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Compositions And Methods For Modulating Immune Responses - EP3214095

The patent EP3214095 was granted to Zymogenetics on Dec 11, 2019. The application was originally filed on May 12, 2006 under application number EP16192149A. The patent is currently recorded with a legal status of "Revoked".

EP3214095

ZYMOGENETICS
Application Number
EP16192149A
Filing Date
May 12, 2006
Status
Revoked
Apr 18, 2025
Grant Date
Dec 11, 2019
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

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F HOFFMANN LA ROCHESep 11, 2020VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE
MERCKSep 11, 2020HOYNG ROKH MONEGIERADMISSIBLE
MEREO BIOPHARMA GROUPSep 10, 2020HOFFMANN EITLEADMISSIBLE

Patent Citations (93) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
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Non-Patent Literature (NPL) Citations (352) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ABBAS ET AL., NAT. MED., (1999), vol. 5, pages 1345 - 6
DESCRIPTION- ADANG ET AL., PLANT MOLEC. BIOL., (1993), vol. 27, page 1131
DESCRIPTION- ALLEN, BIOCHIM. BIOPHYS. ACTA, (1993), vol. 1150, page 9
DESCRIPTION- ALLEN ET AL., BIOCHIM. BIOPHYS. ACTA, (1991), vol. 1068, page 133
DESCRIPTION- ALLEN ET AL., BIOCHIM. BIOPHYS. ACTA, (1991), vol. 7065, page 133
DESCRIPTION- ALLEN ET AL., BIOCHIM. BIOPHYS. ACTA, (1993), vol. 1150, page 9
DESCRIPTION- ALTSCHUL ET AL., BULL. MATH. BIO., (1986), vol. 48, page 603
DESCRIPTION- ALVING ET AL., "Preparation and Use of Liposomes in Immunological Studies", ALVING ET AL., GREGORIADIS, Liposome Technology, 2nd Edition,, CRC PRESS, (1993), vol. III, page 317
DESCRIPTION- ANDERSON ET AL., CANCER RES., (1990), vol. 50, page 1853
DESCRIPTION- ANDERSON ET AL., INFECT. IMMUN., (1981), vol. 31, page 1099
DESCRIPTION- AUSUBEL, DNA CLONING 2: EXPRESSION SYSTEMS, (1995), pages 16-37 - 16-57
DESCRIPTION- AVALLE ET AL., ANN. N YACAD. SCI., (1998), vol. 864, page 118
DESCRIPTION- "Avidin-Biotin Technology", WILCHEK ET AL,, Methods In Enzymology, ACADEMIC PRESS, (1990), vol. 184
DESCRIPTION- AVIV; LEDER, PROC. NAT'L ACAD. SCI. USA, (1972), vol. 69, page 1408
DESCRIPTION- BAILEY ET AL., "Manipulation of Baculovirus Vectors", BAILEY ET AL., MURRAY, Methods in Molecular Biology, Volume 7: Gene Transfer and Expression Protocols, THE HUMANA PRESS, INC., (1991), vol. 7, pages 147 - 168
DESCRIPTION- BAKKER-WOUDENBERG ET AL., EUR. J. CLIN. MICROBIAL. INFECT. DIS., (1993), vol. 12, no. 1, page 61
DESCRIPTION- BAKKER-WOUDENBERG ET AL., EUR. J. CLIN. MICROBIOL. INFECT. DIS., (1993), vol. 12, no. 1, page 61
DESCRIPTION- BALLANCE ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1983), vol. 112, pages 284 - 289
DESCRIPTION- BAMBOT ET AL., PCR METHODS AND APPLICATIONS, (1993), vol. 2, page 266
DESCRIPTION- BARNES; SATO, ANAL BIOCHEM., (1980), vol. 102, page 255
DESCRIPTION- BARTUS ET AL., SCIENCE, (1998), vol. 281, page 1161
DESCRIPTION- BARTUS, SCIENCE, (1998), vol. 281, page 1161
DESCRIPTION- BASS ET AL., PROC. NAT'L ACAD. SCI. USA, (1991), vol. 88, page 4498
DESCRIPTION- BAUMGARTNER ET AL., J. BIOL. CHEM., (1994), vol. 269, pages 29094 - 29101
DESCRIPTION- BAYER ET AL., "Immunochemical Applications of Avidin-Biotin Technology", BAYER ET AL., MANSON, Methods In Molecular Biology, THE HUMANA PRESS, INC., (1992), vol. 10, pages 149 - 162
DESCRIPTION- BAYER; RAPP, CHEM. PEPT. PROT., (1986), vol. 3, page 3
DESCRIPTION- BEACH; NURSE, NATURE, (1981), vol. 300, page 706
DESCRIPTION- BECKER ET AL., METH. CELL BIOL., (1994), vol. 43, page 161
DESCRIPTION- BENOIST ET AL., NATURE, (1981), vol. 290, page 304
DESCRIPTION- BEUTLER ET AL., SCIENCE, (1985), vol. 229, page 869
DESCRIPTION- BIRD ET AL., SCIENCE, (1988), vol. 242, page 423
DESCRIPTION- BOEHNCKE, W. H ET AL., ARCH. DERMATOL. RES., (1999), vol. 291, page 104
DESCRIPTION- BOEHNCKE, W. H ET AL., J. CUTAN. PATHOL., (1997), vol. 24, page 1
DESCRIPTION- BOEHNCKE, W. H ET AL., J. INVEST. DERMATOL., (2001), vol. 116, page 596
DESCRIPTION- BONNING ET AL., J. GEN. VIROL., (1994), vol. 75, page 1551
DESCRIPTION- BOSHART ET AL., CELL, (1985), vol. 41, page 521
DESCRIPTION- BOWIE; SAUER, PROC. NAT'L ACAD. SCI. USA, (1989), vol. 86, page 2152
DESCRIPTION- BRADLEY, Teratocarcinomas and Embryonic Stem Cells: A Practical Approach, IRL, (1987), pages 113 - 152
