM. J. HUM. GENET., (2004), vol. 75, pages 27 - 34-
DESCRIPTION- B. CUNNINGHAM, EMBO J., (1994), vol. 13, no. 11, pages 2508 - 2515-
DESCRIPTION- BENNETT, B.D. ET AL., J. BIOL. CHEM., (1991), vol. 266, pages 23060 - 67-
DESCRIPTION- BIOCHEM. BIOPHYS. RES. COMM., (1992), vol. 183, pages 964 - 969-
DESCRIPTION- BIOCHEM. BIOPHYS. RES. COMMUN., (1990), vol. 168, pages 863 - 870-
DESCRIPTION- BIOCHEM. BIOPHYS. RES. COMMUN., (1991), vol. 177, pages 927 - 931-
DESCRIPTION- BIOCHEM. BIOPHYS. RES. COMMUN., (1994), vol. 198, pages 1177 - 1182-
DESCRIPTION- BIOCHEM. BIOPHYS. RES. COMMUN., (1994), vol. 205, pages 765 - 771-
DESCRIPTION- BIOCHEM. J., (1993), vol. 291, pages 83 - 88-
DESCRIPTION- CALICETI, ADV. DRUG DELIV. REV., (2003), vol. 55, pages 1261 - 77-
DESCRIPTION- CAREY; SUNDBERG, Advanced Organic Chemistry, 3rd Edition,, PLENUM PRESS, (1992), vol. A, B-
DESCRIPTION- CELL, (1994), vol. 78, pages 335 - 342-
DESCRIPTION- CIRC. RES, (2002), vol. 91, pages 1063 - 1069-
DESCRIPTION- CLIN. EXP. PHARMA. PHYSIOL., (1997), vol. 25, pages 986 - 991-
DESCRIPTION- CUNNINGHAM, EMBO, (1994), vol. 13, no. 11, pages 2508 - 15-
DESCRIPTION- CUNNINGHAM, EMBO J., (1994), vol. 13, no. 11, pages 2508 - 15-
DESCRIPTION- CURR. BIOL., (1995), vol. 5, pages 500 - 507-
DESCRIPTION- CURR. OPIN. BIOTECH, (2006), vol. 17, pages 638 - 642-
DESCRIPTION- CURR. OPIN. BIOTECHNOL., (2002), vol. 13, no. 4, pages 297 - 303-
DESCRIPTION- DAVIES, J. PEPTIDE SCI., (2003), vol. 9, pages 471 - 501-
DESCRIPTION- D. N. GLOVER,, DNA Cloning: A Practical Approach, (1985), vol. I, II-
DESCRIPTION- ENDOCRINOLOGY, (1992), vol. 130, pages 229 - 239-
DESCRIPTION- ENDOCRINOLOGY, (2003), vol. 144, pages 2279 - 2284-
DESCRIPTION- FEBS LETT., (1995), vol. 373, pages 108 - 110-
DESCRIPTION- FENG; DOOLITTLE, J. MOL. EVOL., (1987), vol. 35, pages 351 - 360-
DESCRIPTION- FURUYA ET AL., BIOCHEM. BIOPHYS. RES. COMM, (1992), vol. 183, pages 964 - 969-
DESCRIPTION- G. DE PLATER ET AL., TOXICON, (1998), vol. 36, no. 6, pages 847 - 857-
DESCRIPTION- GROWTH HORM. & IGF RES., (2006), vol. 16, pages S6 - S14-
DESCRIPTION- HENIKOFF; HENIKOFF, PROC. NATL. ACAD. SCI. USA, (1989), vol. 89, page 10915-
DESCRIPTION- HE, X.-L. ET AL., SCIENCE, (2001), vol. 293, no. 5535, pages 1657 - 62-
DESCRIPTION- HE, X.-L., J. MOL. BIOL., (2006), vol. 361, no. 4, pages 698 - 714-
DESCRIPTION- HE, X.-L., J. MOL. BIOL., (2006), vol. 361, pages 698 - 714-
DESCRIPTION- HIGGINS; SHARP, CABIOS, (1989), vol. 5, pages 151 - 153-
DESCRIPTION- H. JIN ET AL., J. CLIN. INVEST, (1996), vol. 98, no. 4, pages 969 - 976-
DESCRIPTION- HORTON WA ET AL., "Standard growth curves for achondroplasia", J. PEDIATR., (1978), vol. 93, pages 435 - 8-
DESCRIPTION- HUM. MOL. GENET, (1996), vol. 5, pages 509 - 512-
DESCRIPTION- HYPEITEN., (1997), vol. 30, pages 184 - 190-
DESCRIPTION- HYPERTENSION, (2007), vol. 49, pages 419 - 426-
DESCRIPTION- HYPERTENS. RES., (1998), vol. 21, pages 7 - 13-
DESCRIPTION- J. ALFONZO, RECEPT. SIGNAL. TRANSDUCT. RES., (2006), vol. 26, pages 269 - 297-
