Compositions And Methods For Immunomodulation In An Organism - EP3263581

The patent EP3263581 was granted to University OF Connecticut on Jul 9, 2025. The application was originally filed on May 17, 2006 under application number EP17182599A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3263581

UNIVERSITY OF CONNECTICUT
Application Number
EP17182599A
Filing Date
May 17, 2006
Status
Patent Maintained As Amended
Jun 6, 2025
Publication Date
Jul 9, 2025
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MARGARET DIXONAug 4, 2021MEWBURN ELLISADMISSIBLE
CYTUNE PHARMAAug 4, 2021MAIWALDWITHDRAWN

Patent Citations (47) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

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Non-Patent Literature (NPL) Citations (208) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- AMRANN et al., Gene, (19880000), vol. 69, pages 301 - 315
DESCRIPTION- ANDERSON, D. et al., J. Biol. Chem., (19950000), vol. 270, pages 29862 - 29869
DESCRIPTION- ANDERSON, D.M. et al., J. Biol. Chem., (19950000), vol. 270, pages 29862 - 29869
DESCRIPTION- ARMITAGE,R.J.; MACDUFF,B.M.; EISENMAN,J.; PAXTON,R.; GRABSTEIN,K.H., "IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation", J. Immunol., (19950000), vol. 154, pages 483 - 490, XP000670219
DESCRIPTION- ARNHEIM; LEVINSON, C&EN, (19901001), pages 36 - 47
DESCRIPTION- BALDARI et al., EMBO J., (19870000), vol. 6, pages 229 - 234
DESCRIPTION- BAMFORD,R.N.; BATTIATA,A.P.; BURTON,J.D.; SHARMA,H.; WALDMANN,T.A, "Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation", Proc. Natl. Acad. Sci. U. S. A, (19960000), vol. 93, pages 2897 - 2902
DESCRIPTION- BAMFORD,R.N.; DEFILIPPIS,A.P.; AZIMI,N.; KURYS,G.; WALDMANN,T.A., "The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control", Journal of Immunology, (19980000), vol. 160, pages 4418 - 4426, XP055054209
DESCRIPTION- BAMFORD,R.N. et al., "The Interleukin (Il)-2 Receptor-Beta Chain Is Shared by Il-2 and A Cytokine, Provisionally Designated Il-T, That Stimulates TCell Proliferation and the Induction of Lymphokine-Activated Killer-Cells", Proceedings of the National Academy of Sciences of the United States of America, (19940000), vol. 91, pages 4940 - 4944
DESCRIPTION- BANERJI et al., Cell, (19830000), vol. 33, pages 729 - 740
DESCRIPTION- BARBAS et al., Methods: A Companion to Methods in Enzymology, (19910000), vol. 2, page 119
DESCRIPTION- BARBAS et al., PNAS, (19910000), vol. 88, pages 7978 - 7982
DESCRIPTION- BASS et al., Proc. Natl. Acad. Sci. USA, (19910000), vol. 88, pages 4498 - 4502
DESCRIPTION- BECKER,T.C. et al., "Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells", J. Exp. Med., (20020000), vol. 195, pages 1541 - 1548
DESCRIPTION- BERARD,M.; BRANDT,K.; PAUS,S.B.; TOUGH,D.F., "IL-15 promotes the survival of naive and memory phenotype CD8(+) T cells", Journal of Immunology, (20030000), vol. 170, pages 5018 - 5026, XP002409701
DESCRIPTION- BERGER; KIMMEL, GUIDE TO MOLECULAR CLONING TECHNIQUES, METHODS IN ENZYMOLOGY, Academic Press, Inc., vol. 152
DESCRIPTION- BERGEY'S MANUAL OF SYSTEMATIC BACTERIOLOGY, Williams and Wilkins, (19840000), vol. 1
DESCRIPTION- BOWIE; SAUER, Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 2152 - 2156
DESCRIPTION- BRENNAN et al., Science, (19850000), vol. 229, page 81
DESCRIPTION- BROCKER,T., "Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells", J. Exp. Med., (19970000), vol. 186, pages 1223 - 1232
DESCRIPTION- BRUGGEMAN et al., Eur J Immunol, (19910000), vol. 21, pages 1323 - 1326
DESCRIPTION- BRUGGEMAN et al., Year Immunol, (19930000), vol. 7, pages 33 - 40
DESCRIPTION- BUDAGIAN,V. et al., "Reverse signaling through membrane-bound interleukin-15", J. Biol. Chem., (20040000), vol. 279, pages 42192 - 42201
