Assessing Retinal Pigment Epithelial Cell Populations - EP3240890

The patent EP3240890 was granted to Cell Cure Neurosciences on Jun 16, 2021. The application was originally filed on Dec 30, 2015 under application number EP15832698A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3240890

CELL CURE NEUROSCIENCES
Application Number
EP15832698A
Filing Date
Dec 30, 2015
Status
Granted And Under Opposition
May 14, 2021
Grant Date
Jun 16, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MARGARET DIXONMar 15, 2022MEWBURN ELLISADMISSIBLE
STRAWMANFeb 23, 2022CARPMAELS & RANSFORDADMISSIBLE

Patent Citations (53) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP2128244
DESCRIPTIONGB2327675
DESCRIPTIONUS2013196369
DESCRIPTIONUS3791932
DESCRIPTIONUS3839153
DESCRIPTIONUS3850578
DESCRIPTIONUS3850752
DESCRIPTIONUS3853987
DESCRIPTIONUS3867517
DESCRIPTIONUS3879262
DESCRIPTIONUS3901654
DESCRIPTIONUS3935074
DESCRIPTIONUS3984533
DESCRIPTIONUS3996345
DESCRIPTIONUS4034074
DESCRIPTIONUS4098876
DESCRIPTIONUS4666828
DESCRIPTIONUS4683202
DESCRIPTIONUS4801531
DESCRIPTIONUS4879219
DESCRIPTIONUS5011771
DESCRIPTIONUS5192659
DESCRIPTIONUS5272057
DESCRIPTIONUS5281521
DESCRIPTIONUS5755785
DESCRIPTIONUS5843780
DESCRIPTIONUS5941250
DESCRIPTIONUS5962027
DESCRIPTIONUS6045791
DESCRIPTIONUS8268303
DESCRIPTIONWO0155114
DESCRIPTIONWO02060875
DESCRIPTIONWO03068233
DESCRIPTIONWO2005014549
DESCRIPTIONWO2006040763
DESCRIPTIONWO2006070370
DESCRIPTIONWO2008129554
DESCRIPTIONWO2013114360
DESCRIPTIONWO2013184809
INTERNATIONAL-SEARCH-REPORTUS2013196369
INTERNATIONAL-SEARCH-REPORTWO2015087231
INTERNATIONAL-SEARCH-REPORTWO2015175504
OPPOSITIONUS2012258451
OPPOSITIONUS2013196369
OPPOSITIONWO2008129554
OPPOSITIONWO2011063005
OPPOSITIONWO2013074681
OPPOSITIONWO2013184809
OPPOSITIONWO2014121077
OPPOSITIONWO2015087231
OPPOSITIONWO2015175504
OPPOSITIONWO2016108219
OPPOSITIONWO2016108239

Non-Patent Literature (NPL) Citations (77) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AUSUBEL, R. M.,, Current Protocols in Molecular Biology, (1994), vol. I-III-
DESCRIPTION- BIOCHEM BIOPHYS RES COMMUN, (20000224), vol. 268, no. 3, pages 842 - 6-
DESCRIPTION- BIRREN ET AL., Genome Analysis: A Laboratory Manual Series, COLD SPRING HARBOR LABORATORY PRESS, (1998), vol. 1-4-
DESCRIPTION- BONGSO ET AL., HUM REPROD, (1989), vol. 4, page 706-
DESCRIPTION- CELLIS, J. E.,, Cell Biology: A Laboratory Handbook, (1994), vol. I-III-
DESCRIPTION- CHUNG ET AL., CELL STEM CELL, (20080207), vol. 2, no. 2, pages 113 - 117-
DESCRIPTION- COLIGAN J. E.,, Current Protocols in Immunology, (1994), vol. I-III-
DESCRIPTION- CURR OPIN OPTHALMOL, (199208), vol. 3, no. 4, pages 473 - 81-
DESCRIPTION- CURR. TOP. DEV. BIOL., (1998), vol. 38, page 133-
DESCRIPTION- DOETSCHMAN ET AL., EV BIOL., (1988), vol. 127, pages 224 - 7-
DESCRIPTION- EYE, (1995), vol. 9, pages 6 - 12-
DESCRIPTION- EYE GRAEFES ARCH CLIN EXP OPTHALMOL, (199703), vol. 235, no. 3, pages 149 - 58-
DESCRIPTION- GARDNER ET AL., FERTIL. STERIL., (1998), vol. 69, page 84-
DESCRIPTION- GILES ET AL., MOL REPROD DEV., (1993), vol. 36, pages 130 - 8-
DESCRIPTION- GRAVES; MOREADITH, MOL REPROD DEV., (1993), vol. 36, pages 424 - 33-
DESCRIPTION- JPN J OPHTHALMOL, (199112), vol. 43, no. 6, pages 502 - 8-