DESCRIPTION- J. AM. CHEM. SOC., (1992), vol. 114, no. 1, pages 378 - 380-
DESCRIPTION- J. BIOL. CHEM., (1996), vol. 271, pages 19324 - 19329-
DESCRIPTION- J. BIOL. CHEM., (1999), vol. 274, pages 17587 - 17592-
DESCRIPTION- J. BIOL. CHEM., (2001), vol. 276, pages 22064 - 70-
DESCRIPTION- J. BONE MONER. RES., (2004), vol. 19, page S20-
DESCRIPTION- J. CARDIOVASC. PHARMACOL., (1998), vol. 117, pages 1600 - 06-
DESCRIPTION- J CLIN. ENDOCRINOL. METAB., (1994), vol. 78, pages 1428 - 35-
DESCRIPTION- J. CLIN. ENDOCRINOL. METAB, (1994), vol. 78, pages 1428 - 35-
DESCRIPTION- J. CLIN. ENDOCRINOL. METAB., (1994), vol. 78, pages 1428 - 35-
DESCRIPTION- J. HYPERTENS., (1992), vol. 10, pages 1111 - 1114-
DESCRIPTION- J. HYPERTENS., (1992), vol. 10, pages 907 - 912-
DESCRIPTION- KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 5873 - 5787-
DESCRIPTION- KIDNEY INT., (1996), vol. 49, pages 1732 - 37-
DESCRIPTION- K. INOUE ET AL., PROC. NAT. ACAD. SCI., (2003), vol. 100, no. 17, pages 10079 - 10084-
DESCRIPTION- KOLLER K.J.; GOEDDEL, D.V., CIRCULATION, (1992), vol. 86, pages 1081 - 88-
DESCRIPTION- KREJCI ET AL., J. CELL SCI., (2005), vol. 118, no. 21, pages 5089 - 5100-
DESCRIPTION- LEVIN ET AL., N. ENGL. J. MED., (1998), vol. 339, pages 863 - 870-
DESCRIPTION- M. HONING ET AL., HYPERTENSION, (2001), vol. 37, pages 1179 - 1183-
DESCRIPTION- MOL. BIOL. CELL, (1995), vol. 6, pages 1861 - 73-
DESCRIPTION- M. TAKANO ET AL., ZOOL. SCI., (1994), vol. 11, pages 451 - 454-
DESCRIPTION- NASKI ET AL., DEVELOPMENT USA, (1998), vol. 125, pages 4977 - 4988-
DESCRIPTION- NAT. GENET., (1995), vol. 9, pages 321 - 328-
DESCRIPTION- NAT. GENET., (1996), vol. 4, pages 390 - 397-
DESCRIPTION- NAT. MED., (2004), vol. 10, pages 80 - 86-
DESCRIPTION- NATURE, (1994), vol. 371, pages 252 - 254-
DESCRIPTION- NATURE GENET., (1996), vol. 12, pages 390 - 397-
DESCRIPTION- NEEDLEMAN; WUNSCH, J. MOL. BIOL., (1970), vol. 48, page 443-
DESCRIPTION- OEFNER ET AL., J. MOL. BIOL, (2000), vol. 296, pages 341 - 349-
DESCRIPTION- OEFNER ET AL., J. MOL. BIOL., (2000), vol. 296, pages 341 - 349-
DESCRIPTION- OEFNER, J. MOL. BIOL., (2000), vol. 296, pages 341 - 349-
DESCRIPTION- OGAWA, H. ET AL., J. BIOL. CHEM, (2004), vol. 279, no. 27, pages 28625 - 31-
DESCRIPTION- OGAWA, H. ET AL., J. BIOL. CHEM., (2004), vol. 279, no. 27, pages 28625 - 31-
DESCRIPTION- OGAWA, H. ET AL., J. BIOL. CHEM., (2004), vol. 279, pages 28625 - 31-
DESCRIPTION- OLNEY ET AL., J. CLIN. ENDOCRINOL. METAB., (2006), vol. 91, no. 4, pages 1229 - 1232-
DESCRIPTION- PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, page 2444-
DESCRIPTION- PERLMAN, J. CLIN. ENDO. METAB., (2003), vol. 88, pages 3227 - 35-
DESCRIPTION- PHARMAZIE, (2002), vol. 57, no. 1, pages 5 - 29-
DESCRIPTION- PITKIN, ANTIMICROB. AG. CHEMO., (1986), vol. 29, pages 440 - 444-
DESCRIPTION- P. KREJCI ET AL., J. CELL SCI., (2005), vol. 118, pages 5089 - 5100-
DESCRIPTION- PROC. NATL. ACAD. SCI. USA, (1999), vol. 96, pages 7403 - 08-
