| DESCRIPTION | - AGUILERA ET AL., INTEGR BIOL (CAMB, (200906), vol. 1, no. 5-6, pages 371 - 381 | - |
| DESCRIPTION | - A. HATOUM-ASLAN; I. MANIV; L. A. MARRAFFINI, PROC. NATL. ACAD. SCI. U.S.A., (2011), vol. 108, page 21218 | - |
| DESCRIPTION | - AKYIIREK ET AL., MOL. MED., (2000), vol. 6, page 983 | - |
| DESCRIPTION | - ALI ET AL., HUM GENE THER, (1998), vol. 9, pages 81 - 86 | - |
| DESCRIPTION | - ALI ET AL., HUM MOL GENET, (1996), vol. 5, pages 519 - 594 | - |
| DESCRIPTION | - ALI ET AL., HUM MOL GENET, (1996), vol. 5, pages 531 - 594 | - |
| DESCRIPTION | - ALI ET AL., HUM MOL GENET, (1996), vol. 5, pages 591 - 594 | - |
| DESCRIPTION | - ALTSCHUL ET AL., J. MOL. BIOI., (1990), vol. 215, pages 403 - 10 | - |
| DESCRIPTION | - ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 410 | - |
| DESCRIPTION | - BARBOUR ET AL., "Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase", BIOSCI REP., (20130118), vol. 33, no. 1 | - |
| DESCRIPTION | - BARTGE ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 3648 - 3652 | - |
| DESCRIPTION | - BENNETT ET AL., INVEST OPTHALMOL VIS SCI, (1997), vol. 38, pages 2857 - 2863 | - |
| DESCRIPTION | - BEUMER ET AL., "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases", PNAS, (2008), vol. 105, no. 50, pages 19821 - 19826 | - |
| DESCRIPTION | - BEVAN, NUCL ACID RES., (1984), vol. 12, pages 8711 - 8721 | - |
| DESCRIPTION | - BIOCHEM. | - |
| DESCRIPTION | - BITTER ET AL., METHODS IN ENZYMOLOGY, (1987), vol. 153, pages 516 - 544 | - |
| DESCRIPTION | - BORRAS ET AL., GENE THER, (1999), vol. 6, pages 515 - 524 | - |
| DESCRIPTION | - BOUNDY ET AL., J. NEUROSCI., (1998), vol. 18, page 9989 | - |
| DESCRIPTION | - BOYNTON ET AL., METHODS IN ENZYMOLOGY, (1993), vol. 217, pages 510 - 536 | - |
| DESCRIPTION | - B. P. LEWIS; C. B. BURGE; D. P. BARTEL, CELL, (2005), vol. 120, page 15 | - |
| DESCRIPTION | - B. WIEDENHEFT ET AL., NATURE, (2011), vol. 477, page 486 | - |
| DESCRIPTION | - B. WIEDENHEFT ET AL., PROC. NATL. ACAD. SCI. U.S.A., (2011), vol. 108, page 10092 | - |
| DESCRIPTION | - B. WIEDENHEFT; S. H. STERNBERG; J. A. DOUDNA, NATURE, (2012), vol. 482, page 331 | - |
| DESCRIPTION | - CASANOVA ET AL., GENESIS, (2001), vol. 31, page 37 | - |
| DESCRIPTION | - C. FR0KJSER-JENSEN ET AL., "Single-copy insertion of transgenes in Caenorhabditis elegans", NAT. GENET, (2008), vol. 40, page 1375 | - |
| DESCRIPTION | - CHAKRABARTI, ENDOCRINOL, (2010), vol. 151, page 2408 | - |
| DESCRIPTION | - CHAKRABARTI, ENDOCRINOL., (2010), vol. 151, page 2408 | - |
| DESCRIPTION | - CHANG ET AL., PROC. NATL. ACAD SCI USA, (1987), vol. 84, pages 4959 - 4963 | - |
| DESCRIPTION | - CHEN ET AL., BIOCHEM. BIOPHYS. RES. COMM., (1999), vol. 262, page 187 | - |
| DESCRIPTION | - CHEN ET AL., CELL, (1987), vol. 51, pages 7 - 19 | - |
| DESCRIPTION | - CHRISTOU, BIO/TECHNOLOGY, (1991), vol. 9, pages 957 - 9,4462 | - |
| DESCRIPTION | - CHU ET AL., BIOORG MED CHEM LETT, (20081115), vol. 18, no. 22, pages 5941 - 4 | - |
| DESCRIPTION | - CITARTAN ET AL., BIOSENS BIOELECTRON., (20120415), vol. 34, no. 1, pages 1 - 11 | - |
| DESCRIPTION | - COMB ET AL., EMBO J., (1988), vol. 17, pages 3793 - 3805 | - |
| DESCRIPTION | - C. R. HALE ET AL., CELL, (2009), vol. 139, page 945 | - |
| DESCRIPTION | - C. R. HALE ET AL., MOL. CELL, (2012), vol. 45, page 292 | - |
| DESCRIPTION | - CROOKE ET AL., J. PHARMACOL. EXP. THER., (1996), vol. 277, pages 923 - 937 | - |
| DESCRIPTION | - DANIELI ET AL., NAT. BIOTECHNOL, (1998), vol. 16, pages 345 - 348 | - |
| DESCRIPTION | - D. BHAYA; M. DAVISON; R. BARRANGOU, ANNU. REV. GENET., (2011), vol. 45, page 273 | - |
| DESCRIPTION | - D. CARROLL, GENE THER, (2008), vol. 15, page 1463 | - |
| DESCRIPTION | - D. G. SASHITAL; B. WIEDENHEFT; J. A. DOUDNA, MOL. CELL, (2012), vol. 46, page 606 | - |
| DESCRIPTION | - D. G. SASHITAL; M. JINEK; J. A. DOUDNA, NAT. STRUCT. MOL. BIOL., (2011), vol. 18, page 680 | - |
| DESCRIPTION | - DOHMEN ET AL., SCIENCE, (1994), vol. 263, no. 5151, pages 1273 - 1276 | - |
| DESCRIPTION | - DWAINE A. BRAASCH; DAVID R. COREY, BIOCHEMISTRY, (2002), vol. 41, no. 14, pages 4503 - 4510 | - |
| DESCRIPTION | - E. DELTCHEVA ET AL., NATURE, (2011), vol. 471, page 602 | - |
| DESCRIPTION | - E. M. GESNER; M. J. SCHELLENBERG; E. L. GARSIDE; M. M. GEORGE; A. M. MACMILLAN, NAT. STRUCT. MOL. BIOL., (2011), vol. 18, page 688 | - |
| DESCRIPTION | - ENGLISCH ET AL., ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, (1991), vol. 30, page 613 | - |
| DESCRIPTION | - E. R. WESTRA ET AL., MOL. CELL, (2012), vol. 46, page 595 | - |
| DESCRIPTION | - E. SEMENOVA ET AL., PROC. NATL. ACAD. SCI. U.S.A., (2011), vol. 108, page 10098 | - |
| DESCRIPTION | - F. D. URNOV; E. J. REBAR; M. C. HOLMES; H. S. ZHANG; P. D. GREGORY, NAT. REV. GENET, (2010), vol. 11, page 636 | - |
| DESCRIPTION | - F. J. M. MOJICA; C. DIEZ-VILLASENOR; J. GARCIA-MARTINEZ; C. ALMENDROS, MICROBIOLOGY, (2009), vol. 155, page 733 | - |
| DESCRIPTION | - FLANNERY ET AL., PNAS, (1997), vol. 94, pages 6916 - 6921 | - |
| DESCRIPTION | - FLOTTE ET AL., PNAS, (1993), vol. 90, pages 10613 - 10617 | - |
| DESCRIPTION | - FRANZ ET AL., CARDIOVASC. RES., (1997), vol. 35, pages 560 - 566 | - |
| DESCRIPTION | - FUTAKI ET AL., CURR PROTEIN PEPT SCI., (200304), vol. 4, no. 2, pages 87 - 9,446 | - |
| DESCRIPTION | - GAMA ET AL., BRAIN STRUCT FUNCT., (20091125), vol. 214, no. 2-3 | - |
| DESCRIPTION | - G. HUTVAGNER; M. J. SIMARD, NAT. REV. MOL. CELL BIOL., (2008), vol. 9, page 22 | - |
| DESCRIPTION | - G. K. TAYLOR; D. F. HEITER; S. PIETROKOVSKI; B. L. STODDARD, NUCLEIC ACIDS RES., (2011), vol. 39, page 9705 | - |
| DESCRIPTION | - GORDON-KAMM, PLANT CELL, (1990), vol. 2, pages 603 - 618 | - |
| DESCRIPTION | - GREUSSING ET AL., "Monitoring of ubiquitin-proteasome activity in living cells using a Degron (dgn)-destabilized green fluorescent protein (GFP)-based reporter protein", J VIS EXP., (20121110), no. 69 | - |
| DESCRIPTION | - H. DEVEAU ET AL., J. BACTERIOL., (2008), vol. 190, page 1390 | - |
| DESCRIPTION | - HERRERA-ESTRELLA ET AL., NATURE, (1983), vol. 303, page 209 | - |
| DESCRIPTION | - HUNTER ET AL., HYPERTENSION, (1993), vol. 22, pages 608 - 617 | - |
| DESCRIPTION | - HUSAINI ET AL., GM CROPS., (20110601), vol. 2, no. 3, pages 150 - 62 | - |
| DESCRIPTION | - I. L. HOFACKER; P. F. STADLER, "Memory efficient folding algorithms for circular RNA secondary structures", BIOINFORMATICS, (2006), vol. 22, page 1172 | - |
| DESCRIPTION | - ISHIDA ET AL., NATURE BIOTECH, (1996), vol. 14, pages 745 - 750 | - |
| DESCRIPTION | - J. A. L. HOWARD; S. DELMAS; I. IVANCIC-BACE; E. L. BOLT, BIOCHEM. J., (2011), vol. 439, page 85 | - |
| DESCRIPTION | - J. AM. CHEM. SOC., (2000), vol. 122, pages 8595 - 8602 | - |
| DESCRIPTION | - J. BIOL. CHEM. | - |
| DESCRIPTION | - J. CARTE; R. WANG; H. LI; R. M. TERNS; M. P. TERNS, GENES DEV, (2008), vol. 22, page 3489 | - |
| DESCRIPTION | - J. C. MILLER ET AL., NAT. BIOTECHNOL., (2011), vol. 29, page 143 | - |
| DESCRIPTION | - J. E. GARNEAU ET AL., NATURE, (2010), vol. 468, page 67 | - |
| DESCRIPTION | - JOMARY ET AL., GENE THER, (1997), vol. 4, pages 683 - 690 | - |
| DESCRIPTION | - J. ZHANG ET AL., MOL. CELL, (2012), vol. 45, page 303 | - |
| DESCRIPTION | - KABANOV ET AL., FEBS LETT, (1990), vol. 259, pages 327 - 330 | - |
| DESCRIPTION | - KANEDA ET AL., NEURON, (1991), vol. 6, pages 583 - 594 | - |
| DESCRIPTION | - KAWAI ET AL., "Transformation of Saccharomyces cerevisiae and other fungi: methods and possible underlying mechanism", BIOENG BUGS, (201011), vol. 1, no. 6, pages 395 - 403 | - |
| DESCRIPTION | - K. DARTY; A. DENISE; Y. PONTY, "Interactive drawing and editing of the RNA secondary structure", BIOINFORMATICS, (2009), vol. 25, page 1974 | - |
| DESCRIPTION | - KIM ET AL., MOL. CELL. BIOL., (1997), vol. 17, pages 2266 - 2278 | - |
| DESCRIPTION | - KITA ET AL., BIOCHEM. BIOPHYS. RES. COMM., (2005), vol. 331, page 484 | - |
| DESCRIPTION | - KLEE, BIO/TECHNOLO, (1985), vol. 3, pages 637 - 642 | - |
| DESCRIPTION | - KLEIN ET AL., NATURE, (1987), vol. 327, pages 70 - 73 | - |
| DESCRIPTION | - KNIGHT ET AL., PROC. NATL. ACAD. SCI. USA, (2003), vol. 100, page 14725 | - |
| DESCRIPTION | - KNOBLAUCH ET AL., NAT. BIOTECHNOL, vol. 17, pages 906 - 909 | - |
| DESCRIPTION | - KOSHIMIZU, U. ET AL., DEVELOPMENT, (1996), vol. 122, page 1235 | - |
| DESCRIPTION | - KOSHKIN ET AL., TETRAHEDRON, (1998), vol. 54, pages 3607 - 3630 | - |
| DESCRIPTION | - KROSCHWITZ, J. I.,, The Concise Encyclopedia Of Polymer Science And Engineering, JOHN WILEY & SONS, pages 858 - 859 | - |
| DESCRIPTION | - K. S. MAKAROVA ET AL., NAT. REV. MICROBIOL., (2011), vol. 9, page 467 | - |
| DESCRIPTION | - K. S. MAKAROVA; L. ARAVIND; Y. I. WOLF; E. V. KOONIN, BIOL. DIRECT, (2011), vol. 6, page 38 | - |
| DESCRIPTION | - K. S. MAKAROVA; N. V. GRISHIN; S. A. SHABALINA; Y. I. WOLF; E. V. KOONIN, BIOL. DIRECT, (2006), vol. 1, page 7 | - |
| DESCRIPTION | - KURIKI ET AL., BIOL. PHARM. BULL, (2002), vol. 25, page 1476 | - |
| DESCRIPTION | - KURIKI ET AL., BIOL. PHARM. BULL., (2002), vol. 25, page 1476 | - |
| DESCRIPTION | - L. A. MARRAFFINI; E. J. SONTHEIME, NATURE, (2010), vol. 463, page 568 | - |
| DESCRIPTION | - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533 | - |
| DESCRIPTION | - LETSINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 6553 - 6556 | - |
| DESCRIPTION | - LIBERMAN; 2012 MAY ET AL., WILEY INTERDISCIP REV RNA, vol. 3, no. 3, pages 369 - 84 | - |
| DESCRIPTION | - LIBERMAN ET AL., WILEY INTERDISCIP REV RNA, (201205), vol. 3, no. 3, pages 369 - 84 | - |
| DESCRIPTION | - LI; DAVIDSON, PNAS, (1995), vol. 92, pages 7700 - 7704 | - |
| DESCRIPTION | - LI ET AL., INVEST OPTHALMOL VIS SCI, (1994), vol. 35, pages 2543 - 2549 | - |
| DESCRIPTION | - LI ET AL., J. CELL BIOL., (1996), vol. 132, pages 849 - 859 | - |
| DESCRIPTION | - LINN ET AL., CIRC. RES., (1995), vol. 76, pages 584 - 591 | - |
| DESCRIPTION | - LIU ET AL., GENE THERAPY, (2004), vol. 11, pages 52 - 60 | - |
| DESCRIPTION | - LLEWELLYN ET AL., NAT. MED., (2010), vol. 16, no. 10, pages 1161 - 1166 | - |
| DESCRIPTION | - MANOHARAN ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 660, pages 306 - 309 | - |
| DESCRIPTION | - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1993), vol. 3, pages 2765 - 2770 | - |
| DESCRIPTION | - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1994), vol. 4, pages 1053 - 1060 | - |
| DESCRIPTION | - MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, (1995), vol. 14, pages 969 - 973 | - |
| DESCRIPTION | - MANOHARAN ET AL., TETRAHEDRON LETT., (1995), vol. 36, pages 3651 - 3654 | - |
| DESCRIPTION | - MARTIN ET AL., HELV. CHIM. ACTA, (1995), vol. 78, pages 486 - 504 | - |
| DESCRIPTION | - MASON ET AL., ENDOCRINOL, (1998), vol. 139, page 101 | - |
| DESCRIPTION | - MASON ET AL., ENDOCRINOL., (1998), vol. 139, page 1013 | - |
| DESCRIPTION | - MATSUI, Y. ET AL., CELL, (1992), vol. 70, page 841 | - |
| DESCRIPTION | - MAYFORD ET AL., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, page 13250 | - |
| DESCRIPTION | - MCBRIDE ET AL., PROC. NATI. ACAD. SCI. USA, (1994), vol. 91, pages 7301 - 7305 | - |
| DESCRIPTION | - M. CHRISTIAN ET AL., GENETICS, (2010), vol. 186, page 757 | - |
| DESCRIPTION | - MENDELSON ET AL., VIROL., (1988), vol. 166, pages 154 - 165 | - |
| DESCRIPTION | - M. G. CAPARON; J. R. SCOTT, "Genetic manipulation of pathogenic streptococci", METHODS ENZYMOL., (1991), vol. 204, page 556 | - |
| DESCRIPTION | - MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, (1995), vol. 1264, pages 229 - 237 | - |
| DESCRIPTION | - MIYAGISHI ET AL., NATURE BIOTECHNOLOGY, (2002), vol. 20, pages 497 - 500 | - |
| DESCRIPTION | - MIYOSHI ET AL., PNAS, (1997), vol. 94, pages 10319 - 23 | - |
| DESCRIPTION | - MOESSLER ET AL., DEVELOPMENT, (1996), vol. 122, pages 2415 - 2425 | - |
| DESCRIPTION | - MORRISON ET AL., CELL, (1997), vol. 88, pages 287 - 298 | - |
| DESCRIPTION | - M. P. TERNS; R. M. TERNS, CURR. OPIN. MICROBIOL., (2011), vol. 14, page 321 | - |
| DESCRIPTION | - NAKAMURA ET AL., GENES CELLS, (201205), vol. 17, no. 5, pages 344 - 64 | - |
| DESCRIPTION | - NAT. | - |
| DESCRIPTION | - NEHLS ET AL., SCIENCE, (1996), vol. 272, pages 886 - 889 | - |
| DESCRIPTION | - N. G. LINTNER ET AL., J. BIOL. CHEM., (2011), vol. 286, page 21643 | - |
| DESCRIPTION | - NICOUD ET AL., J. GENE MED., (2007), vol. 9, page 1015 | - |
| DESCRIPTION | - NOGUCHI ET AL., DIABETES, (2003), vol. 52, no. 7, pages 1732 - 1737 | - |
| DESCRIPTION | - OBERDICK ET AL., SCIENCE, (1990), vol. 248, pages 223 - 226 | - |
| DESCRIPTION | - OBERHAUSE ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 533 - 538 | - |
| DESCRIPTION | - OH ET AL., GENE THER, (2009), vol. 16, page 437 | - |
| DESCRIPTION | - O'NEILL ET AL., PLANT J., (1993), vol. 3, pages 729 - 738 | - |
| DESCRIPTION | - PARMACEK ET AL., MOL. CELL. BIOL., (1994), vol. 14, pages 1870 - 1885 | - |
| DESCRIPTION | - PAVJANI ET AL., NAT. MED., (2005), vol. 11, page 797 | - |
| DESCRIPTION | - PLATT ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, page 7490 | - |
| DESCRIPTION | - PROC. NATL. ACAD. SCI. USA | - |
| DESCRIPTION | - RADOVICK ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 3402 - 3406 | - |
| DESCRIPTION | - R. BARRANGOU ET AL., SCIENCE, (2007), vol. 315, page 1709 | - |
| DESCRIPTION | - R. B. DENMAN, "Using RNAFOLD to predict the activity of small catalytic RNAs", BIOTECHNIQUES, (1993), vol. 15, page 1090 | - |
| DESCRIPTION | - R. E. HAURWITZ; M. JINEK; B. WIEDENHEFT; K. ZHOU; J. A. DOUDNA, SCIENCE, (2010), vol. 329, page 1355 | - |
| DESCRIPTION | - ROBBINS ET AL., ANN. N.Y. ACAD. SCI., (1995), vol. 752, pages 492 - 505 | - |
| DESCRIPTION | - ROLLING ET AL., HUM GENE THER, (1999), vol. 10, pages 641 - 648 | - |
| DESCRIPTION | - ROSS ET AL., PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, page 9590 | - |
| DESCRIPTION | - R. SAPRANAUSKAS ET AL., NUCLEIC ACIDS RES., (2011), vol. 39, page 9275 | - |
| DESCRIPTION | - R. WANG; G. PREAMPLUME; M. P. TERNS; R. M. TERNS; H. LI, STRUCTURE, (2011), vol. 19, page 257 | - |
| DESCRIPTION | - SAISON-BEHMOARAS ET AL., EMBO J., (1991), vol. 10, pages 1111 - 1118 | - |
| DESCRIPTION | - SAKAMOTO ET AL., H GENE THER, (1999), vol. 5, pages 1088 - 1097 | - |
| DESCRIPTION | - SAMULSKI ET AL., J. VIR, (1989), vol. 63, pages 3822 - 3828 | - |
| DESCRIPTION | - SAMULSKI ET AL., J. VIR., (1989), vol. 63, pages 3822 - 3828 | - |
| DESCRIPTION | - SANGHVI ET AL.,, Antisense Research and Applications, CRC PRESS, (1993), pages 276 - 278 | - |
| DESCRIPTION | - SANGHVI, Y. S., Antisense Research and Applications, CRC PRESS, (1993), pages 289 - 302 | - |
| DESCRIPTION | - SARTORELLI ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 4047 - 4051 | - |
| DESCRIPTION | - SASAOKA ET AL., MOL. BRAIN RES., (1992), vol. 16, page 274 | - |
| DESCRIPTION | - SATO ET AL., J. BIOL. CHEM., (2002), vol. 277, page 15703 | - |
| DESCRIPTION | - SCHOEBER ET AL., "Conditional fast expression and function of multimeric TRPV5 channels using Shield-1", AM J PHYSIOL RENAL PHYSIOL., (200901), vol. 296, no. 1, pages F204 - 11 | - |
| DESCRIPTION | - SEO ET AL., MOLEC. ENDOCRINOL, (2003), vol. 17, page 1522 | - |
| DESCRIPTION | - SEO ET AL., MOLEC. ENDOCRINOL., (2003), vol. 17, page 1522 | - |
| DESCRIPTION | - S. GOTTESMAN, NATURE, (2011), vol. 471, page 588 | - |
| DESCRIPTION | - SHAMBLOTT ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, page 13726 | - |
| DESCRIPTION | - SHAMBLOTT, M. ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, page 13726 | - |
| DESCRIPTION | - SHAMBLOTT, M. ET AL., PROC. NATL. ACAD. SCI. USA, (2001), vol. 98, page 113 | - |
| DESCRIPTION | - SHEA ET AL., NUCL. ACIDS RES., (1990), vol. 18, pages 3777 - 3783 | - |
| DESCRIPTION | - SINGH ET AL., CHEM. COMMUN., (1998), vol. 4, pages 455 - 456 | - |
| DESCRIPTION | - S. J. J. BROUNS ET AL., SCIENCE, (2008), vol. 321, page 960 | - |
| DESCRIPTION | - SMITH; WATERMAN, ADV. APPL. MATH., (1981), vol. 2, pages 482 - 489 | - |
| DESCRIPTION | - STAUB ET AL., NAT. BIOTECHNOL, (2000), vol. 18, pages 333 - 338 | - |
| DESCRIPTION | - SVAB ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 913 - 917 | - |
| DESCRIPTION | - SVINARCHUK ET AL., BIOCHIMIE, (1993), vol. 75, pages 49 - 54 | - |
| DESCRIPTION | - TABOR ET AL., J. BIOL. CHEM., (1999), vol. 274, page 20603 | - |
| DESCRIPTION | - TAKAHASHI, CELL, (20071130), vol. 131, no. 5, pages 861 - 72 | - |
| DESCRIPTION | - TAKAHASHI ET AL., J VIROL, (1999), vol. 73, pages 7812 - 7816 | - |
| DESCRIPTION | - TAKAHASHI, NAT PROTOC., (2007), vol. 2, no. 12, pages 3081 - 9 | - |
| DESCRIPTION | - TANKA ET AL., "Conformational variations in an infectious protein determine prion strain differences", NATURE, (20040318), vol. 428, no. 6980, pages 323 - 8 | - |
| DESCRIPTION | - THOMSON ET AL., BIOL. REPROD., (1996), vol. 55, page 254 | - |
| DESCRIPTION | - THOMSON ET AL., PROC. NATL. ACAD. SCI USA, (1995), vol. 92, page 7844 | - |
| DESCRIPTION | - THOMSON ET AL., SCIENCE, (1998), vol. 282, page 1145 | - |
| DESCRIPTION | - THOMSON, SCIENCE, (19981106), vol. 282, no. 5391, pages 1145 - 7 | - |
| DESCRIPTION | - TOZZO ET AL., ENDOCRINOL, (1997), vol. 138, page 1604 | - |
| DESCRIPTION | - TOZZO ET AL., ENDOCRINOL., (1997), vol. 138, page 1604 | - |
| DESCRIPTION | - TREHIN ET AL., PHARM. RESEARCH, (2004), vol. 21, pages 1248 - 1256 | - |
| DESCRIPTION | - VASIL, BIO/TECHNOLO, (1993), vol. 10, pages 667 - 674 | - |
| DESCRIPTION | - VAVALLE ET AL., FUTURE CARDIOL., (201205), vol. 8, no. 3, pages 371 - 82 | - |
| DESCRIPTION | - WAHLESTEDT ET AL., PROC. NATL. ACAD. SCI. U.S.A., (2000), vol. 97, pages 5633 - 5638 | - |
| DESCRIPTION | - WAN; LEMEAUX, PLANT PHYSIOL, (1994), vol. 104, pages 37 - 48 | - |
| DESCRIPTION | - WEEKS ET AL., PLANT PHYSIOL, (1993), vol. 102, pages 1077 - 1084 | - |
| DESCRIPTION | - WENDER ET AL., PROC. NATL. ACAD. SCI. U.S.A, (20001121), vol. 97, no. 24, pages 13003 - 8 | - |
| DESCRIPTION | - WENDER ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 13003 - 13008 | - |
| DESCRIPTION | - XIA ET AL., NUCLEIC ACIDS RES., (20030901), vol. 31, no. 17 | - |
| DESCRIPTION | - YANG ET AL., "Titivated for destruction: the methyl degron", MOL CELL, (20121130), vol. 48, no. 4, pages 487 - 8 | - |
| DESCRIPTION | - YOKOYAMA ET AL., EXP EYE RES., (1992), vol. 55, page 225 | - |
| DESCRIPTION | - YOUNG ET AL., OPHTHALMOL. VIS. SCI., (2003), vol. 44, page 4076 | - |
| DESCRIPTION | - YU, SCIENCE, (20071120), vol. 318, no. 5858, pages 1917 - 20 | - |
| DESCRIPTION | - ZENDER ET AL., CANCER GENE THER., (2002), vol. 9, no. 6, pages 489 - 96 | - |
| DESCRIPTION | - ZHANG; MADDEN, GENOME RES., (1997), vol. 7, pages 649 - 656 | - |
| OPPOSITION | - AGUIRRE et al., "Genomic Copy Number Dictates a Gene -Independent Cell Response to CRISPR/Cas9 Targeting", Cancer Discovery, (20160000), vol. 6, pages 914 - 929, XP055464135 | - |
| OPPOSITION | - Alberts B; Et Al, "Chapter 12. Intracellular compartments and protein sorting", Molecular Biology of the cell. 4th ed,, Garland Science, pages 671 - 676, XP055486976 | - |
| OPPOSITION | - Bruce Alberts, "Molecular Biology of the Cell, 4th ed. (passage)", Molecular Biology of the Cell, (20020000), pages 401 - 402, XP055339982 | - |
| OPPOSITION | - "Cheap and easy technique to snip DNA could revolutionize gene therapy", Berkeley News, (20130107), URL: http://news.berkeley.edu/2013/01/07/cheap-and-easy-technique-to-snip-dna-could-revolutionize-ene-thera, XP055206730 | - |
| OPPOSITION | - Deltcheva, "Supplementary Information to CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110331), pages 1 - 35, XP055458423 | - |
| OPPOSITION | - FIECK et al., "Modifications of the E.coli Lac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear accumulation", Nucl. Acids Res., (19920000), vol. 29, pages 1785 - 1791, XP002095852 | - |
| OPPOSITION | - HALL et al., "Effects of inert volume-excluding macromolecules on protein fiber formation. I. Equilibrium models", Biophys. Chem., (20020000), vol. 98, pages 93 - 104, XP055464108 | - |
| OPPOSITION | - KIMCHI-SARFATY et al., "A 'Silent' Polymorphism in the MDR1 Gene Changes Substrate Specificity", Science, (20070000), vol. 315, pages 525 - 528, XP055464126 | - |
| OPPOSITION | - KLUG, A., "The discovera of zink fingers and their applications in gene regulation and genome manipulation", Annu. Rev. Biochem., (20100000), vol. 79, pages 213 - 231, XP055536590 | - |
| OPPOSITION | - "Method of the Year 2011", Nature Methods, (20120100), vol. 9, no. 1, page 1, XP055543411 | - |
| OPPOSITION | - MOHR et al., "Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences", Genes & Development, (20000000), vol. 14, pages 559 - 573, XP055464117 | - |
| OPPOSITION | - MOSCOU, MJ et al., "A simple cipher governs DNA recognition TAL effectors", Science, (20090000), vol. 326, page 1501, XP002599998 | - |
| OPPOSITION | - PANDIKA, "Jennifer Doudna, CRISPR code killer", (20140107), URL: http://www.ozy.com/fast-forward/ill-fitting-genes/1261, XP003035502 | - |
| OPPOSITION | - PANDIKA, "Jennifer Doudna, CRISPR Code Killer", ozy, (20140107), URL: www.ozy.com/rising -stars-and-provocateurs/j ennifer-doudna-crispr-code- killer/4690, XP003035502 | - |
| OPPOSITION | - Rabuka et al., "Genomics redux", Catalyst Magazine, (20140000), vol. 9, no. 1, pages 18 - 20, XP055538309 | - |
| OPPOSITION | - Sanders R., "Cheap and easy technique to snip DNA could revolutionize gene therapy", UC Berkeley Press Release, pages 1 - 3, URL: http://newscenter.berkelev.edu/2013/01/07/cheap-and-easy-technique-to- snip-dna-could-revolutionize-eene-therapy, XP055543406 | - |
| OPPOSITION | - Stedman's Medical Dictionary, (20000000), page 601 | - |
| OPPOSITION | - VAN DEN BERG et al., "Effects of macromolecular crowding on protein folding and aggregation", EMBO J., (19990000), vol. 18, no. 24, pages 6827 - 6933, XP055464113 | - |
| OPPOSITION | - MAERTENS et al., "Gene optimization mechanisms: a multi- gene study reveals a high success rate of full-length human proteins expressed in Escherichia coli", Protein Sci., (20100000), vol. 19, pages 1312 - 1326, XP055441307 | |
| OPPOSITION | - FEIL et al., "Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains", Biochem. Biophys. Res. Commun., (19970000), vol. 237, pages 752 - 757, XP026088101 | |
| OPPOSITION | - CORBI et al., "Chapter 9 Synthetic Zinc Finger Transcription Factors", Zinc finger proteins, (20050000), XP055344640 | |
| OPPOSITION | - CORBI et al., "Chapter 9 ynthetic Zinc Finger Transcription Factors", Zinc finger proteins: from atomic contact to cellular function, Landes Bioscience, (20050000), pages 47 - 55, XP055344640 | |
| OPPOSITION | - XU et al., "Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus", Cell . Mol. Life Sci., (20140000), vol. 72, no. 2, pages 383 - 399, XP035419503 | |
| OPPOSITION | - MOJICA, F.J. et al., "Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements", J. Mol. Evol., (20050000), vol. 60, pages 174 - 182, XP019363173 | |
| OPPOSITION | - MAHFOUZ et al., "Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein", Plant Mol. Biol., (20120000), vol. 78, pages 311 - 321, XP035003111 | |
| OPPOSITION | - MAHFOUZ et al., "Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein", Plant Molecular Biology, (20120000), vol. 78, no. 3, pages 311 - 321, XP035003111 | |
| OPPOSITION | - LI et al., "Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification", Plant Mol. Biol., (20120000), vol. 78, pages 407 - 416, XP035014466 | |
| OPPOSITION | - HALL et al., "Effects of inert volume-excluding macromolecules on protein fiber formation. II. Kinetic models for nucleated fiber growth", Biophys. Chem., (20040000), vol. 107, pages 299 - 316, XP055464109 | |
| OPPOSITION | - QI et al., "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", Cell, (20130000), vol. 152, no. 5, pages 1173 - 1183, XP055299671 | |
| OPPOSITION | - QI, L. S. et al., "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", Cell, (20130000), vol. 152, pages 1173 - 1183, XP055299671 | |
| OPPOSITION | - NISHIMASU et al., "Crystal structure of Cas9 in complex with guide RNA and target DNA", Cell, (20140000), vol. 1565, pages 935 - 949, XP055423859 | |
| OPPOSITION | - NISHIMASU et al., "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA", Cell, (20140000), vol. 156, no. 5, pages 935 - 949, XP028622533 | |
| OPPOSITION | - BURNETT et al., "RNA-based therapeutics: current progress and future prospects", Chemistry & Biology, (20120000), vol. 19, pages 60 - 71, XP055087578 | |