DESCRIPTION- KALKAN ET AL., PHIL. TRANS. R. SOC. B, (2014), vol. 369, page 20130540-
DESCRIPTION- LANNACCONE ET AL., DEV BIOL., (1994), vol. 163, pages 288 - 92-
DESCRIPTION- Methods in Enzymology, ACADEMIC PRESS, vol. 1-317-
DESCRIPTION- MITALIPOVA ET AL., CLONING., (2001), vol. 3, pages 59 - 67-
DESCRIPTION- NOTARIANNI ET AL., REPROD FERTIL, (1991), pages 255 - 60-
DESCRIPTION- OPHTHALMIC SURG LASERS, (199804), vol. 29, no. 4, pages 305 - 8-
DESCRIPTION- OPHTHALMOLOGY, (200004), vol. 107, no. 4, pages 719 - 24-
DESCRIPTION- OPTHALMIC SURG, (199102), vol. 22, no. 2, pages 102 - 8-
DESCRIPTION- PNAS, (20060307), vol. 103, no. 10, pages 3896 - 3901-
DESCRIPTION- PROC. NATL. ACAD. SCI. USA, (1995), vol. 92, page 7844-
DESCRIPTION- REUBINOFF ET AL., NAT BIOTECHNOL, (200005), vol. 18, no. 5, page 559-
DESCRIPTION- SCIENCE, (1998), vol. 282, page 1145-
DESCRIPTION- THOMSON ET AL., BIOL REPROD., (1996), vol. 55, pages 254 - 9-
DESCRIPTION- THOMSON ET AL., PROC NATL ACAD SCI U S A., (1995), vol. 92, pages 7844 - 8-
DESCRIPTION- THOMSON JA ET AL., SCIENCE, (1998), vol. 282, pages 1145 - 7-
DESCRIPTION- WATSON ET AL., Recombinant DNA, SCIENTIFIC AMERICAN BOOKS, NEW YORK-
DESCRIPTION- WHEELER, REPROD FERTIL DEV., (1994), vol. 6, pages 563 - 8-
DESCRIPTION- ZHANG ET AL., PROTEIN CELL, (2014), vol. 5, no. 1, pages 48 - 58-
DESCRIPTION- XU C ET AL., "Feeder-free growth of undifferentiated human embryonic stem cells", NAT BIOTECHNOL., (2001), vol. 19, doi:doi:10.1038/nbt1001-971, pages 971 - 4, XP002672078
INTERNATIONAL-SEARCH-REPORT- HANNA VAAJASAARI ET AL, "Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells.", MOLECULAR VISION, (20110101), vol. 17, ISSN 1090-0535, pages 558 - 575, XP055108414 [A] 1-25 * page 562, column l, paragraph 2 * * page 569, paragraph l - page 570, paragraph 1 *-
INTERNATIONAL-SEARCH-REPORT- Ruchira Singh ET AL, "Retinal Cell Biology Functional Analysis of Serially Expanded Human iPS Cell- Derived RPE Cultures", (20131001), pages 6767 - 6778, URL: http://iovs.arvojournals.org/article.aspx?articleid=2202986, (20150512), XP055188833 [A] 1-25 * page 6771, column l, paragraph 1 - column r, paragraph 3 *-
INTERNATIONAL-SEARCH-REPORT- MARIA IDELSON ET AL, "Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells", CELL STEM CELL, (20091001), vol. 5, no. 4, doi:10.1016/j.stem.2009.07.002, ISSN 1934-5909, pages 396 - 408, XP055046648 [X] 18-24 * page 405, column r, paragraph 2 - paragraph 4 * * figures 4 E, F, I, J, L *
INTERNATIONAL-SEARCH-REPORT- T. MASUDA ET AL, "SOX9, through Interaction with Microphthalmia-associated Transcription Factor (MITF) and OTX2, Regulates BEST1 Expression in the Retinal Pigment Epithelium", JOURNAL OF BIOLOGICAL CHEMISTRY, US, (20100827), vol. 285, no. 35, doi:10.1074/jbc.M110.130294, ISSN 0021-9258, pages 26933 - 26944, XP055257501 [A] 1-16,25 * page 26936, column r, paragraph 2 *
INTERNATIONAL-SEARCH-REPORT- BUZHOR ELLA ET AL, "Cell-based therapy approaches: the hope for incurable diseases", REGENERATIVE MEDICINE, FUTURE MEDICINE, UK, (20140101), vol. 9, no. 5, doi:10.2217/RME.14.35, ISSN 1746-076X, pages 649 - 672, XP009188959 [A] 1-25 * page 656, column r, paragraph 3 - page 657, column l, paragraph 2 *