DESCRIPTION- BREMER ET AL., PHARM. BIOTECHNOL., (1997), vol. 10, page 239
DESCRIPTION- BRODIE ET AL., CURR. BIOL., (2000), vol. 10, pages 333 - 6
DESCRIPTION- CARBONELL ET AL., GENE, (1988), vol. 73, page 409
DESCRIPTION- CARRENO ET AL., ANNU. REV. IMMUNOL., (2002), vol. 20, pages 29 - 53
DESCRIPTION- CARTER ET AL., PROC. NAT'L ACAD. SCI. USA, (1992), vol. 89, page 4285
DESCRIPTION- CATTAN AR; DOUGLAS E, LEUK RES., (1994), vol. 18, pages 513 - 22
DESCRIPTION- CHAMBERS ET AL., ANN. REV. IMMUNOL., (2001), vol. 19, pages 565 - 594
DESCRIPTION- CHANG ET AL., NATURE, (1978), vol. 275, page 615
DESCRIPTION- CHAPOVAL ET AL., NAT. IMMUNOL., (2001), vol. 2, pages 269 - 74
DESCRIPTION- CHASIN ET AL., SOM. CELL, MOLEC. GENET., (1986), vol. 12, page 555
DESCRIPTION- CHAZENBALK; RAPOPORT, J. BIOI. CHEM., (1995), vol. 270, page 1543
DESCRIPTION- CHAZENBALK; RAPOPORT, J. BIOL. CHEM., (1995), vol. 270, page 1543
DESCRIPTION- CHIN, Y. ET AL., SCIENCE, (1996), vol. 272, pages 719 - 722
DESCRIPTION- CHOU-FASMAN; CHOU, "Prediction of Protein Structural Classes from Amino Acid Composition", CHOU-FASMAN; CHOU, FASMAN, Prediction of Protein Structure and the Principles of Protein Conformation, PLENUM PRESS, (1990), pages 549 - 586
DESCRIPTION- CHRISTOPHERS, INT. ARCH. ALLERGY IMMUNOL., (1996), vol. 110, page 199
DESCRIPTION- CHUNG ET AL., PROC. NAT'L ACAD. SCI. USA, (1993), vol. 90, page 10145
DESCRIPTION- CHUNG ET AL., SCIENCE, (1993), vol. 259, page 806
DESCRIPTION- CLAASSEN, BIOCHIM. BIOPHYS. ACTA, (1984), vol. 802, page 428
DESCRIPTION- CLAASSEN ET AL., BIOCHIM. BIOPHYS. ACTA, (1984), vol. 802, page 428
DESCRIPTION- CLIMIE ET AL., PROC. NAT'L ACAD. SCI. USA, (1990), vol. 87, page 633
DESCRIPTION- COHEN ET AL., BIOCHIM. BIOPHYS. ACTA, (1991), vol. 1063, page 95
DESCRIPTION- COLIGAN ET AL., Current Protocols in Immunology, JOHN WILEY & SONS, (1991), vol. 1, pages 2.5.1 - 2.6.7
DESCRIPTION- COLIGAN ET AL., Current Protocols in Immunology, JOHN WILEY & SONS, (1997), pages 9.3.1 - 9.3.5,9.
DESCRIPTION- "Constructing and Screening cDNA Libraries in Xgtl0 and ?gt11", UYNH ET AL., DNA Cloning: A Practical Approach, IRL PRESS, (1985), page 49
DESCRIPTION- CONTENT ET AL., "Expression and preliminary deletion analysis of the 42 kDa 2-5A synthetase induced by human interferon", CONTENT ET AL., CANTELL, Biological Interferon Systems, Proceedings of ISIR-TNO Meeting on Interferon Systems, (1987), pages 65 - 72
DESCRIPTION- COOK; SELF, "Monoclonal Antibodies in Diagnostic Immunoassays", COOK; SELF, RITTER AND LADYMAN, Monoclonal Antibodies: Production, Engineering, and Clinical Application, CAMBRIDGE UNIVERSITY PRESS, (1995), pages 180 - 208
DESCRIPTION- COOMBS; COREY, "Site-Directed Mutagenesis and Protein Engineering", COOMBS; COREY, ANGELETTI, Proteins: Analysis and Design, ACADEMIC PRESS, INC., (1998), pages 259 - 311
DESCRIPTION- CORTESE ET AL., CURR. OPIN. BIOTECHNOL., (1996), vol. 7, page 616
DESCRIPTION- COUMAILLEAU ET AL., J. BIOL. CHEM., (1995), vol. 270, page 29270
DESCRIPTION- COURTENAY-LUCK ET AL., "Genetic Manipulation of Monoclonal Antibodies", COURTENAY-LUCK ET AL., RITTER ET AL., Monoclonal Antibodies: Production, Engineering and Clinical Application, CAMBRIDGE UNIVERSITY PRESS, (1995), page 166
DESCRIPTION- COYLE ET AL., NAT. HNMUNOL., (2001), vol. 2, pages 203 - 9
DESCRIPTION- CREGG ET AL., MOL. CELL BIOL., (1985), vol. 5, page 3376
DESCRIPTION- CUNNINGHAM ET AL., SCIENCE, (1991), vol. 245, pages 821 - 25
DESCRIPTION- CUNNINGHAM ET AL., SCIENCE, (1991), vol. 253, pages 545 - 48
DESCRIPTION- CUNNINGHAM; WELLS, J. MOL. BIOL., (1993), vol. 234, pages 554 - 63
DESCRIPTION- CUNNINGHAM; WELLS, SCIENCE, (1989), vol. 244, page 1081
DESCRIPTION- DAS ET AL., J. BACTERIOL., (1984), vol. 158, page 1165
DESCRIPTION- DAVENPORT ET AL., INTERNAL IMMUNOPHARMACOL., vol. 2, pages 653 - 672
DESCRIPTION- DAVIDOW ET AL., CURR. GENET., (1985), vol. 10, page 380
DESCRIPTION- DAWSON ET AL., SCIENCE, (1994), vol. 266, page 776
DESCRIPTION- DAWSON, METHODS ENZYMOL., (1997), vol. 287, page 34
DESCRIPTION- DEBOER ET AL., PROC. NATL. ACAD. SCI. (USA), (1983), vol. 80, pages 21 - 25
DESCRIPTION- DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, (1992), vol. 9, page 249
DESCRIPTION- DE LOUVENCOURT ET AL., J. BACTERIOL., (1983), vol. 154, page 737