| OPPOSITION | - PAPWORTH et al., "Designer zinc-finger proteins and their applications", Gene, (20060000), vol. 366, no. 1, pages 27 - 38, XP005282076 | |
| OPPOSITION | - MEI et al., "Recent Progress in CRISPR/Cas9 Technology", J. Genetics and Genomics, (20160000), vol. 43, pages 63 - 75, XP029434259 | |
| OPPOSITION | - MEI, YUE et al., "Recent Progress in CRISPR/Cas9 Technology", Genomics, (20160000), vol. 43, pages 63 - 72, XP029434259 | |
| OPPOSITION | - MA et al., "Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes", Molecular Cell, (20150000), vol. 60, pages 398 - 407, XP055448872 | |
| OPPOSITION | - LEENAY et al., "Identifying and Visualizing Functional PAM Diversity across CRISPR- Cas Systems", Mol. Cell, (20160000), vol. 62, pages 1 - 11, XP029496719 | |
| OPPOSITION | - LEENAY et al., "Identifying and visualizing functional PAM diversity across CRISPR-Cas systems", Molecular Cell, (20160000), vol. 61, pages 1 - 11, XP029496719 | |
| OPPOSITION | - LEENAY et al., "Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems", Molecular Cell, (20160000), vol. 62, pages 137 - 147, XP029496719 | |
| OPPOSITION | - MAURO et al., "A critical analysis of codon optimization in human therapeutics", Trends Mol Med., (20140000), vol. 20, no. 11, pages 604 - 613, XP055391316 | |
| OPPOSITION | - Syandan Chakraborty et al, "A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification", STEM CELL REPORTS, (20141201), vol. 3, no. 6, pages 940 - 947, XP055389295 | |
| OPPOSITION | - GAJ et al., "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering", Trends in Biotechnology, (20130000), vol. 31, no. 7, pages 397 - 405, XP028571313 | |
| OPPOSITION | - SNOWDEN A. W. et al., "Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo", Curr. Biol., (20021221), vol. 12, no. 24, pages 2159 - 2166, XP009157323 | |
| OPPOSITION | - SNOWDEN et al., "Gene -specific targeting of H3K9 methylation is sufficient for initiating repression in vivo", Current biology, (20020000), vol. 12, pages 2159 - 2166, XP009157323 | |
| OPPOSITION | - SNOWDEN et al., "Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo", Current Biology, (20020000), vol. 1, no. 24, pages 2159 - 2166, XP009157323 | |
| OPPOSITION | - MARTIN, "Requirement for GroEL/GroES-Dependent Protein Folding under Nonpermissive Conditions of Macromolecular Crowding", Biochemistry, (20020000), vol. 41, pages 5050 - 5055, XP055464111 | |
| OPPOSITION | - NOMURA et al., "In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase", J. Am. Chem. Soc., (20070000), vol. 129, pages 8676 - 8677, XP055344661 | |
| OPPOSITION | - NOMURA et al., "In Vivo Site-Specific DNA Methylation with a Designed Sequence-Enabled DNA Methylase", Journal of the American Chemical Society, (20070000), vol. 129, no. 28, pages 8676 - 8677, XP055344661 | |
| OPPOSITION | - CARROLL, D., "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Ther., (20080000), vol. 15, no. 22, pages 1463 - 1468, XP055041104 | |
| OPPOSITION | - CARROLL, "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Ther., (20080000), vol. 15, pages 1463 - 1468, XP055041104 | |
| OPPOSITION | - ESVELT et al., "Genome-scale engineering for systems and synthetic biology", Molecular Systems Biol, (20130901), vol. 641, pages 1 - 17, XP055339996 | |
| OPPOSITION | - ESVELT et al., "Genome-scale engineering for systems and synthetic biology", Molecular Systems Biology, (20130000), vol. 9, pages 1 - 17, XP055339996 | |
| OPPOSITION | - ESVELT KM et al., "Genome-scale engineering for systems and synthetic biology", Molecular Systems Biology, (20130000), vol. 9, no. 641, pages 1 - 17, XP055339996 | |
| OPPOSITION | - CARROLL, "A CRISPR Approach to Gene Targeting", Molecular Therapy, vol. 20, no. 9, pages 1658 - 1660, XP055106489 | |
| OPPOSITION | - DELTCHEVA, E. et al., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110000), vol. 471, pages 602 - 607, XP055308803 | |
| OPPOSITION | - DELTCHEVA et al., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110000), vol. 471, pages 602 - 607+ 2, XP055308803 | |
| OPPOSITION | - DELTCHEVA et al., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110000), vol. 471, pages 602 - 607, XP055068535 | |
| OPPOSITION | - ANDERS et al., "Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease", Europe PMC Funders Group Author Manuscript, (20140925), vol. 513, no. 7519, pages 1 - 22, XP055538018 | |
| OPPOSITION | - ANDERS et al., "Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease", Nature, (20140000), vol. 513, pages 569 - 573, XP055240929 | |
| OPPOSITION | - RAN et al., "In vivo genome editing using Staphylococcus aureus Cas9", Nature, (20150000), vol. 520, pages 186 - 191, XP055206733 | |
| OPPOSITION | - MILLER et al., "A TALE nuclease architecture for efficient genome editing", Nat. Biotechnol., (20110000), vol. 29, pages 143 - 150, XP002685898 | |
| OPPOSITION | - MILLER, J.C. et al., "A TALE nuclease architecture for efficient genome editing", Nat. Biotechnol., (20110000), vol. 29, pages 143 - 150, XP002685898 | |
| OPPOSITION | - ZHANG et al., "Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription", Nat. Biotechnol., (20110000), vol. 29, pages 149 - 153, XP055005146 | |
| OPPOSITION | - ZHANG et al., "Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription", Nature Biotechnology advance online publication, (20110000), vol. 29, no. 2, pages 1 - 6, XP055458270 | |
| OPPOSITION | - BARRANGOU, "RNA-mediated programmable DNA cleavage", Nat. Biotechnol., (20120000), vol. 30, no. 9, pages 836 - 838, XP055118675 | |
| OPPOSITION | - HWANG et al., "Efficient In Vivo Genome Editing Using RNA-Guided Nucleases", HHS Public Access Author Manuscript, (20130000), vol. 31, pages 1 - 12, XP055538294 | |
| OPPOSITION | - CHO et al., "Targeted genome engineering in human cells with the Cas9 RNA- guided endonuclease", Nat. Biotechnol., (20130000), vol. 313, pages 230 - 232, XP002699850 | |
| OPPOSITION | - MALI, P. et al., "CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering", Nat Biotechnol, (20130000), vol. 31, doi:10.1038/nbt.2675, pages 833 - 838, XP055294730 | |
