Crispr Having Or Associated With Destabilization Domains - EP3237615
The patent EP3237615 was granted to Massachusetts Institute OF Technology on Jul 26, 2023. The application was originally filed on Dec 21, 2015 under application number EP15831022A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".
EP3237615
- Application Number
- EP15831022A
- Filing Date
- Dec 21, 2015
- Status
- Patent Maintained As Amended
- Jun 23, 2023
- Publication Date
- Jul 26, 2023
- External Links
- Slate, Register, Google Patents
Patent Summary
Patent Family
Patent Oppositions (2)
Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
Get instant alerts for new oppositions and patent status changes | |||
| PATENT BOUTIQUE | Nov 12, 2020 | PATENT BOUTIQUE | ADMISSIBLE |
| JAMES POOLE | Nov 11, 2020 | CARPMAELS & RANSFORD | ADMISSIBLE |
Patent Citations (207) New
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | US20040491026 |
| DESCRIPTION | US20070953797 |
| DESCRIPTION | US20090511940 |
| DESCRIPTION | WO1994US05700 |
| DESCRIPTION | WO2007US84654 |
| DESCRIPTION | WO2014US41806 |
| DESCRIPTION | WO2014US62558 |
| DESCRIPTION | WO2014US69925 |
| DESCRIPTION | WO2015US45504 |
| DESCRIPTION | WO2015US51691 |
| DESCRIPTION | WO2015US51830 |
| DESCRIPTION | EP0264166 |
| DESCRIPTION | EP1519714 |
| DESCRIPTION | EP1664316 |
| DESCRIPTION | EP1766035 |
| DESCRIPTION | EP1781593 |
| DESCRIPTION | EP2764103 |
| DESCRIPTION | EP2771468 |
| DESCRIPTION | EP2784162 |
| DESCRIPTION | US2003087817 |
| DESCRIPTION | US2004013648 |
| DESCRIPTION | US2004171156 |
| DESCRIPTION | US2005019923 |
| DESCRIPTION | US2005287127 |
| DESCRIPTION | US2006030837 |
| DESCRIPTION | US2006281180 |
| DESCRIPTION | US2007025970 |
| DESCRIPTION | US2007054961 |
| DESCRIPTION | US2007093878 |
| DESCRIPTION | US2008267903 |
| DESCRIPTION | US2009007284 |
| DESCRIPTION | US2009017543 |
| DESCRIPTION | US2009100536 |
| DESCRIPTION | US2009111106 |
| DESCRIPTION | US2009222937 |
| DESCRIPTION | US2009271881 |
| DESCRIPTION | US2010229252 |
| DESCRIPTION | US2010311124 |
| DESCRIPTION | US2010317109 |
| DESCRIPTION | US2011023139 |
| DESCRIPTION | US2011059502 |
| DESCRIPTION | US2011091441 |
| DESCRIPTION | US2011117189 |
| DESCRIPTION | US2011142917 |
| DESCRIPTION | US2011158957 |
| DESCRIPTION | US2011182867 |
| DESCRIPTION | US2011195123 |
| DESCRIPTION | US2011225664 |
| DESCRIPTION | US2011265198 |
| DESCRIPTION | US2011293571 |
| DESCRIPTION | US2011293703 |
| DESCRIPTION | US2012017290 |
| DESCRIPTION | US2012159653 |
| DESCRIPTION | US2012204282 |
| DESCRIPTION | US2012251560 |
| DESCRIPTION | US2012251618 |
| DESCRIPTION | US2012295960 |
| DESCRIPTION | US2012328580 |
| DESCRIPTION | US2013145487 |
| DESCRIPTION | US2013183282 |
| DESCRIPTION | US2013202678 |
| DESCRIPTION | US2013236946 |
| DESCRIPTION | US2013244279 |
| DESCRIPTION | US2013245107 |
| DESCRIPTION | US2013252281 |
| DESCRIPTION | US2013253040 |
| DESCRIPTION | US2013302401 |
| DESCRIPTION | US2014170753 |
| DESCRIPTION | US2014179006 |
| DESCRIPTION | US2014179770 |
| DESCRIPTION | US2014186843 |
| DESCRIPTION | US2014186919 |
| DESCRIPTION | US2014186958 |
| DESCRIPTION | US2014189896 |
| DESCRIPTION | US2014227787 |
| DESCRIPTION | US2014234972 |
| DESCRIPTION | US2014242664 |
| DESCRIPTION | US2014242699 |
| DESCRIPTION | US2014242700 |
| DESCRIPTION | US2014248702 |
| DESCRIPTION | US2014256046 |
| DESCRIPTION | US2014273231 |
| DESCRIPTION | US2014273232 |
| DESCRIPTION | US2014273234 |
| DESCRIPTION | US2014287938 |
| DESCRIPTION | US2014310830 |
| DESCRIPTION | US2014357530 |
| DESCRIPTION | US2015184139 |
| DESCRIPTION | US2015232881 |
| DESCRIPTION | US4186183 |
| DESCRIPTION | US4217344 |
| DESCRIPTION | US4235871 |
| DESCRIPTION | US4261975 |
| DESCRIPTION | US4485054 |
| DESCRIPTION | US4501728 |
| DESCRIPTION | US4774085 |
| DESCRIPTION | US4797368 |
| DESCRIPTION | US4837028 |
| DESCRIPTION | US4873316 |
| DESCRIPTION | US4897355 |
| DESCRIPTION | US4946787 |
| DESCRIPTION | US5049386 |
| DESCRIPTION | US5173414 |
| DESCRIPTION | US5210015 |
| DESCRIPTION | US5445934 |
| DESCRIPTION | US5543158 |
| DESCRIPTION | US5580859 |
| DESCRIPTION | US5589466 |
| DESCRIPTION | US5593972 |
| DESCRIPTION | US5846946 |
| DESCRIPTION | US5855913 |
| DESCRIPTION | US5985309 |
| DESCRIPTION | US6007845 |
| DESCRIPTION | US6603061 |
| DESCRIPTION | US6750059 |
| DESCRIPTION | US7206639 |
| DESCRIPTION | US7259015 |
| DESCRIPTION | US7303910 |
| DESCRIPTION | US7351585 |
| DESCRIPTION | US7745651 |
| DESCRIPTION | US7776321 |
| DESCRIPTION | US7799565 |
| DESCRIPTION | US7803397 |
| DESCRIPTION | US7838658 |
| DESCRIPTION | US7868149 |
| DESCRIPTION | US7901708 |
| DESCRIPTION | US7915399 |
| DESCRIPTION | US7982027 |
| DESCRIPTION | US8058069 |
| DESCRIPTION | US8101741 |
| DESCRIPTION | US8188263 |
| DESCRIPTION | US8236943 |
| DESCRIPTION | US8283333 |
| DESCRIPTION | US8372951 |
| DESCRIPTION | US8404658 |
| DESCRIPTION | US8454972 |
| DESCRIPTION | US8507272 |
| DESCRIPTION | US8575305 |
| DESCRIPTION | US8642295 |
| DESCRIPTION | US8697359 |
| DESCRIPTION | US8709843 |
| DESCRIPTION | US8771945 |
| DESCRIPTION | US8795965 |
| DESCRIPTION | US8865406 |
| DESCRIPTION | US8871445 |
| DESCRIPTION | US8889356 |
| DESCRIPTION | US8889418 |
| DESCRIPTION | US8895308 |
| DESCRIPTION | US8906616 |
| DESCRIPTION | US8932814 |
| DESCRIPTION | US8945839 |
| DESCRIPTION | US8993233 |
| DESCRIPTION | US8999641 |
| DESCRIPTION | WO2011028929 |
| DESCRIPTION | WO2012135025 |
| DESCRIPTION | WO2013126794 |
| DESCRIPTION | WO2013163628 |
| DESCRIPTION | WO2014018423 |
| DESCRIPTION | WO2014093595 |
| DESCRIPTION | WO2014093622 |
| DESCRIPTION | WO2014093635 |
| DESCRIPTION | WO2014093655 |
| DESCRIPTION | WO2014093661 |
| DESCRIPTION | WO2014093694 |
| DESCRIPTION | WO2014093701 |
| DESCRIPTION | WO2014093709 |
| DESCRIPTION | WO2014093712 |
| DESCRIPTION | WO2014093718 |
| DESCRIPTION | WO2014204723 |
| DESCRIPTION | WO2014204724 |
| DESCRIPTION | WO2014204725 |
| DESCRIPTION | WO2014204726 |
| DESCRIPTION | WO2014204727 |
| DESCRIPTION | WO2014204728 |
| DESCRIPTION | WO2014204729 |
| DESCRIPTION | WO2015048577 |
| DESCRIPTION | WO2015070083 |
| DESCRIPTION | WO2015089351 |
| DESCRIPTION | WO2015089354 |
| DESCRIPTION | WO2015089364 |
| DESCRIPTION | WO2015089419 |
| DESCRIPTION | WO2015089427 |
| DESCRIPTION | WO2015089462 |
| DESCRIPTION | WO2015089465 |
| DESCRIPTION | WO2015089473 |
| DESCRIPTION | WO2015089486 |
| DESCRIPTION | WO2015105928 |
| DESCRIPTION | WO2015134812 |
| DESCRIPTION | WO2015138510 |
| DESCRIPTION | WO2015148670 |
| DESCRIPTION | WO2015148860 |
| DESCRIPTION | WO2015148863 |
| DESCRIPTION | WO2015153780 |
| DESCRIPTION | WO2015153789 |
| DESCRIPTION | WO2015153791 |
| DESCRIPTION | WO2015161276 |
| DESCRIPTION | WO9116024 |
| DESCRIPTION | WO9117424 |
| DESCRIPTION | WO9324641 |
| DESCRIPTION | WO9639154 |
| DESCRIPTION | WO9703211 |
| INTERNATIONAL-SEARCH-REPORT | WO2014093622 |
| INTERNATIONAL-SEARCH-REPORT | WO2015070083 |
| INTERNATIONAL-SEARCH-REPORT | WO2015089351 |
| INTERNATIONAL-SEARCH-REPORT | WO2015089427 |
| OPPOSITION | WO2013176772 |
| OPPOSITION | WO2015089427 |
Non-Patent Literature (NPL) Citations (391) New
NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.
| Citation Phase | Reference Text |
|---|---|
| DESCRIPTION | - ADVANCED DRUG DELIVERY REVIEWS, (2012), vol. 64, pages 1730 - 1737 |
| DESCRIPTION | - AHMAD ET AL., CANCER RES., (1992), vol. 52, pages 4817 - 4820 |
| DESCRIPTION | - AHMAD, S. ET AL., J ROYAL SOC INTERFACE, (2010), vol. 7, pages 423 - 33 |
| DESCRIPTION | - AIUTI ET AL., NAT. MED., (2002), vol. 8, pages 423 - 425 |
| DESCRIPTION | - AKINC ET AL., NAT. BIOTECH., (2010), vol. 26, pages 561 - 569 |
| DESCRIPTION | - ALABI ET AL., PROC NATL ACAD SCI USA., (20130806), vol. 110, no. 32, pages 12881 - 6 |
| DESCRIPTION | - ALTSCHUL ET AL., J. MOL. BIOL., (1990), pages 403 - 410 |
| DESCRIPTION | - ALVAREZ-ERVITI ET AL., NAT BIOTECHNOL, (2011), vol. 29, page 341 |
| DESCRIPTION | - AMRANN ET AL., GENE, (1988), vol. 69, pages 301 - 315 |
| DESCRIPTION | - ANDERSON, SCIENCE, (1992), vol. 256, pages 808 - 813 |
| DESCRIPTION | - A.R. GRUBER ET AL., CELL, (2008), vol. 106, no. 1, pages 23 - 24 |
| DESCRIPTION | - ATSCHUL ET AL., J. MOL. BIOL., (1990), pages 403 - 410 |
| DESCRIPTION | - AUSUBEL ET AL., SHORT PROTOCOLS IN MOLECULAR BIOLOGY, (1999), pages 7 - 58,7-60 |
| DESCRIPTION | - BALAGAAN, J GENE MED, (2006), vol. 8, pages 275 - 285 |
| DESCRIPTION | - BALAGAAN, J Gene Med, WILEY INTERSCIENCE, (20051121), vol. 8, pages 275 - 285 |
| DESCRIPTION | - BALDARI ET AL., EMBO J., (1987), vol. 6, pages 229 - 234 |
| DESCRIPTION | - BANASZYNSKI LA; SELLMYER MA; CONTAG CH; WANDLESS TJ; THORNE SH, "Chemical control of protein stability and function in living mice", NAT MED, (2008), vol. 14, pages 1123 - 1127 |
| DESCRIPTION | - BANEIJI ET AL., CELL, (1983), vol. 33, pages 729 - 740 |
| DESCRIPTION | - BARTLETT ET AL., PNAS, (20070925), vol. 104, no. 39 |
| DESCRIPTION | - BAUER ET AL., SCIENCE, (20131011), vol. 342, no. 6155, pages 253 - 257 |
| DESCRIPTION | - BEHR ET AL., BIOCONJUGATE CHEM, (1994), vol. 5, pages 382 - 389 |
| DESCRIPTION | - BELHAJ ET AL., PLANT METHODS, vol. 9, page 39 |
| DESCRIPTION | - BINLEY ET AL., HUMAN GENE THERAPY, (201209), vol. 23, pages 980 - 991 |
| DESCRIPTION | - BLAESE ET AL., CANCER GENE THER., (1995), vol. 2, pages 291 - 297 |
| DESCRIPTION | - BLOOD, vol. 88, pages 3901 - 3909 |
| DESCRIPTION | - BLUNDELL ET AL., EUR J BIOCHEM, (1988), vol. 172, page 513 |
| DESCRIPTION | - BORTOLANZA ET AL., MOLECULAR THERAPY, (201111), vol. 19, no. 11, pages 2055 - 2064 |
| DESCRIPTION | - BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530 |
| DESCRIPTION | - BOSHART ET AL., CELL, (1995), vol. 41, pages 521 - 530 |
| DESCRIPTION | - BOUDREAU ET AL., MOLECULAR THERAPY, (200906), vol. 17, no. 6 |
| DESCRIPTION | - BOUSSO ET AL., PROC. NATL., ACAD. SCI. USA, (2000), vol. 97, pages 274 - 278 |
| DESCRIPTION | - BUCHSCHER ET AL., J. VIROL., (1992), vol. 66, pages 2731 - 2739 |
| DESCRIPTION | - BUNTING ET AL., HUM. GENE THER., (2000), vol. 11, pages 2353 - 2364 |
| DESCRIPTION | - BUNTING ET AL., NAT. MED., (1998), vol. 4, pages 58 - 64 |
| DESCRIPTION | - BYRNE; RUDDLE, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 5473 - 5477 |
| DESCRIPTION | - CALAME; EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275 |
| DESCRIPTION | - CAMPES; TILGHMAN, GENES DEV., (1989), vol. 3, pages 537 - 546 |
| DESCRIPTION | - CAMPOCHIARO ET AL., HUMAN GENE THERAPY, (200602), vol. 17, pages 167 - 176 |
| DESCRIPTION | - CANDOTTI ET AL., BLOOD, (1996), vol. 87, pages 3097 - 3102 |
| DESCRIPTION | - CAVAZZANA-CALVO ET AL., ANNU. REV. MED., (2005), vol. 56, pages 585 - 602 |
| DESCRIPTION | - CAVAZZANA-CALVO ET AL., SCIENCE, (2000), vol. 288, pages 669 - 672 |
| DESCRIPTION | - CELL, (1993), vol. 73, pages 147 - 157 |
| DESCRIPTION | - CHAN-HUI ET AL., CLINICAL IMMUNOLOGY, (2003), vol. 111, pages 162 - 174 |
| DESCRIPTION | - CHEN ET AL., GENE THERAPY, (2007), vol. 14, pages 11 - 19 |
| DESCRIPTION | - CHO ET AL., "Rapid and Tunable Control of Protein Stability in Caenorhabditis elegans Using a Small Molecule", PLOS ONE, (2013), vol. 8, no. 8, page E72393 |
| DESCRIPTION | - CHOI ET AL., PROC. NATL. ACAD. SCI. USA., (2013), vol. 110, no. 19, pages 7625 - 7630 |
| DESCRIPTION | - CHUNG H, NATURE CHEMICAL BIOLOGY, (201509), vol. 11, pages 713 - 720 |
| DESCRIPTION | - COELHO ET AL., N ENGL J MED, (2013), vol. 369, pages 819 - 29 |
| DESCRIPTION | - COHEN ET AL., NAT GENET, (200502), vol. 37, no. 2, pages 161 - 5 |
| DESCRIPTION | - CRABTREE ET AL., CHEMISTRY & BIOLOGY, (200601), vol. 13, pages 99 - 107 |
| DESCRIPTION | - CRONICAN ET AL., ACS CHEMICAL BIOLOGY, (2010), vol. 5, pages 747 - 752 |
| DESCRIPTION | - CRONICAN ET AL., CHEMISTRY & BIOLOGY, (2011), vol. 18, pages 833 - 838 |
| DESCRIPTION | - CRYSTAL, SCIENCE, (1995), vol. 270, pages 404 - 410 |
| DESCRIPTION | - CUTLER ET AL., J. AM. CHEM. SOC., (2011), vol. 133, pages 9254 - 9257 |
| DESCRIPTION | - CUTLER ET AL., J. AM. CHEM. SOC., (2012), vol. 134, pages 1376 - 1391 |
| DESCRIPTION | - DAHLMAN ET AL., ORTHOGONAL GENE CONTROL WITH A CATALYTICALLY ACTIVE CAS9 NUCLEASE |
| DESCRIPTION | - DALKARA ET AL., SCI TRANSL MED, (2013), vol. 5, page 189RA76 |
| DESCRIPTION | - DAVIS ET AL., NATURE, (20100415), vol. 464 |
| DESCRIPTION | - DEVEREUX ET AL., NUC. ACIDS RESEARCH, (1984), vol. 12, page 387 |
| DESCRIPTION | - DEVEREUX ET AL., NUCLEIC ACIDS RESEARCH, (1984), vol. 12, page 387 |
| DESCRIPTION | - DEY ET AL., PROT SCI, (2013), vol. 22, pages 359 - 66 |
| DESCRIPTION | - DIFIGLIA ET AL., PNAS, (20071023), vol. 104, no. 43, pages 17204 - 17209 |
| DESCRIPTION | - DIGIUSTO ET AL., SCI TRANSL MED, (2010), vol. 2, page 36RA43 |
| DESCRIPTION | - DILLON, TIBTECH, (1993), vol. 11, pages 167 - 175 |
| DESCRIPTION | - DONG ET AL., ANTIVIRAL RES., (20150403), pages 110 - 7 |
| DESCRIPTION | - DONG ET AL., ANTIVIRAL RES., (20150403), vol. 118, pages 110 - 7 |
| DESCRIPTION | - DRAKOPOULOU, "Review Article, The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for ?-Thalassemia", STEM CELLS INTERNATIONAL, vol. 2011, page 10 |
| DESCRIPTION | - DUMITRACHE ET AL., GENETICS, (201108), vol. 188, no. 4, pages 787 - 797 |
| DESCRIPTION | - DUMONCEAUX ET AL., MOLECULAR THERAPY, (201005), vol. 18, no. 5, pages 881 - 887 |
| DESCRIPTION | - DUNBRACK ET AL., FOLDING AND DESIGN, (1997), vol. 2, pages 27 - 42 |
| DESCRIPTION | - EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916 |
| DESCRIPTION | - EL-ANDALOUSSI ET AL., NATURE, (2012), vol. 7, pages 2112 - 2126 |
