Production Of Antibodies With Improved Glycosylation Pattern - EP3255141

The patent EP3255141 was granted to Wyeth on Dec 1, 2021. The application was originally filed on Jul 11, 2007 under application number EP17179340A. The patent is currently recorded with a legal status of "Revoked".

EP3255141

WYETH
Application Number
EP17179340A
Filing Date
Jul 11, 2007
Status
Revoked
Jun 9, 2023
Grant Date
Dec 1, 2021
External Links
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STRAWMANSep 1, 2022VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE
SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBAug 31, 2022SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBADMISSIBLE

Patent Citations (51) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS20050213308
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DESCRIPTIONEP0117060
DESCRIPTIONEP0171496
DESCRIPTIONEP0173494
DESCRIPTIONEP0239400
DESCRIPTIONEP0417014
DESCRIPTIONEP0417563
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DESCRIPTIONUS4522811
DESCRIPTIONUS4816397
DESCRIPTIONUS4816567
DESCRIPTIONUS5078996
DESCRIPTIONUS5166320
DESCRIPTIONUS5380876
DESCRIPTIONUS5549892
DESCRIPTIONUS5593972
DESCRIPTIONUS5723127
DESCRIPTIONUS5817637
DESCRIPTIONUS5981505
DESCRIPTIONUS6005079
DESCRIPTIONUS6015695
DESCRIPTIONUS6383512
DESCRIPTIONUS6765087
DESCRIPTIONWO0018434
DESCRIPTIONWO02098368
DESCRIPTIONWO02098369
DESCRIPTIONWO9206193
DESCRIPTIONWO9213069
DESCRIPTIONWO9817799
DESCRIPTIONWO9820734
DESCRIPTIONWO9943839
OPPOSITIONEP1096017
OPPOSITIONUS6506598
OPPOSITIONUS6610516
OPPOSITIONWO0065070
OPPOSITIONWO2006026408
OPPOSITIONWO2006026445
OPPOSITIONWO2007056062
OPPOSITIONWO2007070315
OPPOSITIONWO2008008360
OPPOSITIONWO9639488
SEARCHEP1096017
SEARCHUS6506598
SEARCHWO2006026408
SEARCHWO2006026445
SEARCHWO2007056062
SEARCHWO2007070315
SEARCHWO9639488

Non-Patent Literature (NPL) Citations (107) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BARD et al., Nat. Med., (20000000), vol. 6, pages 916 - 19
DESCRIPTION- BERKNER et al., BioTechniques, (19880000), vol. 6, page 616
DESCRIPTION- BRETON; IMBERTY, Curr. Opinion in Structural Biol., (19990000), vol. 9, pages 563 - 571
DESCRIPTION- BRUCKNER et al., Nature, (20000000), vol. 406, pages 411 - 415
DESCRIPTION- CAPEL et al., Immunomethods, (19940000), vol. 4, pages 25 - 34
DESCRIPTION- CHANG et al., J. Clin. Invest., (19970000), vol. 100, page 4
DESCRIPTION- CHARTIER; HARLAN et al., Nature, (19910000), vol. 353, page 844
DESCRIPTION- CHOCHOLA et al., J. Biol. Chem., (19930000), vol. 268, pages 2312 - 2318
DESCRIPTION- COUVINEAU et al., Biochemistry, (19960000), vol. 35, no. 6, pages 1745 - 52
DESCRIPTION- DATTA, R. et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 10149 - 10153
DESCRIPTION- DE HAAS et al., J. Lab. Clin. Med., (19950000), vol. 126, pages 330 - 41
DESCRIPTION- Deutscher, M.P., Simon, M.I., Abelson, J.N., Guide to Protein Purification : Methods in Enzymology, Academic Press, (19970000), vol. 182
DESCRIPTION- DEVRIES et al., Science, (19920000), vol. 255, pages 989 - 991
DESCRIPTION- DODEL et al., The Lancet, (20030000), vol. 2, page 215
DESCRIPTION- DREWS, Nature Biotechnology, (19960000), vol. 14, page 1516
DESCRIPTION- DUFF et al., Nature, (19950000), vol. 373, page 476
DESCRIPTION- ELLIOTT et al., Nature Biotechnology, (20030000), vol. 21, no. 4, pages 414 - 21
DESCRIPTION- FLOTTE et al., Am. J. Respir. Cell. Mol. Biol, (19920000), vol. 7, pages 349 - 356
DESCRIPTION- FLOTTE et al., J. Biol. Chem., (19930000), vol. 268, pages 3781 - 3790
DESCRIPTION- Focus, (19930000), vol. 15, page 73
DESCRIPTION- GAMES et al., Nature, (19950000), vol. 373, page 523
DESCRIPTION- GETHING et al., Nature, (19810000), vol. 293, pages 620 - 625
DESCRIPTION- GOATE et al., Nature, (19910000), vol. 349, page 704
DESCRIPTION- GRAHAM et al., J. Gen Virol., (19770000), vol. 36, page 59
DESCRIPTION- GRAHAM; VAN DER ERB, Virology, (19780000), vol. 52, pages 456 - 457
DESCRIPTION- HAJ-AHMAND; GRAHAM, J. Virol., (19860000), vol. 57, page 267
DESCRIPTION- HARDY, TINS, (19970000), vol. 20, page 154
DESCRIPTION- HERMONAT et al., Proc. Natl. Acad. Sci. USA, (19840000), vol. 81, pages 6466 - 6470
DESCRIPTION- HERZ; GERARD, Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 2812 - 2816
DESCRIPTION- JOHNSON-WOOD et al., Proc. Natl. Acad. Sci. USA, (19970000), vol. 94, page 1550
DESCRIPTION- KAUFMAN et al., EMBO J., (19870000), vol. 6, pages 187 - 195
DESCRIPTION- KEOWN et al., Methods in Enzymology, (19900000), vol. 185, pages 527 - 537
DESCRIPTION- KOZBOR et al., Immunology Today,, (19830000), vol. 4, page 7279
DESCRIPTION- LEMARCHAND et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 6482 - 6486
DESCRIPTION- LIFELY et al., Glycobiology, (19950000), vol. 5, no. 8, pages 813 - 22
DESCRIPTION- MADER, S.; WHITE, J.H., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 5603 - 5607
DESCRIPTION- MALONEY et al., Journal of Biol. Chem., (20000000), vol. 275, no. 13
DESCRIPTION- MANOME, Y. et al., Biochemistry, (19930000), vol. 32, pages 10607 - 10613
DESCRIPTION- MANSOUR, Nature, (19880000), vol. 336, pages 348 - 352
DESCRIPTION- MANTEI et al., Nature, (19790000), vol. 281, pages 40 - 46
DESCRIPTION- MATHER, Biol. Reprod., (19800000), vol. 23, pages 243 - 251
DESCRIPTION- Mather et al.,, Annals N.Y. Acad. Sci.,, (19820000), vol. 383, pages 44 - 68
DESCRIPTION- MCLAUGHLIN et al., J. Virol, (19890000), vol. 62, pages 1963 - 1973
DESCRIPTION- MILLER, A.D., Blood, (19900000), vol. 76, page 271
DESCRIPTION- MILLIGAN, G.; REES, S., TIPS, (19990000), vol. 20, pages 118 - 124
DESCRIPTION- MILSTEIN et al., Nature, (19830000), vol. 537, page 3053
DESCRIPTION- MODY et al., Neuropharmacology, (19990000), vol. 38, no. 10, pages 1485 - 92
DESCRIPTION- MOLONEY et al., J. Biol. Chem, (20000000), vol. 275, no. 13, pages 9604 - 9611
DESCRIPTION- MORRISON, Proc. Natl. Acad. Sci. U.S.A., (19850000), vol. 81, page 6851
DESCRIPTION- MULLAN et al., Nature Genet., (19920000), vol. 1, page 345
DESCRIPTION- MURRELL et al., Science, (19910000), vol. 254, page 97
DESCRIPTION- MUSTONEN; ALITALO, J. Cell Biol., (19950000), vol. 129, pages 895 - 898
DESCRIPTION- MUZYCZKA et al., Curr. Topics in Micro. and Immunol., (19920000), vol. 158, pages 97 - 129
DESCRIPTION- NAISMITH; SPRANG, Jlnflamm, (19950000), vol. 47, no. 1-2, pages 1 - 7
DESCRIPTION- OKAYAMA et al., Mol. Cell Biol., (19850000), vol. 5, pages 1136 - 1142
DESCRIPTION- OLSSON et al., Meth. Enzymol., (19820000), vol. 92, pages 3 - 16
DESCRIPTION- PRZYBYLO et al., Cancer Cell International, (20020000), vol. 2, no. 1, page 6
DESCRIPTION- QUANTIN et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 2581 - 2584
DESCRIPTION- RAVETCH; KINET, Annu. Rev. Immunol, (19910000), vol. 9, pages 457 - 92
DESCRIPTION- ROSENFELD et al., Cell, (19920000), vol. 68, pages 143 - 155
DESCRIPTION- ROSENFELD et al., Science, (19910000), vol. 252, pages 431 - 434
DESCRIPTION- SAMULSKI et al., J. Virol, (19890000), vol. 63, pages 3822 - 3828
DESCRIPTION- SATO et al., Nature, (19950000), vol. 376, no. 6535, pages 70 - 74
DESCRIPTION- SCHENK et al., Nature, (19990000), vol. 400, page 173
DESCRIPTION- SEED, B., Nature, (19870000), vol. 329, page 840
DESCRIPTION- SELKOE, J. Neuropathol. Exp. Neurol., (19940000), vol. 53, page 438
DESCRIPTION- SELKOE, TINS, (19930000), vol. 16, page 403
