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Targeted Rna Editing - EP3234134

The patent EP3234134 was granted to Proqr Therapeutics II on May 27, 2020. The application was originally filed on Dec 17, 2015 under application number EP15813826A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3234134

PROQR THERAPEUTICS II
Application Number
EP15813826A
Filing Date
Dec 17, 2015
Status
Granted And Under Opposition
Apr 24, 2020
Grant Date
May 27, 2020
External Links
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Patent Summary

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Patent Family

Patent Oppositions (2)

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MARGARET DIXONFeb 25, 2021MAIWALDADMISSIBLE
STRAWMANFeb 25, 2021LEONARDADMISSIBLE

Patent Citations (7) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
EXAMINATIONEP3323890
EXAMINATIONWO2017050306
INTERNATIONAL-SEARCH-REPORTWO2014011053
OPPOSITIONEP3353299
OPPOSITIONUS9650627
OPPOSITIONWO2005094370
OPPOSITIONWO2014011053

Non-Patent Literature (NPL) Citations (27) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
INTERNATIONAL-SEARCH-REPORT- GRÉGOIRE MASLIAH ET AL, "RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES., DE, (20120824), doi:10.1007/s00018-012-1119-x, ISSN 1420-682X, XP055260674 [A] 1-29 * the whole document *
INTERNATIONAL-SEARCH-REPORT- BIN TIAN ET AL, "The double-stranded-RNA-binding motif: interference and much more", NATURE REVIEWS MOLECULAR CELL BIOLOGY, GB, (20041201), vol. 5, no. 12, doi:10.1038/nrm1528, ISSN 1471-0072, pages 1013 - 1023, XP055260670 [A] 1-29 * the whole document *
INTERNATIONAL-SEARCH-REPORT- M. F. MONTIEL-GONZALEZ ET AL, "Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, US, (20131009), vol. 110, no. 45, doi:10.1073/pnas.1306243110, ISSN 0027-8424, pages 18285 - 18290, XP055260494 [AD] 1-29 * the whole document *
INTERNATIONAL-SEARCH-REPORT- M. F. SCHNEIDER ET AL, "Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans", NUCLEIC ACIDS RESEARCH, GB, (20140417), vol. 42, no. 10, doi:10.1093/nar/gku272, ISSN 0305-1048, pages e87 - e87, XP055260764 [A] 1-29 * the whole document *
INTERNATIONAL-SEARCH-REPORT- M. HALLEGGER ET AL, "RNA aptamers binding the double-stranded RNA-binding domain", RNA, US, (20060927), vol. 12, no. 11, doi:10.1261/rna.125506, ISSN 1355-8382, pages 1993 - 2004, XP055260667 [A] 1-29 * the whole document *
OPPOSITION- KAZUKO NISHIKURA, "Functions and Regulation of RNA Editing by ADAR Deaminases", Annu Rev Biochem., (20100000), vol. 79, pages 321 - 349, XP055800809-
OPPOSITION- MACBETH et al., "Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding", RNA, (20040000), vol. 10, pages 1563 - 1571, XP055800800-
OPPOSITION- MONTIEL-GONZALEZ et al., "Correction of D2 mutations within the cystic fibrosis transmembrane ( WO /ISA) conductance regulator by site-directed RNA editing", PNAS, (20130000), vol. 110, no. 45, pages 18285 - 18290, XP055800806-
OPPOSITION- VOGEL et al., "Improving Site-Directed RNA Editing In vitro and in Cell Culture by Chemical Modification of the GuideRNA", Angewandte Chemie, (20140000), vol. 53, no. 24, doi:10.1002/anie.201402634, pages 6267 - 6271, XP055763014
OPPOSITION- SVOBODA et al., "Hairpin RNA: a secondary structure of primary importance", Cell Mol Life Sci, (20060000), vol. 7- 8, doi:10.1007/s00018-005-5558-5, pages 901 - 8, XP019419150
OPPOSITION- HIGUCHI M., ET AL., "RNA EDITING OF AMPA RECEPTOR SUBUNIT GLUR-B: A BASE-PAIRED INTRON- EXON STRUCTURE DETERMINES POSITION AND EFFICIENCY.", Cell, Elsevier, Amsterdam NL, Amsterdam NL, (19931231), vol. 75., doi:10.1016/0092-8674(93)90622-W, ISSN 0092-8674, pages 1361 - 1370., XP002044941
OPPOSITION- SCHADE et al., "A 6 bp Z-DNA hairpin binds two Z alpha domains from the human RNA editing enzyme ADAR1", FEBS Lett, (19990000), vol. 458, no. 1, doi:10.1016/S0014-5793(99)01119-9, pages 27 - 31, XP004260222