DESCRIPTION- PROC. NATL. ACAD. SCI. USA, (2001), vol. 98, pages 4016 - 4021-
DESCRIPTION- PROC. NATL. ACAD. SCI. USA, (2003), vol. 100, pages 1426 - 1431-
DESCRIPTION- PROC. NATL. ACAD. SCI USA, (2004), vol. 101, pages 17300 - 05-
DESCRIPTION- R. B. MERRIFIELD, J. AM. CHEM. SOC., (1963), vol. 85, no. 14, pages 2149 - 2154-
DESCRIPTION- Remington's Pharmaceutical Sciences, 18th Edition,, MACK PUBLISHING CO., (1990), pages 1435 - 1712-
DESCRIPTION- R. ROSE; W. GILES, J. PHYSIOL., (2008), vol. 586, pages 353 - 366-
DESCRIPTION- SCHILLER, BIOCHEM. BIOPHYS. RES. COMMUN., (1986), vol. 138, pages 880 - 886-
DESCRIPTION- SCIENCE, (1987), vol. 238, pages 675 - 678-
DESCRIPTION- SCIENCE, (1991), vol. 252, pages 120 - 123-
DESCRIPTION- SCIENCE, (2001), vol. 293, pages 1657 - 1662-
DESCRIPTION- SCIENCE, (2004), vol. 303, pages 480 - 482-
DESCRIPTION- S. COLOWICK AND N. KAPLAN, Methods In Enzymology, ACADEMIC PRESS, INC-
DESCRIPTION- SMITH; WATERMAN, ADV. APPL. MATH., (1981), vol. 2, page 482-
DESCRIPTION- S. PANNIER ET AL., BIOCHIM. BIOPHYS. ACTA, (2009), vol. 1792, no. 2, pages 140 - 147-
DESCRIPTION- SUGA, S. ET AL., ENDOCRINOLOGY, (1992), vol. 130, pages 229 - 39-
DESCRIPTION- THOMPSON, NUCLEIC ACIDS RESEARCH, (1994), vol. 22, pages 4673 - 4680-
DESCRIPTION- VEHASKARI, KIDNEY INT'L, (1982), vol. 22, pages 127 - 135-
DESCRIPTION- VT YEUNG, PEPTIDES, (1996), vol. 17, pages 101 - 106-
DESCRIPTION- WANG ET AL., ADV. DRUG DELIVERY REV, (2005), vol. 57, pages 1049 - 76-
DESCRIPTION- WANG ET AL., EUR J HEART FAIL., (2007), vol. 9, pages 548 - 57-
DESCRIPTION- WANG ET AL., PROC. NATL ACAD. SCI. USA, (1999), vol. 96, no. 8, pages 4455 - 4460-
DESCRIPTION- WU, J. BIOL. CHEM., (2003), vol. 278, pages 25847 - 852-
DESCRIPTION- YAMASHITE ET AL., J. BIOCHEM., (2000), vol. 127, pages 177 - 179-
DESCRIPTION- YASODA ET AL., NAT. MED, (2004), vol. 10, pages 80 - 86-
DESCRIPTION- YASODA ET AL., NAT. MED., (2004), vol. 10, pages 80 - 86-
EXAMINATION- Anonymous, "UniProtKB -Q9QZ96 (Q9QZ96_CAVPO)", (20000501), pages 1 - 4, URL: http://www.uniprot.org/uniparc/UPI00000E7708, (20180328), XP055463352-
EXAMINATION- MAYUMI FURUYA ET AL, "Structural requirements of C-type natriuretic peptide for elevation of cyclic GMP in cultured vascular smooth muscle cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, AMSTERDAM, NL, (19920301), vol. 183, no. 3, doi:10.1016/S0006-291X(05)80284-0, ISSN 0006-291X, pages 964 - 969, XP055675426
EXAMINATION- D. J. WENDT ET AL, "Neutral Endopeptidase-Resistant C-Type Natriuretic Peptide Variant Represents a New Therapeutic Approach for Treatment of Fibroblast Growth Factor Receptor 3-Related Dwarfism", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (20150203), vol. 353, no. 1, doi:10.1124/jpet.114.218560, pages 132 - 149, XP055282054
OPPOSITION- Caliceti P; Veronese F M, "Improvement of the physicochemical and biopharmaceutical properties of insulin by poly(ethylene glycol) conjugation", SCIENCES TECHNIQUES ET PRATIQUES - STP PHARMA SCIENCES., Ed. de Santé, FR, FR , (19990101), vol. 9, no. 1, ISSN 1157-1489, pages 107 - 113, XP008111726-
OPPOSITION- Carpenter John F., Chang Beyong S., Garzon-Rodriguez Wiliam, Randolph Theodore W., "Chapter 5 - Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice", Carpenter John F., Chang Beyong S., Garzon-Rodriguez Wiliam, Randolph Theodore W., Carpenter John F., Rational Design of Stable Protein Formulations, (20020101), pages 109 - 133, XP055961696-
OPPOSITION- De Plater Greg M, Martin Rosemary L, Milburn Peter J, "A C-type natriuretic peptide from the venom of the platypus (Ornithorhynchus anatinus): Structure and pharmacology", Comparative Biochemistry and Physiology Part C, (19980101), vol. 120, pages 99 - 110, XP055961836-
OPPOSITION- EDMAN P, "METHOD FOR DETERMINATION OF THE AMINO ACID SEQUENCE IN PEPTIDES", ACTA CHEMICA SCANDINAVICA, DK , (19500101), vol. 04, ISSN 0904-213X, pages 283 - 293, XP009008397-
OPPOSITION- Elmore D.T., "Chapter 2 - Peptide Synthesis", Elmore D.T., Walker et al., Techniques in Molecular Biology, (19870101), pages 32 - 54, XP055961707-
OPPOSITION- ERDOS E G, SKIDGEL R A, "NEUTRAL ENDOPEPTIDASE 24.11 (ENKEPHALINASE) AND RELATED REGULATORS OF PEPTIDE HORMONES", The FASEB Journal, US, (19890201), vol. 3, no. 2, ISSN 0892-6638, pages 145 - 151, XP000882350-
OPPOSITION- FIELDS GREGG B, "Introduction to peptide synthesis", Current Protocols in Protein Science, US , (20011226), no. SUPPLEMENT 26, ISSN 1934-3655, pages 18.1.1 - 18.1.10, XP002522466-
OPPOSITION- Minamino Naoto, Horio Takeshi, Nishikimi Toshio, "Chapter 165 - Natriuretic Peptides in the Cardiovascular System", Handbook of Biologically Active Peptides, (20060101), pages 1199 - 1207, XP055961818-
OPPOSITION- "RecName: Full=C-type natriuretic peptide {ECO:0000256|ARBA:ARBA00018109}", UniProtKB, (20000501), Database accession no. Q9QZ96, XP055961829-
OPPOSITION- Takano Masayoshi, Sasayama Yuichi, Takei Yoshio, "Molecular evolution of shark C-type natriuretic peptides", Zoological Science, (19940101), vol. 11, pages 451 - 454, XP055961840-
OPPOSITION- "Voxzogo EPAR Product Information", (20211210), URL: https://www.ema.europa.eu/en/documents/product-information/voxzogo-epar-product-information_en.pdf-
OPPOSITION- "VOXZOGO (vosoritide) for injection, for subcutaneous use", HIGHLIGHTS OF PRESCRIBING INFORMATION, (20211101), URL: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214938s000lbl.pdf, XP055961638-
OPPOSITION- VIDOVIC VERICA ET AL, "Production and isotope labeling of antimicrobial peptides in Escherichia coli by means of a novel fusion partner that enables high-yield insoluble expression and fast purification.", Journal of peptide sience, (20090401), vol. 15, no. 4, doi:10.1002/PSC.1112, ISSN 1075-2617, pages 278 - 284, XP002603018
OPPOSITION- Oefner, C. D'Arcy, A. Hennig, M. Winkler, F.K. Dale, G.E., "Structure of human neutral endopeptidase (neprilysin) complexed with phosphoramidon", Journal of Molecular Biology, United Kingdom , (20000219), vol. 296, no. 2, doi:10.1006/jmbi.1999.3492, ISSN 0022-2836, pages 341 - 349, XP004461544
OPPOSITION- Lincoln R. Potter et al., "Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications", Drug Transporters - Part of the Handbook of Experimental Pharmacology book series (HEP, volume 201) ISSN 0171-2004, SPRINGER VERLAG, BERLIN, DE, BERLIN, DE , (20090101), vol. 191, no. 1, doi:10.1007/978-3-540-68964-5_15, ISSN 0171-2004, ISBN 978-3-642-14540-7, pages 341 - 366, XP055464846
OPPOSITION- NAOTO MINAMINO, KENJI KANGAWA, HISAYUKI MATSUO, "N-TERMINALLY EXTENDED FORM OF C-TYPE NATRIURETIC PEPTIDE (CNP-53) IDENTIFIED IN PORCINE BRAIN.", Biochemical and Biophysical Research Communications, Amsterdam NL , (19900731), vol. 170, no. 2, doi:10.1016/0006-291X(90)92187-5, ISSN 0006-291X, pages 973 - 979, XP000138021
OPPOSITION- SUDOH T. et al., "C-TYPE NATRIURETIC PEPTIDE (CNP): A NEW MEMBER OF NATRIURETIC PEPTIDE FAMILY IDENTIFIED IN PORCINE BRAIN.", Biochemical and Biophysical Research Communications, Amsterdam NL , (19900430), vol. 168, no. 2, doi:10.1016/0006-291X(90)92401-K, ISSN 0006-291X, pages 863 - 870, XP002027115
OPPOSITION- Minamino, N. ; Makino, Y. ; Tateyama, H. ; Kangawa, K. ; Matsuo, H., "Characterization of immunoreactive human C-type natriuretic peptide in brain and heart", Biochemical and Biophysical Research Communications, Amsterdam NL , (19910830), vol. 179, no. 1, doi:10.1016/0006-291X(91)91404-Z, ISSN 0006-291X, pages 535 - 542, XP024836364
OPPOSITION- TAWARAGI Y. et al., "GENE AND PRECURSOR STRUCTURES OF HUMAN C-TYPE NATRIURETIC PEPTIDE", Biochemical and Biophysical Research Communications, Amsterdam NL , (19910315), vol. 175., no. 02., doi:10.1016/0006-291X(91)91614-I, ISSN 0006-291X, pages 645 - 651., XP002028200
OPPOSITION- Ishizaka, Y. ; Kangawa, K. ; Minamino, N. ; Ishii, K. ; Takano, S. ; Eto, T. ; Matsuo, H., "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1", Biochemical and Biophysical Research Communications, Amsterdam NL , (19921215), vol. 189, no. 2, doi:10.1016/0006-291X(92)92257-X, ISSN 0006-291X, pages 697 - 704, XP024838377
OPPOSITION- REIKO SUZUKI et al., "ISOLATION OF HIGH-MOLECULAR-WEIGHT C-TYPE NATRIURETIC PEPTIDE FROM THE HEART OF A CARTILAGINOUS FISH (EUROPEAN DOGFISH, SCYLIORHINUS CANICULA).", FEBS Letters, NL , (19910506), vol. 282., no. 02., doi:10.1016/0014-5793(91)80505-W, ISSN 0014-5793, pages 321 - 325., XP000201450
OPPOSITION- Mayumi Furuya et al., "Structural requirements of C-type natriuretic peptide for elevation of cyclic GMP in cultured vascular smooth muscle cells", Biochemical and Biophysical Research Communications, (19920331), vol. 183, no. 3, doi:10.1016/S0006-291X(05)80284-0, pages 964 - 969, XP055653570
OPPOSITION- Kenneth D. Hinds, Sung Wan Kim, "Effects of PEG conjugation of insulin properties", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (20020617), vol. 54, doi:10.1016/S0169-409X(02)00025-X, ISSN 0169-409X, pages 505 - 530, XP003004966