OPPOSITION- AHMADO et al., "induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19", Invest Ophthalmol Vis Sci., (20110000), vol. 52, no. 10, pages 7148 - 7159, XP055906815-
OPPOSITION- Anonymous , "PMEL premelanosome protein [ Homo sapiens (human) ]", Gene, (20221026), Database accession no. ID: 6490, URL: Ncbi, XP093003147-
OPPOSITION- Anonymous , "RLBP1 retinaldehyde binding protein 1 [ Homo sapiens (human) ]", Gene, (20220805), Database accession no. ID: 6017, URL: ncbi, XP093003151-
OPPOSITION- Atala et al, "Human embryonic stem cells: early hints on safety and efficacy", The Lancet, (20120125), vol. 379, pages 689 - 690, XP093231215-
OPPOSITION- Brandl Caroline, Stephanie J Zimmermann, Vladimir M Milenkovic, Sibylle M G Rosendahl, Felix Grassmann, Andrea Milenkovic, Ute Hehr, Marianne Federlin, Christian H Wetzel, Horst Helbig, Bernhard H F Weber, "In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC)", Neuromol Med, (20140101), vol. 16, pages 551 - 564, XP055847574-
OPPOSITION- BRANDL et al., "In-depth characterisation of retinal pigment epithelium, (RPE) cells derived from human induced pluripotent stem cells (hiPSC", Neuromuscular Med, (20140000), vol. 16, no. 3, pages 551 - 564, XP055847574-
OPPOSITION- Charles Irving, "BioTime Annual Meeting Shareholder Update:", Cell Cure - NeuroSciences Ltd., (20141104), pages 1 - 22, XP055906813-
OPPOSITION- Danhong Zhu, Et Al., "Polarized Secretion of PEDF from Human Embryonic Stem Cell–Derived RPE Promotes Retinal Progenitor Cell Survival", Invest Ophtalmol vis Sci. 2011, (20110321), Invest Ophtalmol vis Sci. 2011 , URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183377/, (20160713), XP055288066-
OPPOSITION- DEEG et al., "CRALBP is a highly prevalent autoantigen for human autoimmune uveitis", Clin Dev Immunol., (20070000), page 39245-
OPPOSITION- "FDA Guidance: Content and Content and Review of Chemistry, Manufacturing, and Control (CMC) Information for Human Somatic Cell Therapy Investigational New Drug Applications (INDs)of Chemistry, - Manufacturing, and Control (CMC) Information for Human Somatic", Guidance for FDA Reviewers and Sponsors, (20080400), XP055906821-
OPPOSITION- Hanna Vaajasaari, Tanja Ilmarinen, Kati Juuti Uusitalo, Kristiina Rajala, Niina Onnela, Susanna Narkilahti, Riitta Suuronen, Jari Hyttinen, Hannu Uusitalo, Heli Skottman, "Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells.", Molecular vision, (20110101), vol. 17, ISSN 10900535, pages 558 - 575, XP055108414-
OPPOSITION- KOKKINAKI et al., "Human iPS-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized VEGF secretion and gene expression pattern similar to native RPE", Stem Cells., (20110000), vol. 29, no. 5, pages 825 - 835, XP055906811-
OPPOSITION- MCGILL et al., "Long-term efficacy of GMP grade xeno-free hESC-derived RPE cells following transplantation", Transl Vis Sci Technol., (20170000), vol. 6, no. 3, page 17, XP055847603-
OPPOSITION- Mcgill, Et Al., "Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation", Trans Vis Sci Tech., (20170101), vol. 6, no. 3, pages 1 - 18, XP055847603-
OPPOSITION- mTeSR medium product information sheet-
OPPOSITION- Pineal Body, URL: https://maayanlab.cloud/Harmonizome/geneset/pineal+body/Allen+Brain+Atlas+Prenatal+H uman+Brain+Tissue+Gene+Expression+Profiles-
OPPOSITION- VAAJASAARI et al., "Toward the defined and xeno-free differentiation of functional human pluripotent stem cell -derived retinal pigment epithelial cells", Mol Vis., (20110000), vol. 17, pages 558 - 575, XP055108414-
OPPOSITION- LU BIN, ET AL, "Embryonic Stem Cells/Induced Pluripotent Stem Cells Long-Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration", Stem Cells, Wiley, (20090101), vol. 27, no. 9, doi:10.1002/STEM.149, ISSN 1066-5099, pages 2126 - 2135, XP002545384
OPPOSITION- BUCHHOLZ et al., "Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells", Stem Cells., (20090000), vol. 27, no. 10, doi:10.1002/STEM.189, pages 2427 - 2434, XP002696526
OPPOSITION- Parvini Maryam; Satarian Leila; Parivar Kazem; Javan Mohammad; Tondar Mahdi; Ahmad Sajjad; Baharvand Hossein, "Human Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium in Retinal Treatment: from Bench to Bedside", Molecular Neurobiology, Springer US, New York, New York, (20140403), vol. 50, no. 2, doi:10.1007/s12035-014-8684-y, ISSN 0893-7648, pages 597 - 612, XP035401679
OPPOSITION- Ferrington Deborah A., Ebeling Mara C., Kapphahn Rebecca J., Terluk Marcia R., Fisher Cody R., Polanco Jorge R., Roehrich Heidi, Leary Michaela M., Geng Zhaohui, Dutton James R., Montezuma Sandra R., "Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration", Redox Biology, Elsevier, NL, NL , (20171001), vol. 13, doi:10.1016/j.redox.2017.05.015, ISSN 2213-2317, pages 255 - 265, XP093277696
OPPOSITION- IDELSON et al., "Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells", Cell Stem Cell, (20090000), vol. 5, no. 4, doi:10.1016/j.stem.2009.07.002, pages 396 - 408, XP055046648
OPPOSITION- Maria Idelson, Ruslana Alper, Alexey Obolensky, Etti Ben-Shushan, Itzhak Hemo, Nurit Yachimovich-Cohen, Hanita Khaner, Yoav Smith, Ofer Wiser, Michal Gropp, Malkiel A. Cohen, Sharona Even-Ram, Yael Berman-Zaken, Limor Matzrafi, Gideon Rechavi, Eyal Banin, Benjamin Reubinoff, "Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells", Cell Stem Cell, Elsevier, Cell Press, (20091001), vol. 5, no. 4, doi:10.1016/j.stem.2009.07.002, ISSN 19345909, pages 396 - 408, XP055046648
OPPOSITION- Hiroyuki Kamao, Michiko Mandai, Satoshi Okamoto, Noriko Sakai, Akiko Suga, Sunao Sugita, Junichi Kiryu, Masayo Takahashi, "Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application", Stem Cell Reports, (20140201), vol. 2, no. 2, doi:10.1016/j.stemcr.2013.12.007, ISSN 22136711, pages 205 - 218, XP055144196
OPPOSITION- Steven D Schwartz, Hubschman Jean-Pierre, Heilwell Gad, Franco-Cardenas Valentina, Pan Carolyn K, Ostrick Rosaleen M, Mickunas Edmund, Gay Roger, Klimanskaya Irina, Lanza Robert, "Embryonic stem cell trials for macular degeneration: a preliminary report", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120124), vol. 379, no. 9817, doi:10.1016/S0140-6736(12)60028-2, ISSN 0140-6736, pages 713 - 720, XP055111985
OPPOSITION- David A. Carter, Smart Matthew J. K., Letton William V. G., Ramsden Conor M., Nommiste Britta, Chen Li Li, Fynes Kate, Muthiah Manickam N., Goh Pollyanna, Lane Amelia, Powner Michael B., Webster Andrew R., Da Cruz Lyndon, Moore Anthony T., Coffey Peter J., Carr Amanda-Jayne F., "Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC)", Scientific Reports, (20161201), vol. 6, no. 1, doi:10.1038/srep33792, page 33792, XP055722257
