IP Verse

Lyophilization Of Rna - EP3283125

The patent EP3283125 was granted to Curevac on Dec 29, 2021. The application was originally filed on Apr 15, 2016 under application number EP16719206A. The patent is currently recorded with a legal status of "Revoked".

EP3283125

CUREVAC
Application Number
EP16719206A
Filing Date
Apr 15, 2016
Status
Revoked
Mar 28, 2025
Grant Date
Dec 29, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

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BIONTECHSep 29, 2022HOPFNERADMISSIBLE
SANOFISep 29, 2022CARPMAELS & RANSFORDADMISSIBLE

Patent Citations (23) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP1083232
DESCRIPTIONWO03086280
DESCRIPTIONWO2009030481
DESCRIPTIONWO2009095226
DESCRIPTIONWO2010037539
DESCRIPTIONWO2011026641
DESCRIPTIONWO2011069586
DESCRIPTIONWO2012013326
DESCRIPTIONWO2012019780
DESCRIPTIONWO2012113513
DESCRIPTIONWO2013143700
EXAMINATIONWO2012170889
INTERNATIONAL-SEARCH-REPORTUS2011182941
INTERNATIONAL-SEARCH-REPORTWO2011069586
OPPOSITIONEP3336082
OPPOSITIONUS2009238797
OPPOSITIONUS6932971
OPPOSITIONWO2009056651
OPPOSITIONWO2011069586
OPPOSITIONWO2011071860
OPPOSITIONWO2012170889
OPPOSITIONWO2014197970
OPPOSITIONWO2016165831

Non-Patent Literature (NPL) Citations (27) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- MEISTER EVA ET AL, Freeze-dry microscopy: impact of nucleation temperature and excipient concentration on collapse temperature data., AAPS PHARMSCITECH 2009, VOL. 10, NR. 2, PAGE(S) 582 - 588, (2009), ISSN 1530-9932-
EXAMINATION- YADAVA PREETI ET AL, "Effect of lyophilization and freeze-thawing on the stability of siRNA-liposome complexes", AAPS PHARMSCITECH, SPRINGER NEW YORK LLC, US, vol. 9, no. 2, doi:10.1208/S12249-007-9000-1, ISSN 1530-9932, (20080601), pages 335 - 341, (20071229), XP002511465
OPPOSITION- Adams Gerald, "Cryopreservation and Freeze-Drying Protocols", Methods in Molecular Biology. 2nd ed. Vol 368, Human Press, (20070101), vol. 368, pages 15 - 38, XP055969235-
OPPOSITION- Anonymous, "Basic Principles of Freeze Drying", SP Scientific - Technical Note, (20090506), pages 1 - 14, SP Scientific - Technical Note, (20221010), XP055969237-
OPPOSITION- Anonymous , "Enterobacteria phage Qbeta RNA, complete genome, isolate: Anc(P1)", Nucleotide, (20150701), Database accession no. AB971354.1, URL: ncbi, XP055969245-
OPPOSITION- Anonymous, "Freeze-dryer ALPHA 1-4 LSC& ALPHA 2-4 LSC&", CHRIST - Operating Manual, (20110101), pages 1 - 121, CHRIST - Operating Manual, (20221010), XP055969227-
OPPOSITION- Anonymous , "Hepatitis C virus core gene, partial cds, isolate: E-b1", Nucleotide, (20160724), Database accession no. D10123.1, URL: ncbi, XP055969292-
OPPOSITION- Anonymous , "Hepatitis C virus subtype 4d isolate p9-24 NS3 (NS3) gene, partial cds", Nucleotide, (20160724), Database accession no. FJ890494.1, URL: ncbi, XP055969289-
OPPOSITION- Anonymous , "Human poliovirus 1 Mahoney, complete genome", Nucleotide, (20030210), Database accession no. V01149.1, URL: ncbi, XP055969251-
OPPOSITION- Anonymous , "Human poliovirus 2 strain MEF-1 polyprotein gene, complete cds", Nucleotide, (20040923), Database accession no. AY238473.1, XP055969275-
OPPOSITION- Anonymous, "mMESSAGE mMACHINE® Kit High Yield Capped RNA Transcription Kit", Ambion by life technologies, (20120101), pages 1 - 36, XP093232428-
OPPOSITION- Anonymous, "Smart Freeze Drying Basic principles, optimum procedures and applications", Martin Christ, (20100101), Martin Christ, (20221010), XP055969231-
OPPOSITION- Anonymous , "Synthetic construct Kunjin virus replicon, complete sequence", Nucleotide, (20071006), Database accession no. EF536932.1, URL: ncbi, XP055969283-
OPPOSITION- D38: NCBI Nucleotide database excerpt-
OPPOSITION- Gennaro Alfonso R., "Frrrze-Drying", Remington's Pharmaceutical Sciences, Mack Publishing, (19900101), page 1585, 1500, XP055969286-
OPPOSITION- Ishihama Yasushi et al, "Protein abundance profiling of the Escherichia coli cytosol", BMC Genomics, BioMed Central Ltd, London, UK, London, UK , (20080227), vol. 9, no. 1, ISSN 1471-2164, page 102, XP021032822-
OPPOSITION- Kasper Julia Casper, Sarah Hedtrich, Wolfgang Friess, "Lyophilization of Synthetic Gene Carriers", Nanotechnology for Nucleic Acid Delivery: Methods and Protocols, Methods in Molecular Biology, Springer, (20130101), vol. 948, pages 113 - 147, XP055969257-
OPPOSITION- Swarbrick James, Boylan James C., "Free Drying", EIMCYCLOPEDIA OF PHARIVIACEUTICAL TECHNOLOGY, Marcel Dekker, (19880101), pages 276 - 301, XP055969280-
OPPOSITION- Varnavski, A.N. Khromykh, A.A., "Noncytopathic Flavivirus Replicon RNA-Based System for Expression and Delivery of Heterologous Genes", Virology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (19990315), vol. 255, no. 2, doi:10.1006/viro.1998.9564, ISSN 0042-6822, pages 366 - 375, XP004440024
OPPOSITION- KRAAN et al., "Development of Thermostable Lyophilized Inactivated Polio Vaccine", Pharm Res, (20140000), vol. 31, doi:10.1007/s11095-014-1359-6, pages 2618 - 2629, XP002745680
OPPOSITION- Kasper Julia Christina; Troiber Christina; Küchler Sarah; Wagner Ernst; Friess Wolfgang , "Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes", European journal of pharmaceutics and biopharmaceutics, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, NL , (20130605), vol. 85, no. 2, doi:10.1016/j.ejpb.2013.05.010, ISSN 0939-6411, pages 294 - 305, XP028737344
OPPOSITION- Endres Thomas, Zheng Mengyao, Beck-Broichsitter Moritz, Kissel Thomas, "Lyophilised ready-to-use formulations of PEG-PCL-PEI nano-carriers for siRNA delivery", International Journal of Pharmaceutics, ELSEVIER, NL, NL , (20120501), vol. 428, no. 1-2, doi:10.1016/j.ijpharm.2012.03.003, ISSN 0378-5173, pages 121 - 124, XP055969225
OPPOSITION- YADAVA PREETI ET AL, "Effect of lyophilization and freeze-thawing on the stability of siRNA-liposome complexes.", AAPS PHARMSCITECH, Springer New York LLC, US, US , (20080601), vol. 9, no. 2, doi:10.1208/S12249-007-9000-1, ISSN 1530-9932, pages 335 - 341, XP002511465
OPPOSITION- Meister Eva, Šaši Slobodan, Gieseler Henning, "Freeze-Dry Microscopy: Impact of Nucleation Temperature and Excipient Concentration on Collapse Temperature Data", AAPS PharmSciTech, (20090601), vol. 10, no. 2, doi:10.1208/s12249-009-9245-y, pages 582 - 588, XP055926264
OPPOSITION- JONES K.L., DRANE D. & GOWANS E.J., "Long-term storage of DNA-free RNA for use in vaccine studies", Biotechniques, Informa Healthcare, US, US , (20071101), vol. 43, no. 5, doi:10.2144/000112593, ISSN 0736-6205, pages 675 - 681, XP002581476
OPPOSITION- Alicia Rodriguez-Gascon, Ana Del Pozo-Rodríguez, María Angeles Solinís, "Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles", International Journal of Nanomedicine, DOVE Medical Press, (20140401), vol. 9, doi:10.2147/IJN.S39810, ISSN 11769114, pages 1833 - 183, XP055200967
OPPOSITION- Leclercq Sébastien, Gilbert Clément, Cordaux Richard, "Cargo capacity of phages and plasmids and other factors influencing horizontal transfers of prokaryote transposable elements", MOBILE GENETIC ELEMENTS, Taylor & Francis Inc., US, US , (20120301), vol. 2, no. 2, doi:10.4161/mge.20352, ISSN 2159-2543, pages 115 - 118, XP055969242

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