| OPPOSITION | - GUILINGER, J. et al., "Fusion of catalytically inactive Cas9 to Fokl nuclease improves the specificity of genome modification", Nat Biotechnol, (20140000), vol. 32, doi:10.1038/nbt.2909, pages 577 - 582, XP055157221 | |
| OPPOSITION | - CONG et al., "Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains", Nature Commun, (20120000), vol. 3, pages 1 - 9, XP002700145 | |
| OPPOSITION | - CONG et al., "Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains", Nature Communications, (20120000), vol. 3, pages 1 - 6, XP002700145 | |
| OPPOSITION | - CONG, L. et al., "Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains", Nature Comm, (20120000), vol. 3, no. 968, pages 1 - 6, XP002700145 | |
| OPPOSITION | - CHAVEZ, A. et al., "Highly efficient Cas9-mediated transcriptional programming", Nat Methods, (20150000), vol. 12, doi:10.1038/nmeth.3312, pages 326 - 328, XP055694813 | |
| OPPOSITION | - SANJANA et al., "A Transcription Activator-Like Effector (TALE) Toolbox for Genome Engineering", Nat. Proto., (20110000), vol. 7, pages 171 - 192, XP009170390 | |
| OPPOSITION | - SANJANA et al., "A transcription activator-like effector toolbox for genome engineering", Nature Protocols, (20120000), vol. 7, no. 1, pages 171 - 192, XP009170390 | |
| OPPOSITION | - SANJANA, N. E. et al., "A transcription activator-like effector toolbox for genome engineering", Nature Prot., (20120000), vol. 7, no. 1, pages 171 - 192, XP009170390 | |
| OPPOSITION | - URNOV et al., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Genet., (20100000), vol. 11, pages 636 - 646, XP008150557 | |
| OPPOSITION | - URNOV, F. D. et al., "Genome editing with engineered zinc finger nucleases", Nature Rev. Genet., (20101106), pages 636 - 646, XP055198280 | |
| OPPOSITION | - URNOV, F. et al., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Gene, (20100000), vol. 11, pages 636 - 646, XP055198280 | |
| OPPOSITION | - DOMINGUEZ et al., "Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation", Nat. Rev. Mol. Cell . Biol., (20160000), vol. 17, pages 5 - 15, XP055345154 | |
| OPPOSITION | - JOUNG et al., "TALENS: a widely applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., (20120000), vol. 14, pages 49 - 55, XP055282847 | |
| OPPOSITION | - JOUNG et al, "'TALENS: A WIDELY APPLICABLE TECHNOLOGY FOR TARGETED GENOME EDITING", Nat. Rev. Mol. Cell . Biol., (20130100), vol. 14, no. 1, pages 49 - 55, XP055282847 | |
| OPPOSITION | - JOUNG et al., "TALENs: a widely applicable technology for targeted genome editing", Nature Rev. Mol Cell Biol., (20130100), vol. 14, no. 1, pages 49 - 55, XP055282847 | |
| OPPOSITION | - JOUNG, J. et al., "TALENs: a widely applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., (20120000), vol. 14, pages 49 - 55, XP055282847 | |
| OPPOSITION | - MAKAROVA, K.S. et al., "An Updated Evolutionary Classification of CRISPR- Cas Systems", Nature, (20150000), vol. 13, pages 722 - 736, XP055271841 | |
| OPPOSITION | - BEERLI et al., "Positive and negative regulation of endogenous genes by designed transcription factors", PNAS, (20000000), vol. 97, no. 4, pages 1495 - 1500, XP001050653 | |
| OPPOSITION | - BEERLI et al., "Positive and negative regulation of endogenous genes by designed transcription factors", PNAS, (20000000), vol. 97, pages 1495 - 1500, XP002188512 | |
| OPPOSITION | - BEERLI, R. R. et al., "POSITIVE AND NEGATIVE REGULATION OF ENDOGENOUS GENES BY DESIGNED TRANSCRIPTION FACTORS", Proc. Natl. Acad. Sci. USA, (20000000), vol. 97, pages 1495 - 1500, XP001050653 | |
| OPPOSITION | - GRYLLOS et al., "The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+", PNAS, (20030000), vol. 100, pages 4227 - 4232, XP055464121 | |
| OPPOSITION | - GORDLEY et al., "Synthesis of programmable integrases", PNAS, (20090000), vol. 106, no. 13, pages 5053 - 5058, XP002544501 | |
| OPPOSITION | - GORDLEY et al., "Synthesis of programmable integrases", PNAS, (20090000), vol. 106, pages 5053 - 5058, XP002544501 | |
| OPPOSITION | - GORDLEY, R. M. et al., "Synthesis of programmable integrases", Proc. Natl. Acad. Sci. USA, (20090000), vol. 106, no. 13, pages 5053 - 5058, XP002544501 | |
| OPPOSITION | - GASIUNAS et al., "Cas9-crRNA ribonucleoprotein complex mediates specif- ic DNA cleavage for adaptive immunity in bacteria", PNAS, (20120000), vol. 109, no. 39, pages E2579 - E2586, XP055068588 | |
| OPPOSITION | - GASIUNAS et al., "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PNAS, (20120000), vol. 109, pages E2579 - E2586, XP055068588 | |
| OPPOSITION | - GASIUNAS, G. et al., "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PNAS, (20120000), vol. 109, no. 39, pages E2579 - E2586, XP055068588 | |
| OPPOSITION | - AKOPIAN et al., "Chimeric recombinases with designed DNA sequence recognition", PNAS, (20030000), vol. 100, no. 15, pages 8688 - 8691, XP002289806 | |
| OPPOSITION | - AKOPIAN et al., "Chimeric recombinases with designed DNA sequence recognition", PNAS, (20030000), vol. 100, pages 8688 - 8691, XP002289806 | |
| OPPOSITION | - AKOPIAN et al., "Chimeric recombinases with designed DNA sequence recognition", Proc. Natl. Acad. Sci. USA, (20030000), vol. 100, pages 8688 - 8691, XP002289806 | |
| OPPOSITION | - TAN et al., "Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity", PNAS, (20030000), vol. 100, no. 21, pages 11997 - 12002, XP002541834 | |
| OPPOSITION | - TAN et al., "Zinc-finger protein-targeted gene regulation: genomewide single- gene specificity", PNAS, (20030000), vol. 100, pages 11997 - 12002, XP002541834 | |
| OPPOSITION | - PAPWORTH et al., "Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors", PNAS, (20030000), vol. 100, no. 4, pages 1621 - 1626, XP002514674 | |
| OPPOSITION | - PAPWORTH et al., "Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors", PNAS, (20030000), vol. 100, pages 1621 - 1626, XP002514674 | |
| OPPOSITION | - BEERLI et al., "Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks", PNAS, (19980000), vol. 95, no. 25, pages 14628 - 14633, XP002187156 | |
| OPPOSITION | - BEERLI et al., "Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks", PNAS, (19980000), vol. 95, pages 14628 - 14633, XP002187156 | |
| OPPOSITION | - BEERLI, R. R. et al., "Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks", Proc. Natl. Acad. Sci. USA, (19980000), vol. 95, pages 14628 - 14633, XP002187156 | |
| OPPOSITION | - HANDEL et al., "Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors", Human Gene Ther, (20120000), vol. 23, pages 321 - 329, XP002730956 | |
| OPPOSITION | - LACASSE et al., "Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-bindin proteins", Nucleic Acids Research, (19950000), vol. 23, pages 1647 - 1656, XP055464125 | |
| OPPOSITION | - CERMAK T et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acid research, (20110000), vol. 39, no. 12, XP002659530 | |
| OPPOSITION | - SAPRANAUSKAS, "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", Nucl. Acids Res., (20110000), vol. 39, pages 9275 - 9282, XP055011535 | |
| OPPOSITION | - FONFARA et al., "Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems", Nucleic Acids Research, (20140000), vol. 42, no. 4, pages 2577 - 2590, XP055097853 | |
| OPPOSITION | - GAO, X. et al., "Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers", Nucleic Acids Research, (20140000), vol. 42, no. 20, doi:10.1093/nar/gku836, page e155, XP055194437 | |
| OPPOSITION | - POURCEL, C. et al., "CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies", JOURNAL OF GENERAL MICROBIOLOGY, (20050000), vol. 151, pages 653 - 663, XP002460396 | |
| OPPOSITION | - BOLOTIN, A. et al., "Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin", Microbiology, (20050000), vol. 151, pages 2551 - 2561, XP002424872 | |
| OPPOSITION | - IHRY et al., "P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells", BIORXIV, (20170000), XP055464138 | |
| OPPOSITION | - PADDISON et al., "Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells", Genes & Development, (20020000), vol. 16, pages 948 - 958, XP002204653 | |
| OPPOSITION | - PENG, R. et al., "Potential pitfalls of CRISPR/Cas9-mediated genome editing", FEBS Journal, (20160000), vol. 283, pages 1218 - 1231, XP055377561 | |
| OPPOSITION | - BLANCAFORT et al., "Designing transcription factor architectures for drug discovery", Molecular Pharmacol., (20040000), vol. 66, pages 1361 - 1371, XP055015595 | |
| OPPOSITION | - BLANCAFORT et al., "Designing Transcription Factor Architectures for Drug Discovery", Molecular pharmacology, (20040000), vol. 66, no. 6, pages 1361 - 1371, XP055015595 | |
| OPPOSITION | - BLANCAFORT, P. et al., "Designing Transcription Factor Architectures for Drug Discovery", Mol. Pharmacol., (20040000), vol. 66, no. 6, pages 1361 - 1371, XP055015595 | |
| OPPOSITION | - BARRANGOU, R. et al., "CRISPR provides acquired resistance against viruses in prokaryotes", Science, (20070000), vol. 315, pages 1709 - 1712, XP002428071 | |
| OPPOSITION | - BROUNS, S. J. J. et al., "Small CRISPR RNAs guide antiviral defense in prokaryotes", Science, (20080000), vol. 321, pages 960 - 964, XP002559962 | |
| OPPOSITION | - MARRAFFINI, L.A. et al., "CRISPR interference limits horizontal gene transfer in Staphylococci by targeting DNA", NIH Public Acces Author Manuscript, (20080000), vol. 322, pages 1843 - 1845, XP055463182 | |
| OPPOSITION | - BOGDANOVE et al., "TAL Effectors: Customizable Proteins for DNA Targeting", Science, (20110930), vol. 333, no. 6051, pages 1843 - 1846, XP055093385 | |
| OPPOSITION | - JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", including Supplementary Materials , Sci- ence, (20120817), vol. 337, XP055299674 | |
| OPPOSITION | - JINEK et al., "A programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120000), vol. 337, pages 816 - 821, XP055299674 | |
| OPPOSITION | - JINEK, M et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120000), vol. 337, pages 816 - 821, XP055299674 | |
| OPPOSITION | - JINEK, M. et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120628), vol. 337, pages 816 - 821, XP055067740 | |
| OPPOSITION | - CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", including Supplementary Materials, Science, (20130103), vol. 339, no. 6121, XP055067744 | |
| OPPOSITION | - CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, pages 819 - 823, XP055067741 | |
| OPPOSITION | - Cong et al., "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE,, (20120705), pages 1 - 28, XP055067744 | |
| OPPOSITION | - CONG, L. et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, pages 819 - 823, XP055181426 | |
| OPPOSITION | - CONG, L. et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130215), vol. 339, no. 6121, pages 819 - 23, XP055181426 | |
| OPPOSITION | - MALI et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055111247 | |
| OPPOSITION | - MALI et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130103), vol. 339, pages 823 - 826, XP055111247 | |
| OPPOSITION | - Mali et al., "Supplementary Materials for RNA-Guided Human Genome Engineering via Cas9", Science, (20130215), pages 1 - 36, XP002723674 | |
| OPPOSITION | - MALI, P. et al., "RNA Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, no. 6121, pages 823 - 826, XP055469277 | |
| OPPOSITION | - MALI, P. et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055111247 | |
| OPPOSITION | - DOUDNA et al., "The new frontier of genome engineering with CRISPR-Cas9", Science, (20140000), vol. 346, no. 6213, XP055162699 | |
| OPPOSITION | - JIANG et al., "Successful transient expression of Cas9 and single guide RNA genes in Chlamydomonas reinhardtii", Eukaryot Cell, (20140000), vol. 13, pages 1465 - 1469, XP055435460 | |
| OPPOSITION | - NEEF et al., "Deletion of a cation transporter promotes lysis in Streptococcus pneumoniae", Infection and immunity, (20110000), vol. 79, pages 2314 - 2323, XP055464123 | |
| OPPOSITION | - ISHINO Y et al., "Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product", Journal of Bacteriology, (19870000), vol. 169, no. 12, pages 5429 - 5433, XP055463130 | |
| OPPOSITION | - TAN et al., "Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells", Journal of virology, (20060000), vol. 80, pages 1939 - 1948, XP055344657 | |
| OPPOSITION | - TAN et al., "Human Immunodeficiency Virus Type 1 Incorporated with Fusion Proteins Consisting of Integrase and the Designed Polydactyl Zinc Finger Protein E2C Can Bias Integration of Viral DNA into a Predetermined Chromosomal Region in Human Cells", J Virol, (20060000), vol. 80, no. 4, pages 1939 - 1948, XP055344657 | |
| OPPOSITION | - WANG, H. et al., "CRISPR/Cas9 in Genome Editing and Beyond", Annu. Rev. Biochem., (20160000), vol. 85, pages 227 - 64, XP055290311 | |
| OPPOSITION | - JIANG, F. et al., "CRISPR-Cas9 Structures and Mechanisms", Annu. Rev. Biophys., (20170000), vol. 46, pages 505 - 529, XP055362997 | |
| OPPOSITION | - ENYEART et al., "Biotechnological applications of mobile group II introns and their reverse transcriptases", RNA-seq, and non-coding RNA analysis'' Mob DNA, (20140000), vol. 5, no. 1, pages 1 - 19, XP021175117 | |
| OPPOSITION | - MINTON, "How can biochemical reactions within cells differ from those in test tubes?", J. Cell . Sci., (20060000), vol. 119, pages 2862 - 2866+1pp, XP055464107 | |
| OPPOSITION | - PRUETT-MILLER et al., "Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels", PLoS Genetics, (20090000), vol. 5, no. 2, pages 1 - 11, XP055089245 | |
| OPPOSITION | - MASTROIANNI et al., "Group II Intron-Based Gene Targeting Reactions in Eukaryotes", PLoS One, (20080000), vol. 3, no. 9, pages 1 - 15, XP055149290 | |
| OPPOSITION | - GEI(3LER et al., "Transcriptional Activators of Human Genes with Programmable DNA-Specificity", PLOS ONE, (20110000), vol. 6, no. 5, pages 1 - 7, XP055077345 | |
| OPPOSITION | - LAWHORN, I.E.B. et al., "Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53", PLoS ONE, (20140000), vol. 9, no. 11, doi:10.1371/journal.pone.0113232, page e113232, XP055194435 | |
| OPPOSITION | - CHRISTIAN et al., "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", Genetics, (20100000), vol. 186, pages 757 - S1, XP002632806 | |
| OPPOSITION | - CARROLL, "Genome Engineering With Zinc-Finger Nucleases", Genetics, (20110000), vol. 188, pages 773 - 782, XP055036700 | |
| OPPOSITION | - RICHTER, C. et al., "Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems", Viruses, (20120000), vol. 4, no. 12, pages 2291 - 2311, XP055299758 | |
| OPPOSITION | - RICHTER et al., "Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems", Viruses, (20120000), vol. 4, pages 2291 - 2311, XP055299758 | |
| OPPOSITION | - RIVENBARK, A. G. et al., "Epigenetic reprogramming of cancer cells via targeted DNA methylation", Epigenetics, (20120000), vol. 7, no. 4, pages 350 - 360, XP002756482 | |
| OPPOSITION | - RIVENBARK et al., "Epigenetic reprogramming of cancer cells via targeted DNA methylation", Epigenetics, (20120000), vol. 7, no. 4, pages 350 - 360, XP002756482 | |
| OPPOSITION | - RIVENBARK et al., "Epigenetic reprogramming of cancer cells via targeted DNA methylation", Epigenetics, (20120000), vol. 7, pages 350 - 360, XP002756482 | |
| OPPOSITION | - KARVELIS et al., "crRNA and tracrRNA guide Cas9-mediated DNA interfer- ence in Streptococcus thermophilus", RNA Biology, (20130500), vol. 10, no. 5, pages 841 - 851, XP055202455 | |
| OPPOSITION | - CHYLINSKI, K. et al., "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA Biol., (20130000), vol. 10, no. 5, pages 726 - 737, XP055116068 | |
| OPPOSITION | - JINEK et al., "RNA-programmed genome editing in human cells", eLife, (20130000), vol. 2, pages 1 - 9, XP002699851 | |
| OPPOSITION | - JINEK et al., "RNA-programmed genome editing in human cells", eLife 2013, (20130129), page e00471, XP002699851 | |
| OPPOSITION | - JINEK, M. et al., "RNA-programmed genome editing in human cells", eLife, (20130000), pages 1 - 9, XP002699851 | |
| OPPOSITION | - JINEK M et al., "RNA-programmed genome editing in human cells", eLife, (20130107), pages 1 - 9, URL: http://news.berkelev.edu/ 2013/01/07 /cheap-and-easv- technique-to-snip-dna-could-revolutionize-qene-therapv, XP002699851 | |
| SEARCH | - PAPWORTH M ET AL, "Designer zinc-finger proteins and their applications", GENE, ELSEVIER, AMSTERDAM, NL, vol. 366, no. 1, doi:10.1016/J.GENE.2005.09.011, ISSN 0378-1119, (20060117), pages 27 - 38, (20060117), XP024934269 [A] 1-21 * the whole document * | |
| SEARCH | - ELITZA DELTCHEVA ET AL, "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", NATURE, (20110331), vol. 471, no. 7340, doi:10.1038/nature09886, ISSN 0028-0836, pages 602 - 607, XP055308803 [A] 1-21 * the whole document * | |
| SEARCH | - BLAKE WIEDENHEFT ET AL, "RNA-guided genetic silencing systems in bacteria and archaea", NATURE, (20120215), vol. 482, no. 7385, doi:10.1038/nature10886, ISSN 0028-0836, pages 331 - 338, XP055116249 [A] 1-21 * the whole document * | |
| SEARCH | - MAKAROVA KIRA S ET AL, "Evolution and classification of the CRISPR-Cas systems", NATURE REVIEWS. MICROBIO, NATURE PUBLISHING GROUP, GB, (20110509), vol. 9, no. 6, doi:10.1038/NRMICRO2577, ISSN 1740-1526, pages 467 - 477, XP009155547 [A] 1-21 * the whole document * | |
| SEARCH | - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055299674 [AP] 1-21 * the whole document * | |
| SEARCH | - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, page 821, XP055067747 [P] * the whole document * | |
| SEARCH | - L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067741 [AP] 1-21 * the whole document * | |
| SEARCH | - L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067744 [P] * the whole document * | |
| SEARCH | - P. MALI ET AL, "RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055111247 [AP] 1-21 * the whole document * | |
| SEARCH | - P. Mali ET AL, "Supplementary information for RNA-Guided Human Genome Engineering via Cas9 (XP 055337932)", Science, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055403737 [P] * the whole document * | |
| SEARCH | - MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", E-LIFE, SAM LTD, GB, vol. 2, doi:10.7554/ELIFE.00471, ISSN 2050-084X, (20130129), pages e00471 - 1, (20130628), XP002699851 [AP] 1-21 * the whole document * | |
| SEARCH | - Martin Jinek ET AL, "RNA-programmed genome editing in human cells (Figures and figure supplements)", eLife, (20130129), vol. 2, doi:10.7554/eLife.00471, XP055167481 [P] * the whole document * | |