DESCRIPTION- BULFONE-PAUS, S. et al., FASEB, (19990000), vol. 13, pages 1575 - 1585
DESCRIPTION- BURKETT,P.R. et al., "Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis", J Exp. Med., (20040000), vol. 200, pages 825 - 834
DESCRIPTION- BURTON,J.D. et al., "A Lymphokine, Provisionally Designated Interleukin-T and Produced by A Human Adult T-Cell Leukemia Line, Stimulates T-Cell Proliferation and the Induction of Lymphokine-Activated Killer-Cells", Proceedings of the National Academy of Sciences of the United States of America, (19940000), vol. 91, pages 4935 - 4939
DESCRIPTION- BYRNE; RUDDLE, Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 5473 - 5477
DESCRIPTION- CALAME; EATON, Adv. Immunol., (19880000), vol. 43, pages 235 - 275
DESCRIPTION- CAMPES; TILGHMAN, Genes Dev., (19890000), vol. 3, pages 537 - 546
DESCRIPTION- CASTELLI,J.; THOMAS,E.K.; GILLIET,M.; LIU,Y.J.; LEVY,J.A., "Mature Dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15", Blood, (20040000), vol. 103, pages 2699 - 2704
DESCRIPTION- CHAPOVAL,A.I.; FULLER,J.A.; KREMLEV,S.G.; KAMDAR,S.J.; EVANS,R., "Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model: NK and T cell-mediated effects antagonized by B cells", J. Immunol., (19980000), vol. 161, pages 6977 - 6984
DESCRIPTION- CHEN et al., Proc. Natl. Acad. Sci. USA, (19940000), vol. 91, pages 3054 - 3057
DESCRIPTION- CHITNIS,V.; PAHWA,R.; PAHWA,S., "Determinants of HIV-Specific CD8 T-cell responses in HIV-infected pediatric patients and enhancement of HIV-gagspecific responses with exogenous IL-15", Clin. Immunol, (20030000), vol. 107, pages 36 - 45
DESCRIPTION- CHO,B.K.; RAO,V.P.; GE,Q.; EISEN,H.N.; CHEN,J., "Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells", J. Exp. Med., (20000000), vol. 192, pages 549 - 556
DESCRIPTION- CHOTHIA, C. et al., J. Mol. Biol., (19870000), vol. 196, pages 901 - 917
DESCRIPTION- CLACKSON et al., Nature, (19910000), vol. 352, pages 624 - 628
DESCRIPTION- COLE et al., MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., (19850000), pages 77 - 96
DESCRIPTION- COOPER,M.A. et al., "In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells", Blood, (20020000), vol. 100, pages 3633 - 3638
DESCRIPTION- COTE et al., Proc Natl Acad Sci USA, (19830000), vol. 80, pages 2026 - 2030
DESCRIPTION- CUNNINGHAM; WELLS, Science, (19890000), vol. 244, pages 1081 - 1085
DESCRIPTION- CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Greene Publishing Associates, Inc. and John Wiley & Sons, Inc.
DESCRIPTION- DE JONG,J.L.; FARNER,N.L.; WIDMER,M.B.; GIRI,J.G.; SONDEL,P.M., "Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex", J. Immunol., (19960000), vol. 156, pages 1339 - 1348
DESCRIPTION- DERBYSHIRE et al., Gene, (19860000), vol. 46, page 145
DESCRIPTION- DE VOS et al., Science, (19920000), vol. 255, pages 306 - 312
DESCRIPTION- DUBOIS, S. et al., J. Biol. Chem., (19990000), vol. 274, pages 26978 - 26984
DESCRIPTION- DUMMER,W. et al., "T cell homeostatic proliferation elicits effective antitumor autoimmunity", J. Clin. Invest, (20020000), vol. 110, pages 185 - 192
DESCRIPTION- EDLUND et al., Science, (19850000), vol. 230, pages 912 - 916
DESCRIPTION- ELISA, Theory and Practice: Methods in Molecular Biology, Human Press, (19950000), vol. 42
DESCRIPTION- EPSTEIN et al., Proc. Natl. Acad. Sci. USA, (19850000), vol. 82, page 3688
DESCRIPTION- FERRARI-LACRAZ,S. et al., "Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis", J. Immunol, (20040000), vol. 173, pages 5818 - 5826, XP002345721
DESCRIPTION- FISHWILD et al., Nature Biotechnology, (19960000), vol. 14, pages 845 - 851
DESCRIPTION- FORCINA,G. et al., "Interleukin-15 modulates interferon-gamma and betachemokine production in patients with HIV infection: implications for immune-based therapy", Cytokine, (20040000), vol. 25, pages 283 - 290
DESCRIPTION- FUCHS et al., Bio/Technology, (19910000), vol. 9, pages 1370 - 1372
DESCRIPTION- GABIZON et al., J. National Cancer Inst., (19890000), vol. 81, no. 19, page 1484
DESCRIPTION- GARRAD et al., Bio/Technology, (19910000), vol. 9, pages 1373 - 1377
DESCRIPTION- GIRI, J.G. et al., EMBO., (19950000), vol. 14, pages 3654 - 3663
DESCRIPTION- GIRI,J.G. et al., "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor", EMBO J, (19950000), vol. 15, pages 3654 - 3633
DESCRIPTION- GIRI,J.G. et al., "Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15", EMBO J., (19940000), vol. 13, pages 2822 - 2830
DESCRIPTION- GOEDDEL, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, Academic Press, (19900000), vol. 185
DESCRIPTION- GOLDRATH,A.W.; BEVAN,M.J., "Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ TCells in Lymphopenic Hosts", Immunity, (20000000), vol. 11, pages 183 - 190
DESCRIPTION- GOLDRATH,A.W. et al., "Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells", J. Exp. Med., (20020000), vol. 195, pages 1515 - 1522
DESCRIPTION- GORDON, Intl. Rev. Cytol., (19890000), vol. 115, pages 171 - 229
DESCRIPTION- GOTTESMAN, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, Academic Press, (19900000), vol. 185, pages 119 - 128
DESCRIPTION- GRAM et al., PNAS, (19920000), vol. 89, pages 3576 - 3580
DESCRIPTION- GREEN, L. L. et al., Nature Genet., (19940000), vol. 7, pages 13 - 21
DESCRIPTION- GRIFFTHS et al., EMBO J., (19930000), vol. 12, pages 725 - 734
DESCRIPTION- GRUBER et al., J. Immunol., (19940000), vol. 152, page 5368
DESCRIPTION- HARLOW et al., Antibodies: A Laboratory Manual, Cold Spring Harbor Pub., (19880000), page 726
DESCRIPTION- HAWKINS et al., J Mol Biol, (19920000), vol. 226, pages 889 - 896
DESCRIPTION- HAY et al., Hum Antibod Hybridomas, (19920000), vol. 3, pages 81 - 85
DESCRIPTION- HOLLINGER et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 6444 - 6448
DESCRIPTION- HOOGENBOOM et al., Nuc Acid Res, (19910000), vol. 19, pages 4133 - 4137
DESCRIPTION- HOOGENBOOM; WINTER, J. Mol. Biol., (19910000), vol. 227, page 381
DESCRIPTION- HOPP; WOODS, Proc. Nat. Acad. Sci. USA, (19810000), vol. 78, pages 3824 - 3828
DESCRIPTION- HUSE et al., Science, (19890000), vol. 246, pages 1275 - 1281
DESCRIPTION- HWANG et al., Proc. Natl Acad. Sci. USA, (19800000), vol. 77, page 4030
DESCRIPTION- JONES et al., Nature, (19860000), vol. 321, page 522
DESCRIPTION- JUDGE,A.D.; ZHANG,X.; FUJII,H.; SURH,C.D.; SPRENT,J., "Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T Cells", J. Exp. Med, (20020000), vol. 196, pages 935 - 946
DESCRIPTION- KASSIOTIS,G.; GARCIA,S.; SIMPSON,E.; STOCKINGER,B., "Impairment of immunological memory in the absence of MHC despite survival of memory T cells", Nat. Immunol., (20020000), vol. 3, pages 244 - 250
DESCRIPTION- KAUFMNAN et al., EMBO J., (19870000), vol. 6, pages 187 - 195
DESCRIPTION- KENNEDY,M.K. et al., "Reversible defects in natural killer and memory CD8 T cell lineages in Interleukin-15-deficient mice", J. Exp. Med., (20000000), vol. 191, pages 771 - 780
DESCRIPTION- KESSEL; GRUSS, Science, (19900000), vol. 249, pages 374 - 379
DESCRIPTION- KHAN,I.A.; KASPER,L.H., IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice
DESCRIPTION- KIEPER,W.C.; JAMESON,S.C., "Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands", PNAS, (20000000), vol. 96, pages 13306 - 13311
DESCRIPTION- KLEBANOFF,C.A. et al., "IL-15 enhances the in vivo antitumor activity of tumorreactive CD8+ T cells", PNAS, vol. 101, pages 1969 - 1974
DESCRIPTION- KLEBANOFF,C.A. et al., "IL-15 enhances the in vivo antitumor activity of tumorreactive CD8+ T cells", Proc. Natl. Acad. Sci. U. S. A, (20040000), vol. 101, pages 1969 - 1974
DESCRIPTION- KOKA,R. et al., "Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice", J. Exp. Med., (20030000), vol. 197, pages 977 - 984
DESCRIPTION- KOSTELNY et al., J. Immunol., (19920000), vol. 148, no. 5, pages 1547 - 1553
DESCRIPTION- KOZBOR et al., Immunol Today, (19830000), vol. 4, page 72
DESCRIPTION- KURJAN; HERSKOWITZ, Cell, (19820000), vol. 30, pages 933 - 943
DESCRIPTION- KYTE; DOOLITTLE, J. Mol. Biol., (19820000), vol. 157, pages 105 - 142
DESCRIPTION- LAVITRANO et al., Cell, (19890000), vol. 57, pages 717 - 723
DESCRIPTION- LODOLCE,J.P.; BURKETT,P.R.; BOONE,D.L.; CHIEN,M.; MA,A. T, "cell independent interleukin 15Ralpha signals are required for bystander proliferation", J Exp. Med., (20010000), vol. 194, pages 1187 - 1194
DESCRIPTION- LODOLCE,J.P. et al., "IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation", Immunity, (19980000), vol. 9, pages 669 - 676
DESCRIPTION- LOGAN; SHENK, Proc. Natl. Acad. Sci. U.S.A., (19840000), vol. 81, pages 3655 - 3659
DESCRIPTION- LO, Mol. Cell Biol., (19830000), vol. 3, pages 1803 - 1814
DESCRIPTION- LONBERG et al., Nature, (19940000), vol. 368, pages 856 - 859
DESCRIPTION- LONBERG; HUSZAR, Intern. Rev. Immunol., (19950000), vol. 13, pages 65 - 93
DESCRIPTION- LONBERG, N. et al., Nature, (19940000), vol. 368, pages 856 - 859
DESCRIPTION- LOWMAN et al., Biochem., (19910000), vol. 30, pages 10832 - 10837
DESCRIPTION- LOWY et al., Cell, (19800000), vol. 22, page 817
DESCRIPTION- LUCKLOW; SUMMERS, Virology, (19890000), vol. 170, pages 31 - 39
DESCRIPTION- LUENG et al., "A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction", Technique: J Methods Cell Molec Biol, (19890000), vol. 1, no. 1, pages 11 - 15
DESCRIPTION- LUM,J.J. et al., "Differential Effects of Interleukin-7 and Interleukin-15 on NK Cell AntiHuman Immunodeficiency Virus Activity", J. Virol., (20040000), vol. 78, pages 6033 - 6042
DESCRIPTION- MAEURER,M.J. et al., "Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice", Infect. Immun., (20000000), vol. 68, pages 2962 - 2970
DESCRIPTION- MARKS et al., Bio/Technology, (19920000), vol. 10, pages 779 - 783
DESCRIPTION- MARKS et al., J. Mol. Biol., (19910000), vol. 222, page 581
DESCRIPTION- MARTIN et al., J. Biol. Chem., (19820000), vol. 257, pages 286 - 288
DESCRIPTION- MASOPUST,D.; JIANG,J.; SHEN,H.; LEFRAN OIS,L., "Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection", J. Immunol., (20010000), vol. 166, pages 2348 - 2356
DESCRIPTION- MASTROIANNI,C.M. et al., "Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection", Blood, (20000000), vol. 96, pages 1979 - 1984
DESCRIPTION- MILSTEIN; CUELLO, Nature, (19830000), vol. 305, pages 537 - 539
DESCRIPTION- MORRISON, Nature, (19940000), vol. 368, pages 812 - 813
DESCRIPTION- MORRISON, S. L. et al., Proc. Natl. Acad. Sci. USA, (19940000), vol. 81, pages 6851 - 6855
DESCRIPTION- MUELLER,Y.M. et al., "IL-15 enhances survival and function of HIV-specific CD8+ T cells", Blood, vol. 101, pages 1024 - 1029
DESCRIPTION- MURALI-KRISHNA,K. et al., "Persistence of memory CD8 T cells in MHC class I-deficient mice", Science, (19990000), vol. 286, pages 1377 - 1381
DESCRIPTION- NER et al., DNA, (19880000), vol. 7, page 127
DESCRIPTION- NEUBERGER, Nature Biotechnology, (19960000), vol. 14, page 826
DESCRIPTION- NGUYEN,L.T. et al., "TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions", Eur. J. Immunol., (20000000), vol. 30, pages 683 - 688
DESCRIPTION- NISHIMURA,H. et al., "A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing", FASEB J, (20050000), vol. 19, pages 19 - 28
DESCRIPTION- OEHEN,S.; BRDUSCHA-RIEM,K., "Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division", J Immunol, (19980000), vol. 161, pages 5338 - 5346
DESCRIPTION- OH,S.; PERERA,L.P.; BURKE,D.S.; WALDMANN,T.A.; BERZOFSKY,J.A., "IL-15/IL- 15R{alpha}-mediated avidity maturation of memory CD8+ T cells", Proc. Natl. Acad. Sci. U. S. A, (20040000), vol. 101, pages 15154 - 15159
