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Methods Of Shifting An Isoelectric Profile Of A Protein Product And Uses Thereof - EP3207132

The patent EP3207132 was granted to Alexion Pharmaceuticals on Jul 31, 2019. The application was originally filed on Oct 13, 2015 under application number EP15795064A. The patent is currently recorded with a legal status of "Revoked".

EP3207132

ALEXION PHARMACEUTICALS
Application Number
EP15795064A
Filing Date
Oct 13, 2015
Status
Revoked
Oct 25, 2024
Grant Date
Jul 31, 2019
External Links
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STOLMARApr 30, 2020SIMMONS & SIMMONS MUNICHADMISSIBLE

Patent Citations (3) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTWO2009041643
OPPOSITIONEP2359834
OPPOSITIONUS2014056888

Non-Patent Literature (NPL) Citations (18) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- O'FARRELL P H, "HIGH RESOLUTION TWO-DIMENSIONAL ELECTROPHORESIS OF PROTEINS", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19750525), vol. 250, no. 10, ISSN 0021-9258, pages 4007 - 4021, XP008005139-
OPPOSITION- Maria Elisa Rodrigues, Costa Ana Rita, Henriques Mariana, Azeredo Joana, Oliveira Ros�rio, "Technological progresses in monoclonal antibody production systems", Biotechnology Progress, (20091230), vol. 26, doi:10.1002/btpr.348, ISSN 87567938, pages 332 - 351, XP055117107
OPPOSITION- WANG W; SINGH S; ZENG D L; KING K; NEMA S, "ANTIBODY STRUCTURE, INSTABILITY, AND FORMULATION", Journal of Pharmaceutical Sciences, US, (20070101), vol. 96, no. 1, doi:10.1002/jps.20727, ISSN 0022-3549, pages 1 - 26, XP009084505
OPPOSITION- Amanda L Pace, Et Al, "Asparagine Deamidation Dependence on Buffer Type, pH, and Temperature", Journal of Pharmaceutical Sciences, (20130601), vol. 102, no. 6, pages 1712 - 1723, XP055738745
OPPOSITION- Harris, R.J., "Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture", Journal of Chromatography A, AMSTERDAM, NL, (19950623), vol. 705, no. 1, doi:10.1016/0021-9673(94)01255-D, ISSN 0021-9673, pages 129 - 134, XP004038942
OPPOSITION- Birch, J.R. Racher, A.J., "Antibody production", Advanced Drug Delivery Reviews, AMSTERDAM, NL, (20060807), vol. 58, no. 5-6, doi:10.1016/j.addr.2005.12.006, ISSN 0169-409X, pages 671 - 685, XP005611421
OPPOSITION- Goyon Alexandre; Excoffier Melissa; Janin-Bussat Marie-Claire; Bobaly Balazs; Fekete Szabolcs; Guillarme Davy; Beck Alain, "Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies", Journal of Chromatography B, NL, (20171015), vol. 1065, doi:10.1016/j.jchromb.2017.09.033, ISSN 1570-0232, pages 119 - 128, XP085233861
OPPOSITION- Reed J. Harris, Bruce Kabakoff, Frank D. Macchi, Felicity J. Shen, May Kwong, James D. Andya, Steven J. Shire, Nancy Bjork, Klara Totpal, Anthony B. Chen, "Identification of multiple sources of charge heterogeneity in a recombinant antibody.", Journal of Chromatography B, NL, (20010310), vol. 752, no. 2, doi:10.1016/S0378-4347(00)00548-X, ISSN 0378-4347, pages 233 - 245, XP002682609
OPPOSITION- Alain Beck, Elsa Wagner-Rousset, Daniel Ayoub, Alain Van Dorsselaer, Sarah Sanglier-Cianf?rani, "Characterization of Therapeutic Antibodies and Related Products", Analytical Chemistry, (20130115), vol. 85, no. 2, doi:10.1021/ac3032355, ISSN 0003-2700, pages 715 - 736, XP055383165
OPPOSITION- CHIRINO A J, MIRE-SLUIS A, "Characterizing biological products and assessing comparability following manufacturing changes.", Nature Biotechnology, us, (20041104), vol. 22, no. 11, doi:10.1038/nbt1030, ISSN 1087-0156, pages 1383 - 1391, XP002409409
OPPOSITION- Laura Gimenez;Claire Simonet;Laetitia Malphettes, "Scale-up considerations for monoclonal antibody production process: an oxygen transfer flux approach", BMC Proceedings, London UK, (20131204), vol. 7, no. Suppl 6, doi:10.1186/1753-6561-7-S6-P49, ISSN 1753-6561, page P49, XP021170347
OPPOSITION- Chartrain M; Chu L, "Development and production of commercial therapeutic monoclonal antibodies in mammalian cell expression systems: An overview of the current upstream technologies", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, NL, (20081201), vol. 9, no. 6, doi:10.2174/138920108786786367, ISSN 1389-2010, pages 447 - 467, XP008116146
OPPOSITION- Li Fan, Liang Zhao, Yating Sun, Tianci Kou, Yan Zhou, Wen-Song Tan, "A high-yielding, generic fed-batch process for recombinant antibody production of GS-engineered cell lines", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY., KR, (20091228), vol. 19, no. 12, doi:10.4014/jmb.0904.04054, ISSN 1017-7825, pages 1695 - 1702, XP008160830
OPPOSITION- Yi Du, Walsh Alison, Ehrick Robin, Xu Wei, May Kimberly, Liu Hongcheng, "Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies", mAbs, (20120901), vol. 4, no. 5, doi:10.4161/mabs.21328, ISSN 19420862, pages 578 - 585, XP055077895
OPPOSITION- L. Tang, Et Al, "Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry", MABS, (20130201), vol. 5, no. 1, pages 114 - 125, XP055738740
OPPOSITION- Ivan R Correia, "Stability of IgG isotypes in serum", mAbs, (20100101), vol. 2, doi:10.4161/mabs.2.3.11788, pages 221 - 232, XP055125978
OPPOSITION- Feng Li, Natarajan Vijayasankaran, Amy (yijuan) Shen, Robert Kiss, Ashraf Amanullah, "Cell culture processes for monoclonal antibody production", mAbs, (20100901), vol. 2, no. 5, doi:10.4161/mabs.2.5.12720, ISSN 19420862, pages 466 - 479, XP055166177
OPPOSITION- Leslie A. Khawli, Sirj Goswami, Ryan Hutchinson, Zephania W. Kwong, Jihong Yang, Xiangdan Wang, Zhenling Yao, Alavattam Sreedhara, Tony Cano, Devin Tesar, Ihsan Nijem, David E. Allison, Pin Yee Wong, Yung-Hsiang Kao, Cynthia Quan, Amita Joshi, Reed J. Harris, Paul Motchnik, "Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats", mAbs, (20101101), vol. 2, no. 6, doi:10.4161/mabs.2.6.13333, ISSN 19420862, pages 613 - 624, XP055090171

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