Highly Sensitive Cell-Based Assay To Detect The Presence Of Active Botulinum Neurotoxin Serotype-A - EP3279335

The patent EP3279335 was granted to Abel on Mar 10, 2021. The application was originally filed on Dec 28, 2012 under application number EP17178062A. The patent is currently recorded with a legal status of "Revoked".

EP3279335

ABEL
Application Number
EP17178062A
Filing Date
Dec 28, 2012
Status
Revoked
Aug 19, 2022
Publication Date
Mar 10, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MERZ PHARMADec 8, 2021ALTMANN STOSSEL DICK PATENTANWALTE PARTG MBB -

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS20100723474
DESCRIPTIONUS2004166514
DESCRIPTIONUS2004220386
DESCRIPTIONUS2008096248
DESCRIPTIONUS2008161543
DESCRIPTIONUS2008241881
DESCRIPTIONUS2010112727
DESCRIPTIONUS2011287517
DESCRIPTIONUS7223577
DESCRIPTIONUS7419676
DESCRIPTIONUS8198034
OPPOSITIONWO2009114748
OPPOSITIONWO2010105234
SEARCHWO2009114748
SEARCHWO2010105234

Non-Patent Literature (NPL) Citations (21) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- DAVID J. KING, Applications and Engineering of Monoclonal Antibodies, (19980000), page 240
DESCRIPTION- GIOVANNA LALLI et al., "The Journey of Tetanus and Botulinum Neurotoxins in Neurons", Trends Microbiol., (20030000), vol. 11, no. 9, pages 431 - 437
DESCRIPTION- YANN HUMEAU et al., "How Botulinum and Tetanus Neurotoxins Block Neurotransmitter Release", Biochimie, (20000000), vol. 82, no. 5, pages 427 - 446
DESCRIPTION- R. BARRY; M, SOLOVIEV, "Quantitative Protein Profiling using Antibody Arrays", Proteomics, (20040000), vol. 4, no. 12, doi:doi:10.1002/pmic.200300877, pages 3717 - 3726, XP002545158
DESCRIPTION- U. B. NIELSEN; B. H. GEIERSTANGER, "Multiplexed Sandwich Assays in Microarray Format", J. Immunol. Methods., (20040000), vol. 290, no. 1-2, doi:doi:10.1016/j.jim.2004.04.012, pages 107 - 120, XP004521984
DESCRIPTION- KATHRYN TURTON et al., "Botulinum and Tetanus Neurotoxins: Structure, Function and Therapeutic Utility", Trends Biochem. Sci., (20020000), vol. 27, no. 11, doi:doi:10.1016/S0968-0004(02)02177-1, pages 552 - 558, XP004390740
DESCRIPTION- S. X. LENG et al., "ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research", J Gerontol A Biol Sci Med Sci., (20080000), vol. 63, no. 8, doi:doi:10.1093/gerona/63.8.879, pages 879 - 884, XP008154409
DESCRIPTION- M. M. LING et al., "Multiplexing Molecular Diagnostics and Immunoassays using Emerging Microarray Technologies", Expert Rev Mol Diagn., (20070000), vol. 7, doi:doi:10.1586/14737159.7.1.87, pages 87 - 98, XP009080968
OPPOSITION- Karadag M., Merve Arslana , Nazli Eda Kalelia , Sibel Kalyoncu, "Physicochemical determinants of antibody-protein interactions", Computational chemistry methods in structural biology, Elsevier, NL, NL , (20200101), ISSN 1876-1623, ISBN 978-0-12-386485-7, pages 85 - 114, XP055894903
OPPOSITION- UNIPROT Blast results SNAP-25 sequences
OPPOSITION- Vinod P. Shah, Kamal Shah, Shrikant Midha, Iain Dighe, Jerome Mcgilveray, Avraham Skelly, Thomas Yacobi, Layloff, Viswanathan, Cook, Kenneth Mcdowall, Sidney Pittman, Spector, "Analytical methods validation: Bioavailability, bioequivalence, and pharmacokinetic studies", Journal of Pharmaceutical Sciences, American Chemical Society and American Pharmaceutical Association, (19920301), vol. 81, no. 3, doi:10.1002/jps.2600810324, ISSN 00223549, pages 309 - 312, XP055147418
