The patent EP3272764 was granted to Novartis on Feb 7, 2024. The application was originally filed on Dec 17, 2010 under application number EP17188657A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| OPPOSITION | EP0333474 |
| OPPOSITION | EP2513134 |
| OPPOSITION | US4704366 |
| OPPOSITION | WO2007109163 |
| OPPOSITION | WO2008031020 |
| OPPOSITION | WO2011073389 |
| SEARCH | EP0333474 |
| SEARCH | US2007060741 |
| SEARCH | US2008051340 |
| SEARCH | WO2008031020 |
NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.
| Citation Phase | Reference Text |
|---|---|
| EXAMINATION | - SHUKLA ABHINAV A ET AL, "Host cell protein clearance during protein A chromatography: development of an improved column wash step", BIOTECHNOLOGY PROGRESS, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 24, no. 5, doi:10.1002/BTPR.50, ISSN 1520-6033, (20080901), pages 1115 - 1121, (20081014), XP002562071 |
| OPPOSITION | - Anna Gronberg, Elin Monie, Maria Murby, Gustav Rodrigo, Elisabeth Wallby, Hans J. Johansson, "A Strategy for Developing a Monoclonal Antibody Purification Platform", BioProcess International, (20070101), vol. 5, no. 1, pages 48 - 55, XP055495108 |
| OPPOSITION | - Anonymous, " Chapter 1 Introduction", Design of Experiments in Protein Production and Purification Handbook - 29-1038-50 AA, (20140501), pages 8 - 12, XP093236987 |
| OPPOSITION | - Embl, European Moleculas Biology Laboratory, "Protein Purification EXTRACTION AND CLARIFICATION CHOICE OF LYSIS BUFFER AND ADDITIVES", (20191108), pages 1 - 3, XP093236889 |
| OPPOSITION | - Healthcare Ge, "High-throughput screening and optimization of a Protein A capture step in a monoclonal antibody purification process", High-throughput process development - Application note - 28-9468-58 AB, (20090901), pages 1 - 8, High-throughput process development - Application note - 28-9468-58 AB, URL: https://cdn.cytivalifesciences.com/api/public/content/digi-14414-pdf, XP093236996 |
| OPPOSITION | - John M Walker, "Affi-Prep - Protein A Matrix Instruction Manual LIT-230 Rev B", Bio-Rad, US, (20000101), pages 993 - 994 , 999-1001 and 1121-1128, (20131128), XP055090731 |
| OPPOSITION | - Monie Elin, "Evaluation of the 96-well format for screening of chromatographic buffer conditions ", Master's Degree Project, (20061001), ISSN 1401-2138, pages 1 - 58, XP093236898 |
| OPPOSITION | - Murphy Regina M., Tsai Amos M., " Protein Folding, Misfolding, Stability, and Aggregation: An Overview", Misbehaving Proteins Protein (Mis)Folding, Aggregation, and Stability, Springer, (20060101), pages 3 - 9, ISBN 978-0-387-30508-0, XP093236954 |
| OPPOSITION | - Rehm Hubert, "6.1 Herstellung von polyklonalen Antikörpern ; 6.2.1 Immunpräzipitation mit immobilisiertem Protein A ", Proteinbiochemie / Proteomics - 4. überarbeitete Auflag, (20020101), pages 161 - 163, ISBN 978-3-8274-1195-2, XP093236864 |
| OPPOSITION | - "Tech tip 34 - Binding characteristics of antibody-binding proteins: Protein A, Protein G, Protein A/G and Protein L", Thermo Scientific, (20130101), page 1, Thermo Scientific, URL: https://assets.thermofisher.com/TFS-Assets/LSG/Application-Notes/TR0034-Ab-binding-proteins.pdf, XP093237001 |
| OPPOSITION | - "What is DOE? Design of Experiments Basics for Beginners", Umetrics is now part of Sartorius Stedim Biotech, (20180809), pages 1 - 8, Umetrics as part of Sartorius Stedim Biotech, XP093236972 |
| OPPOSITION | - Abhinav A. Shukla; Peter Hinckley, "Host cell protein clearance during protein a chromatography: Development of an improved column wash step", Biotechnology Progress, US, (20081014), vol. 24, no. 5, doi:10.1002/btpr.50, ISSN 8756-7938, pages 1115 - 1121, XP072292681 |
| SEARCH | - "Affi-Prep - Protein A Matrix Instruction Manual LIT-230 Rev B", (20000101), URL: http://www.bio-rad.com/webroot/web/pdf/lsr/literature/LIT230.pdf, (20131128), XP055090731 [Y] 9-13 * page 3, step 2 * |
| SEARCH | - "GE Healthcare Data File 18-1149-94 AE Affinity chromatography: MabSelect", Uppsala, (20080401), URL: http://www.gelifesciences.co.jp/catalog/pdf/18114994.pdf, (20131128), XP055090722 [Y] 9-13 * "Operation: Method development" * |
| SEARCH | - "Protein A Antibody Purification Handbook", Littleton, MA, USA, (20050101), URL: http://www.protein-chem.com/Resources/proteus%20A.3.pdf, (20131128), XP055090724 [Y] 9-13 * page 17 * * page 24, column r * |
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Feb 20, 2024
Jan 11, 2024
Decision to grant a European patent
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Dec 28, 2023
(Electronic) Receipt
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Dec 28, 2023
Filing of the translations of the claims
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Dec 28, 2023
French translation of claims
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Dec 28, 2023
German translation of the claims
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Oct 16, 2023
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Intention to grant (signatures)
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Oct 16, 2023
Text intended for grant (clean copy)
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Oct 16, 2023
May 30, 2023
(Electronic) Receipt
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May 30, 2023
Amended claims with annotations
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May 30, 2023
Amended description with annotations
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May 30, 2023
Claims
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May 30, 2023
Description
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May 30, 2023
May 30, 2023
Summary of subsequently filed documents
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Mar 24, 2023
Annex to the communication
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Mar 24, 2023
Communication from the Examining Division
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Jun 28, 2022
Apr 22, 2021
Decision to allow further processing
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Apr 13, 2021
(Electronic) Receipt
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Apr 13, 2021
Amended claims with annotations
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Apr 13, 2021
Claims
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Apr 13, 2021
Apr 13, 2021
Request for further processing
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Feb 3, 2021
Oct 28, 2020
Oct 22, 2020
Jun 17, 2020
Annex to the communication
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Jun 17, 2020
Communication from the Examining Division
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Jun 2, 2020
(Electronic) Receipt
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Jun 2, 2020
Amended claims with annotations
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Jun 2, 2020
Amended description with annotations
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Jun 2, 2020
Claims
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Jun 2, 2020
Description
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Jun 2, 2020
Letter accompanying subsequently filed items
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Jun 2, 2020
Sep 27, 2019
Decision to allow further processing
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Sep 16, 2019
(Electronic) Receipt
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Sep 16, 2019
Amended claims with annotations
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Sep 16, 2019
Claims
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Sep 16, 2019
Letter accompanying subsequently filed items
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Sep 16, 2019
Request for further processing
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Jul 4, 2019
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Jan 21, 2019
Annex to the communication
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Jan 21, 2019
Dec 18, 2018
(Electronic) Receipt
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Dec 18, 2018
Letter accompanying subsequently filed items
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Dec 18, 2018
Matter concerning the application
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Nov 26, 2018
Annex to the communication
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Nov 26, 2018
Communication from the Examining Division
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Nov 20, 2018
Examination started
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Jul 12, 2018
(Electronic) Receipt
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Jul 12, 2018
Letter accompanying subsequently filed items
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Jul 12, 2018
Maintenance of the application
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Jul 5, 2018
Jul 5, 2018
Jun 28, 2018
(Electronic) Receipt
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Jun 28, 2018
Letter accompanying subsequently filed items
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Jun 28, 2018
Jan 29, 2018
Jan 4, 2018
Notification of forthcoming publication
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Dec 6, 2017
Refund of fees
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Nov 29, 2017
Nov 29, 2017
European search opinion
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Nov 29, 2017
European search report
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Nov 29, 2017
Information on Search Strategy
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Nov 21, 2017
Search started
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Oct 23, 2017
Communication to designated inventor
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Oct 23, 2017
Communication to designated inventor
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Aug 30, 2017
Abstract
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Aug 30, 2017
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Claims
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Aug 30, 2017
Description
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Aug 30, 2017
Designation of inventor
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Aug 30, 2017
Previously filed application
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Aug 30, 2017
Request for grant of a European patent
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Jul 11, 2011