| DESCRIPTION | - ESVELT ET AL., CONCERNING RNA-GUIDED GENE DRIVES FOR THE ALTERATION OF WILD POPULATIONS ELIFE, (2014), vol. 3, page E03401 |
| DESCRIPTION | - EULALIO ET AL., NATURE, (2012), vol. 492, page 376 |
| DESCRIPTION | - FEMS MICROBIOL LETT., (1999), vol. 174, no. 2, pages 247 - 50 |
| DESCRIPTION | - FEMS MICROBIOL LETT, (1999), vol. 177, no. 1, pages 187 - 8 |
| DESCRIPTION | - FINE ET AL., SCI REP, (20150701), vol. 5, page 10777 |
| DESCRIPTION | - FINE ET AL., SCI REP., (20150701), vol. 5, page 10777 |
| DESCRIPTION | - FISCHER ET AL., IMMUNOL. REV., (2005), vol. 203, pages 98 - 109 |
| DESCRIPTION | - GAO ET AL., GENE THERAPY, (1995), vol. 2, pages 710 - 722 |
| DESCRIPTION | - GARRETT, N.L. ET AL., J BIOPHOTONICS, (2012), vol. 5, no. 5-6, pages 458 - 68 |
| DESCRIPTION | - GARRETT, N.L. ET AL., J RAMAN SPECT, (2012), vol. 43, no. 5, pages 681 - 688 |
| DESCRIPTION | - GASPAR ET AL., LANCET, (2004), vol. 364, pages 2181 - 2187 |
| DESCRIPTION | - GEISBERT ET AL., LANCET, (2010), vol. 375, pages 1896 - 905 |
| DESCRIPTION | - GHORBAL ET AL., "Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system", NATURE BIOTECHNOLOGY, (20140601), vol. 32, pages 819 - 821 |
| DESCRIPTION | - GHORBAL ET AL., "Genome editing in the human malaria parasite Plasmodium falciparumusing the CRISPR-Cas9 system", NATURE BIOTECHNOLOGY, (20140601), vol. 32, pages 819 - 821 |
| DESCRIPTION | - GIBLETT ET AL., LANCET, (1972), vol. 2, pages 1067 - 1069 |
| DESCRIPTION | - GIULIANO AVANZINI, JEFFREY L. NOEBELS,, Genetics of Epilepsy and Genetic Epilepsies, MARIANI FOUNDATION PAEDIATRIC NEUROLOGY, (2009), vol. 20 |
| DESCRIPTION | - GOEDDEL, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185 |
| DESCRIPTION | - GREER, SCIENCE, (1985), vol. 228, page 1055 |
| DESCRIPTION | - GRIMM, D ET AL., J. VIROL., (2008), vol. 82, pages 5887 - 5911 |
| DESCRIPTION | - GRIMM ET AL., NATURE, (20060526), vol. 441 |
| DESCRIPTION | - GROENEN ET AL., MOL. MICROBIOL., (1993), vol. 10, pages 1057 - 1065 |
| DESCRIPTION | - HACEIN-BEY ET AL., BLOOD, (1998), vol. 92, pages 4090 - 4097 |
| DESCRIPTION | - HAGSTROM ET AL., MOLECULAR THERAPY, (200408), vol. 10, no. 2 |
| DESCRIPTION | - HAO ET AL., SMALL, (2011), vol. 7, pages 3158 - 3162 |
| DESCRIPTION | - HARRISON ET AL., GENES & DEVELOPMENT, vol. 28, pages 1859 - 1872 |
| DESCRIPTION | - HEO ET AL., STEM CELLS DEV, (20141103), vol. 24, no. 3, pages 393 - 402 |
| DESCRIPTION | - HERMONAT; MUZYCZKA, PNAS, (1984), vol. 81, pages 6466 - 6470 |
| DESCRIPTION | - HIGGINS DG; SHARP PM, GENE, (1988), vol. 73, no. 1, pages 237 - 244 |
| DESCRIPTION | - HIRSCHHORN ET AL., NAT. GENET, (1996), vol. 13, pages 290 - 295 |
| DESCRIPTION | - HOE ET AL., EMERG. INFECT. DIS., (1999), vol. 5, pages 254 - 263 |
| DESCRIPTION | - HOLT, N. ET AL., NATURE BIOTECHNOLOGY, (2010), vol. 28, pages 839 - 847 |
| DESCRIPTION | - HORWELL DC, TRENDS BIOTECHNOL., (1995), vol. 13, no. 4, pages 132 - 134 |
| DESCRIPTION | - HUTTER, G. ET AL., THE NEW ENGLAND JOURNAL OF MEDICINE, (2009), vol. 360, pages 692 - 698 |
| DESCRIPTION | - ISHINO ET AL., J. BACTERIOL., (1987), vol. 169, pages 5429 - 5433 |
| DESCRIPTION | - JANSEN ET AL., MOL. MICROBIOL., (2002), vol. 43, pages 1565 - 1575 |
| DESCRIPTION | - JANSSEN ET AL., OMICS J. INTEG. BIOL., (2002), vol. 6, pages 23 - 33 |
| DESCRIPTION | - JAYARAMAN, ANGEW. CHEM. INT. ED., (2012), vol. 51, pages 8529 - 8533 |
| DESCRIPTION | - JENSEN ET AL., SCI. TRANSL. MED., (2013), vol. 5, page 209RA152 |
| DESCRIPTION | - JIANG ET AL., NANO LETT., (20130313), vol. 13, no. 3, pages 1059 - 64 |
| DESCRIPTION | - JOHANN ET AL., J. VIROL., (1992), vol. 66, pages 1635 - 1640 |
| DESCRIPTION | - JONES ET AL., "San Diego, Calif.: Molecular Simulations", ACTA CRYSTALLOGRAPHY, (1991), vol. A47, pages 110 - 119 |
| DESCRIPTION | - JUDGE, J. CLIN. INVEST., (2009), vol. 119, pages 661 - 673 |
| DESCRIPTION | - JUNG ET AL., MOLECULAR THERAPY, (201304), vol. 21, no. 4, pages 834 - 841 |
| DESCRIPTION | - KARAGIANNIS ET AL., ACS NANO, (20121023), vol. 6, no. 10, pages 8484 - 7 |
| DESCRIPTION | - KARIMOVA ET AL., SCI REP., (20150903), vol. 5, page 13734 |
| DESCRIPTION | - KAUFMAN ET AL., EMBO J., (1987), vol. 6, pages 187 - 195 |
| DESCRIPTION | - KESSEL; GRUSS, SCIENCE, (1990), vol. 249, pages 374 - 379 |
| DESCRIPTION | - KINOUCHI ET AL., GENE THERAPY, (2008), vol. 15, pages 1126 - 1130 |
| DESCRIPTION | - KONERMANN ET AL., GENOME-SCALE TRANSCRIPTION ACTIVATION BY AN ENGINEERED CRISPR-CAS9 COMPLEX |
| DESCRIPTION | - KONERMANN ET AL., NATURE, (20150129), vol. 517, pages 583 - 588 |
| DESCRIPTION | - KONERMANN S; BRIGHAM MD; TREVINO AE; HSU PD; HEIDENREICH M; CONG L; PLATT RJ; SCOTT DA; CHURCH GM; ZHANG F, "Optical control of mammalian endogenous transcription and epigenetic states", NATURE, (20130823), vol. 500, no. 7463, pages 472 - 6 |
| DESCRIPTION | - KONNERMAN ET AL., NATURE, (20150129), vol. 517, pages 583 - 588 |
| DESCRIPTION | - KOTIN, HUMAN GENE THERAPY, (1994), vol. 5, pages 793 - 801 |
| DESCRIPTION | - KREMER; PERRICAUDET, BRITISH MEDICAL BULLETIN, (1995), vol. 51, no. 1, pages 31 - 44 |
| DESCRIPTION | - KUIJAN; HERSKOWITZ, CELL, (1982), vol. 30, pages 933 - 943 |
| DESCRIPTION | - LALATSA, A. ET AL., J CONTR REL, (2012), vol. 161, no. 2, pages 523 - 36 |
| DESCRIPTION | - LALATSA, A. ET AL., MOL PHARM, (2012), vol. 9, no. 6, pages 1665 - 80 |
| DESCRIPTION | - LALATSA, A. ET AL., MOL PHARM, (2012), vol. 9, no. 6, pages 1764 - 74 |
| DESCRIPTION | - LALATSA ET AL., J CONTROL RELEASE., (20120720), vol. 161, no. 2, pages 523 - 36 |
| DESCRIPTION | - LAWRENCE ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2007), vol. 129, pages 10110 - 10112 |
| DESCRIPTION | - LEACHMAN ET AL., MOLECULAR THERAPY, (201002), vol. 18, no. 2, pages 442 - 446 |
| DESCRIPTION | - LEE ET AL., NAT NANOTECHNOL, (20120603), vol. 7, no. 6, pages 389 - 93 |
| DESCRIPTION | - LEE ET AL., PROC NATL ACAD SCI USA., (20140520), vol. 111, no. 20, pages 7260 - 5 |
| DESCRIPTION | - LEWIS ET AL., NAT. GEN, (2002), vol. 32, pages 107 - 108 |
| DESCRIPTION | - LI ET AL., J GEN VIROL., (20150408), vol. 96, no. 8, pages 2381 - 93 |
| DESCRIPTION | - LI ET AL., MOLECULAR THERAPY, (200912), vol. 17, no. 12, pages 2067 - 2077 |
| DESCRIPTION | - LI, GENE THERAPY, (2012), vol. 19, pages 775 - 780 |
| DESCRIPTION | - LI, L ET AL., MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, (2013), vol. 21, pages 1259 - 1269 |
| DESCRIPTION | - LI, L. ET AL., MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, (2013), vol. 21, pages 1259 - 1269 |