OPPOSITION- Schade, M. Behlke, J. Lowenhaupt, K. Herbert, A. Rich, A. Oschkinat, H., "A 6 bp Z-DNA hairpin binds two Z@a domains from the human RNA editing enzyme ADAR1", FEBS Letters, ELSEVIER, AMSTERDAM., NL, NL, (19990910), vol. 458, no. 1, doi:10.1016/S0014-5793(99)01119-9, ISSN 0014-5793, pages 27 - 31, XP004260222
OPPOSITION- ARUSCAVAGE et al., "A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing", RNA, (20000000), vol. 6, no. 2, doi:10.1017/S1355838200991921, pages 257 - 269, XP055539609
OPPOSITION- WONG et al., "Substrate recognition by ADAR1 and ADAR2", RNA, (20010000), vol. 7, no. 6, doi:10.1017/S135583820101007X, pages 846 - 858, XP055763013
OPPOSITION- K A Lennox, M A Behlke, "Chemical modification and design of anti-miRNA oligonucleotides", Gene Therapy, Macmillan Press Ltd., (20111214), vol. 18, no. 12, doi:10.1038/gt.2011.100, ISSN 09697128, pages 1111 - 1120, XP055156922
OPPOSITION- Rieder Leila E., Staber Cynthia J., Hoopengardner Barry, Reenan Robert A., "Tertiary structural elements determine the extent and specificity of messenger RNA editing", Nature Communications, (20131001), vol. 4, no. 1, doi:10.1038/ncomms3232, XP055801328
OPPOSITION- Merkle Tobias; Merz Sarah; Reautschnig Philipp; Blaha Andreas; Li Qin; Vogel Paul; Wettengel Jacqueline; Li Jin Billy; Stafforst Thorsten, "Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides", Nature Biotechnology, Gale Group Inc., New York, New York, (20190128), vol. 37, no. 2, doi:10.1038/s41587-019-0013-6, ISSN 1087-0156, pages 133 - 138, XP036688633
OPPOSITION- Masatora Fukuda et al, "Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing", Scientific Reports, (20171201), vol. 7, no. 1, doi:10.1038/srep41478, pages 1 - 13, XP055537262
OPPOSITION- M. F. Montiel-Gonzalez, I. Vallecillo-Viejo, G. A. Yudowski, J. J. C. Rosenthal, "Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing", Proceedings of the National Academy of Sciences, National Academy of Sciences, US, US, (20131105), vol. 110, no. 45, doi:10.1073/pnas.1306243110, ISSN 0027-8424, pages 18285 - 18290, XP055260494
OPPOSITION- WOOLF et al., "Toward the therapeutic editing of mutated RNA sequences", PNAS, (19950000), vol. 92, no. 18, doi:10.1073/pnas.92.18.8298, pages 8298 - 8302, XP000574995
OPPOSITION- WOOLF T. M., CHASE J. M., STINCHCOMB D. T., "TOWARD THE THERAPEUTIC EDITING OF MUTATED RNA SEQUENCES.", Proceedings of the National Academy of Sciences, National Academy of Sciences, US, US, (19950801), vol. 92., doi:10.1073/pnas.92.18.8298, ISSN 0027-8424, pages 8298 - 8302., XP000574995
OPPOSITION- Nose Kanako, Hidaka Kota, Yano Takashi, Tomita Yohei, Fukuda Masatora, "Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing", Nucleic Acid Therapeutics, Mary Ann Liebert, Inc. Publishers, US, US, (20210201), vol. 31, no. 1, doi:10.1089/nat.2020.0866, ISSN 2159-3337, pages 58 - 67, XP055801188
OPPOSITION- L OMELI et al., "Control of kinetic properties of AMPA receptor channels by nuclear RNA editing", Science, (19940000), vol. 266, no. 5191, doi:10.1126/science.7992055, pages 1709 - 1713, XP055763015
OPPOSITION- Desterro Joana M. P., Et Al, "Dynamic association of RNA-editing enzymes with the nucleolus", JOURNAL OF CELL SCIENCE, Company of Biologists Limited, Cambridge, Cambridge, (20030501), vol. 116, no. 9, doi:10.1242/jcs.00371, ISSN 0021-9533, pages 1805 - 1818, XP055801325
OPPOSITION- STEFL et al., "A novel RNA pentaloop fold involved in targeting ADAR2", RNA, (20050000), vol. 11, no. 5, doi:10.1261/rna.7276805, pages 592 - 597, XP055763012
OPPOSITION- Garncarz Wojciech, Et Al, "A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing", RNA BIOLOGY, (20130201), vol. 10, no. 2, doi:10.4161/rna.23208, ISSN 1547-6286, pages 192 - 204, XP055801181

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