OPPOSITION- Bark, I. ; Wilson, M.C., "Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25", Gene, Elsevier Amsterdam, NL, NL , (19940225), vol. 139, no. 2, doi:10.1016/0378-1119(94)90773-0, ISSN 0378-1119, pages 291 - 292, XP025501961
OPPOSITION- Rivera, V.R. ; Gamez, F.J. ; Keener, W.K. ; White, J.A. ; Poli, M.A., "Rapid detection of Clostridium botulinum toxins A, B, E, and F in clinical samples, selected food matrices, and buffer using paramagnetic bead-based electrochemiluminescence detection", Analytical Biochemistry, Academic Press, Amsterdam, NL, Amsterdam, NL , (20060615), vol. 353, no. 2, doi:10.1016/j.ab.2006.02.030, ISSN 0003-2697, pages 248 - 256, XP024942177
OPPOSITION- VAIDYANATHAN V.V, ET AL, "Proteolysis of SNAP-25 isoforms by botulinum neurotoxin: types A, C and E: Domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage", Journal of Neurochemistry, Wiley-Blackwell Publishing Ltd., GB, GB , (19990101), vol. 72, no. 1, doi:10.1046/j.1471-4159.1999.0720327.x, ISSN 0022-3042, pages 327 - 337, XP002959188
OPPOSITION- Kathryn E. Tiller, Peter M. Tessier, "Advances in Antibody Design", Annual Review of Biomedical Engineering, ANNUAL REVIEWS, US, US , (20151207), vol. 17, no. 1, doi:10.1146/annurev-bioeng-071114-040733, ISSN 1523-9829, pages 191 - 216, XP055556978
OPPOSITION- Gerald R Prescott;Luke H Chamberlain, "Regional and developmental brain expression patterns of SNAP25 splice variants", BMC NEUROSCIENCE, BIOMED CENTRAL, LONDON, GB, GB , (20110428), vol. 12, no. 1, doi:10.1186/1471-2202-12-35, ISSN 1471-2202, page 35, XP021099705
OPPOSITION- Ester Fernandez-Salas, Wang Joanne, Molina Yanira, Nelson Jeremy B., Jacky Birgitte P. S., Aoki K. Roger, "Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay", PLoS ONE, (20120101), vol. 7, no. 11, doi:10.1371/journal.pone.0049516, pages 1 - 13, XP055070996
OPPOSITION- TODD J, ET AL, "Ultrasensitive flow-based immunoassays using single-molecule counting", Clinical Chemistry, Oxford University Press, US, US , (20071101), vol. 53, no. 11, doi:10.1373/clinchem.2007.091181, ISSN 0009-9147, pages 1990 - 1995, XP008089655
SEARCH- JOSHI S G ET AL, "Modulation of botulinum toxin-induced changes in neuromuscular function with antibodies directed against recombinant polypeptides or fragments", NEUROSCIENCE, NEW YORK, NY, US, vol. 179, doi:10.1016/J.NEUROSCIENCE.2011.01.033, ISSN 0306-4522, (20110120), pages 208 - 222, (20110126), XP028162853 [A] 1-8 * abstract *
SEARCH- KARINE BAGRAMYAN ET AL, "Attomolar Detection of Botulinum Toxin Type A in Complex Biological Matrices", PLOS ONE, (20080430), vol. 3, no. 4, doi:10.1371/journal.pone.0002041, page e2041, XP055192571 [A] 1-8 * abstract *
SEARCH- ESTER FERNÁNDEZ-SALAS ET AL, "Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay", PLOS ONE, (20121121), vol. 7, no. 11, doi:10.1371/journal.pone.0049516, page e49516, XP055070996 [AP] 1-8 * abstract *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents