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Engineered Gamma Delta T-Cells - EP3220926

The patent EP3220926 was granted to Adicet BIO on Dec 25, 2024. The application was originally filed on Nov 17, 2015 under application number EP15860648A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3220926

ADICET BIO
Application Number
EP15860648A
Filing Date
Nov 17, 2015
Status
Granted And Under Opposition
Nov 22, 2024
Publication Date
Dec 25, 2024
External Links
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STRAWMANSep 25, 2025LEONARDADMISSIBLE

Patent Citations (11) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTUS2006122130
INTERNATIONAL-SEARCH-REPORTUS2006205089
INTERNATIONAL-SEARCH-REPORTUS2008026986
INTERNATIONAL-SEARCH-REPORTUS5185250
INTERNATIONAL-SEARCH-REPORTWO2013074916
INTERNATIONAL-SEARCH-REPORTWO2013079174
OPPOSITIONWO2012156958
OPPOSITIONWO2015061694
OPPOSITIONWO2016198480
OPPOSITIONWO2019147735
OTHERWO2012156958

Non-Patent Literature (NPL) Citations (21) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
EXAMINATION- GROH V ET AL, "COSTIMULATION OF CD8ALPHABETA T CELLS BY NKG2D VIA ENGAGEMENT BY MIC INDUCED ON VIRUS-INFECTED CELLS", NATURE IMMULOGY, NATURE PUBLISHING GROUP US, NEW YORK, (20010301), vol. 2, no. 3, doi:10.1038/85321, ISSN 1529-2908, pages 255 - 260, XP008016411
EXAMINATION- NING KANG ET AL, "Adoptive immunotherapy of lung cancer with immobilized anti-TCR[gamma][delta] antibody-expanded human [gamma][delta] T Cells in peripheral blood", CANCER BIOLOGY & THERAPY, US, (20090815), vol. 8, no. 16, doi:10.4161/cbt.8.16.8950, ISSN 1538-4047, pages 1540 - 1549, XP055727385
INTERNATIONAL-SEARCH-REPORT- YOON et al., "The Cell Cycle Time of CD 8+ T Cells Responding In Vivo Is Controlled by the Type of Antigenic Stimulus", PLoS One, (20101108), vol. 5, no. 11, pages 1 - 12, XP055443335 [Y] 1, 9-11, 17-23, 25-28, 34-37, 41, 48, 55, 59-62, 72-74, 132 * . entire document *
INTERNATIONAL-SEARCH-REPORT- GRA et al., "Analysis of T- Cell Receptor- Gene Rearrangements Using Oligonucleotide Microchip", Journal of Molecular Diagnostics, (20070401), vol. 9, no. 2, pages 249 - 257, XP009161616 [Y] 164 * . entire document *
OPPOSITION- D10 - Response to European search opinion filed by applicant on EP15860648.3 (the application which was granted as the opposed patent) 23 May 2019
OPPOSITION- D11 - Response to A94(3) EPC communication filed by applicant on EP15860648.3 (the application which was granted as the opposed patent) 22 March 2021
OPPOSITION- D13 - European Search Opinion issued on EP15860648.3 (the application which was granted as the opposed patent) July 2018
OPPOSITION- Kress, E. ; Hedges, J.F. ; Jutila, M.A., "Distinct gene expression in human V@d1 and V@d2 @c@d T cells following non-TCR agonist stimulation", Molecular Immunology, PERGAMON, GB, GB , (20060501), vol. 43, no. 12, ISSN 0161-5890, pages 2002 - 2011, XP027899386
OPPOSITION- Vargas Correia Daniel, "MOLECULAR MECHANISMS OF HUMAN γδ T CELL ACTIVATION AND TUMOR CELL RECOGNITION", Dissertation, UNIVERSIDADE DE LISBOA, FACULDADE DE MEDICINA DE LISBOA, (20111122), pages 1 - 259, XP093322267
OPPOSITION- Siegers Gabrielle M., Emeline J. Ribot, Armand Keating & Paula J. Foster , "Electronic supplementary material: Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI", Cancer immunology immunotherapy, Springer, Berlin/Heidelberg, Berlin/Heidelberg , (20130301), vol. 62, no. 3, doi:10.1007/s00262-012-1353-y, ISSN 0340-7004, pages 1 - 6, XP093322227
OPPOSITION- Siegers Gabrielle M., Ribot Emeline J., Keating Armand, Foster Paula J., "Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI", Cancer immunology immunotherapy, Springer, Berlin/Heidelberg, Berlin/Heidelberg , (20130301), vol. 62, no. 3, doi:10.1007/s00262-012-1353-y, ISSN 0340-7004, pages 571 - 583, XP093322221