DESCRIPTION- SHIBUYA et al., Oncogene, (19900000), vol. 5, pages 519 - 524
DESCRIPTION- SPENCER, D.M. et al., Science, (19930000), vol. 262, pages 1019 - 1024
DESCRIPTION- TAKEDA et al., Nature, (19850000), vol. 314, page 452
DESCRIPTION- TENG et al., Proc. Natl. Acad. Sci. U.S.A., (19830000), vol. 80, pages 7308 - 7312
DESCRIPTION- TERMAN et al., Oncogene, (19910000), vol. 6, pages 1677 - 83
DESCRIPTION- THOMAS et al., Cell, (19870000), vol. 51, pages 503 - 512
DESCRIPTION- TRATSCHIN et al., J. Virol, (19840000), vol. 51, pages 611 - 619
DESCRIPTION- TRATSCHIN et al., Mol. Cell. Biol., (19850000), vol. 4, pages 2072 - 2081
DESCRIPTION- TRATSCHIN et al., Mol. Cell. Biol, (19850000), vol. 5, pages 3251 - 3260
DESCRIPTION- ULLRICH; SCHLESSINGER, Cell, (19900000), vol. 61, pages 243 - 254
DESCRIPTION- URLAUB; CHASIN, Proc. Natl. Acad. Sci. USA, (19800000), vol. 77, page 4216
DESCRIPTION- WATSON, S.; S. ARKINSTALL, The G- Protein Linked Receptor Facts Book, Academic Press, (19940000), pages 130 - 132
DESCRIPTION- WILSON et al., J. Biol. Chem., (19920000), vol. 267, pages 963 - 967
DESCRIPTION- WONDISFORD et al., Mol. Endocrinol., (19880000), vol. 2, pages 32 - 39
DESCRIPTION- WU, G.; WU, C.H., J. Biol. Chem., (19880000), vol. 263, page 14621
DESCRIPTION- YARDEN; ULLRICH, Ann. Rev. Biochem., (19880000), vol. 57, pages 433 - 478
OPPOSITION- Anonymous, "G 3126 PRODUCT INFORMATION ", sigma, (20031101), sigma , (20220913), XP055960202
OPPOSITION- Bruckner Katja, Lidia Perez , Henrik Clausen , Stephen Cohen , "Glycosyltransferase activity of fringe modulates notch-delta interactions ", Nature, (20000727), vol. 406, pages 411 - 514, XP055960194
OPPOSITION- Crowel Christopher Kenyon, "Depleted amino acids and sodium butyrate alter the phenotype and genotype cell lines expressing rHuEPO", PhD thesis, (20060101), PhD thesis, URL: University of California Santa Barbara, (20220912), XP055959645
OPPOSITION- James D. Crawley Et Al, "Enzymes and Proteins Containing 2000 Manganese: An Overview", Metal lons in Biological Systems, Marcel Dekker , (20000101), pages 209 - 278, ISBN 978-0-8247-0288-5, XP055335086
OPPOSITION- "M8179 PRODUCT SPECIFICATION", S igma-Aldrich
OPPOSITION- RAJU T SHANTHA, "GLYCOSYLATION VARIATIONS WITH EXPRESSION SYSTEMSAND THEIR IMPACT ON BIOLOGICAL ACTIVITY OF THERAPEUTIC IMMUNOGLOBULINS", BIOPROCESS INTERNATIONAL, INFORMA LIFE SCIENCES GROUP, US, US , (20030401), vol. 1, no. 4, ISSN 1542-6319, pages 44 - 53, XP001247475
OPPOSITION- RESTELLI V, BUTLER M, "THE EFFECT OF CELL CULTURE PARAMETERS ON PROTEIN GLYCOSYLATION", CELL ENGINEERING, XX, XX, XX , (20020101), vol. 03, pages 61 - 92, XP001203473
OPPOSITION- Smales Mark C, James David C , "Production of Recombinant Therapeutic Proteins by Mammalian Cells in Suspension Culture", THERPEUTIC PROTEINS METHODSBAND PROTOCOLS , (20050101), pages 107 - 121, XP055960207
OPPOSITION- WITSELL D L, CASEY C E, NEVILLE M C, "DIVALENT CATION ACTIVATION OF GALACTOSYLTRANSFERASE IN NATIVE MAMMARY GOLGI VESICLES", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (19900915), vol. 265, no. 26, ISSN 0021-9258, pages 15731 - 15737, XP002454614
OPPOSITION- ANDERSEN D C, ET AL, "Multiple cell culture factors can affect the glycosylation of Asn-184 in CHO-produced tissue-type plasminogen activator", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20001001), vol. 70, no. 1, doi:10.1002/1097-0290(20001005)70:1<25::AID-BIT4>3.0.CO;2-Q, ISSN 0006-3592, pages 25 - 31, XP003011129
OPPOSITION- KAUFMANN H, ET AL, "Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline-regulated gene expression, and productivity", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20010320), vol. 72, no. 6, doi:10.1002/1097-0290(20010320)72:6<592::AID-BIT1024>3.0.CO;2-J, ISSN 0006-3592, pages 592 - 602, XP002331692
OPPOSITION- Tharmala Tharmalingam; Chao‐Hsiang Wu; Susan Callahan; Chetan T. Goudar, "A framework for real‐time glycosylation monitoring (RT‐GM) in mammalian cell culture", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20150417), vol. 112, no. 6, doi:10.1002/bit.25520, ISSN 0006-3592, pages 1146 - 1154, XP071145693
OPPOSITION- BUTLER MICHAEL, "Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals", Applied Microbiology and Biotechnology, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20050801), vol. 68, no. 3, doi:10.1007/s00253-005-1980-8, ISSN 0175-7598, pages 283 - 291, XP002457678
OPPOSITION- M. Butler, "Optimisation of the Cellular Metabolism of Glycosylation for Recombinant Proteins Produced by Mammalian Cell Systems", Cytotechnology, Kluwer Academic Publishers, Do, Do , (20060609), vol. 50, no. 1-3, doi:10.1007/s10616-005-4537-x, ISSN 1573-0778, pages 57 - 76, XP019393897
OPPOSITION- Furukawa, K. ; Kobata, A., "Protein glycosylation", Current Opinion in Biotechnology, LONDON, GB, GB , (19921001), vol. 3, no. 5, doi:10.1016/0958-1669(92)90085-W, ISSN 0958-1669, pages 554 - 559, XP023601265
OPPOSITION- Powell J T, Brew K, "Metal ion activation of galactosyltransferase.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (19760601), vol. 251, no. 12, doi:10.1016/S0021-9258(17)33393-8, ISSN 0021-9258, pages 3645 - 3652, XP055959642
OPPOSITION- BRETON C, IMBERTY A, "STRUCTURE/FUNCTION STUDIES OF GLYCOSYLTRANSFERASES", Current Opinion in Structural Biology, Elsevier Ltd., GB, GB , (19991001), vol. 09, no. 05, doi:10.1016/S0959-440X(99)00006-8, ISSN 0959-440X, pages 563 - 571, XP001026532
OPPOSITION- HENDRICKSON T L, IMPERIALI B, "Metal ion dependence of oligosaccharyl transferase: Implications for catalysis.", Biochemistry, (19950101), vol. 34, no. 29, doi:10.1021/bi00029a020, ISSN 0006-2960, pages 9444 - 9450, XP002155998
OPPOSITION- KAUFMAN RANDAL J, SWAROOP M, MURTHA-RIEL P, "Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells", Biochemistry, (19940823), vol. 33, no. 33, doi:10.1021/bi00199a001, ISSN 0006-2960, pages 9813 - 9819, XP002454613
OPPOSITION- Daniel J. Moloney, Louisa H. Shair, Frederick M. Lu, Jie Xia, Robert Locke, Khushi L. Matta, Robert S. Haltiwanger, "Mammalian Notch1 Is Modified with Two Unusual Forms of O -Linked Glycosylation Found on Epidermal Growth Factor-like Modules", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20000331), vol. 275, no. 13, doi:10.1074/jbc.275.13.9604, ISSN 0021-9258, pages 9604 - 9611, XP055533886
OPPOSITION- Ricardo J. Solá, Griebenow Kai, "Glycosylation of Therapeutic Proteins", BioDrugs, (20100201), vol. 24, no. 1, doi:10.2165/11530550-000000000-00000, ISSN 11738804, pages 9 - 21, XP055016446
SEARCH- RESTELLI V ET AL, "THE EFFECT OF CELL CULTURE PARAMETERS ON PROTEIN GLYCOSYLATION", CELL ENGINEERING, (2002), vol. 3, pages 61 - 92, XP001203473 [A] 1-22 * chpts. 5.4, 5.6; pages 78-81 *
SEARCH- ANDERSEN D C ET AL, "Multiple cell culture factors can affect the glycosylation of Asn-184 in CHO-produced tissue-type plasminogen activator", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, (200010), vol. 70, no. 1, ISSN 0006-3592, pages 25 - 31, XP003011129 [A] 1-22 * pages 27-29; figure 3 *
SEARCH- KAUFMAN R J ET AL, "Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells.", BIOCHEMISTRY 23 AUG 1994, (19940823), vol. 33, no. 33, ISSN 0006-2960, pages 9813 - 9819, XP002457774 [Y] 10 * abstract *

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