DESCRIPTION- DERBYSHIRE ET AL., GENE, (1986), vol. 46, page 145
DESCRIPTION- DE VOS ET AL., SCIENCE, (1992), vol. 255, page 306
DESCRIPTION- DE WET ET AL., MOL. CELL. BIOL., (1987), vol. 7, page 725
DESCRIPTION- DIJKEMA ET AL., EMBO J., (1985), vol. 4, page 761
DESCRIPTION- DONG ET AL., NAT. MED., (1999), vol. 5, pages 1365 - 9
DESCRIPTION- DONG ET AL., NATURE MED., (1999), vol. 5, pages 1365 - 1369
DESCRIPTION- DOUGLAS; CURIEL, SCIENCE & MEDICINE, (1997), vol. 4, page 44
DESCRIPTION- DUDLEY ET AL., SCIENCE, (2002), vol. 298, pages 850 - 854
DESCRIPTION- DUMITRU ET AL., CELL, (2000), vol. 103, pages 1071 - 1083
DESCRIPTION- DUMONTIER ET AL., J. IMMUNOL., (2000), vol. 164, pages 1814 - 1819
DESCRIPTION- DUMOUTIER, L. ET AL., FROC. NAT'L. ACAD. SCI., (2000), vol. 97, pages 10144 - 10149
DESCRIPTION- DUNCAN; SPREAFICO, CLIN. PHARMACOKINET., (1994), vol. 27, page 290
DESCRIPTION- EDELMAN ET AL., Methods in Enzymology, ACADEMIC PRESS, (1967), vol. 1, page 422
DESCRIPTION- EGEN ET AL., NATURE IMMUNOL., (2002), vol. 3, pages 611 - 618
DESCRIPTION- ELLMAN, METHODS ENZYMOL., (1991), vol. 202, page 301
DESCRIPTION- EMINI ET AL., J. VIROLOGY, (1985), vol. 55, page 836
DESCRIPTION- ETCHEVERRY ET AL., "Expression of Engineered Proteins in Mammalian Cell Culture", ETCHEVERRY ET AL., CLELAND ET AL., Protein Engineering: Principles and Practice, JOHN WILEY & SONS, INC., (1996), pages 163 - 181
DESCRIPTION- ETCHEVERRY ET AL., "Expression of Engineered Proteins in Mammalian Cell Culture", ETCHEVERRY ET AL., CLELAND ET AL., Protein Engineering: Principles and Practice, WILEY-LISS, INC., (1996), page 163
DESCRIPTION- FLAVELL, DJ, HEMATOLOGICAL ONCOLOGY, (1996), vol. 14, pages 67 - 82
DESCRIPTION- FOECKING, GENE, (1980), vol. 45, page 101
DESCRIPTION- FORD ET AL., PROTEIN EXPRESSION AND PURIFICATION, (1991), vol. 2, page 95
DESCRIPTION- FRANCIS ET AL., INT J HEMATOL, (1998), vol. 68, page 1
DESCRIPTION- FREEMAN ET AL., J. EXP. MED., (2000), vol. 192, pages 1027 - 34
DESCRIPTION- FRIBOULET ET AL., APPL. BIOCHEM. BIOTECHNOL, (1994), vol. 47, page 229
DESCRIPTION- FUKUNAGA ET AL., J. BIOL. CHERN., (1995), vol. 270, page 25291
DESCRIPTION- GABAY, EXPERT. OPIN. BIOL. THER., (2002), vol. 2, no. 2, pages 135 - 149
DESCRIPTION- GAILLARDIN ET AL., CURR. GENET., (1985), vol. 10, page 49
DESCRIPTION- GAMIER ET AL., CYTOTECHNOL., (1994), vol. 15, page 145
DESCRIPTION- GARNIER-ROBSON; GAMIER ET AL., J. MOL. BIOL., (1978), vol. 120, page 97
DESCRIPTION- "Genetic Manipulation and Expression of Antibodies", WARD ET AL., Monoclonal Antibodies: Principles and Applications, WILEY-LISS, INC., (1995), page 137
DESCRIPTION- GEORGIOU ET AL., "Expression of Proteins in Bacteria", GEORGIOU ET AL., CLELAND ET AL., Protein Engineering: Principles and Practice, JOHN WILEY & SONS, INC., (1996), page 101
DESCRIPTION- GEYSEN, PROC. NAT'LACAD. SCI. USA, (1983), vol. 81, page 3998
DESCRIPTION- GLAUSNER ET AL., LANCET, (1991), vol. 338, page 732
DESCRIPTION- GLEESON ET AL., J. GEN. MICROBIAL., (1986), vol. 132, page 3459
DESCRIPTION- GLEESON ET AL., J. GEN. MICROBIOL., (1986), vol. 732, page 3459
DESCRIPTION- GLICK, J. IND. MICROBIOL., (1987), vol. 1, page 277
DESCRIPTION- GOEDDEL ET AL., NATURE, (1979), vol. 281, page 544
DESCRIPTION- GOEDDEL ET AL., NUCLEIC ACIDS RES., (1980), vol. 8, page 4057
DESCRIPTION- GOMBOTZ; PETTIT, BIOCONJUGATE CHEM., (1995), vol. 6, page 332
DESCRIPTION- GOMBOTZ, TIBTECH, (1998), vol. 16, page 343
DESCRIPTION- GORMAN ET AL., PROC. NAT'L ACAD. SCI. USA, (1982), vol. 79, page 6777
DESCRIPTION- GORMAN ET AL., PROC. NATL. ACAD. SCI. (USA), (1982), vol. 79, page 6777
DESCRIPTION- GRANTHAM, NUCL. ACIDS RES., (1980), vol. 8, page 1893
DESCRIPTION- GREEN ET AL., NATURE GENET., (1994), vol. 7, page 13
DESCRIPTION- GREEN ET AL., "Production of Polyclonal Antisera", GREEN ET AL., MANSON, Immunochemical Protocols, HUMANA PRESS, (1992), pages 1 - 5
DESCRIPTION- GREEN ET AL., "Production of Polyclonal Antisera", GREEN ET AL., MANSON, Methods In Molecular Biology: Immunochemical Protocols, HUMANA PRESS, (1992), pages 1 - 12
DESCRIPTION- GREF ET AL., PHARM. BIOTECHNOL., (1997), vol. 10, page 167
DESCRIPTION- GRISSHAMMER ET AL., "Purification t of over-produced proteins from E. coli cells", GRISSHAMMER ET AL., GLOVER ET AL., DNA Cloning 2: Expression Systems, 2nd Edition,, OXFORD UNIVERSITY PRESS, (1995), pages 59 - 92
DESCRIPTION- GROSJEAN; FIERS, GENE, (1982), vol. 18, page 199
DESCRIPTION- GRUSSENMEYER ET AL., PROC. NAT'L ACAD. SCI., (1985), vol. 82, page 7952
DESCRIPTION- GRUSSENMEYER ET AL., PROC. NATL. ACAD. SCI. USA, (1985), vol. 82, page 7952
DESCRIPTION- HAAS ET AL., CURR. BIOL., (1996), vol. 6, page 315
DESCRIPTION- HACKENG ET AL., PROC. NAT'L ACAD. SCI. USA, (1997), vol. 94, page 7845
DESCRIPTION- HAMER ET AL., J. MOLEC. APPL. GENET, (1982), vol. I, page 273
DESCRIPTION- HAM; WALLACE, METH. ENZ., (1979), vol. 58, page 44
DESCRIPTION- HARASYM ET AL., ADV. DRUG DELIV. REV., (1998), vol. 32, page 99
DESCRIPTION- HENIKOFF; HENIKOFF, PROC. NAT'L ACAD. SCI. USA, (1992), vol. 89, page 10915
DESCRIPTION- HENIKOFF; HENIKOFF, PROC. NATL. ACAD, SCI. USA, (1992), vol. 89, page 10915
DESCRIPTION- HILL-PERKINS; POSSEE, J. GEN. VIROL., (1990), vol. 71, page 971
DESCRIPTION- HILTON ET AL., J. BIOI. CHEM., (1996), vol. 271, page 4699
DESCRIPTION- HINCHCLIFFE; ILIUM, ADV. DRUG DELIV. REV., (1999), vol. 35, page 199
DESCRIPTION- HOLLIGER P; HOOGENBOOM, H, NATURE BIOTECH., (1998), vol. 16, pages 1015 - 1016
DESCRIPTION- HOLM, NUC. ACIDS RES., (1986), vol. 14, page 3075
DESCRIPTION- HOLOWACHUK ET AL., PCR METHODS APPL., (1995), vol. 4, page 299
DESCRIPTION- HOPP, BIOTECHNOLOGY, (1988), vol. 6, pages 1204 - 1210
DESCRIPTION- HOPP ET AL., BIOTECHNOLOGY, (1988), vol. 6, page 1204
DESCRIPTION- HOPP ET AL., PROC. NATL. ACAD. SCI., (1981), vol. 78, pages 3824 - 3828
DESCRIPTION- HOPP ET AL., PROC. NAT'L ACAD. SCI. USA, (1981), vol. 78, page 3824
DESCRIPTION- HOPP, J. IMMUN. METH., (1986), vol. 88, pages 1 - 18
DESCRIPTION- HORISBERGER; DI MARCO, PHARMAC. THER., (1995), vol. 66, page 507
DESCRIPTION- HORSCH ET AL., SCIENCE, (1985), vol. 227, page 1229
DESCRIPTION- HUGHES C ET AL., J. IMMUNOL, (1994), vol. 153, pages 3319 - 3325
DESCRIPTION- IKEMURA, J. MOL. BIOI., (1982), vol. 158, page 573
DESCRIPTION- "Implants in Drug Delivery", RANADE, Drug Delivery Systems, CRC PRESS, (1995), pages 95 - 123
DESCRIPTION- INBAR ET AL., PROC. NAT'L ACAD. SCI. USA, (1972), vol. 69, page 2659
DESCRIPTION- "Information Superhighway and Computer Databases of Nucleic Acids and Proteins", WU ET AL., Methods in Gene Biotechnology, CRC PRESS, INC., (1997), pages 123 - 151
DESCRIPTION- ITAKURA ET AL., ANNU. REV. BIOCHEM., (1984), vol. 53, page 323
DESCRIPTION- ITO ET AL., J. BACTERIOL., (1983), vol. 153, page 163
DESCRIPTION- IWAI ET AL., J. IMMUNOL., (2002), vol. 169, page 4332
DESCRIPTION- JAMESON; WOLF, CABIOS, (1988), vol. 4, page 181
DESCRIPTION- JONES ET AL., NATURE, (1986), vol. 321, page 522
DESCRIPTION- JORON ET AL., ANN. N Y ACAD. SCI., (1992), vol. 672, page 216
DESCRIPTION- KAMPS ET AL., PROC. NAT'L ACAD. SCI. USA, (1997), vol. 94, page 11681
DESCRIPTION- KANE, CURR. OPIN. BIOTECHNOL., (1995), vol. 6, page 494
DESCRIPTION- KARLSSON, J. IMMUNOL. METHODS, (1991), vol. 145, pages 229 - 40
DESCRIPTION- KARPLUS; SCHULTZ, NATURWISSENSCHAFTEN, (1985), vol. 72, page 212
DESCRIPTION- KATO ET AL., BIOI. PHANN. BULL., (1993), vol. 16, page 960
DESCRIPTION- KATO ET AL., BIOL. PHARM. BULL., (1993), vol. 16, page 960
DESCRIPTION- KATO; SUGIYAMA, CRIT. REV. THER. DRUG CARRIER SVST., (1997), vol. 14, page 287
DESCRIPTION- KATO; SUGIYAMA, CRIT. REV. THER. DRUG CARRIER SYST., (1997), vol. 14, page 287
DESCRIPTION- KAUFMAN ET AL., NUCL. ACIDS RES., (1991), vol. 19, page 4485
DESCRIPTION- KELLEY ET AL., "Engineering Therapeutic Antibodies", KELLEY ET AL., CLELAND ET AL,, Protein Engineering: Principles and Practice, JOHN WILEY & SONS, INC., (1996), pages 399 - 434
DESCRIPTION- KELLY; HYNES, EMBO J., (1985), vol. 4, page 475479
DESCRIPTION- KENNEDY ET AL., CLIN. CHIM. ACTA, (1976), vol. 70, page 1
DESCRIPTION- KIM, DRUGS, (1993), vol. 46, page 618
DESCRIPTION- KLEIN ET AL., BIOTECHNOLOGY, (1992), vol. 10, page 268
DESCRIPTION- KNOWN ET AL., METHODS IN ENZYMOLOGY, (1990), vol. 185, pages 527 - 537
DESCRIPTION- KOHLER ET AL., NATURE, (1975), vol. 256, page 495
DESCRIPTION- KOIDE ET AL., BIOCHEM., (1994), vol. 33, page 7470
DESCRIPTION- KOTENKO SV ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 2725 - 2732
DESCRIPTION- KUHNEL ET AL., PROC. NAT'L. ACAD. SCI., (2004), vol. 101, page 17027
DESCRIPTION- KUNZE ET AL., J. BASIC MICROBIAL., (1985), vol. 25, page 141
