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Botulinum Toxin Assay With Improved Sensitivity - EP3270162

The patent EP3270162 was granted to Biomadison on Aug 16, 2023. The application was originally filed on Aug 8, 2014 under application number EP17183975A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3270162

BIOMADISON
Application Number
EP17183975A
Filing Date
Aug 8, 2014
Status
Patent Maintained As Amended
Jul 14, 2023
Publication Date
Aug 16, 2023
External Links
Slate, Register, Google Patents

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MERZ PHARMAMar 30, 2021ALTMANN STOSSEL DICK PATENTANWALTE PARTG MBB -

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2004191887
DESCRIPTIONUS2006134722
DESCRIPTIONUS2011033866
DESCRIPTIONUS7183066
DESCRIPTIONUS7208285
DESCRIPTIONWO2014060373
OPPOSITIONUS2006134722
OPPOSITIONUS2008064054
OPPOSITIONUS2010209955
OPPOSITIONWO2009035476
OPPOSITIONWO2012166943
OPPOSITIONWO2013103737
SEARCHWO2009014854
SEARCHWO2009035476
SEARCHWO2013103737

Non-Patent Literature (NPL) Citations (14) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- FOSTER; STRINGER, "Genetic Regulatory Elements Introduced Into Neural Stem and Progenitor Cell Populations", Brain Pathology, (19990000), vol. 9, pages 547 - 567, XP000997670
OPPOSITION- Dennis Higgins, Gary Banker, "Chapter 3 - Primary Dissociated Cell Cultures", Dennis Higgins, Gary Banker, Gary Banker and Kimberly Goslin, Culturing Nerve Cells, second edition, MIT Press, (19980000), pages 3pp, 37 - 78, XP055796092
OPPOSITION- Jennifer A. Kim and Barry W. Connors, "High temperatures alter physiological properties dis of pyramidal cells and inhibitory interneurons in hippocampus", Frontiers in Cellular Neuroscience, (20120706), vol. 6, pages 1 - 12, XP055796095
OPPOSITION- Daniel R Ruge; Mark Dunning F; Timothy M Piazza; Brian E Molles; Michael Adler; Füsûn N Zeytin; Ward C Tucker, "Detection of six serotypes of botulinum neurotoxin using fluorogenic reporters", Anal. Biochem., (20110000), vol. 411, pages 200 - 209, XP002672446
OPPOSITION- Pirazzini Marco; Rossetto Ornella; Bertasio Cristina; Bordin Fulvio; Shone Clifford C; Binz Thomas; Montecucco Cesare, "Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons", Biochemical and Biophysical Research Communications, (20130000), vol. 430, pages 38 - 42, XP028962880
OPPOSITION- Min Dong; William H Tepp; Eric A Johnson; and Edwin R Chapman, "Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells", PNAS, (20040000), vol. 101, pages 14701 - 14706, XP008156528
OPPOSITION- Jason R. Barash and Stephen S. Amon, "A Novel Strain of Clostridium botulinum That Produces Type B and Type H Botulinum Toxins", The Journal of Infectious Diseases, (20140000), vol. 209, no. 2, pages 183 - 191, XP055796122
OPPOSITION- Nir Dover, Jason R. Barash, Karen K. Hill, Gary Xie, and Stephen S. Arnon, "Molecular Characterization of a Novel Botulinum Neurotoxin Type H Gene", J Infect Dis, (20131007), vol. 209, no. 2, pages 192 - 202, XP055796067
OPPOSITION- Eric A. Johnson, "Validity of Botulinum Neurotoxin Serotype H", The Journal of Infectious Diseases, (20140915), vol. 210, no. 6, pages 992 - 993, XP055796127
OPPOSITION- Susan E. Maslanka, Carolina Luquez, Janet K. Dykes, William H. Tepp, Christina L. Pier Sabine Pellett, Brian H. Raphael, Suzanne R. Kalb, John R. Barr, Agam Rao, and Eric A. Johnson, "A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regionsof Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin", The Journal of Infectious Diseases, (20160201), vol. 213, no. 3, pages 379 - 385, XP055796135
OPPOSITION- Sabine Pellett, William H. Tepp,a Marite Bradshaw, Suzanne R. Kalb, Janet K. Dykes, Guangyun Lin, Erin M. Nawrocki, Christina L. Pier,3 John R. Barr, Susan E. Maslanka, Eric A. Johnson, "Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain", mSphere, (20160000), vol. 1, no. 1, pages 1 - 18, XP055500222
OPPOSITION- Koji Shibasaki, Makoto Suzuki, Atsuko Mizuno, and Makoto Tominaga, "Effects of Body Temperature on Neural Activity in the Hippocampus: Regulation of Resting Membrane Potentials by Transient Receptor Potential Vanilloid 4", J. Neurosci., (20070000), vol. 27, no. 7, pages 1566 - 1575, XP055796104
SEARCH- F. M. DUNNING ET AL, "Detection of Botulinum Neurotoxin Serotype A, B, and F Proteolytic Activity in Complex Matrices with Picomolar to Femtomolar Sensitivity", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (20120824), vol. 78, no. 21, doi:10.1128/AEM.01664-12, ISSN 0099-2240, pages 7687 - 7697, XP055151398 [A] 1-9 * page 7689, figure 1 and column 1, last paragraph *
SEARCH- NUSS JONATHAN E ET AL, "Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies", JOURNAL OF BIOMOLECULAR SCREENING, SAGE; LIEBERT, US, (20100101), vol. 15, no. 1, doi:10.1177/1087057109354779, ISSN 1087-0571, pages 42 - 51, XP008124093 [A] 1-9 * page 43, column 2 first line; page 44 first passage. *

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