| DESCRIPTION | - LIN ET AL., MOL THER NUCLEIC ACIDS, (20140819), vol. 3, page EL86 |
| DESCRIPTION | - LIN ET AL., MOL THER NUCLEIC ACIDS., (20140819), vol. 3, page EL86 |
| DESCRIPTION | - LING ET AL., BMC PLANT BIOLOGY, (2014), vol. 14, page 327 |
| DESCRIPTION | - LIN-YANGA ET AL., PNAS, (20090310), vol. 106, no. 10 |
| DESCRIPTION | - LIU ET AL., J GEN VIROL., (20150422), vol. 96, no. 8, pages 2252 - 61 |
| DESCRIPTION | - LIU, R. ET AL., CELL, (1996), vol. 86, pages 367 - 377 |
| DESCRIPTION | - LIVINGSTONE C.D.; BARTON G.J., "Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation", COMPUT. APPL. BIOSCI., (1993), vol. 9, pages 745 - 756 |
| DESCRIPTION | - LOMBARDO ET AL., NAT BIOTECHNOL., (200711), vol. 25, no. 11, pages 1298 - 306 |
| DESCRIPTION | - LOWDER ET AL., PLANT PHYSIOL., (20150821), page 00636 |
| DESCRIPTION | - LUCKLOW; SUMMERS, VIROLOGY, (1989), vol. 170, pages 31 - 39 |
| DESCRIPTION | - MA ET AL., MOL PLANT., (20150803), vol. 8, no. 8, pages 1274 - 84 |
| DESCRIPTION | - MALI P ET AL., "RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (2013), vol. 339, no. 6121, pages 823 - 826 |
| DESCRIPTION | - MANDAL ET AL., CELL STEM CELL, (20141106), vol. 15, no. 5, pages 643 - 652 |
| DESCRIPTION | - MASEPOHL ET AL., BIOCHIM. BIOPHYS. ACTA, (1996), vol. 1307, pages 26 - 30 |
| DESCRIPTION | - MAYNARD-SMITH LA; CHEN LC; BANASZYNSKI LA; OOI AG; WANDLESS TJ, "A directed approach for engineering conditional protein stability using biologically silent small molecules", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2007), vol. 282, pages 24866 - 24872 |
| DESCRIPTION | - MAZZA ET AL., ACS NANO., (20130226), vol. 7, no. 2, pages 1016 - 26 |
| DESCRIPTION | - MAZZA, M. ET AL., ACSNANO, (2013), vol. 7, no. 2, pages 1016 - 1026 |
| DESCRIPTION | - MCBRIDE ET AL., MOLECULAR THERAPY, (201112), vol. 19, no. 12, pages 2152 - 2162 |
| DESCRIPTION | - MCLVOR EI; POLAK U; NAPIERALA M, "New insights into repeat instability: role of RNA.DNA hybrids", RNA BIOL., (201009), vol. 7, no. 5, pages 551 - 8 |
| DESCRIPTION | - MCNAUGHTON ET AL., PROC. NATL. ACAD. SCI. USA, (2009), vol. 106, pages 6111 - 6116 |
| DESCRIPTION | - ., METHODS IN ENZYMOLOGY, ACADEMIC PRESS, INC |
| DESCRIPTION | - METHODS IN MOLECULAR BIOLOGY, (20150210), vol. 1284, pages 239 - 255 |
| DESCRIPTION | - MILLER ET AL., J. VIROL., (1991), vol. 65, pages 2220 - 2224 |
| DESCRIPTION | - MILLER, NATURE, (1992), vol. 357, pages 455 - 460 |
| DESCRIPTION | - MILLINGTON-WARD ET AL., MOLECULAR THERAPY, (201104), vol. 19, no. 4, pages 642 - 649 |
| DESCRIPTION | - MIRKIN ET AL., SMALL, vol. 10, pages 186 - 192 |
| DESCRIPTION | - MIRKIN, NANOMEDICINE, (2012), vol. 7, pages 635 - 638 |
| DESCRIPTION | - MITANI; CASKEY, TIBTECH, (1993), vol. 11, pages 162 - 166 |
| DESCRIPTION | - MIYAZAKI, J AM CHEM SOC., (20120307), vol. 134, no. 9, pages 3942 - 3945 |
| DESCRIPTION | - MOJICA ET AL., MOL. MICROBIOL., (1995), vol. 17, pages 85 - 93 |
| DESCRIPTION | - MOJICA ET AL., MOL. MICROBIOL., (2000), vol. 36, pages 244 - 246 |
| DESCRIPTION | - MOL. CELL. BIOL., (1988), vol. 8, no. 1, pages 466 - 472 |
| DESCRIPTION | - MOLITORIS ET AL., J AM SOC NEPHROL, (2009), vol. 20, pages 1754 - 1764 |
| DESCRIPTION | - MORRELL ET AL., "Crop genomics: advances and applications", NAT REV GENET., (20111229), vol. 13, no. 2, pages 85 - 96 |
| DESCRIPTION | - MORRELL ET AL., "Crop genomics:advances and applications", NAT REV GENET, (20111229), vol. 13, no. 2, pages 85 - 96 |
| DESCRIPTION | - MORRISSEY ET AL., NATURE BIOTECHNOLOGY, (200508), vol. 23, no. 8 |
| DESCRIPTION | - MUKHEIJEA ET AL., ANTIOXIDANTS & REDOX SIGNALING, (2010), vol. 13, no. 5 |
| DESCRIPTION | - MUSUNURU ET AL., N ENGL J MED., (20101202), vol. 363, no. 23, pages 2220 - 7 |
| DESCRIPTION | - MUZYCZKA, J. CLIN. INVEST., (1994), vol. 94, page 1351 |
| DESCRIPTION | - NABEL; FEIGNER, TIBTECH, (1993), vol. 11, pages 211 - 217 |
| DESCRIPTION | - NAKAGAWA ET AL., NAT. BIOTECHNOL., (2008), vol. 26, pages 101 - 106 |
| DESCRIPTION | - NAKATA ET AL., J. BACTERIOL., (1989), vol. 171, pages 3553 - 3556 |
| DESCRIPTION | - NAT BIOTECHNOL., (201406), vol. 32, no. 6, pages 551 - 3 |
| DESCRIPTION | - NATURE, (1995), vol. 377, pages 65 - 68 |
| DESCRIPTION | - NATURE METHODS, (2008), vol. 5 |
| DESCRIPTION | - NISHIKOMORI ET AL., BLOOD, (2004), vol. 103, pages 4565 - 4572 |
| DESCRIPTION | - NOVOBRANTSEVA, MOLECULAR THERAPY-NUCLEIC ACIDS, (2012), vol. 1, page E4 |
| DESCRIPTION | - OKITA ET AL., NATURE, (2007), vol. 448, pages 260 - 262 |
| DESCRIPTION | - PA CARR; GM CHURCH, NATURE BIOTECHNOLOGY, (2009), vol. 27, no. 12, pages 1151 - 62 |
| DESCRIPTION | - PAULMURUGAN; GAMBHIR, CANCER RES, (20050815), vol. 65, page 7413 |
| DESCRIPTION | - PEREZ, E.E. ET AL., NATURE BIOTECHNOLOGY, (2008), vol. 26, pages 808 - 816 |
| DESCRIPTION | - P. GOODFORD, J. MED. CHEM, (1985), vol. 28, pages 849 - 57 |
| DESCRIPTION | - PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277 |
| DESCRIPTION | - PLATT, CELL, (2014), vol. 159, no. 2, pages 440 - 455 |
| DESCRIPTION | - PLATT ET AL., CELL, (2014), vol. 159, no. 2, pages 440 - 455 |
| DESCRIPTION | - PROC. NATL. ACAD. SCI. USA., (1981), vol. 78, no. 3, pages 1527 - 31 |
| DESCRIPTION | - QASIM ET AL., "First Clinical Application of Talen Engineered Universal CAR19 T Cells in B-ALL", ASH 57TH ANNUAL MEETING AND EXPOSITION, (201511), URL: https://ash.confex.com/ash/2015/webprogram/Paper81653.html |
| DESCRIPTION | - QI ET AL., GENE THERAPY, (2013), pages 1 - 9 |
| DESCRIPTION | - QUEEN; BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748 |
| DESCRIPTION | - QU, X., BIOMACROMOLECULES, (2006), vol. 7, no. 12, pages 3452 - 9 |
| DESCRIPTION | - REICH ET AL., MOL. VISION, (2003), vol. 9, pages 210 - 216 |
| DESCRIPTION | - REICH ET AL., MOL. VISION., (2003), vol. 9, pages 210 - 216 |
| DESCRIPTION | - REJALI ET AL., HEAR RES, (200706), vol. 228, no. 1-2, pages 180 - 7 |
| DESCRIPTION | - REMY ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 647 - 654 |
| DESCRIPTION | - RODRIGUEZ, CHEM BIOL., (20120323), vol. 19, no. 3, pages 391 - 398 |
| DESCRIPTION | - ROSIN ET AL., MOLECULAR THERAPY, (201112), vol. 19, no. 12, pages 1286 - 2200 |
| DESCRIPTION | - SALT; PLONTKE, DRUG DISCOVERY TODAY, (2005), vol. 10, pages 1299 - 1306 |
| DESCRIPTION | - SAMULSKI ET AL., J. VIROL., (1989), vol. 63, pages 03822 - 3828 |
| DESCRIPTION | - SCHIFFELERS ET AL., NUCLEIC ACIDS RESEARCH, (2004), vol. 32, no. 19 |
| DESCRIPTION | - SCHROEDER, A.; LEVINS, C.; CORTEZ, C.; LANGER, R.; ANDERSON, D., "Lipid-based nanotherapeutics for siRNA delivery", JOURNAL OF INTERNAL MEDICINE, (2010), vol. 267, pages 9 - 21 |
| DESCRIPTION | - SCHULTZ ET AL., GENE, (1987), vol. 54, pages 113 - 123 |
| DESCRIPTION | - SCHWANK ET AL., CELL STEM CELL, (2013), vol. 13, pages 653 - 58 |
| DESCRIPTION | - SEED, NATURE, (1987), vol. 329, page 840 |
| DESCRIPTION | - SEMPLE ET AL., NATURE BIOTECHNOLOGY, (201002), vol. 28, no. 2, pages 172 - 177 |
| DESCRIPTION | - SHALEM, O.; SANJANA, NE.; HARTENIAN, E.; SHI, X.; SCOTT, DA.; MIKKELSON, T.; HECKL, D.; EBERT, BL.; ROOT, DE; DOENCH, JG., SCIENCE, (20131212), vol. 343, no. 6166, pages 84 - 87 |
| DESCRIPTION | - SHEN ET AL., "Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9", MBIO, (2014), vol. 5, pages E01114 - 14 |
| DESCRIPTION | - SHEN ET AL., FEBS LET., (2003), vol. 539, pages 111 - 114 |
| DESCRIPTION | - SHIMIZU ET AL., J AM SOC NEPHROL, (2010), vol. 21, pages 622 - 633 |
| DESCRIPTION | - SIDIK ET AL., "Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9", PLOS ONE, (20140627), vol. 9, page EL00450 |
| DESCRIPTION | - SIEW, A. ET AL., MOL PHARM, (2012), vol. 9, no. L, pages 14 - 28 |
| DESCRIPTION | - SIMEONI ET AL., NAR, (2003), vol. 31, no. 11, pages 2717 - 2724 |
| DESCRIPTION | - SIMON RJ ET AL., PNAS, (1992), vol. 89, no. 20, pages 9367 - 9371 |
| DESCRIPTION | - SMITH ET AL., MOL. CELL. BIOL., (1983), vol. 3, pages 2156 - 2165 |
| DESCRIPTION | - SMITH; JOHNSON, GENE, (1988), vol. 67, pages 31 - 40 |
| DESCRIPTION | - SOMASUNTHARAM ET AL., BIOMATERIALS, (2013), vol. 34, page 7790 |
| DESCRIPTION | - SOMMNERFELT ET AL., VIROL., (1990), vol. 176, pages 58 - 59 |
| DESCRIPTION | - SONG ET AL., STEM CELLS DEV, (20150205), vol. 24, no. 9, pages 1053 - 65 |
| DESCRIPTION | - SORENSEN ET AL., J. MOL. BIOL., (2003), vol. 327, pages 761 - 766 |
| DESCRIPTION | - SOUDAIS ET AL., BLOOD, (2000), vol. 95, pages 3071 - 3077 |
| DESCRIPTION | - SPUCH; NAVARRO, JOURNAL OF DRUG DELIVERY, (2011), vol. 2011, page 12 |
| DESCRIPTION | - STEPHAN ET AL., N. ENGL. J. MED., (1996), vol. 335, pages 1563 - 1567 |
| DESCRIPTION | - STILES ET AL., EXPERIMENTAL NEUROLOGY, (2012), vol. 233, pages 463 - 471 |
| DESCRIPTION | - STUDIER ET AL., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185, pages 60 - 89 |
| DESCRIPTION | - SUGANO ET AL., PLANT CELL PHYSIOL., (20140118), vol. 55, no. 3, pages 475 - 81 |
| DESCRIPTION | - TABERNERO ET AL., CANCER DISCOVERY, (201304), vol. 3, no. 4, pages 363 - 470 |
| DESCRIPTION | - TAKAHASHI ET AL., CELL, (2007), vol. 131, no. 5, pages 861 - 872 |
| DESCRIPTION | - TAKAHASHI; YAMANAKA, CELL, (2006), vol. 126, pages 663 - 76 |
| DESCRIPTION | - TAN ET AL., PROC NATL ACAD SCI USA., (20131008), vol. 110, no. 41, pages 16526 - 16531 |
| DESCRIPTION | - TAYLOR ET AL., BLOOD, (1996), vol. 87, pages 3103 - 3107 |
| DESCRIPTION | - TEBAS ET AL., N ENGL J MED., (20140306), vol. 370, no. 10, pages 901 - 10 |
| DESCRIPTION | - TEBAS, P. ET AL., THE NEW ENGLAND JOURNAL OF MEDICINE, (2014), vol. 370, pages 901 - 910 |
| DESCRIPTION | - THE CCP4 SUITE: PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY, ACTA CRYSTALLOGRAPHICA, (1994), vol. D50, pages 760 - 763 |
| DESCRIPTION | - THOMPSON, D.B. ET AL., CHEMISTRY & BIOLOGY, (2012), vol. 19, no. 7, pages 831 - 843 |
| DESCRIPTION | - THOMPSON ET AL., METHODS IN ENZYMOLOGY, (2012), vol. 503, pages 293 - 319 |
| DESCRIPTION | - THOMPSON ET AL., NUCLEIC ACID THERAPEUTICS, (2012), vol. 22, no. 4 |
| DESCRIPTION | - TOLENTINO ET AL., RETINA, vol. 24, no. 4, page 660 |
| DESCRIPTION | - TRATSCHIN ET AL., MOL. CELL. BIOL, (1984), vol. 4, pages 2072 - 2081 |
| DESCRIPTION | - TRATSCHIN ET AL., MOL. CELL. BIOL., (1985), vol. 5, pages 3251 - 3260 |
| DESCRIPTION | - TSAI ET AL., BLOOD, (2002), vol. 100, pages 72 - 79 |
| DESCRIPTION | - TSAI ET AL., "Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing", NATURE BIOTECHNOLOGY, (2014), vol. 32, no. 6, pages 569 - 77, XP055378307 |
| DESCRIPTION | - TSAI ET AL., NATURE BIOTECHNOLOGY, (201406), vol. 32, no. 6 |
| DESCRIPTION | - UCHEGBU, I.F. ET AL., INT J PHARM, (2001), vol. 224, pages 185 - 199 |
| DESCRIPTION | - UCHEGBU, I.F., EXPERT OPIN DRUG DELIV, (2006), vol. 3, no. 5, pages 629 - 40 |
| DESCRIPTION | - UCHEGBU; SIEW, J PHARM SCI., (2013), vol. 102, no. 2, pages 305 - 10 |
| DESCRIPTION | - UNO ET AL., HUMAN GENE THERAPY, (201106), vol. 22, pages 711 - 719 |
| DESCRIPTION | - VAN BRUNT, BIOTECHNOLOGY, (1988), vol. 6, no. 10, pages 1149 - 1154 |
| DESCRIPTION | - VAN EMBDEN ET AL., J. BACTERIOL., (2000), vol. 182, pages 2393 - 2401 |
| DESCRIPTION | - VIGNE, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, (1995), vol. 8, pages 35 - 36 |
| DESCRIPTION | - VYAS ET AL., "A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families", SCIENCE ADVANCES, (20150403), vol. 1, page E1500248 |
| DESCRIPTION | - WADA ET AL., PROC. NATL. ACAD. SCI. USA, (2001), vol. 98, pages 8697 - 8702 |
| DESCRIPTION | - WAHLGREN ET AL., NUCLEIC ACIDS RESEARCH, (2012), vol. 40, no. 17, page E130 |
| DESCRIPTION | - WALTERS ET AL., DRUG DISCOVERY TODAY, (1998), vol. 3, no. 4, pages 160 - 178 |
| DESCRIPTION | - WANG ET AL., PLOS ONE., (20141226), vol. 9, no. 12, page 15987 |
| DESCRIPTION | - WANG ET AL., PLOS ONE, (20141226), vol. 9, no. 12, page EL 15987 |
| DESCRIPTION | - WANG ET AL., WORLD J GASTROENTEROL., (20150828), vol. 21, no. 32, pages 9554 - 65 |
| DESCRIPTION | - WATTS, "Hematopoietic Stem Cell Expansion and Gene Therapy", CYTOTHERAPY, (2011), vol. 13, no. 10, pages 1164 - 1171 |
| DESCRIPTION | - WEINTRAUB, NATURE, (2013), vol. 495, pages S14 - S16 |
| DESCRIPTION | - WEST ET AL., VIROLOGY, (1987), vol. 160, pages 38 - 47 |
| DESCRIPTION | - WHITEHEAD ET AL., ACS NANO., (20120828), vol. 6, no. 8, pages 6922 - 9 |
| DESCRIPTION | - WILLIAMS, "Broadening the Indications for Hematopoietic Stem Cell Genetic Therapies", CELL STEM CELL, (2013), vol. 13, pages 263 - 264 |
| DESCRIPTION | - WILSON ET AL., J. VIROL., (1989), vol. 63, pages 2374 - 2378 |
| DESCRIPTION | - WINOTO; BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733 |
| DESCRIPTION | - WOODDELL ET AL., MOLECULAR THERAPY, (201305), vol. 21, no. 5, pages 973 - 985 |
| DESCRIPTION | - WU, CELL STEM CELL, (2013), vol. 13, pages 659 - 62 |
| DESCRIPTION | - XIA ET AL., NAT. BIOTECH, (2002), vol. 20, pages 1006 - 1010 |