OPPOSITION- UCHIO T,ET AL, "Site-specific insulin conjugates with enhanced stability and extended action profile", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (19990101), vol. 35, no. 2-3, doi:10.1016/S0169-409X(98)00078-7, ISSN 0169-409X, pages 289 - 306, XP002363507
OPPOSITION- NESHER MAOZ ET AL, "Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide", Bioconjugate Chemistry, US , (20080101), vol. 19, no. 1, doi:10.1021/bc700294w, ISSN 1043-1802, pages 342 - 348, XP002493772
OPPOSITION- Ken Hinds, Jae Joon Koh, Lisa Joss, Feng Liu, Miroslav Baudyš, Sung Wan Kim, "SYNTHESIS AND CHARACTERIZATION OF POLY(ETHYLENE GLYCOL)-INSULIN CONJUGATES", Bioconjugate Chemistry, American Chemical Society, US, US , (20000301), vol. 11, no. 2, doi:10.1021/bc9901189, ISSN 1043-1802, pages 195 - 201, XP008066796
OPPOSITION- YASODA AKIHIRO et al., "Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.", Nature Medicine, New York, (20040101), vol. 10, no. 1, doi:10.1038/nm971, ISSN 1078-8956, pages 80 - 86, XP002539064
OPPOSITION- Smith John Bryan, "Peptide Sequencing by Edman Degradation", Smith John Bryan, Whisson Stephen C, ENCYCLOPEDIA OF LIFE SCIENCES, Chichester , John Wiley & Sons, Ltd , (20010101), pages 1 - 3, doi:10.1038/npg.els.0002688, ISBN 978-0-470-01590-2, XP055961684
OPPOSITION- CHUSHO H. et al., "Dwarfism and early death in mice lacking C-type natriuretic peptide", Proceedings of the National Academy of Sciences, (20010327), vol. 98, no. 7, doi:10.1073/pnas.071389098, ISSN 0027-8424, pages 4016 - 4021, XP002982869
OPPOSITION- MURAYAMA NOBUHIRO et al., "Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide.", Proceedings of the National Academy of Sciences, (19970201), vol. 94, no. 4, doi:10.1073/pnas.94.4.1189, ISSN 0027-8424, pages 1189 - 1193, XP002252616
OPPOSITION- Wu Chengliang, Wu Faye, Pan Junliang, Morser John, Wu Qingyu, "Furin-mediated Processing of Pro-C-type Natriuretic Peptide", Journal of Biological Chemistry, US , (20030418), vol. 278, no. 28, doi:10.1074/jbc.M301223200, ISSN 0021-9258, pages 25847 - 25852, XP055961650
OPPOSITION- Bartels Cynthia F., Bükülmez Hülya, Padayatti Pius, Rhee David K., Van Ravenswaaij-Arts Conny, Pauli Richard M., Mundlos Stefan, Chitayat David, Shih Ling-Yu, Al-Gazali Lihadh I., Kant Sarina, Cole Trevor, Morton Jenny, Cormier-Daire Valérie, Faivre Laurence, Lees Melissa, Kirk Jeremy, Mortier Geert R., Leroy Jules, Zabel Bernhard, Kim Chong Ae, Crow Yanick, Braverman Nancy E., Van Den Akker Focco, Warman Matthew L., "Mutations in the Transmembrane Natriuretic Peptide Receptor NPR-B Impair Skeletal Growth and Cause Acromesomelic Dysplasia, Type Maroteaux", The American Journal of Human Genetics, US , (20040701), vol. 75, no. 1, doi:10.1086/422013, ISSN 0002-9297, pages 27 - 34, XP055961648
OPPOSITION- Itaba S., Chijiiwa Y., Matsuzaka H., Motomura Y., Nawata H., "Presence of C-type natriuretic peptide (CNP) in guinea pig caecum: role and mechanisms of CNP in circular smooth muscle relaxation", NEUROGASTROENTEROLOGY AND MOTILITY, GB , (20040601), vol. 16, no. 3, doi:10.1111/j.1365-2982.2004.00506.x, ISSN 1350-1925, pages 375 - 382, XP055961834