OPPOSITION- BHARTI et al., "The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells", Pigment Cell Melanoma Res, (20100000), vol. 24, no. 1, doi:10.1111/j.1755-148X.2010.00772.x, pages 21 - 34, XP055116027
OPPOSITION- WATT et al., "PMEL: A pigment cell -specific model for functional amyloid formation", Pigment Cell Melanoma Res, (20130000), vol. 26, no. 3, doi:10.1111/pcmr.12067, pages 300 - 315, XP055304913
OPPOSITION- Arvydas Maminishkis, Shan Chen, Stephen Jalickee, Tina Banzon, Guangpu Shi, Fei E. Wang, Todd Ehalt, Jeffrey A. Hammer, Sheldon S. Miller, "Confluent Monolayers of Cultured Human Fetal Retinal Pigment Epithelium Exhibit Morphology and Physiology of Native Tissue", Investigative Opthalmology & Visual Science, Association for Research in Vision and Ophthalmology, US, US , (20060801), vol. 47, no. 8, doi:10.1167/iovs.05-1622, ISSN 1552-5783, page 3612, XP055453547
OPPOSITION- Amanda-Jayne Carr, Vugler Anthony A., Hikita Sherry T., Lawrence Jean M., Gias Carlos, Chen Li Li, Buchholz David E., Ahmado Ahmad, Semo Ma'ayan, Smart Matthew J. K., Hasan Shazeen, Da Cruz Lyndon, Johnson Lincoln V., Clegg Dennis O., Coffey Pete J., "Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat", PLoS ONE, vol. 4, no. 12, doi:10.1371/journal.pone.0008152, page e8152, XP055070946
OPPOSITION- CARR et al., "Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat", PLoS One, (20090000), vol. 4, no. 12, doi:10.1371/journal.pone.0008152, page e8152, XP055070946
OPPOSITION- BUZHOR et al., "Cell -based therapy approaches: the hope for incurable diseases", Regen Med., (20140000), vol. 9, no. 5, doi:10.2217/rme.14.35, pages 649 - 672, XP009188959
OPPOSITION- Foltz Leah P., Howden Sara E., Thomson James A., Clegg Dennis O., "Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9", International journal of molecular sciences, Molecular Diversity Preservation International (MDPI), Basel, CH, Basel, CH , (20181201), vol. 19, no. 12, doi:10.3390/ijms19124127, ISSN 1422-0067, pages 4127 - 17, XP093277693
OPPOSITION- MARUOTTI JULIEN ET AL, "A Simple and Scalable Process for the Differentiation of Retinal Pigment Epithelium From Human Pluripotent Stem Cells", STEM CELLS TRANSLATIONAL MEDICINE, (20130501), vol. 2, no. 5, doi:10.5966/sctm.2012-0106, pages 341 - 354, XP002794364
OPPOSITION- David Buchholz et al, "Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium", Stem Cells Translational Medicine, AlphaMed Press, Inc., US, US , (20130418), vol. 2, no. 5, doi:10.5966/sctm.2012-0163, ISSN 2157-6564, pages 384 - 393, XP055114659
OPPOSITION- A. Lane, L. R. Philip, L. Ruban, K. Fynes, M. Smart, A. Carr, C. Mason, P. Coffey, "Engineering Efficient Retinal Pigment Epithelium Differentiation From Human Pluripotent Stem Cells", Stem Cells Translational Medicine, AlphaMed Press, Inc., US, US , (20141101), vol. 3, no. 11, doi:10.5966/sctm.2014-0094, ISSN 2157-6564, pages 1295 - 1304, XP055303892
OPPOSITION- LANE et al., "Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells", Stem Cells Transl Med., (20140000), vol. 3, no. 11, doi:10.5966/sctm.2014-0094, pages 1295 - 1304, XP055303892

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents