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IP Verse

Antibodies With Modified Affinity To Fcrn That Promote Antigen Clearance - EP3181581

The patent EP3181581 was granted to Chugai Seiyaku Kabushiki Kaisha on Sep 25, 2024. The application was filed on Mar 30, 2011 under application number EP17154576A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3181581

CHUGAI SEIYAKU KABUSHIKI KAISHA
Application Number
EP17154576A
Filing Date
Mar 30, 2011
Status
Granted And Under Opposition
Aug 22, 2024
Publication Date
Sep 25, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Antigen-binding molecules, such as antibodies, that facilitate antigen uptake into cells by leveraging human FcRn binding activity in acidic pH environments. The molecules exhibit enhanced FcRn binding in neutral pH conditions and reduced antigen binding affinity in acidic pH conditions, enabling efficient antigen internalization and recycling. This property enables the molecules to repeatedly bind and eliminate multiple antigens, reducing plasma antigen concentrations and enhancing pharmacokinetics. The molecules can be engineered through targeted amino acid substitutions in the FcRn binding domain or antigen binding domain to optimize their properties.

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status
STRAWMANJun 25, 2025PLASSERAUDADMISSIBLE

Patent Citations (60) New

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Dossier Documents

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