OPPOSITION- D. J. Wendt, M. Dvorak-Ewell, S. Bullens, F. Lorget, S. M. Bell, J. Peng, S. Castillo, M. Aoyagi-Scharber, C. A. O'neill, P. Krejci, W. R. Wilcox, D. L. Rimoin, S. Bunting, "Neutral Endopeptidase-Resistant C-Type Natriuretic Peptide Variant Represents a New Therapeutic Approach for Treatment of Fibroblast Growth Factor Receptor 3-Related Dwarfism", Journal of Pharmacology and Experimental Therapeutics, (20150227), vol. 353, no. 1, doi:10.1124/jpet.114.218560, pages 132 - 149, XP055282054
OPPOSITION- Breinholt Vibeke Miller, Rasmussen Caroline E., Mygind Per Holse, Kjelgaard-Hansen Mads, Faltinger Frank, Bernhard Ana, Zettler Joachim, Hersel Ulrich, "TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3-Related Skeletal Dysplasias", Journal of pharmacology and experimental therapeutics, US , (20190919), vol. 370, no. 3, doi:10.1124/jpet.119.258251, ISSN 0022-3565, pages 459 - 471, XP055923295
OPPOSITION- Yasoda A; Kitamura H; Fujii T et al, "Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias.", Endocrinology, US , (20090701), vol. 150, no. 7, doi:10.1210/en.2008-1576, ISSN 0013-7227, pages 3138 - 3144, XP008110039
OPPOSITION- POTTER L R, ABBEY-HOSCH S,DICKEY D M, "Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions", ENDOCRINE REVIEWS, (20060201), vol. 27, no. 1, doi:10.1210/er.2005-0014, pages 47 - 72, XP003021926
OPPOSITION- P J Hunt, A M Richards, E A Espiner, M G Nicholls, T G Yandle, "Bioactivity and metabolism of C-type natriuretic peptide in normal man", The Journal of Clinical Endocrinology & Metabolism, (19940601), vol. 78, no. 6, doi:10.1210/jcem.78.6.8200946, pages 1428 - 1435, XP055961665
OPPOSITION- Barrett Alan, Rawlings Neil, "Oligopeptidases, and the Emergence of the Prolyl Oligopeptidase Family", Biological Chemistry Hoppe-Seyler, De Gruyter, Berlin, New York, Berlin, New York, (19920701), vol. 373, no. 2, doi:10.1515/bchm3.1992.373.2.353, ISSN 0177-3593, pages 353 - 360, XP009555311
OPPOSITION- Veronese Francesco M, "The impact of PEGylation on biological therapies", BIODRUGS, NZ , (20080101), vol. 22, no. 5, doi:10.2165/00063030-200822050-00004, ISSN 1173-8804, pages 315 - 329, XP009116032
OPPOSITION- Mahesh Sriram, Tang Kuei-Chien, Raj Monika, "Amide Bond Activation of Biological Molecules", Molecules, vol. 23, no. 10, doi:10.3390/molecules23102615, page 2615, XP055961688
OTHER- FURUYA et al., "Structural requirements of C-type natriuretic peptide for elevation of cyclic GMP in cultured vascular smooth muscle cells", Biochem Biophys Res Commun, (19920331), vol. 183, no. 3, pages 964 - 969, XP055653570
SEARCH- MILTON HARRIS J ET AL, "EFFECT OF PEGYLATION ON PHARMACEUTICALS", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, (20030301), vol. 2, no. 3, doi:10.1038/NRD1033, ISSN 1474-1784, pages 214 - 221, XP009042217 [Y] 2-3 * abstract; figure 4 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents