Method For The Production Of A Glycosylated Immunoglobulin - EP3202785

The patent EP3202785 was granted to Chugai Seiyaku Kabushiki Kaisha on May 8, 2024. The application was originally filed on Oct 25, 2010 under application number EP17155939A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3202785

CHUGAI SEIYAKU KABUSHIKI KAISHA
Application Number
EP17155939A
Filing Date
Oct 25, 2010
Status
Granted And Under Opposition
Apr 5, 2024
Grant Date
May 8, 2024
External Links
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Patent Citations (23) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0409607
DESCRIPTIONEP0628639
DESCRIPTIONJPH0899902
DESCRIPTIONJPS62258252
DESCRIPTIONUS2006127975
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DESCRIPTIONUS5670373
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OPPOSITIONUS2006127975
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OPPOSITIONWO2004048556
OPPOSITIONWO2004104186
OPPOSITIONWO2009112250
OPPOSITIONWO9841611
SEARCHUS2006127975
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SEARCHWO9841611

Non-Patent Literature (NPL) Citations (86) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- "Antibody Engineering", JEFFERIS, R.; LUND, J., Chem. Immunol., KARGER, (1997), vol. 65, pages 111 - 128-
DESCRIPTION- ASHWELL, G.; HARFORD, J., ANN. REV. BIOCHEM., (1982), vol. 51, pages 531 - 554-
DESCRIPTION- AUSUBEL, F.M., Current Protocols in Molecular Biology, WILEY AND SONS, (1997), vol. I- III-
DESCRIPTION- BAENZIGER, J.U., AM. J. PATH., (1985), vol. 121, pages 382 - 391-
DESCRIPTION- BAKER, K.N. ET AL., BIOTECHNOL. BIOENG., (2001), vol. 73, pages 188 - 202-
DESCRIPTION- BAUMANN, H.; JAHREIS, G.P., J. BIOL. CHEM., (1983), vol. 258, pages 3942 - 3949-
DESCRIPTION- BORYS, M.C. ET AL., BIO/TECHNOLOGY, (1993), vol. 11, pages 720 - 724-
DESCRIPTION- BRADSHAW, J.P ET AL., BIOCHIM. BIOPHYS. ACTA, (1985), vol. 847, pages 344 - 351-
DESCRIPTION- CHAN, V.T.; WOLF, G., BIOCHEM. J., (1987), vol. 247, pages 53 - 62-
DESCRIPTION- DAVIDSON, S.K.; HUNT, L.A., J. GEN. VIROL., (1985), vol. 66, pages 1457 - 1468-
DESCRIPTION- DWEK, R.A. ET AL., J. ANAT., (1995), vol. 187, pages 279 - 292-
DESCRIPTION- ELBEIN, A.D., ANN. REV. BIOCHEM., (1987), vol. 56, pages 497 - 534-
DESCRIPTION- ENDO, T. ET AL., MOL. IMMUNOL., (1995), vol. 32, pages 931 - 940-
DESCRIPTION- FEIZI, T.; CHILDS, R.A., BIOCHEM. J., (1987), vol. 245, pages 1 - 11-
DESCRIPTION- GAWLITZEK, M. ET AL., BIOTECHNOL. BIOENG., (1995), vol. 46, pages 536 - 544-
DESCRIPTION- GAWLITZEK, M. ET AL., J. BIOTECHNOL., (1995), vol. 42, no. 2, pages 117 - 131-
DESCRIPTION- GERSHMAN, H.; ROBBINS, P.W., J. BIOL. CHEM., (1981), vol. 256, pages 7774 - 7780-
DESCRIPTION- GLOVER, N.D., DNA Cloning: A Practical Approach, (1985), vol. I, II-
DESCRIPTION- HAHN, T.J.; GOOCHEE, C.F., J. BIOL. CHEM., (1992), vol. 267, pages 23982 - 23987-
DESCRIPTION- HAYTER, P.M. ET AL., BIOTECHNOL. BIOENG., (1992), vol. 39, pages 327 - 335-
DESCRIPTION- HILLS, A.E. ET AL., BIOTECHNOL. BIOENG., (2001), vol. 75, pages 239 - 251-
DESCRIPTION- IP, C.C. ET AL., ARCH. BIOCHEM. BIOPHYS., (1994), vol. 308, pages 387 - 399-
DESCRIPTION- JEFFERIS, R., BIOTECHNOL. PROG., (2005), vol. 21, pages 11 - 16-
DESCRIPTION- JENKINS, N. ET AL., NAT. BIOTECHNOL., (1996), vol. 14, pages 975 - 981-
DESCRIPTION- KONDO, A. ET AL., AGRIC. BIOL. CHEM., (1990), vol. 54, pages 2169 - 2170-
DESCRIPTION- KUNKEL, J.P. ET AL., J. BIOTECHNOL., (1998), vol. 62, pages 55 - 71-
DESCRIPTION- LIN, A.A. ET AL., BIOTECHNOL. BIOENG., (1993), vol. 42, pages 339 - 350-
DESCRIPTION- LUND, J. ET AL., J. IMMUNOL., (1996), vol. 157, pages 4963 - 4969-
DESCRIPTION- LUND, J. ET AL., MOL. IMMUNOL., (1993), vol. 30, pages 741 - 748-
DESCRIPTION- LUND, J., FASEB J., (1995), vol. 9, pages 115 - 119-
DESCRIPTION- MATHER, J.P. ET AL., ENCYCLOPEDIA OF BIOPROCESS TECHNOLOGY: FERMENTATION, BIOCATALYSIS, AND BIOSEPARATION, (1999), vol. 2, pages 777 - 785-
DESCRIPTION- MCFARLANE, I.G., CLIN. SCI., (1983), vol. 64, pages 127 - 135-
DESCRIPTION- MIZUOCHI, T. ET AL., ARCH. BIOCHEM. BIOPHYS., (1987), vol. 257, pages 387 - 394-
DESCRIPTION- MUTHING, J. ET AL., BIOTECHNOL. BIOENG., (2003), vol. 83, pages 321 - 334-
DESCRIPTION- PAREKH, R.B. ET AL., NATURE, (1985), vol. 316, pages 452 - 457-
DESCRIPTION- PATEL, T.P. ET AL., BIOCHEM. J., (1992), vol. 285, pages 839 - 845-
DESCRIPTION- REARICK, J.I. ET AL., J. BIOL. CHEM., (1981), vol. 256, pages 6255 - 6261-
DESCRIPTION- RIFAI, A. ET AL., J. EXP. MED., (2000), vol. 191, pages 2171 - 2182-
DESCRIPTION- ROBINSON, D.K. ET AL., BIOTECHNOL. BIOENG., (1994), vol. 44, pages 727 - 735-
DESCRIPTION- SABA, J.A. ET AL., ANAL. BIOCHEM., (2002), vol. 305, pages 16 - 31-
DESCRIPTION- SABA, J.A. ET AL., BIOCHEM., (2002), vol. 305, pages 16 - 31-
DESCRIPTION- SCHAUER, R., ADV. EXP. MED. BIOL., (1988), vol. 228, pages 47 - 72-
DESCRIPTION- STARK, N.J.; HEATH, E.C., ARCH. BIOCHEM. BIOPHYS., (1979), vol. 192, pages 599 - 609-
DESCRIPTION- STRUBE, K.-H. ET AL., J. BIOL. CHEM., (1988), vol. 263, pages 3762 - 3771-
DESCRIPTION- TACHIBANA, H. ET AL., CYTOTECHNOLOGY, (1994), vol. 16, pages 151 - 157-
DESCRIPTION- TAKUMA, S. ET AL., BIOTECHNOL. BIOENG, (2007), vol. 97, pages 1479 - 1488-
DESCRIPTION- TANIGUCHI, T. ET AL., BIOCHEM., (1985), vol. 24, pages 5551 - 5557-
DESCRIPTION- TURCO, S.J., ARCH. BIOCHEM. BIOPHYS., (1980), vol. 205, pages 330 - 339-
DESCRIPTION- VIJAYALAKSHMI, M.A., APPL. BIOCHEM. BIOTECH., (1998), vol. 75, pages 93 - 102-
DESCRIPTION- WEST, C.M., MOL. CELL. BIOCHEM., (1986), vol. 72, pages 3 - 20-
DESCRIPTION- WONG, D.C.F. ET AL., BIOTECHNOL. BIOENG., (2005), vol. 89, pages 164 - 177-
DESCRIPTION- WRIGHT, A. ET AL., GLYCOBIOLOGY, (2000), vol. 10, pages 1347 - 1355-
DESCRIPTION- WRIGHT, A.; MORRISON, S.L., J. IMMUNOL., (1998), vol. 160, pages 3393 - 3402-
DESCRIPTION- YOUINGS, A. ET AL., BIOCHEM. J., (1996), vol. 314, pages 621 - 630-
DESCRIPTION- ZUKIER, L.S. ET AL., CANCER RES., (1998), vol. 58, pages 3905 - 3908-
OPPOSITION- D26- Communication pursuant to Art. 94(3) EPC concerning EP 17 155939.6 dated May 24, 2019-
OPPOSITION- D27 - Submission of the Proprietor concerning EP 17 155 939.6 dated March 13, 2020-
OPPOSITION- Harcum Sarah, "Protein Glycosylation Chapter 5", Harcum Sarah, Ozturk, S., Hu, W.-S, Cell Culture Technology for Pharmaceutical and Cell Based Therapies, CRC Press, (20050101), pages 129 - 128, ISBN 978-0-8493-5106-8, XP093262535-
OPPOSITION- Müthing Johannes; Kemminer Sven E; Conradt Harald S; Sagi Dijana; Nimtz Manfred; Kärst Uwe; Peter-Katalinic Jasna, "Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody", Biotechnology and Bioengineering, Hoboken, USA, (20030805), vol. 83, no. 3, ISSN 0006-3592, pages 321 - 334, XP009131808-
OPPOSITION- RESTELLI V, BUTLER M, "THE EFFECT OF CELL CULTURE PARAMETERS ON PROTEIN GLYCOSYLATION", CELL ENGINEERING, XX , (20020101), vol. 03, pages 61 - 92, XP001203473-
OPPOSITION- Venkiteshwaran Adith, "Tocilizumab.", mAbs, US , (20090901), vol. 1, no. 5, ISSN 1942-0870, pages 432 - 438, XP009142850-
OPPOSITION- Xie Liangzhi, Zhou Weichang, "Fed-Batch Cultivation of Mammalian Cells for the Production of Recombinant Proteins", Xie Liangzhi, Zhou Weichang, Ozturk, S., & Hu, W.-S, Cell Culture Technology for Pharmaceutical and Cell-Based Therapies, Taylor & Francis , (20050101), vol. 30, pages 470 - 473, doi:10.1201/9780849351068.ch10, ISSN 2154-4948, ISBN 978-0-8493-5106-8, XP093262587-
OPPOSITION- Genovese Mark C., Mckay James D., Nasonov Evgeny L., Mysler Eduardo F., Da Silva Nilzio A., Alecock Emma, Woodworth Thasia, Gomez‐reino Juan J., "Interleukin‐6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease‐modifying antirheumatic drugs: The tocilizumab in combination with traditional disease‐modifying antirheumatic drug therapy study", Arthritis & Rheumatism, US , (20081001), vol. 58, no. 10, doi:10.1002/art.23940, ISSN 0004-3591, pages 2968 - 2980, XP093262604
OPPOSITION- Shinya Takuma; Chikashi Hirashima; James M. Piret, "Dependence on glucose limitation of the pCO2 influences on CHO cell growth, metabolism and IgG production", Biotechnology and Bioengineering, Hoboken, USA, (20070222), vol. 97, no. 6, doi:10.1002/bit.21376, ISSN 0006-3592, pages 1479 - 1488, XP071166445
OPPOSITION- Efren Pacis; Marcella Yu; Jennifer Autsen; Robert Bayer; Feng Li, "Effects of Cell Culture Conditions on Antibody N-linked Glycosylation—What Affects High Mannose 5 Glycoform", Biotechnology and Bioengineering, Hoboken, USA, (20110524), vol. 108, no. 10, doi:10.1002/bit.23200, ISSN 0006-3592, pages 2348 - 2358, XP071115329
OPPOSITION- Hayter Paul M ,Curling Elisabeth M. A., Baines Anthony J., Jenkins Nigel, Salmon Ian, Strange Phillip G., Tong Jeremy M., Bull Alan T., "Glucose‐limited chemostat culture of chinese hamster ovary cells producing recombinant human interferon‐γ", Biotechnology and Bioengineering, Hoboken, USA, (19920101), vol. 39, no. 03, doi:10.1002/bit.260390311, ISSN 0006-3592, pages 327 - 335, XP001183149
OPPOSITION- ROBINSON D K, "Characterization of a recombinant antibody produced in the course of a high yield fed-batch process.", Biotechnology and Bioengineering, Hoboken, USA, (19940905), vol. 44, no. 6, doi:10.1002/bit.260440609, ISSN 0006-3592, pages 727 - 735, XP002559794
OPPOSITION- Konstantin B. Konstantinov, "Monitoring and Control of the Physiological State of Cell Cultures", Biotechnology and Bioengineering, Hoboken, USA, (19961020), vol. 52, no. 2, doi:10.1002/bit.260520203, ISSN 0006-3592, pages 271 - 289, XP001536483
OPPOSITION- Patrick H. C. van Berkel; Jolanda Gerritsen; Gerrard Perdok; Jesper Valbjørn; Tom Vink; Jan G. J. van de Winkel; Paul W. H. I. Parren, "N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG", Biotechnology Progress, Hoboken, USA, (20090113), vol. 25, no. 1, doi:10.1002/btpr.92, ISSN 8756-7938, pages 244 - 251, XP072296059
OPPOSITION- Taga Atsushi, Kita Soichiro, Nishiura Kaori, Hayashi Tomonori, Kinoshita Mitsuhiro, Sato Atsushi, Suzuki Kentaro, Kodama Shuji, Kakehi Kazuaki, "Analysis of an antibody pharmaceutical, tocilizumab, by capillary electrophoresis using a carboxylated capillary", Journal of separation science, DE , (20080301), vol. 31, no. 5, doi:10.1002/jssc.200700500, ISSN 1615-9306, pages 853 - 858, XP093262611
OPPOSITION- XIE L., WANG D.I.C., "HIGH CELL DENSITY AND HIGH MONOCLONAL ANTIBODY PRODUCTION THROUGH MEDIUM DESIGN AND RATIONAL CONTROL IN A BIOREACTOR.", Biotechnology and Bioengineering, Hoboken, USA, (19960101), vol. 51., doi:10.1002/(SICI)1097-0290(19960920)51:6<725::AID-BIT12>3.0.CO;2-C, ISSN 0006-3592, pages 725 - 729., XP002069739
OPPOSITION- ANDERSEN D.C. UND GOOCHEE C.F., "The effect of cell-culture conditions on the oligosaccharide structures of secreted glycoproteins", Current Opinion in Biotechnology, GB , (19940101), vol. 05., doi:10.1016/0958-1669(94)90072-8, ISSN 0958-1669, pages 546 - 549., XP002085767
OPPOSITION- Raju, T.S., "Terminal sugars of Fc glycans influence antibody effector functions of IgGs", Current Opinion in Immunology, GB , (20080801), vol. 20, no. 4, doi:10.1016/j.coi.2008.06.007, ISSN 0952-7915, pages 471 - 478, XP025771206
OPPOSITION- Gershmantg Howard, P.W. Robbins, "Transitory effects of glucose starvation on the synthesis of dolichol-linked oligosaccharides in mammalian cells", The journal of biological chemistry, (19810101), vol. 256, no. 15, doi:10.1016/S0021-9258(18)43344-3, pages 7774 - 7780, XP093262637
OPPOSITION- Royston Jefferis, "Glycosylation of Recombinant Antibody Therapeutics", Biotechnology Progress, Hoboken, USA, (20080905), vol. 21, no. 1, doi:10.1021/bp040016j, ISSN 8756-7938, pages 11 - 16, XP072298581
OPPOSITION- Sewell Robert, Bäckström Malin, Dalziel Martin, Gschmeissner Steven, Karlsson Hasse, Noll Thomas, Gätgens Jochem, Clausen Henrik, Hansson Gunnar C., Burchell Joy, Taylor-Papadimitriou Joyce, "The ST6GalNAc-I Sialyltransferase Localizes throughout the Golgi and Is Responsible for the Synthesis of the Tumor-associated Sialyl-Tn O-Glycan in Human Breast Cancer", Journal of Biological Chemistry, US , (20060201), vol. 281, no. 6, doi:10.1074/jbc.M511826200, ISSN 0021-9258, pages 3586 - 3594, XP093262628
OPPOSITION- Alexandra J. McCraw; Lais C. G. F. Palhares; Jenifer L. Hendel; Richard A. Gardner; Aida Santaolalla; Silvia Crescioli; James McDonnell; Mieke Van Hemelrijck; Alicia Chenoweth; Daniel I. R. Spencer; Gerd K. Wagner; Sophia N. Karagiannis, "IgE glycosylation and impact on structure and function: A systematic review", ALLERGY, United Kingdom , (20240804), vol. 79, no. 10, doi:10.1111/all.16259, ISSN 0105-4538, pages 2625 - 2661, XP072709460
OPPOSITION- ELBEIN A D, "INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS", ANNUAL REVIEW OF BIOCHEMISTRY, US , (19870101), vol. 56, doi:10.1146/annurev.bi.56.070187.002433, ISSN 0066-4154, pages 497 - 534, XP008032420
SEARCH- MATTHIAS PEIPP ET AL, Chapter 8: Molecular Engineering III: Fc Engineering, HANDBOOK OF THERAPEUTIC ANTIBODIES, WILEY-VCH, WEINHEIM, PAGE(S) 171 - 196, (20070101), ISBN 9783527314539, XP007911266 [A] 17-20 * pages 180-183 *-
SEARCH- MÜTHING JOHANNES ET AL, "Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24.", BIOTECHNOLOGY AND BIOENGINEERING 5 AUG 2003 LNKD- PUBMED:12783488, (20030805), vol. 83, no. 3, ISSN 0006-3592, pages 321 - 334, XP009131808 [A] 1-20 * the whole document *-
SEARCH- VENKITESHWARAN ADITH, "Tocilizumab.", MABS 2009 SEP-OCT LNKD- PUBMED:20065633, (200909), vol. 1, no. 5, ISSN 1942-0870, pages 432 - 438, XP009142850 [Y] 16-20 * the whole document *-
SEARCH- TAKUMA SHINYA ET AL, "Dependence on glucose limitation of the pCO(2) influences on CHO cell growth, metabolism and IgG production", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US LNKD- DOI:10.1002/BIT.21376, (20070801), vol. 97, no. 6, ISSN 0006-3592, pages 1479 - 1488, XP002537214 [A] 1-20 * abstract *
SEARCH- JEFFERIS ROYSTON, "Glycosylation of recombinant antibody therapeutics", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, (20050101), vol. 21, no. 1, doi:10.1021/BP040016J, ISSN 8756-7938, pages 11 - 16, XP002456627 [A] 1-20 * abstract; figures *
SEARCH- BORYS M C ET AL, "Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese hamster ovary (CHO) cells", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, (19930601), vol. 11, no. 6, doi:10.1038/NBT0693-720, ISSN 0733-222X, pages 720 - 724, XP002486307 [A] 1-20 * figures * * abstract *
SEARCH- ELBEIN A D, "INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, (19870101), vol. 56, doi:10.1146/ANNUREV.BI.56.070187.002433, ISSN 0066-4154, pages 497 - 534, XP008032420 [A] 1-20 * pg. 498, 514; fig. 1, 2 *
SEARCH- ELBEIN A D, "Inhibitors of the biosynthesis and processing of N-linked oligosaccharides.", CRC CRITICAL REVIEWS IN BIOCHEMISTRY 1984 LNKD- PUBMED:6232113, (1984), vol. 16, no. 1, ISSN 0045-6411, pages 21 - 49, XP009143062 [A] 1-20 * whole document, in particular pages 21, 33-34; figure 1; reference 125 *

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