| DESCRIPTION | - XIA ET AL., NAT. BIOTECH., (2002), vol. 20, pages 1006 - 1010 |
| DESCRIPTION | - XU ET AL., SCIENCE, (20111118), vol. 334, no. 6058, pages 993 - 996 |
| DESCRIPTION | - XU ET AL., SCI REP., (20150709), vol. 5, page 12065 |
| DESCRIPTION | - XU, "Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice", RICE, (2014), vol. 7, page 5 |
| DESCRIPTION | - YATES ET AL., BLOOD, (2002), vol. 100, pages 3942 - 3949 |
| DESCRIPTION | - YOUNG ET AL., NANO LETT., (2012), vol. 12, pages 3867 - 71 |
| DESCRIPTION | - YUAN ET AL., AM J PHYSIOL RENAL PHYSIOL, (2008), vol. 295, pages F605 - F617 |
| DESCRIPTION | - YU ET AL., CELL, (20120831), vol. 150, pages 895 - 908 |
| DESCRIPTION | - YU ET AL., GENE THERAPY, (1994), vol. 1, pages 13 - 26 |
| DESCRIPTION | - YU, J. ET AL., SCIENCE, (2007), vol. 318, no. 5858, pages 1917 - 1920 |
| DESCRIPTION | - ZAEHRES; SCHOLER, CELL, (2007), vol. 131, no. 5, pages 834 - 835 |
| DESCRIPTION | - ZAMORA ET AL., AM J RESPIR CRIT CARE MED, (2011), vol. 183, pages 531 - 538 |
| DESCRIPTION | - ZHANG C. ET AL., "Efficient editing of malaria parasite genome using the CRISPR/Cas9 system", MBIO, (20140701), vol. 5, no. 4, pages E01414 - 14 |
| DESCRIPTION | - ZHANG ET AL., ACS NANO., (2011), vol. 5, pages 6962 - 6970 |
| DESCRIPTION | - ZHANG ET AL., ADV MATER., (20130906), vol. 25, no. 33, pages 4641 - 5 |
| DESCRIPTION | - ZHANG ET AL., "Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System", MBIO, (201407), vol. 5, pages E01414 - 14 |
| DESCRIPTION | - ZHANG ET AL., J. AM. CHEM. SOC., (2012), vol. 134, pages 16488 - 1691 |
| DESCRIPTION | - ZHANG ET AL., NATURE, (2012), vol. 490, no. 7421, pages 556 - 60 |
| DESCRIPTION | - ZHAO ET AL., NAT GENET, (2006), vol. 38, pages 1341 - 7 |
| DESCRIPTION | - ZHENG ET AL., PNAS, (20120724), vol. 109, no. 30, pages 11975 - 11980 |
| DESCRIPTION | - ZHENG ET AL., PROC. NATL. ACAD. SCI. USA., (2012), vol. 109, pages 11975 - 80 |
| DESCRIPTION | - ZHOU ET AL., "Exploiting SNPs for biallelic CRISPR mutations in the outcrossing woody perennial Populus reveals 4-coumarate: CoA ligase specificity and Redundancy", NEW PHYTOLOGIST, (2015), pages 1 - 4 |
| DESCRIPTION | - ZHOU ET AL., NEW PHYTOLOGIST, (201510), vol. 208, no. 2, pages 298 - 301 |
| DESCRIPTION | - ZIMMERMAN ET AL., NATURE LETTERS, (20060504), vol. 441 |
| DESCRIPTION | - ZOU ET AL., HUMAN GENE THERAPY, (201104), vol. 22, pages 465 - 475 |
| DESCRIPTION | - ZUKER; STIEGLER, NUCLEIC ACIDS RES., (1981), vol. 9, pages 133 - 148 |
| DESCRIPTION | - CHO, S.; GOLDBERG, M.; SON, S.; XU, Q.; YANG, F.; MEI, Y.; BOGATYREV, S.; LANGER, R.; ANDERSON, D., "Lipid-like nanoparticles for small interfering RNA delivery to endothelial cells", ADVANCED FUNCTIONAL MATERIALS, (2010), vol. 19, doi:doi:10.1002/adfm.200900519, pages 3112 - 3118, XP001548633 |
| DESCRIPTION | - BANASZYNSKI LA; CHEN LC; MAYNARD-SMITH LA; OOI AG; WANDLESS TJ, "A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules", CELL, (2006), vol. 126, doi:doi:10.1016/j.cell.2006.07.025, pages 995 - 1004, XP008119027 |
| DESCRIPTION | - WANG H.; YANG H.; SHIVALILA CS.; DAWLATY MM.; CHENG AW.; ZHANG F.; JAENISCH R, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", CELL, (20130509), vol. 153, no. 4, doi:doi:10.1016/j.cell.2013.04.025, pages 910 - 8, XP028538358 |
| DESCRIPTION | - NISHIMASU ET AL., "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA", CELL, (2014), vol. 156, no. 5, doi:doi:10.1016/j.cell.2014.02.001, pages 935 - 949, XP028667665 |
| DESCRIPTION | - NISHIMASU, H.; RAN, FA; HSU, PD.; KONERMANN, S.; SHEHATA, SI; DOHMAE, N.; ISHITANI, R.; ZHANG, F.; NUREKI, O., "Crystal structure of cas9 in complex with guide RNA and target DNA", CELL, (20140227), vol. 156, no. 5, doi:doi:10.1016/j.cell.2014.02.001, pages 935 - 49, XP028667665 |
| DESCRIPTION | - HSU ET AL., "Development and Applications of CRISPR-Cas9 for Genome Engineering", CELL, (20140605), vol. 157, doi:doi:10.1016/j.cell.2014.05.010, pages 1262 - 1278, XP028849523 |
| DESCRIPTION | - PLATT ET AL., "CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling", CELL, (2014), vol. 159, no. 2, doi:doi:10.1016/j.cell.2014.09.014, pages 440 - 455, XP029073412 |
| DESCRIPTION | - CHEN S; SANJANA NE; ZHENG K; SHALEM O; LEE K; SHI X; SCOTT DA; SONG J; PAN JQ; WEISSLEDER R, "Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis", CELL, (20150312), vol. 160, doi:doi:10.1016/j.cell.2015.02.038, pages 1246 - 1260, XP029203797 |
| DESCRIPTION | - PARNAS ET AL., "A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks", CELL, (20150730), vol. 162, doi:doi:10.1016/j.cell.2015.06.059, pages 675 - 686, XP029248090 |
| DESCRIPTION | - NISHIMASU ET AL., "Crystal Structure of Staphylococcus aureus Cas9", CELL, (20150827), vol. 162, doi:doi:10.1016/j.cell.2015.08.007, pages 1113 - 1126, XP055304450 |
| DESCRIPTION | - ZETSCHE ET AL., "Cpfl Is ? Single RNA-Guided Endonuclease of ? Class 2 CRISPR-Cas System", CELL, (20150925), vol. 163, doi:doi:10.1016/j.cell.2015.09.038, pages 759 - 71, XP055267511 |
| DESCRIPTION | - SHMAKOV ET AL., "Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems", MOLECULAR CELL, (20151022), vol. 60, no. 3, doi:doi:10.1016/j.molcel.2015.10.008, pages 385 - 397, XP055481389 |
| DESCRIPTION | - KIEM, "Hematopoietic stem cell-based gene therapy for HIV disease", CELL STEM CELL, (20120203), vol. 10, no. 2, doi:doi:10.1016/j.stem.2011.12.015, pages 137 - 147, XP002731081 |
| DESCRIPTION | - MANDAL ET AL., "Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9", CELL STEM CELL, (20141106), vol. 15, no. 5, doi:doi:10.1016/j.stem.2014.10.004, pages 643 - 652, XP055348680 |
| DESCRIPTION | - TAYLOR W.R., "The classification of amino acid conservation", J. THEOR. BIOL., (1986), vol. 119, doi:doi:10.1016/S0022-5193(86)80075-3, pages 205 - 218, XP055050432 |
| DESCRIPTION | - SU X; FRICKE J; KAVANAGH DG; IRVINE DJ, "In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles", MOL PHARM., (20110401), vol. 8, no. 3, doi:doi:10.1021/mp100390w, pages 774 - 87, XP055127583 |
| DESCRIPTION | - FENG, "Efficient genome editing in plants using a CRISPR/Cas system", CELL RESEARCH, (20130820), vol. 23, doi:doi:10.1038/cr.2013.114, pages 1229 - 1232, XP055153531 |
| DESCRIPTION | - CAVAZZANA-CALVO, "Transfusion independence and HMGA2 activation after gene therapy of human ?-thalassaemia", NATURE, (20100916), vol. 467, doi:doi:10.1038/nature09328, pages 318 - 322, XP055258772 |
| DESCRIPTION | - KONERMANN S; BRIGHAM MD; TREVINO AE; JOUNG J; ABUDAYYEH 00; BARCENA C; HSU PD; HABIB N; GOOTENBERG JS; NISHIMASU H, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", NATURE, (20150129), vol. 517, no. 7536, doi:doi:10.1038/nature14136, pages 583 - 8, XP055206834 |
| DESCRIPTION | - RAN FA; CONG L; YAN WX; SCOTT DA; GOOTENBERG JS; KRIZ AJ; ZETSCHE B; SHALEM O; WU X; MAKAROVA KS, "In vivo genome editing using Staphylococcus aureus Cas9", NATURE, (20150401), vol. 520, no. 7546, doi:doi:10.1038/nature14299, pages 186 - 91, XP055484527 |
| DESCRIPTION | - CANVER ET AL., "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis", NATURE, (20150916), vol. 527, no. 7577, doi:doi:10.1038/nature15521, pages 192 - 7, XP055274680 |
| DESCRIPTION | - MICHAEL S D KORMANN ET AL., "Expression of therapeutic proteins after delivery of chemically modified mRNA in mice", NATURE BIOTECHNOLOGY, (2011), vol. 29, doi:doi:10.1038/nbt.1733, pages 154 - 157, XP002696192 |
| DESCRIPTION | - JIANG ET AL., "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NATURE BIOTECHNOLOGY, (201303), vol. 31, doi:doi:10.1038/nbt.2508, pages 233 - 9, XP055249123 |
| DESCRIPTION | - JIANG W.; BIKARD D.; COX D.; ZHANG F; MARRAFFINI LA, "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NAT BIOTECHNOL, (201303), vol. 31, no. 3, doi:doi:10.1038/nbt.2508, pages 233 - 9, XP055249123 |
| DESCRIPTION | - SHAN, "Targeted genome modification of crop plants using a CRISPR-Cas system", NATURE BIOTECHNOLOGY, (2013), vol. 31, doi:doi:10.1038/nbt.2650, pages 686 - 688, XP055216828 |
| DESCRIPTION | - FU ET AL., "Improving CRISPR-Cas nuclease specificity using truncated guide RNAs", NATURE BIOTECHNOLOGY, (20131117), vol. 32, doi:doi:10.1038/nbt.2808, pages 279 - 284, XP055259718 |
| DESCRIPTION | - BIKARD ET AL., "Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials", NATURE BIOTECHNOLOGY, (20141005), vol. 32, doi:doi:10.1038/nbt.3043, pages 1146 - 1150, XP002742966 |
| DESCRIPTION | - ZETSCHE B; VOLZ SE; ZHANG F., "A split-Cas9 architecture for inducible genome editing and transcription modulation", NAT BIOTECHNOL., (20150202), vol. 33, no. 2, doi:doi:10.1038/nbt.3149, pages 139 - 42, XP055227889 |
| DESCRIPTION | - ZETSCHE ET AL., "A split-Cas9 architecture for inducible genome editing and transcription modulation", NATURE BIOTECHNOLOGY, (20150202), vol. 33, doi:doi:10.1038/nbt.3149, pages 139 - 142, XP055227889 |
| DESCRIPTION | - CALIANDO ET AL., "Targeted DNA degradation using a CRISPR device stably carried in the host genome", NATURE COMMUNICATIONS, vol. 6, doi:doi:10.1038/ncomms7989, page 6989, XP055311048 |
| DESCRIPTION | - WAGNER ET AL., "Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum", NATURE METHODS, (2014), vol. 11, doi:doi:10.1038/nmeth.3063, pages 915 - 918, XP055336954 |
| DESCRIPTION | - EL-ANDALOUSSI S ET AL., "Exosome-mediated delivery of siRNA in vitro and in vivo", NAT PROTOC, (20121115), vol. 7, no. 12, doi:doi:10.1038/nprot.2012.131, pages 2112 - 26, XP055129954 |
| DESCRIPTION | - RAN, FA.; HSU, PD.; WRIGHT, J.; AGARWALA, V.; SCOTT, DA.; ZHANG, F, "Genome engineering using the CRISPR-Cas9 system.", NATURE PROTOCOLS, (201311), vol. 8, no. 11, doi:doi:10.1038/nprot.2013.143, pages 2281 - 308, XP009174668 |
| DESCRIPTION | - SHALEM ET AL., "High-throughput functional genomics using CRISPR-Cas9,", NATURE REVIEWS GENETICS, (201505), vol. 16, doi:doi:10.1038/nrg3899, pages 299 - 311, XP055207968 |
| DESCRIPTION | - RAMANAN ET AL., "CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus", SCIENTIFIC REPORTS, (20150602), vol. 5, doi:doi:10.1038/srep10833, page 10833, XP055305966 |
| DESCRIPTION | - YOUSEF ET AL., "Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria", PROC. NATL. ACAD. SCI. USA, (20150518), vol. 112, doi:doi:10.1073/pnas.1500107112, pages 7267 - 7272, XP002742965 |
| DESCRIPTION | - XIE, "RNA-guided genome editing in plants using a CRISPR-Cas system", MOL PLANT., (20130817), vol. 6, no. 6, doi:doi:10.1093/mp/sst119, pages 1975 - 83, XP055154141 |
| DESCRIPTION | - XIE, "RNA-guided genome editing in plants using a CRISPR-Cas system", MOL PLANT., (201311), vol. 6, no. 6, doi:doi:10.1093/mp/sst119, pages 1975 - 83, XP055154141 |
| DESCRIPTION | - NAKAMURA, Y. ET AL., "Codon usage tabulated from the international DNA sequence databases: status for the year 2000", NUCL. ACIDS RES, (2000), vol. 28, doi:doi:10.1093/nar/28.1.292, page 292, XP002941557 |
| DESCRIPTION | - NAKAMURA, Y. ET AL., "Codon usage tabulated from the international DNA sequence databases: status for the year 2000", NUCL. ACIDS RES., (2000), vol. 28, doi:doi:10.1093/nar/28.1.292, page 292, XP002941557 |
| DESCRIPTION | - XU ET AL., "Sequence determinants of improved CRISPR sgRNA design", GENOME RESEARCH, (201508), vol. 25, doi:doi:10.1101/gr.191452.115, pages 1147 - 1157, XP055321186 |
| DESCRIPTION | - CONG, L.; RAN, F.A; COX, D.; LIN, S.; BARRETTO, R.; HABIB, N.; HSU, P.D.; WU, X.; JIANG, W.; MARRAFFINI, L.A., "Multiplex genome engineering using CRISPR/Cas systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:doi:10.1126/science.1231143, pages 819 - 23, XP055469277 |
| DESCRIPTION | - WANG ET AL., "Genetic screens in human cells using the CRISPR/Cas9 system", SCIENCE, (20140103), vol. 343, no. 6166, doi:doi:10.1126/science.1246981, pages 80 - 84, XP055294787 |
| DESCRIPTION | - NEKRASOV, "Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system", PLANT METHODS, (2013), vol. 9, doi:doi:10.1186/1746-4811-9-39, page 39, XP021164954 |
| EXAMINATION | - IWAMOTO M ET AL, "A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 17, no. 9, ISSN 1074-5521, (20100924), pages 981 - 988, (20100923), XP027299452 |
| EXAMINATION | - Yusuke Miyazaki ET AL, "Destabilizing Domains Derived from the Human Estrogen Receptor", Journal of the American Chemical Society, US, (20120307), vol. 134, no. 9, doi:10.1021/ja209933r, ISSN 0002-7863, pages 3942 - 3945, XP055387238 |
| INTERNATIONAL-SEARCH-REPORT | - BALBOA DIEGO ET AL, "Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation. (plus Supplemental Information)", STEM CELL REPORTS, (20150908), vol. 5, no. 3, doi:10.1016/j.stemcr.2015.08.001, ISSN 2213-6711, pages 448 - 459+16PP, XP002756302 [XP] 1,18 * the whole document * |
| INTERNATIONAL-SEARCH-REPORT | - J. M. GEISINGER ET AL.,, "In vivo blunt-end cloning through CRISPR/CAS9-facilitated non-homologous end-joining", NUCLEIC ACID RESEARCH ADVANCE ACCESS PUBLISHED JANUARY 13, 2016, (20160113), pages 1 - 15, XP002756304 [T] * the whole document * |
| INTERNATIONAL-SEARCH-REPORT | - S. Senturk et al.,, "A rapid and tunable method to temporally control cas9 expression enables the identification of essential genes and the interrogtion of functional gene interactions in vitro and in vivo", doi:10.1101/023366, (20150728), pages 1 - 27, URL: http://biorxiv.org/content/early/2015/07/28/023366, (20160411), XP002756303 [XP] 1,2,9,25-31,33-43 * the whole document * |
| INTERNATIONAL-SEARCH-REPORT | - HARRISON MELISSA M ET AL, "A CRISPR view of development.", GENES & DEVELOPMENT, (20140901), vol. 28, no. 17, ISSN 1549-5477, pages 1859 - 1872, XP002756301 [A] 1-43 * page 1864, column r, line 41 - line 45 * |
| OPPOSITION | - Assignment of Zetsche to Broad |
| OPPOSITION | - Assignment of Zhang to Broad and MIT |
| OPPOSITION | - BALBOA et al., "Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation", Stem Cell Reports, (20150908), vol. 5, doi:10.1016/j.stemcr.2015.08.001, pages 448 - 459 |
| OPPOSITION | - Chu et al., "Recent Progress with FKBP-Derived Destabilizing Domains",Bioorg Med Chem Lett., 18(22), 5941 -5944 (2008), plus supplementary material (15.11.2008) |
| OPPOSITION | - Chylinski et al., "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA Biology,10(5), 726-737, plus Supplementary Material (05.04.2013) |
| OPPOSITION | - copy of the PCT Request form in respect of the International patent application PCT/US2015/067177 |
| OPPOSITION | - Declaration from Ellen Law |
| OPPOSITION | - Dohmen et al., "Heat-inducible degron: a method for constructing temperature-sensitive mutants", Science, 263(5151), 1273-1276,(04.03.1994) |
| OPPOSITION | - extract from the Public PAIR database of the US Patent and Trademark Office (“USPTO”) in respect of the International patent application PCT/US2015/067177 |
| OPPOSITION | - Harvard University's Intellectual Property Policy |
| OPPOSITION | - Hoffmann et al. “Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells", Gene Therapy 24: 298-307 (20.04.2017) |
| OPPOSITION | - Hsu et al. “DNA targeting specificity of RNA-guided Cas9 nucleases”,Nature Biotechnology 31(9): 827-832 (21.07.2013) |
| OPPOSITION | - Iwamoto et al. "A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System”, Chemistry & Biology 17: 981-988 (24.09.2010) |
| OPPOSITION | - Kanemaki (2012) Frontiers of protein expression control with conditional degrons, Pflugers Arch Eur J Physiol. 465:419-425 |
| OPPOSITION | - Maji et al., 2017 Multidimensional chemical control of CRISPR-Cas9, Nat Chem Biol. Jan; 13(1):9-11 |
| OPPOSITION | - MIT Intellectual Property Policy |
| OPPOSITION | - Miyazaki et al. “Destabilizing Domains Derived from the Human Estrogen Receptor”, Journal of the American Chemical Society 134(9): 3942-3945(14.02.2012) |
| OPPOSITION | - Nishimasu et al. “Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA", Cell 156: 935-949 (27,02.2014) |
| OPPOSITION | - printout of an extract from the UniProt database entry for the E. coli dihydrofolate reductase (“DHFR") protein |
| OPPOSITION | - printout of an extract from the UniProt database entry for the human estrogen receptor |
| OPPOSITION | - print out of the online Addgene catalogue entry for the E. coli DHFR-containing plasmid “pBMN DHFR(DD)-YFP” |
| OPPOSITION | - Pruett-Miller et al. “Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels”, PLoS Genetics 5(2): e 1000376.(13.02.2009) |
| OPPOSITION | - Ran et al., "In vivo genome editing using Staphylococcus aureus Cas9",Nature, 520, 186-191, plus supplementary material (01.04.2015) |
| OPPOSITION | - SCHOEBER et al., "Conditional fast expression and function of multimeric TRPV5 channels using Shield- 1", Am J Physiol., (20081008), vol. 296, pages F204 - F211, XP055754877 |
| OPPOSITION | - Schoeber et al., "Conditional fast expression and function of multimericTRPV5 channels using Shield 1", Am J Physiol., 296, F204-F211(08.10.2008) |
| OPPOSITION | - Search strategy and results from sequence alignment of "HD2" with Cas9from various organisms |
| OPPOSITION | - Society of Fellows of Harvard University extract |
| OPPOSITION | - The Broad Institute Intellectual Property and Proprietary Information Agreement for Bernd Zetsche |
| OPPOSITION | - Voon DC et al. (2005) Use of mRNA- and protein- destabilizing elements to develop a highly responsive reporter system. Nucleic Acids Research.33(3):e27 |
| OPPOSITION | - Wu et al. “Target specificity of the CRISPR-Cas9 system”, Quantitative Biology 2(2 ):59-70 (06.08.2014) |
| OPPOSITION | - CH U et al., "Recent Progress with FKBP-Derived Destabilizing Domains", Bioorg Med Chem Lett., (20081115), vol. 18, no. 22, doi:10.1016/j.bmcl.2008.09.043, pages 5941 - 5944, XP025627175 |
| OPPOSITION | - NISHIMASU et al., "Crystal Structure of Cas9 in Complex 27 February with Guide RNA and Target DNA", Cell, (20140227), vol. 156, pages 935 - 949, XP028622533 |
| OPPOSITION | - IWAMOTO et al., "A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System", Chemistry & Biology, (20100924), vol. 17, doi:10.1016/j.chembiol.2010.07.009, pages 981 - 988, XP055552908 |
| OPPOSITION | - BALBOA et al., "Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation", Stem Cell Reports, (20150908), vol. 5, doi:10.1016/j.stemcr.2015.08.001, pages 448 - 459, XP002756302 |
| OPPOSITION | - MIYAZAKI et al., "Destabilizing Domains Derived from the Human Estrogen Receptor", J Am Chem Soc., (20120307), vol. 134, no. 9, doi:10.1021/ja209933r, pages 3942 - 3945, XP055387238 |
| OPPOSITION | - RAN et al., "In vivo genome editing using Staphylococcus aureus Cas9", Nature, (20150401), vol. 520, doi:10.1038/nature14299, pages 186 - 191, XP055484527 |
| OPPOSITION | - SENTURK et al., "A rapid and tunable method to temporally control Cas9 expression enables the identification of essential genes and the interrogation of functional gene interactions in vitro and in vivo", BioRxiv 023366, (20150708), XP002756303 |
| OPPOSITION | - DOHMEN et al., "Heat-inducible degron: a method for constructing temperature-sensitive mutants", Science, (19940304), vol. 263, no. 5151, doi:10.1126/science.8122109, pages 1273 - 1276, XP002742294 |
| OPPOSITION | - CHYLINSKI et al., "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA Biology, (20130405), vol. 10, no. 5, doi:10.4161/rna.24321, pages 726 - 737, XP055116068 |
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