DESCRIPTION- KUNZE ET AL., J. BASIC MICROBIOL., (1985), vol. 25, page 141
DESCRIPTION- KURTZ ET AL., MOL. CELL. BIOL., (1986), vol. 6, page 142
DESCRIPTION- LANE; STEPHEN, CURR. OPIN. IMMUNOL., (1993), vol. 5, page 268
DESCRIPTION- LARRICK, METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, (1991), vol. 2, page 106
DESCRIPTION- LATCHMAN ET AL., NAT. IMMUNOL., (2001), vol. 2, pages 261 - 8
DESCRIPTION- LEBACQ-VERHEYDEN ET AL., MOL. CELL. BIOL., (1988), vol. 8, page 3129
DESCRIPTION- LIANG ET AL., CURR. OPIN. IMMUNOL., (2002), vol. 14, pages 384 - 90
DESCRIPTION- LI ET AL., CELL, (1992), vol. 69, page 915
DESCRIPTION- LING ET AL., J. IMMUNOL., (2000), vol. 164, pages 1653 - 7
DESCRIPTION- LONBERG ET AL., NATURE, (1994), vol. 368, page 856
DESCRIPTION- LOSMAN ET AL., INT. J. CANCER, (1990), vol. 46, page 310
DESCRIPTION- LOWMAN ET AL., BIOCHEM., (1991), vol. 30, page 10832
DESCRIPTION- LUCKNOW ET AL., "Insect Cell Expression Technology", LUCKNOW ET AL., CLELAND ET AL., Protein Engineering: Principles and Practice, JOHN WILEY & SONS, INC., (1996), pages 183 - 218
DESCRIPTION- LUCKOW ET AL., BIO/TECHNOLOGY, (1988), vol. 6, pages 47 - 55
DESCRIPTION- LUCKOW ET AL., J. VIROL., (1993), vol. 67, page 4566
DESCRIPTION- LUO ET AL., ARCH. BIOCHEM. BIOPHYS., (1996), vol. 329, page 215
DESCRIPTION- MAEDA ET AL., NATURE, (1985), vol. 315, pages 592 - 594
DESCRIPTION- MAKRIDES, MICROBIAL. REV., (1996), vol. 60, page 512
DESCRIPTION- MARTIN ET AL., DNA, (1988), vol. 7, page 99
DESCRIPTION- MATHEY-PREVOT ET AL., MOL. CELL. BIOL., (1986), vol. 6, pages 4133 - 4135
DESCRIPTION- MCKNIGHT, CELL, (1982), vol. 31, page 355
DESCRIPTION- M. DEUTSCHER,, METH. ENZYMOL., (1990), vol. 182, page 529
DESCRIPTION- MEISEL ET AL., PLANT MOLEC. BIOL., (1996), vol. 30, page 1
DESCRIPTION- MERRIFIELD, J. AM. CHEM. SOC., (1963), vol. 85, page 2149
DESCRIPTION- MILLER ET AL., ANN. REV. MICROBIOL., (1988), vol. 42, page 177
DESCRIPTION- MILLER ET AL., GENERIC ENGINEERING, (1986), vol. 8, pages 277 - 279
DESCRIPTION- MIM ET AL., "Procedures for Introducing Foreign DNA into Plants", MIM ET AL., GLICK ET AL., Methods in Plant Molecular Biology and Biotechnology, CRC PRESS, (1993), pages 67 - 88
DESCRIPTION- MITRAGOTRI ET AL., SCIENCE, (1995), vol. 269, page 850
DESCRIPTION- MIYAJIMA ET AL., GENE, (1987), vol. 58, page 273
DESCRIPTION- MOLE, "Epitope Mapping", MOLE, MANSON, Methods in Molecular Biology, THE HUMANA PRESS, INC., (1992), vol. 10, pages 105 - 116
DESCRIPTION- MONFARDINI ET AL., PROC. ASSOC. AM. PHYSICIANS, (1996), vol. 108, page 420
DESCRIPTION- MONKARSH ET AL., ANAL. BIOCHEM., (1997), vol. 247, page 434
DESCRIPTION- MORGANTI ET AL., BIOTECHNOL. APPL. BIOCHEM., (1996), vol. 23, page 67
DESCRIPTION- MOSMAN, J. IMMUNOL. METH., (1983), vol. 65, pages 55 - 63
DESCRIPTION- MUIR ET AL., PROC. NAT'L ACAD. SCI. USA, (1998), vol. 95, page 6705
DESCRIPTION- MURAHASHI ET AL., BIOL. PHARM. BULL., (1997), vol. 20, page 259
DESCRIPTION- MYERS ET AL., LIFE SCI., (1997), vol. 61, pages 1861 - 78
DESCRIPTION- NEEDLEMAN; WUNSCH, J. MOL. BIOI., (1970), vol. 48, page 444
DESCRIPTION- NER, DNA, (1988), vol. 7, page 127
DESCRIPTION- NEURATH ET AL., INTERN. REV. IMMUNOL., (2000), vol. 19, pages 51 - 62
DESCRIPTION- NICKOLOFF, B. J. ET AL., AM. J. PATHOL., (1995), vol. 146, page 580
DESCRIPTION- NIEFORTH ET AL., CLIN. PHANIIACOL. THER., (1996), vol. 59, page 636
DESCRIPTION- NILSSON, EMBO J., (1985), vol. 4, page 1075
DESCRIPTION- NILSSON ET AL., METHODS ENZYMOL., (1991), vol. 198, page 3
DESCRIPTION- NISONOFF, ARCH BIOCHEM. BIOPHYS., (1960), vol. 89, page 230
DESCRIPTION- "Oral Delivery of Microencapsulated Proteins", DIBASE; MORREL, Protein Delivery: Physical Systems, PLENUM PRESS, (1997), pages 255 - 288
DESCRIPTION- ORLANDI ET AL., PROC. NAT'L ACAD. SCI. USA, (1989), vol. 86, page 3833
DESCRIPTION- OSTRO, AMERICAN J. HOSP. PHANN., (1989), vol. 46, page 1576
DESCRIPTION- OSTRO ET AL., AMERICAN J. HOSP. PHARM., (1989), vol. 46, page 1576
DESCRIPTION- PACK ET AL., BIO/TECHNOLOGY, (1993), vol. 11, page 1271
DESCRIPTION- PALACIOS; STEINMETZ, CELL, (1985), vol. 41, pages 727 - 734
DESCRIPTION- PARDOLL, NATURE BIOTECH., (2002), vol. 20, pages 1207 - 1208
DESCRIPTION- PATEL ET AL., "The baculovirus expression system", PATEL ET AL., GLOVER ET AL., DNA Cloning 2: Expression Systems, 2nd Edition,, OXFORD UNIVERSITY PRESS, (1995), pages 205 - 244
DESCRIPTION- PATTON ET AL., ADV. DRUG DELIV. REV., (1999), vol. 35, page 235
DESCRIPTION- PEARSON; LIPMAN, PROC. NAT'L ACAD. SCI. USA, (1988), vol. 85, page 2444
DESCRIPTION- PEARSON, METH. ENZYMOL., (1990), vol. 183, page 63
DESCRIPTION- PERRY, "The Role of Monoclonal Antibodies in the Advancement of Immunoassay Technology", PERRY, BIRCH AND LENNOX, Monoclonal Antibodies: Principles and Applications, WILEY-LISS, INC., (1995), pages 107 - 120
DESCRIPTION- PICKSLEY ET AL., "Production of monoclonal antibodies against proteins expressed in E. coli,", PICKSLEY ET AL., GLOVER ET AL., DNA Cloning 2: Expression Systems 2nd Edition,, OXFORD UNIVERSITY PRESS, (1995), page 93
DESCRIPTION- PORTER, BIOCHEM. J., (1959), vol. 73, page 119
DESCRIPTION- POTTS ET AL., PHANN. BIOTECHNOL., (1997), vol. 10, page 213
DESCRIPTION- POULSEN, L.K. ET AL., J. BIOL. CHEM., (1998), vol. 273, pages 6229 - 6232
DESCRIPTION- PRICE, "Production and Characterization of Synthetic Peptide-Derived Antibodies", PRICE, RITTER AND LADYMAN, Monoclonal Antibodies: Production, Engineering, and Clinical Application, CAMBRIDGE UNIVERSITY PRESS, (1995), pages 60 - 84
DESCRIPTION- "Protein Delivery with Infusion Pumps", BREMER ET AL., Protein Delivery: Physical Systems, PLENUM PRESS, (1997), pages 239 - 254
DESCRIPTION- "Purification of Immunoglobulin G (IgG", BAINES ET AL., Methods in Molecular Biology, THE HUMANA PRESS, INC., (1992), vol. 10, pages 79 - 104
DESCRIPTION- PUTNEY; BURKE, NATURE BIOTECHNOLOGY, (1998), vol. 16, page 153
DESCRIPTION- PUTNEY, CURR. OPIN. CHEM. BIOL., (1998), vol. 2, page 548
DESCRIPTION- RAYCHAUDHURI, S. P. ET AL., BR. J. DERMATOL., (2001), vol. 144, page 931
DESCRIPTION- RAYMOND ET AL., YEAST, (1998), vol. 14, pages 11 - 23
DESCRIPTION- REIDHAAR-OLSON; SAUER, SCIENCE, (1988), vol. 241, page 53
DESCRIPTION- ROBERTSON ET AL., J. AM. CHEM. SOC., (1991), vol. 113, page 2722
DESCRIPTION- ROGGENKAMP ET AL., MOL. GEN. GENET., (1986), vol. 202, page 302
DESCRIPTION- "Role of Polymers in Drug Delivery", RANADE, Drug Delivery Systems, CRC PRESS, (1995), pages 51 - 93
DESCRIPTION- ROMANOS ET AL., "Expression of Cloned Genes in Yeast", ROMANOS ET AL., GLOVER AND HAMES, DNA Cloning 2: A Practical Approach, 2nd Edition, OXFORD UNIVERSITY PRESS, (1995), pages 123 - 167
DESCRIPTION- ROSKOS; MASKIEWICZ, "Degradable Controlled Release Systems Useful for Protein Delivery", ROSKOS; MASKIEWICZ, SANDERS AND HENDREN, Protein Delivery: Physical Systems, PLENUM PRESS, (1997), pages 45 - 92
DESCRIPTION- SADOWSKI, H. ET AL., SCIENCE, (1993), vol. 261, pages 1739 - 1744
DESCRIPTION- SANDHU, CRIT. REV. BIOTECH, (1992), vol. 12, page 437
DESCRIPTION- SANDHU, CRIT. REV. BIOTECH., (1992), vol. 12, page 437
DESCRIPTION- SCATCHARD, ANN. NY ACAD. SCI., (1949), vol. 51, page 660
DESCRIPTION- SCATCHARD, ANN. NY ACAD. SCI., (1949), vol. 51, pages 660 - 72
DESCRIPTION- SCHENBORN; GOIFFIN, PROINEGA_NOTES, (1993), vol. 41, page 11
DESCRIPTION- SCHERPHOF ET AL., ANN. N.Y. ACAD. SCI., (1985), vol. 446, page 368
DESCRIPTION- SCHMITT-NEY, M. ET AL., MOL. CELL. BIOL., (1991), vol. 11, pages 3745 - 3755
DESCRIPTION- SCHURS ET AL., CLIN. CHIM. ACTA, (1977), vol. 81, page 1
DESCRIPTION- SEIDEL, H. ET AL., PROC. NATL. ACAD. SCI., (1995), vol. 92, pages 3041 - 3045
DESCRIPTION- SELLERS, SIAM J. APPL. MATH., (1974), vol. 26, page 787
DESCRIPTION- SEVERINOV; MUIR, J. BIOL. CHEM., (1998), vol. 273, page 16205
DESCRIPTION- SHARP; MATASSI, CURR. OPIN. GENET. DEV., (1994), vol. 4, page 851
DESCRIPTION- SHAW, CELL, (1989), vol. 56, pages 563 - 572
DESCRIPTION- SHIH ET AL., INT'L J. CANCER, (1990), vol. 46, page 1101
DESCRIPTION- SHIMIZU ET AL., BIOL. PHARM. BULL., (1997), vol. 20, page 881
DESCRIPTION- SIEBENLIST ET AL., CELL, (1980), vol. 20, page 269
DESCRIPTION- SINGER ET AL., J. IMINUN., (1993), vol. 150, page 2844
DESCRIPTION- "Site-Specific Drug Delivery Using Liposomes as Carriers", RANADE, Drug Delivery Systems, CRC PRESS, (1995), pages 3 - 24
DESCRIPTION- SMITH ET AL., J. MOL. BIOI., (1992), vol. 224, page 899
DESCRIPTION- SMITH ET AL., J. MOL. BIOL., (1992), vol. 224, page 899
DESCRIPTION- SMITH ET AL., PROC. NATL. ACAD. SCI. (USA), (1985), vol. 82, page 8844
DESCRIPTION- SMITH JA ET AL., J. IMMUNOL., (1998), vol. 160, pages 4841 - 4849
DESCRIPTION- SMITH; JOHNSON, GENE, (1988), vol. 67, page 31
DESCRIPTION- "Solid-Phase Peptide Synthesis", FIELDS; COLOWICK, Methods in Enzymology, ACADEMIC PRESS, (1997), vol. 289
DESCRIPTION- STEIN, CANCER RES., (1990), vol. 50, page 1330
DESCRIPTION- STEMMER ET AL., GENE (AMSTERDAM, (1995), vol. 164, no. 1, pages 49 - 53
DESCRIPTION- STEMMER, NATURE, (1994), vol. 370, page 389
DESCRIPTION- STEMMER, NATURE, (1994), vol. 370, pages 389 - 391
DESCRIPTION- STEMMER, PROC. NAT'L ACAD. SCI. USA, (1994), vol. P7, page 10747
DESCRIPTION- SUGAI, J., M. ET AL., J. DERMATOL. SCI., (1998), vol. 17, page 85
DESCRIPTION- SULKOWSKI, TRENDS IN BIOCHERN., (1985), vol. 3, page 1
DESCRIPTION- SUN ET AL., J. ?TNMUNO?., (2002), vol. 168, pages 6294 - 7
DESCRIPTION- SUTCLIFFE ET AL., SCIENCE, (1983), vol. 219, page 660
DESCRIPTION- SWALLOW ET AL., IMMUNITY, (1999), vol. 11, pages 423 - 32
DESCRIPTION- TAYLOR ET AL., INT. IMMUN., (1994), vol. 6, page 579
DESCRIPTION- "The EGF Receptor", HERSCHMAN ET AL., Control of Animal Cell Proliferation,, ACADEMIC PRESS, (1985), vol. 1, pages 169 - 199
DESCRIPTION- THOMAS; CAPECCHI, CELL, (1987), vol. 51, page 503
DESCRIPTION- TILBURN ET AL., GENE, (1983), vol. 26, pages 205 - 221
DESCRIPTION- TREUTER ET AL., MOLEC. GEN. GENET, (1993), vol. 240, page 113
DESCRIPTION- TRIQUIER ET AL., PROTEIN ENGINEERING, (1998), vol. 11, pages 153 - 169
DESCRIPTION- TSENG ET AL., J. EXP. MED., (2001), vol. 193, pages 839 - 46
DESCRIPTION- TUAN, CONNECTIVE TISSUE RESEARCH, (1996), vol. 34, no. 1
DESCRIPTION- TUAN ET AL., CONNECTIVE TISSUE RESEARCH, (1996), vol. 34, pages 1 - 9
DESCRIPTION- TURCATTI, J. BIOL. CLZEM., (1996), vol. 271, page 19991
DESCRIPTION- TUTT, AL ET AL., J IMMUNOL., (1998), vol. 161, pages 3175 - 3185
DESCRIPTION- "Use of Degenerate Oligonucleotide Primers and the Polymerase Chain Reaction to Clone Gene Family Members", PRESTON, Methods in Molecular Biology, Vol. 15: PCR Protocols: Current Methods and Applications, HUMANA PRESS, INC., (1993), vol. 15
DESCRIPTION- "Use of the Polymerase Chain Reaction for the Rapid Construction of' Synthetic Genes", DILLON ET AL., Methods in Molecular Biology, Vol. 15: PCR Protocols: Current Methods and Applications, HUMANA PRESS, INC., (1993), vol. 15, pages 263 - 268
DESCRIPTION- "Use of the Polymerase Chain Reaction to Screen Phage Libraries", YU ET AL., Methods in Molecular Biology, Vol. 15: PCR Protocols: Current Methods and Applications, HUMANA PRESS, INC., (1993), vol. 15
DESCRIPTION- VAN DEN BERG ET AL., BIO/TECHNOLOGY, (1990), vol. 8, page 135
DESCRIPTION- VARTHAKAVI; MINOCHA, J. GEN. VIROL., (1996), vol. 77, page 1875
DESCRIPTION- VILLADSEN L.S. ET AL., J. CLIN. INVEST.., (2003), vol. 112, page 1571
DESCRIPTION- VLAK ET AL., J. GEN. VIROL., (1988), vol. 69, pages 765 - 776
DESCRIPTION- WAIN-HOBSON ET AL., GENE, (1981), vol. 13, page 355
DESCRIPTION- WANG ET AL., BLOOD, (2000), vol. 96, pages 2808 - 13
DESCRIPTION- WANG ET AL., IMMUNOL., (1995), vol. 92, pages 8955 - 959
DESCRIPTION- WASSEF ET AL., METH. ENZYMOL., (1987), vol. 149, page 124
DESCRIPTION- WETMUR, CRIT. REV. BIOCHEM. MOL. BIOI., (1990), vol. 26, page 227
DESCRIPTION- WHITLOW ET AL., METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, (1991), vol. 2, page 97
DESCRIPTION- WILLIAMS ET AL., "Expression of Foreign Proteins in E. coli Using Plasmid Vectors and Purification of Specific Polyclonal Antibodies", WILLIAMS ET AL., GLOVER AND HAMES, DNA Cloning 2: A Practical Approach, 2nd Edition,, OXFORD UNIVERSITY I PRESS, (1995), pages 15 - 58
DESCRIPTION- WILLIAMS ET AL., "Expression of foreign proteins in E. coli using plasmid vectors and purification of specific polyclonal antibodies", WILLIAMS ET AL., GLOVER ET AL., DNA Cloning 2: Expression Systems, 2nd Edition,, OXFORD UNIVERSITY PRESS, (1995), page 15
DESCRIPTION- WILLIAMS ET AL., IMMUNOL., (1992), vol. 89, pages 9784 - 788
DESCRIPTION- WLODAVER ET AL., FEBS LETT., (1992), vol. 309, page 59
DESCRIPTION- WOOLEY, CURR. OPIN. RHEUM., (1999), vol. 3, pages 407 - 20
DESCRIPTION- WU ET AL., HEMATOLOGY, (1998), vol. 27, page 772
DESCRIPTION- WU ET AL., HEPATOLOGY, (1998), vol. 27, page 772
DESCRIPTION- WYNN; RICHARDS, PROTEIN SCI., (1993), vol. 2, page 395
DESCRIPTION- XIE MH ET AL., J. BIOL. CHEM., (2000), vol. 275, pages 31335 - 31339
DESCRIPTION- YAMAGUCHI, BIOCHEM. PHARMACOL., (1995), vol. 50, page 1295
DESCRIPTION- YAMANAKA, N. ET AL., MICROBIO.L IMMUNOL., (2001), vol. 45, page 507
DESCRIPTION- YELTON ET AL., PROC. . NATL. ACAD. SCI. (USA), (1984), vol. 81, pages 1470 - 1474
DESCRIPTION- YOSHINAGA, NATURE, (1999), vol. 402, pages 827 - 32
DESCRIPTION- ZEIGLER, M. ET AL., LAB INVEST, (2001), vol. 81, page 1253
DESCRIPTION- ZHENG ET AL., GENE, (1997), vol. 186, page 55
DESCRIPTION- ZHOU ET AL., MOL. CELL. BIOL., (1990), vol. 10, page 4529
DESCRIPTION- ZOLLNER, T. M. ET AL., J. CLIN. INVEST., (2002), vol. 109, page 671
DESCRIPTION- YEWEY ET AL., "Delivery of Proteins from a Controlled Release Injectable Implant", YEWEY ET AL., SANDERS AND HENDREN, Protein Delivery: Physical Systems, PLENUM PRESS, (1997), pages 93 - 117, doi:doi:10.1007/0-306-46803-4_3, XP000879350
OPPOSITION- HOLLIGER et al., "Antibodies come back from the brink", Nature Biotech, (19981100), vol. 16, pages 1015 - 1016, XP055771021
OPPOSITION- RECHES et al., "Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity", J ImmunoTherapy of Cancer, (20200000), vol. 8, pages 1 - 9, XP055771008
OPPOSITION- SHARPE et al., "THE B7-CD28 SUPERFAMILY", Nature Reviews, (20020200), vol. 2, pages 116 - 126, XP055771033
OPPOSITION- STARBUCK, "Poster Session TIGIT ligands CD155, CD112, and galectin-9 are associated withimmune infiltration and increased overall survival in ovarian cancer", Gynecologic Oncology, (20180000), vol. 149, page 56, XP055771003
OPPOSITION- TUTT et al., "Monoclonal antibody therapy of B cell lymphoma: signaling activity on tumor cells appears more important than recruitment of effectors", J Immunol, (19980000), vol. 161, pages 3176 - 3185, XP002213374
OPPOSITION- LEVIN et al., "Vstm3 is a member of the CD28 family and an important modulator of T-cell function", Eur J Immunol, (20110000), vol. 41, pages 902 - 915, XP055215809
OPPOSITION- JOHNSTON et al., "The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+T Cell Effector Function", Cancer Cell, (20140000), vol. 26, pages 923 - 937, XP029111576
OPPOSITION- PEGGS et al., "Principles and use of anti-CTLA4 antibody in human cancer immunotherapy", Current Opinion in Immunology, (20060200), vol. 18, pages 206 - 213, XP005321331
OPPOSITION- PEACH et al., "BOTH EXTRACELLULAR IMMUNOGLOBIN-LIKE DOMAINS OF CD80 CONTAIN RESIDUES CRITICAL FOR BINDINGT CELL SURFACE RECEPTORS CTLA-4 AND CD28", J Biol Chem., (19950908), vol. 270, no. 36, pages 21181 - 21187, XP002912152
OPPOSITION- BOTTINO et al., "Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule", J. Exp. Med., (20030818), vol. 198, no. 4, pages 557 - 567, XP055011690
OPPOSITION- CARRENO et al., "THE B7 FAMILY OF LIGANDS AND ITS RECEPTORS: NEW PATHWAYS FOR COSTIMULATION AND INHIBITION OF IMMUNE RESPONSES", Annu Rev Immunol, (20020000), vol. 20, pages 29 - 53, XP009004805
OPPOSITION- CASTRICONI et al., "Natural Killer Cell-Mediated Killing of Freshly Isolated Neuroblastoma Cells : Critical Role of DNAX Accessory Molecule-1-Poliovirus Receptor Interaction", CANCER RESEARCH, (20041215), vol. 64, pages 9180 - 9184, XP055633969
OPPOSITION- SLOAN et al., "CD155/PVR plays a key role in cell motility during tumor cell invasion and migration", BMC Cancer, (20040000), vol. 4, XP021004676
OPPOSITION- TRENEVSKA et al., "Therapeutic Antibodies against Intracellular Tumor Antigens", Frontiers in Immunology, (20170000), vol. 8, XP055652470
SEARCH- NOBIS P ET AL, "PRODUCTION OF A MONOCLONAL ANTIBODY AGAINST AN EPITOPE ON HELA CELLS THAT IS THE FUNCTIONAL POLIOVIRUS BINDING SITE", JOURNAL OF GENERAL VIROLOGY, (1985), vol. 66, no. 12, ISSN 0022-1317, pages 2563 - 2670, XP009075227 [A] 1-14 * the whole document *
SEARCH- BAURY B ET AL, "Identification of secreted CD155 isoforms", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20030912), vol. 309, no. 1, doi:10.1016/S0006-291X(03)01560-2, ISSN 0006-291X, pages 175 - 182, XP004448805 [A] 1-14 * the whole document *
SEARCH- FREEMAN G ET AL, "ENGAGEMENT OF THE PD-1 IMMUNOINHIBITORY RECEPTOR BY A NOVEL B7 FAMILY MEMBER LEADS TO NEGATIVE REGULATION OF LYMPHOCYTE ACTIVATION", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, (20001002), vol. 192, no. 7, ISSN 0022-1007, pages 1027 - 1034, XP000971650 [A] 1-14 * the whole document *

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