OPPOSITION- Mao Yujia, Yin Shanshan, Zhang Jianmin, Hu Yu, Huang Bo, Cui Lianxian, Kang Ning, He Wei, "A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells", Cellular & Molecular Immunology, Nature Publishing Group UK, London, London, (20160301), vol. 13, no. 2, doi:10.1038/cmi.2015.07, ISSN 1672-7681, pages 217 - 228, XP055852192
OTHER- Correia Daniel Vargas, " MOLECULAR MECHANISMS OF HUMAN JG T CELL ACTIVATION AND TUMOR CELL RECOGNITION", Dissertation, (20110101), pages 1 - 259, XP093215880
OTHER- Siegers Gabrielle M, Ribot Emeline J, Keating Armand, Foster Paula J, "Extensive expansion of primary human gamma delta T cells generates cytotoxic eVector memory cells that can be labeled with Feraheme for cellular MRI", Cancer Immunol Immunother, (20130101), pages 571 - 583, Cancer Immunol Immunother, URL: https://link.springer.com/content/pdf/10.1007/s00262-012-1353-y.pdf?pdf=button, (20230120), XP093015887
SEARCH- W SCHEPER ET AL, "Hunting for clinical translation with innate-like immune cells and their receptors", LEUKEMIA., US, (20131218), vol. 28, no. 6, doi:10.1038/leu.2013.378, ISSN 0887-6924, pages 1181 - 1190, XP055486243 [A] 1-17 * the whole document *
SEARCH- GROH V ET AL, "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19990608), vol. 96, no. 12, doi:10.1073/PNAS.96.12.6879, ISSN 0027-8424, pages 6879 - 6884, XP002240479 [X] 1-17 * abstract * * Table 1 BT-238-29 sample 100% V delta 1 gamma delta T cells; page 6881, column 2, paragraph 2 - page 6882, column 1; table 1 *
SEARCH- D. KABELITZ ET AL, "The Multifunctionality of Human V[gamma]9V[delta]2 [gamma][delta] T Cells: Clonal Plasticity or Distinct Subsets? : Plasticity of Human [gamma][delta] T Cells", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, GB, (20120901), vol. 76, no. 3, doi:10.1111/j.1365-3083.2012.02727.x, ISSN 0300-9475, pages 213 - 222, XP055486714 [X] 1-17 * abstract * * Introduction, pages 213-214, especially p. 214 4th sentence from end. Gamma delta 2 T cells account for between 50 - 95% of Gamma delta T cell population in blood *
SEARCH- SIEGERS GABRIELLE M ET AL, "Human V delta 1 gamma delta T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells", CYTOTHE, ISIS MEDICAL MEDIA, OXFORD, GB, (20110701), vol. 13, no. 6, doi:10.3109/14653249.2011.553595, ISSN 1465-3249, pages 753 - 764, XP009163636 [X] 1-17 * Columns 6 , 8, 13 and Legend.; figure 1 * * Proliferation, Activation by ligand, Clone generation (pure cell populations).; figures 3, 4, 5 * * abstract *
SEARCH- B. A. MANGAN ET AL, "Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells", THE JOURNAL OF IMMUNOLOGY, US, (20130605), vol. 191, no. 1, doi:10.4049/jimmunol.1300121, ISSN 0022-1767, pages 30 - 34, XP055486724 [X] 1-17 * Expansion of delta 3 T cells in vivo, Results and discussion,; page 31, column 2 - page 32, column 2, paragraph 1; figures 1, 2 * * Materials and Methods; page 30, column 2, paragraph 3 - page 31, column 1, paragraph 4 *
SEARCH- O. NUSSBAUMER ET AL, "Essential Requirements of Zoledronate-Induced Cytokine and T Cell Proliferative Responses", THE JOURNAL OF IMMUNOLOGY, US, (20130621), vol. 191, no. 3, doi:10.4049/jimmunol.1300603, ISSN 0022-1767, pages 1346 - 1355, XP055486564 [X] 1-17 * abstract * * Magnetic cell separation Cell culture , stimulationand gamma delta T cell expansion.; page 3, column 1, paragraph 2 - page 3, column 2, paragraph 2 * * And legend.; figures 5, 6 *
SEARCH- DANG WU ET AL, "Ex vivo expanded human circulating V[delta]1 [gamma][delta]T cells exhibit favorable therapeutic potential for colon cancer", ONCOIMMUNOLOGY, US, (20150304), vol. 4, no. 3, doi:10.4161/2162402X.2014.992749, ISSN 2162-4011, page e992749, XP055291880 [XP] 1-17 * abstract * * Materials and Methods "cell preparation and isolation", "Fluorescence activated cell sorting" *

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