DESCRIPTION- OHTEKI,T.; SUZUE,K.; MAKI,C.; OTA,T.; KOYASU,S., "Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response", Nat. Immunol., (20010000), vol. 2, pages 1138 - 1143
DESCRIPTION- PARK,C.S.; YOON,S.O.; ARMITAGE,R.J.; CHOI,Y.S., "Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form", J. Immunol., (20040000), vol. 173, pages 6676 - 6683
DESCRIPTION- "Peptide And Protein Drug Delivery", Advances In Parenteral Sciences, M. Dekker, (19910000), vol. 4
DESCRIPTION- PINKERT et al., Genes Dev., (19870000), vol. 1, pages 268 - 277
DESCRIPTION- Production of Polyclonal Antisera in Immunochemical Processes, Humana Press, (19920000), pages 1 - 5
DESCRIPTION- QUEEN; BALTIMORE, Cell, (19830000), vol. 33, pages 741 - 748
DESCRIPTION- REIDHAAR-OLSON; SAUER, Science, (19880000), vol. 241, pages 53 - 57
DESCRIPTION- ROYCHOWDHURY,S. et al., "Failed adoptive immunotherapy with tumorspecific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2", Cancer Res., (20040000), vol. 64, pages 8062 - 8067
DESCRIPTION- RUBINSTEIN,M.P. et al., "Systemic Administration of IL-15 Augments the Antigen-Specific Primary CD8+ T Cell Response Following Vaccination with Peptide-Pulsed Dendritic Cells", J. Immunol, (20020000), vol. 169, pages 4928 - 4935, XP008123375
DESCRIPTION- RUCHATZ,H.; LEUNG,B.P.; WEI,X.Q.; MCINNES,I.B.; LIEW,F.Y., "Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen- induced immunopathology", J. Immunol., (19980000), vol. 160, pages 5654 - 5660, XP002941876
DESCRIPTION- RUCKERT,R. et al., "Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses", Eur. J. Immunol., (20030000), vol. 33, pages 3493 - 3503
DESCRIPTION- SAMBROOK et al., MOLECULAR CLONING--A LABORATORY MANUAL, Cold Spring Harbor Laboratory, (19890000), vol. 1-3
DESCRIPTION- SANDAU,M.M.; SCHLUNS,K.S.; LEFRANCOIS,L.; JAMESON,S.C., "Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R by the same cells", J. Immunol., (20040000), vol. 173
DESCRIPTION- SCHLUNS,K.S. et al., "Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression", Proc. Natl. Acad. Sci. U. S. A, (20040000), vol. 101, pages 5616 - 5621
DESCRIPTION- SCHLUNS,K.S.; KIEPER,W.C.; JAMESON,S.C.; LEFRAN OIS,L., "Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo", Nat. Immunol., (20000000), vol. 1, pages 426 - 432
DESCRIPTION- SCHLUNS,K.S.; WILLIAMS,K.; MA,A.; ZHENG,X.X.; LEFRAN OIS,L., "Cutting Edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells", J. Immunol., (20020000), vol. 168, pages 4827 - 4831
DESCRIPTION- SCHULTZ et al., Gene, (19870000), vol. 54, pages 113 - 123
DESCRIPTION- SEED, Nature, (19870000), vol. 329, page 840
DESCRIPTION- SHALABY et al., J. Exp. Med., (19920000), vol. 175, pages 217 - 225
DESCRIPTION- SINGER et al., J. Immunol., (19930000), vol. 150, page 2844
DESCRIPTION- SMITH et al., J. Mol. Biol., (19920000), vol. 224, pages 899 - 904
DESCRIPTION- SMITH et al., Mol. Cell. Biol., (19830000), vol. 3, pages 2156 - 2165
DESCRIPTION- SMITH; JOHNSON, Gene, Pharmacia Biotech Inc, (19880000), vol. 67, pages 31 - 40
DESCRIPTION- SMITH,X.G. et al., "Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival", J. Immunol., (20000000), vol. 165, pages 3444 - 3450, XP002445754
DESCRIPTION- STUDIER et al., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, Academic Press, (19900000), vol. 185, pages 60 - 89
DESCRIPTION- SURESH et al., Methods in Enzymology, (19860000), vol. 121, page 210
DESCRIPTION- SZYBALSKA; SZYBALSKI, Proc. Natl. Sci. U.S.A., (19620000), vol. 48, page 2026
DESCRIPTION- TAKEDA et al., Nature, (19850000), vol. 314, pages 544 - 546
DESCRIPTION- TAN,J.T. et al., "Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells", J. Exp. Med., (20020000), vol. 195, pages 1523 - 1532
DESCRIPTION- THOMPSON et al., Cell, (19890000), vol. 56, pages 313 - 321
DESCRIPTION- TRAUNECKER et al., EMBO J., (19910000), vol. 10, pages 3655 - 3659
DESCRIPTION- TUAILLON et al., PNAS, (19930000), vol. 90, pages 3720 - 3724
DESCRIPTION- TUTT et al., J. Immunol., (19910000), vol. 147, page 60
DESCRIPTION- UMEMURA,M.; NISHIMURA,H.; HIROSE,K.; MATSUGUCHI,T.; YOSHIKAI,Y., "Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guerin infection via augmentation of NK and T cytotoxic 1 responses", J. Immunol., (20010000), vol. 167, pages 946 - 956
DESCRIPTION- VAN DER PUTTEN et al., Proc. Natl. Acad. Sci. USA, (19850000), vol. 82, pages 6148 - 6152
DESCRIPTION- VITETTA et al., Science, (19870000), vol. 238, page 1098
DESCRIPTION- WADA et al., Nucl. Acids Res., (19920000), vol. 20, pages 2111 - 2118
DESCRIPTION- WALDEMANN, T.A.; Y. TAGAYA, Ann. Rev. Immunol., (19990000), vol. 17, pages 19 - 49
DESCRIPTION- WARREN,H.S.; KINNEAR,B.F.; KASTELEIN,R.L.; LANIER,L.L., "Analysis of the costimulatory role of IL-2 and IL-15 in initiating proliferation of resting (CD56dim) human NK cells", J. Immunol., (19960000), vol. 156, pages 3254 - 3259
DESCRIPTION- WIGLER et al., Cell, (19770000), vol. 11, page 233
DESCRIPTION- WINOTO; BALTIMORE, EMBO J., (19890000), vol. 8, pages 729 - 733
DESCRIPTION- WLODAVER et al., FEBS Lett., (19920000), vol. 309, pages 59 - 64
DESCRIPTION- WYSOCKA,M. et al., "Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15", Blood, (20040000), vol. 104, pages 4142 - 4149
DESCRIPTION- TSUNOBUCHI,H. et al., "A Protective Role of Interleukin-15 in a Mouse Model for Systemic Infection with Herpes Simplex Virus", Virol., (20000000), vol. 275, doi:doi:10.1006/viro.2000.0455, pages 57 - 66, XP004435908
DESCRIPTION- LYONS,A.B.; PARISH,C.R., "Determination of lymphocyte division by flow cytometry", J. Immunol. Methods, (19940000), vol. 171, doi:doi:10.1016/0022-1759(94)90236-4, pages 131 - 137, XP023986976
DESCRIPTION- WRZESINSKI,C.; RESTIFO,N.P., "Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based antitumor immunotherapy", Curr. Opin. Immunol., (20050000), vol. 17, doi:doi:10.1016/j.coi.2005.02.002, pages 195 - 201, XP025299768
DESCRIPTION- ALPDOGAN,0.; VAN DEN BRINK,M.R.M., "IL-7 and IL-15: therapeutic cytokines for immunodeficiency", Trends Immunol., (20050000), vol. 26, doi:doi:10.1016/j.it.2004.11.002, pages 56 - 64, XP004698883
DESCRIPTION- VILLINGER,F. et al., "IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques", Vaccine, (20040000), vol. 22, doi:doi:10.1016/j.vaccine.2003.07.022, pages 3510 - 3521, XP004526930
DESCRIPTION- JUNG,S. et al., "In vivo depletion of CDl lc(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens", Immunity, (20020000), vol. 17, doi:doi:10.1016/S1074-7613(02)00365-5, pages 211 - 220, XP002397258
DESCRIPTION- DUBOIS,S.; MARINER,J.; WALDMANN,T.A.; TAGAYA,Y., "IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells", Immunity, (20020000), vol. 17, doi:doi:10.1016/S1074-7613(02)00429-6, pages 537 - 547, XP002521795
DESCRIPTION- OH,S.; BERZOFSKY,J.A.; BURKE,D.S.; WALDMANN,T.A.; PERERA,L.P., "Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity", PNAS, (20030000), vol. 100, doi:doi:10.1073/pnas.0630592100, pages 3392 - 3397, XP002977722
DESCRIPTION- BURKETT,P.R. et al., "IL-15Ralpha expression on CD8+ T cells is dispensable for T cell memory", Proc. Natl. Acad. Sci. U. S. A, (20030000), vol. 100, doi:doi:10.1073/PNAS.0737048100, pages 4724 - 4729, XP002521794
DESCRIPTION- KIM,S.K. et al., "Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals", Proc. Natl. Acad. Sci. USA, (19980000), vol. 95, doi:doi:10.1073/pnas.95.18.10814, pages 10814 - 10819, XP002954055
DESCRIPTION- CARSON,W.E. et al., "Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor", J. Exp. Med., (19940000), vol. 180, doi:doi:10.1084/jem.180.4.1395, pages 1395 - 1403, XP002244734
DESCRIPTION- PRLIC,M.; BLAZAR,B.R.; FARRAR,M.A.; JAMESON,S.C., "In vivo survival and homeostatic proliferation of natural killer cells", J. Exp. Med., (20030000), vol. 197, doi:doi:10.1084/jem.20021847, pages 967 - 976, XP002452473
DESCRIPTION- ZENG,R. et al., "Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function", J. Exp. Med, (20050000), vol. 201, doi:doi:10.1084/jem.20041057, pages 139 - 148, XP002465517
DESCRIPTION- ALTMAN,J.D. et al., "Phenotypic analysis of antigen-specific T lymphocytes", Science, (19960000), vol. 274, doi:doi:10.1126/science.274.5284.94, pages 94 - 96, XP002135711
DESCRIPTION- KU,C.C.; MURAKAMI,M.; SAKAMOTO,A.; KAPPLER,J.; MARRACK,P., "Control of homeostasis of CD8+ memory T cells by opposing cytokines", Science, (20000000), vol. 288, doi:doi:10.1126/science.288.5466.675, pages 675 - 678, XP003013443
DESCRIPTION- GRABSTEIN,K.H. et al., "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor", Science, (19940000), vol. 264, doi:doi:10.1126/science.8178155, pages 965 - 968, XP002464028
DESCRIPTION- ALPDOGAN,0. et al., "Interleukin-15 enhances immune reconstitution after allogenic bone marrow transplantation", Blood, (20050000), vol. 105, doi:doi:10.1182/blood-2003-09-3344, pages 865 - 873, XP002604499
DESCRIPTION- DUDLEY,M.E. et al., "Adoptive cell transfer therapy following nonmyeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma", J. Clin. Oncol., (20050000), vol. 23, doi:doi:10.1200/JCO.2005.00.240, pages 2346 - 2357, XP002433186
DESCRIPTION- DUNNE,J. et al., "Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15", J. Immunol., (20010000), vol. 167, doi:doi:10.4049/jimmunol.167.6.3129, pages 3129 - 3138, XP055221094
OPPOSITION- Dubois et al., "IL -15Ra Recycles and Presents IL-15 In Trans November to Neighbouring Cells", Immunity, (20020101), vol. 17, pages 537 - 547, XP055622333
OPPOSITION- GIRI et al., "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.", The EMBO journal, Oxford , (19950101), vol. 14, no. 15, ISSN 0261-4189, pages 3654 - 3663, XP002096594
OPPOSITION- MORTIER et al., "Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist", The Journal of Immunology, US , (20040801), vol. 173, no. 3, ISSN 0022-1767, pages 1681 - 1688, XP002445753
OPPOSITION- RUCHATZ et al., "SOLUBLE IL-15 RECEPTOR ALPHA-CHAIN ADMINISTRATION PREVENTS MURINE COLLAGEN-INDUCED ARTHRITIS: A ROLE FOR IL-15 IN DEVELOPMENT OF ANTIGEN-INDUCED IMMUNOPATHOLOGY", The Journal of Immunology, US , (19980101), vol. 160, ISSN 0022-1767, pages 5654 - 5660, XP002941876
OPPOSITION- WEI et al., "The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo.", The Journal of Immunology, US , (20010701), vol. 167, no. 1, ISSN 0022-1767, pages 277 - 282, XP002394329
OPPOSITION- CHAMOW et al., "IMMUNOADHESINS: PRINCIPLES AND APPLICATIONS.", TRENDS IN BIOTECHNOLOGY, GB , (19960101), vol. 14, doi:10.1016/0167-7799(96)80921-8, ISSN 0167-7799, pages 52 - 60, XP000961257
OPPOSITION- Pflanz et al., "A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130", FEBS Letters, NL , (19990430), vol. 450, no. 1-2, doi:10.1016/S0014-5793(99)00477-9, ISSN 0014-5793, pages 117 - 122, XP004259602
OPPOSITION- FISCHER et al., "A BIOACTIVE DESIGNER CYTOKINE FOR HUMAN HEMATOPOIETIC PROGENITOR CELL EXPANSION", Nature Biotechnology, New York, (19970201), vol. 15, no. 2, doi:10.1038/nbt0297-142, ISSN 1087-0156, pages 142 - 145, XP002047603
OPPOSITION- BURKETT et al., "IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory", Proceedings of the National Academy of Sciences, (20030415), vol. 100, no. 8, doi:10.1073/PNAS.0737048100, ISSN 0027-8424, pages 4724 - 4729, XP002521794
OPPOSITION- Dubois et al., "Natural Splicing of Exon 2 of Human Interleukin-15 Receptor α-Chain mRNA Results in a Shortened Form with a Distinct Pattern of Expression", Journal of Biological Chemistry, US , (19990901), vol. 274, no. 38, doi:10.1074/jbc.274.38.26978, ISSN 0021-9258, pages 26978 - 26984, XP055923223
OPPOSITION- BERNARD J, et al, "Identification of an interleukin-15alpha receptor-binding site on human interleukin-15.", Journal of Biological Chemistry, US , (20040604), vol. 279, no. 23, doi:10.1074/jbc.M312458200, ISSN 0021-9258, pages 24313 - 24322, XP002286785
OPPOSITION- MORTIER et al., "Soluble Interleukin-15 Receptor a ( IL -15Ra)-sushi as a Selective and Potent Agonist of IL -15 Action through IL - 15Rbeta/gamma", The Journal of Biological Chemistry, (20060000), vol. 281, no. 3, doi:10.1074/jbc.M508624200, pages 1612 - 1619, XP002394330
OPPOSITION- MORTIER et al., "Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.", Journal of Biological Chemistry, US , (20060120), vol. 281, no. 3, doi:10.1074/jbc.M508624200, ISSN 0021-9258, pages 1612 - 1619, XP002394330
OPPOSITION- Kermer et al., "An antibody fusion protein for cancer immunotherapy mimicking IL-15 trans-presentation at the tumor site.", Molecular Cancer Therapeutics, US , (20120406), vol. 11, no. 6, doi:10.1158/1535-7163.MCT-12-0019, ISSN 1535-7163, pages 1279 - 1288, XP002683666
OPPOSITION- Koka et al., "Cutting Edge: Murine Dendritic Cells Require IL-15Rα to Prime NK Cells", The Journal of Immunology, US , (20040915), vol. 173, no. 6, doi:10.4049/jimmunol.173.6.3594, ISSN 0022-1767, pages 3594 - 3598, XP055923232
SEARCH[ ] - STOKLASEK THOMAS A ET AL, "Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 NOV 2006, (20061101), vol. 177, no. 9, ISSN 0022-1767, pages 6072 - 6080, XP002521797
SEARCH- VAN BELLE TOM ET AL, "IL-15 and IL-15Ralpha in CD4+T cell immunity", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, POLISH ACADEMY OF SCIENCES, WROCLAW, PL, (20050415), vol. 53, no. 2, ISSN 0004-069X, pages 115 - 126, XP009114557 [A] 1-20 * the whole document *
SEARCH- WEI X Q ET AL, "The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (20010701), vol. 167, no. 1, ISSN 0022-1767, pages 277 - 282, XP002394329 [A] 1-20 * the whole document *
SEARCH- PFLANZ S ET AL, "A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (19990430), vol. 450, no. 1-2, ISSN 0014-5793, pages 117 - 122, XP004259602 [X] 1,7 * abstract * [Y] 2-6,8-20
SEARCH- DUBOIS SIGRID ET AL, "IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells.", IMMUNITY NOV 2002, (200211), vol. 17, no. 5, ISSN 1074-7613, pages 537 - 547, XP002521795 [X] 1-20 * page 544, column R - page 545, column R * * page 539, column L *
SEARCH- FISCHER MARTINA ET AL, "A bioactive designer cytokine for human hematopoietic progenitor cell expansion", 19970101; 19970000, (19970101), vol. 15, no. 2, pages 142 - 145, XP002279305 [X] 1,7 * abstract * [Y] 2-6,8-20
SEARCH- RUBINSTEIN MARK P ET AL, "Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 13 JUN 2006, (20060613), vol. 103, no. 24, ISSN 0027-8424, pages 9166 - 9171, XP002521796 [PX] 1-20 * the whole document *
SEARCH- BURKETT PATRICK R ET AL, "IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 15 APR 2003, (20030415), vol. 100, no. 8, ISSN 0027-8424, pages 4724 - 4729, XP002521794 [DX] 1-20 * page 4725, column L * * page 4728, column L *
SEARCH- MORTIER ERWAN ET AL, "Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, (20060120), vol. 281, no. 3, ISSN 0021-9258, pages 1612 - 1619, XP002394330 [PX] 1-20 * the whole document *
SEARCH- GIRON-MICHEL JULIEN ET AL, "Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20051001), vol. 106, no. 7, ISSN 0006-4971, pages 2302 - 2310, XP002394327 [PX] 1-20 * the whole document *

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