IP Verse

Methods For Enhancing Efficacy Of Therapeutic Immune Cells - EP3253865

The patent EP3253865 was granted to National University OF Singapore on Jun 22, 2022. The application was originally filed on Feb 5, 2016 under application number EP16746922A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3253865

NATIONAL UNIVERSITY OF SINGAPORE
Application Number
EP16746922A
Filing Date
Feb 5, 2016
Status
Granted And Under Opposition
May 20, 2022
Grant Date
Jun 22, 2022
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

PATENT BOUTIQUEMar 21, 2023PATENT BOUTIQUEADMISSIBLE

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONEP0404097
DESCRIPTIONEP2247619
DESCRIPTIONUS4946778
DESCRIPTIONUS5260203
DESCRIPTIONUS8399645
DESCRIPTIONWO2006003179
DESCRIPTIONWO8801649
DESCRIPTIONWO9311161
INTERNATIONAL-SEARCH-REPORTUS2006034834
INTERNATIONAL-SEARCH-REPORTUS2007036773
SEARCHWO2014124143
SEARCHWO2015075468
SEARCHWO2015150771
SEARCHWO2016055551
SEARCHWO2016102965

Non-Patent Literature (NPL) Citations (73) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, page 403
DESCRIPTION- APPELBAUM, FR, Nature, (20010000), vol. 411, no. 6835, pages 385 - 389
DESCRIPTION- AUSUBEL et al., Current Protocols in Molecular Biology
DESCRIPTION- BRENTJENS RJ et al., Blood, (20110000), vol. 118, no. 18, pages 4817 - 4828
DESCRIPTION- BRENTJENS RJ et al., NatMed, (20030000), vol. 9, no. 3, pages 279 - 286
DESCRIPTION- BRENTJENS RJ et al., NatMed., (20030000), vol. 9, no. 3, pages 279 - 286
DESCRIPTION- BRENTJENS RJ et al., Sci Transl Med., (20130000), vol. 5, no. 177, page 177ral38
DESCRIPTION- CAMPANA D et al., Cancer J., (20140000), vol. 20, no. 2, pages 134 - 140
DESCRIPTION- CHANG YH et al., Cancer Res., (20130000), vol. 73, no. 6, pages 1777 - 1786
DESCRIPTION- COOLEY S et al., Blood, (20100000), vol. 116, no. 14, pages 2411 - 2419
DESCRIPTION- COOPER LJ et al., Blood, (20030000), vol. 101, no. 4, pages 1637 - 1644
DESCRIPTION- COOPER LJ et al., Blood., (20030000), vol. 101, no. 4, pages 1637 - 1644
DESCRIPTION- ESHHAR, Z. et al., PNAS, (19930000), vol. 90, no. 2, pages 720 - 724
DESCRIPTION- GAO C et al., Trends in Plant Science, (20140000), vol. 19, pages 508 - 515
DESCRIPTION- GEIGER TL et al., J Immunol., (19990000), vol. 162, no. 10, pages 5931 - 5939
DESCRIPTION- "GenBank", Database accession no. NM_013614.2
DESCRIPTION- GROVENDER, E.A. et al., Kidney Int., (20040000), vol. 65, no. 1, pages 310 - 322
DESCRIPTION- GRUPP SA et al., NEngl J Med., (20130000), vol. 368, no. 16, pages 1509 - 1518
DESCRIPTION- HENIKOFFHENIKOFF, Proc. Natl. Acad. Sci. USA, (19890000), vol. 89, page 10915
DESCRIPTION- HOLLIGER et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 6444 - 6448
DESCRIPTION- IMAI, C. et al., Leukemia, (20040000), vol. 18, pages 676 - 684
DESCRIPTION- JOSHI, S.N. et al., MAbs, (20120000), vol. 4, no. 6, pages 686 - 693
DESCRIPTION- KALOS M et al., SciTranslMed., (20110000), vol. 3, no. 95, page 95ra73
DESCRIPTION- KOCHENDERFER JN et al., Blood, (20120000), vol. 119, no. 24, pages 5697 - 5705
DESCRIPTION- KOLB, HJ et al., Blood, (19950000), vol. 86, no. 5, pages 2041 - 2050
DESCRIPTION- KOLLER, BH et al., Science, (19900000), vol. 248, no. 4960, pages 1227 - 1230
DESCRIPTION- KUDO, K et al., Cancer Res., (20140000), vol. 74, no. 1, pages 93 - 103
DESCRIPTION- LEE DW et al., Blood, (20140000), vol. 124, no. 2, pages 188 - 195
DESCRIPTION- MAUDE SL et al., NEngl J Med., (20140000), vol. 371, no. 16, pages 1507 - 1517
DESCRIPTION- MAUDE SL et al., NEnglJMed., (20140000), vol. 371, no. 16, pages 1507 - 1517
DESCRIPTION- MILLER JS et al., Blood, (20050000), vol. 106, pages 3051 - 3057
DESCRIPTION- MILLER JS, Hematology Am Soc Hematol Educ Program., (20130000), vol. 2013, pages 247 - 253
DESCRIPTION- NEEDLEMANWUNSCH, J. Mol. Biol., (19700000), vol. 48, page 443
DESCRIPTION- PARDOLL DM., Nat Rev Cancer, (20120000), vol. 12, no. 4, pages 252 - 264
DESCRIPTION- PARDOLL DM., Nat Rev Cancer., (20120000), vol. 12, no. 4, pages 252 - 264
DESCRIPTION- PEARSONLIPMAN, Proc. Nat'l. Acad. Sci. USA, (19880000), vol. 85, page 2444
DESCRIPTION- PEIPP et al., Cancer Res, (20020000), vol. 62, pages 2848 - 2855
DESCRIPTION- PLUCKTHUN, The Pharmacology of Monoclonal Antibodies, Springer-Verlag, (19940000), vol. 113, pages 269 - 315
DESCRIPTION- PORTER, DL et al., N. Engl. J. Med., (19940000), vol. 330, no. 2, pages 100 - 106
DESCRIPTION- RUBNITZ JE et al., J Clin Oncol., (20100000), vol. 28, no. 6, pages 955 - 959
DESCRIPTION- RUGGERI L et al., Science, (20020000), vol. 295, no. 5562, pages 2097 - 2100
DESCRIPTION- SCHWARTZ RH, Annu Rev Immunol., (20030000), vol. 21, pages 305 - 334
DESCRIPTION- SHARMA P et al., Nat Rev Cancer, (20110000), vol. 11, no. 11, pages 805 - 812
DESCRIPTION- SLAVIN, S. et al., Blood, (19960000), vol. 87, no. 6, pages 2195 - 2204
DESCRIPTION- SMITHWATERMAN, Adv. Appl. Math., (19810000), vol. 2, page 482
DESCRIPTION- STREBE N. et al., J Immunol Methods, (20090000), vol. 341, no. 1-2, pages 30 - 40
DESCRIPTION- TODOROVSKA et al., J. Immunol. Methods, (20010000), vol. 248, no. 1-2, pages 47 - 66
DESCRIPTION- TOPP MS et al., J. Clin.Oncol., (20110000), vol. 29, no. 18, pages 2493 - 2498
DESCRIPTION- VIVIER E et al., Science, (20110000), vol. 331, no. 6013, pages 44 - 49
DESCRIPTION- WEIDEN, PL et al., N. Engl. J. Med., (19790000), vol. 300, no. 19, pages 1068 - 1073
DESCRIPTION- ZANG XALLISON JP, Clin Cancer Res., (20070000), vol. 13, no. 18, pages 5271 - 5279
DESCRIPTION- ZHAN J et al., Cancer Immunol Immunother, (19980000), vol. 46, pages 55 - 60
DESCRIPTION- PORTER DL et al., "Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia", N Engl J Med., (20110000), vol. 365, no. 8, doi:10.1056/NEJMoa1103849, pages 725 - 733, XP055579937
EXAMINATION- Grimshaw B D et al., BGST Abstracts 2012, #P023
EXAMINATION- B�LDICKE T, "Blocking translocation of cel surface molecules the ER to the cell surface by intracellular antibodies targeted to the ER", J. CELL. MOL. MED., (2007), vol. 11, no. 1, doi:10.1111/j.1582-4934.2007.00002.x, pages 54 - 70, XP055965875
INTERNATIONAL-SEARCH-REPORT- ROWLEY, J. et al., "Expression of IL -15RA or an IL -15/ IL -15RA fusion on CD 8+ T cells modifies adoptively transferred T- cell function in cis", European Journal of Immunology, vol. 39, (20090000), pages 491 - 506, URL: http://onlinelibrary.wiley.com/store/10.1002/eji.200838594/asset/supinfo/eji_200838594_sm_SupplInfoFig.pdf?v=1&s=e1af9b5afdd17fd4ee46bb089fdc6ea077f8e692 [X] 1-22 * Abstract; Figures 4, 6; Suppl. Figure 1; para.4 of col. 1 on p.500; Figure 7 *
INTERNATIONAL-SEARCH-REPORT- ZHOU, P. et al., "Cells transfected with a non-neutralizing antibody gene are resistant to HIV infection: targeting the endoplasmic reticulum and trans-Golgi network", The Journal of Immunology, (19980000), vol. 160, pages 1489 - 1496, XP001155619 [A] 0 * Abstract; Figure 2 *
INTERNATIONAL-SEARCH-REPORT- SANZ, L. et al., "Antibodies and gene therapy: teaching old 'magic bullets' new tricks", Trends in Immunology, (20040000), vol. 25, pages 85 - 91, XP004487052 [X] 1-22 * Abstract; Figure 1; Tables 1-3; "Chimeric immune receptors" on p.88-89; "Intracellular antibodies" *
INTERNATIONAL-SEARCH-REPORT- LO, A.S.Y. et al., "Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T- cell growth and activation", Molecular Immunology, (20080000), vol. 45, pages 1276 - 1287, XP022402160 [X] 1-22 * Abstract; Sections 2.1, 2.4, 2.7, 3.6; Figures 1, 3, 6 *
INTERNATIONAL-SEARCH-REPORT- ROSSIG, C. et al., "Genetic modification of T lymphocytes for adoptive immunotherapy", Molecular Therapy, (20040000), vol. 10, pages 5 - 18, XP004552176 [X] 1-22 * Abstract; Figures 1, 4; Table 1; para. bridging col. 1-2 on p.6; para.2 of col.2 on p.7; para. bridging col.1-2 on p.8; para.3, 4 of col.1 on p.13 *
INTERNATIONAL-SEARCH-REPORT- HEGDE, M. et al., "Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma", Molecular Therapy, vol. 21, (20130000), pages 2087 - 2101, URL: http://www.nature.com/mt/journal/v21/n11/extref/mt2013185x1.pdf, XP002725708 [X] 1-22 * Abstract; para.3 of col.2 on p.2098; Figures 4-6, 8; Suppl. Figures 5, 7-9 *
INTERNATIONAL-SEARCH-REPORT- KLOSS, C.C. et al., "Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells", Nature Biotechnology, vol. 31, (20130000), pages 71 - 75, URL: http://www.nature.com/nbt/journal/v31/n1/extref/nbt.2459-S1.pdf, XP055130697 [X] 1-22 * Abstract; para.2 of col.2 on p.71; Suppl. Figure 1; Figure 1 *
INTERNATIONAL-SEARCH-REPORT- KUDO, K. et al., "T lymphocytes expressing a CD 16 signaling receptor exert antibody- dependent cancer cell killing", Cancer Research, (20140000), vol. 74, pages 93 - 103, XP055222596 [X] 1-22 * Abstract; Figures 1, 2; para.3 of col.2 on p.95 *
INTERNATIONAL-SEARCH-REPORT- LANITIS, E. et al., "Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo", Cancer Immunology Research, vol. 1, (20130000), pages 43 - 53, XP055170306 [X] 1-22 * Abstract; Figure 1-3; para.2, 7 on p.3; Figures 5, 6 *
INTERNATIONAL-SEARCH-REPORT- IMAMURA. M. et al., "Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15", Blood, vol. 124, (20140000), pages 1081 - 1088, URL: http://www.bloodjournal.org/content/bloodjournal/suppl/2014/07/08/blood-2014-02-556837.DC1/blood-2014-02-556837-1.pdf, XP055237400 [X] 1-22 * Abstract; Figure 1; para.3 of col.1 on p. 1082; para.2 of col. on p. 1086; Figure 4; Suppl. Table 1; para. 1 of col.1 on p. 1085; Suppl. Figures 4, 5; Figure 5; Supp. Figure 6 *
OPPOSITION- Anonymous, "Membrane receptors for antigen", Anonymous, Delves, Peter J. Martin, Seamus J. Burton, Dennis R. Roitt, Ivan M., Roitt’s essential immunology, Wiley-Blackwell, (20110101), pages 79 - 112, ISBN 978-1-4051-9683-3, XP093104148
OPPOSITION- Grimshaw Ben, David Linch, Martin Pule, "Creating a 'null' T cell for use in adoptive immunotherapy", Research Department of Haematology, (20120530), pages 1 - 1, XP093083435
OPPOSITION- Grimshaw Benjamin D, Martin A Pule , David C Linch, "Creating a ’null’ T cell for use in adoptive immunotherapy", British Society for Gene Therapy, (20120309), vol. 23, no. 5, page A15, XP093083414
OPPOSITION- F. Arakawa, M. Kuroki, M. Kuwahara, T. Senba, H. Ozaki, Y. Matsuoka, Y. Misumi, H. Kanda, T. Watanabe, "Cloning and Sequencing of the V H and V K Genes of an Anti-CD3 Monoclonal Antibody, and Construction of a Mouse/Human Chimeric Antibody", Journal of Biochemistry, GB , (19960901), vol. 120, no. 3, doi:10.1093/oxfordjournals.jbchem.a021462, ISSN 0021-924X, pages 657 - 662, XP055415710
SEARCH[ ] - MACIOCIA P M ET AL, "A simple protein-based method for generation of 'off the shelf' allogeneic chimeric antigen receptor T-cells", EMBASE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20180501), Database accession no. EMB-623339718, XP002784541 [ ] * abstract *
SEARCH- MACIOCIA P M ET AL, "A simple protein-based method for generation of 'off the shelf' allogeneic chimeric antigen receptor T-cells", MOLECULAR THERAPY 20180501 CELL PRESS NLD, (20180501), vol. 26, no. 5, Supplement 1, ISSN 1525-0024, pages 296 20180516 to 20180519 Chicago, IL - 297 CONF, XP002784541
SEARCH[ ] - PNG YT ET AL, "Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies", BLOOD ADVANCES, (20171128), vol. 1, no. 25, doi:10.1182/bloodadvances.2017009928, ISSN 2473-9529, pages 2348 - 2360, XP055452690
SEARCH[ ] - KAMIYA T ET AL, "A novel method to generate T-cell receptor-deficient chimeric antigen receptor T cells", BLOOD ADVANCES, (20180313), vol. 2, no. 5, doi:10.1182/bloodadvances.2017012823, pages 517 - 528, XP055505570

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents