| INTERNATIONAL-SEARCH-REPORT | - Anonymous, "ENTRESTO PRESCRIBING INFORMATION", (20150801), URL: https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/entresto.pdf, (20160616), XP055280940 [XP] 1-61 * See section 2.1: Dosing. * | - |
| INTERNATIONAL-SEARCH-REPORT | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients - Full Text View - ClinicalTrials.gov", (20130812), URL: https://clinicaltrials.gov/ct2/show/NCT01922089?term=NCT01922089&rank=1, (20160616), XP055281080 [XD] 1-61 * the whole document * | - |
| INTERNATIONAL-SEARCH-REPORT | - KOBALAVA, Z; PAVLIKOVA, E; AVERKOV, O; MOISEEV, V; ALBRECHT, D; FENG, A; CHANDRA, P; JORDAAN, P J, "First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure", CIRCULATION, (20101123), vol. 122, no. 21 (supplement), ISSN 0009-7322, XP009190562 [X] 1-61 * the whole document * | - |
| INTERNATIONAL-SEARCH-REPORT | - JOHN J.V. MCMURRAY ET AL, "Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure", NEW ENGLAND JOURNAL OF MEDICINE, (20140911), vol. 371, no. 11, doi:10.1056/NEJMoa1409077, ISSN 0028-4793, pages 993 - 1004, XP055175908 [X] 1-61 * the whole document * | |
| INTERNATIONAL-SEARCH-REPORT | - JOHN J. V. MCMURRAY ET AL, "Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact", EUROPEAN JOURNAL OF HEART FAILURE, NL, (20130405), vol. 15, no. 9, doi:10.1093/eurjhf/hft052, ISSN 1388-9842, pages 1062 - 1073, XP055161544 [X] 1-61 * abstract * * figure 1 * * page 1064, 'LC active run-in period' * * page 1068, column 1, line 17 - column 2, line 31 * | |
| INTERNATIONAL-SEARCH-REPORT | - KAZUOMI KARIO ET AL, "LCZ696, a First-in-Class Angiotensin Receptor-Neprilysin Inhibitor: The First Clinical Experience in Patients With Severe Hypertension", THE JOURNAL OF CLINICAL HYPERTENSION, US, (20150924), vol. 18, no. 4, doi:10.1111/jch.12667, ISSN 1524-6175, pages 308 - 314, XP055280953 [XP] 1-61 * the whole document * | |
| INTERNATIONAL-SEARCH-REPORT | - GU J ET AL, "Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)", JOURNAL OF CLINICAL PHARMACOLOGY, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 50, no. 4, doi:10.1177/0091270009343932, ISSN 1552-4604, (20100401), pages 401 - 414, (20091123), XP002718352 [A] 1-61 * the whole document * | |
| OPPOSITION | - Abda, "Vergleichstabelle: ACE-Hemmer", ABDA - Arzneimitte Kommission Deutschen Apotheker, (20200525), pages 1 - 3, ABDA - Arzneimitte Kommission Deutschen Apotheker, URL: https://www.abda.de/fileadmin/user_upload/assets/Arzneimittelkommission/Aequivalenzdosistabellen/ACEi_AEquivalenzdosistabelle.pdf, (20240404), XP093147891 | - |
| OPPOSITION | - Aktories, Klaus ; Förstermann, Ulrich ; Hofmann, Franz ; Starke, Klaus ; Forth, Wolfgang , "7.2 Beeinflussung der Kontraktionskraft des Herzens; 17.2 Beeinflussung der Kontraktionskraft des Herzens", Aktories, Klaus ; Förstermann, Ulrich ; Hofmann, Franz ; Starke, Klaus ; Forth, Wolfgang , Aktories/Förstermann/Hofmann/Starke, Allgemeine und spezielle Pharmakologie und Toxikologie, Urban & Fischer, (20050101), vol. 130, pages 421 - 434, ISBN 978-3-437-44490-6, XP009553238 | - |
| OPPOSITION | - Anonymous, "COMMISSION DECISION of 22.1.2009 concerning, in the framework of Article 29 of Regulation (EC) No 1901/2006 of the European Parliament and of the Council, the marketing authorisation of "Cozaar and associated names", medicinal products for human use which contain the active substance "losartan potassium"", COMMISSION OF THE EUROPEAN COMMUNITIES, (20090122), COMMISSION OF THE EUROPEAN COMMUNITIES, XP093194472 | - |
| OPPOSITION | - Anonymous, "DIOVAN - HIGHLIGHTS OF PRESCRIBING INFORMATION ", (20140901), (20240404), XP093148134 | - |
| OPPOSITION | - Anonymous, "Diovan (Valsartan) Tablets. FDA label. Reference ID: 3199353", Novartis Pharmaceuticals Corp., (20121001), pages 1 - 20, XP055780468 | - |
| OPPOSITION | - Anonymous, "Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction (PARAGON-HF)", ClinicalTrials.gov; NCT01920711, (20130812), ClinicalTrials.gov; NCT01920711, URL: https://classic.clinicaltrials.gov/ct2/show/NCT01920711, (20240405), XP093148484 | - |
| OPPOSITION | - Anonymous, "ENTRESTO PRESCRIBING INFORMATION", (20150801), URL: https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/entresto.pdf, (20160616), XP055280940 | - |
| OPPOSITION | - Anonymous, "Entresto - Summary of Product Characteristics", (20151119), (20240404), XP093148148 | - |
| OPPOSITION | - Anonymous , "Herzinsuffizienz", Anonymous , Mutschler, Geisslinger, Kroemer, Menzel, Ruth, Mutschler - Arzneimittelwirkungen, Stuttgart , Wissenschaftliche Verlagsgesellschaft , (20130101), pages 510,541 - 545, ISBN 978-3-8047-2898-1, XP093148934 | - |
| OPPOSITION | - Anonymous, "LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction", ClinicalTrials.gov; NCT00887588, (20130814), ClinicalTrials.gov; NCT00887588, URL: https://clinicaltrials.gov/study/NCT00887588?tab=histoiy&a=12, (20240326), XP093145907 | - |
| OPPOSITION | - Anonymous, "LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction", ClinicalTrials.gov, U.S. National Library of Medicine, Internet, Internet, (20090424), pages 1 - 12, ClinicalTrials.gov, URL: https://clinicaltrials.gov/ct2/show/record/NCT00887588, (20211124), XP055865148 | - |
| OPPOSITION | - Anonymous, "LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction - History of Changes for Study: NCT00887588", ClinicalTrials.gov; NCT00887588, (20140625), ClinicalTrials.gov; NCT00887588, URL: https://classic.clinicaltrials.gov/ct2/history/NCT00887588?A=12&B=12&C=merged#StudyPageTop, XP093172721 | - |
| OPPOSITION | - Anonymous, "New heart failure agent safe and tolerated in clinical practice ", Pace-cme, (20150526), pages 1 - 2, Pace-cme, URL: https://pace-cme.org/2015/05/25/new-haert-fallure-agent-safe-and-tolerated-in-clinical-practice/, (20240408), XP093148728 | - |
| OPPOSITION | - Anonymous, " Novartis' heart failure medicine LCZ696 granted FDA priority review", Novartis, (20150213), XP093148356 | - |
| OPPOSITION | - Anonymous, "PRAC assessment report - For renin-angiotensin system (RAS)-acting agents Procedure number: EMEA/H/A-31/1370", European Medicines Agency (EMA); EMA/PRAC/294920/2014 Pharmacovigilance Risk Assessment Committee (PRAC), (20140522), European Medicines Agency (EMA); EMA/PRAC/294920/2014 Pharmacovigilance Risk Assessment Committee (PRAC), (20240322), XP093144500 | - |
| OPPOSITION | - Anonymous, "Restriction of combined use of medicines affecting the renin-angiotensin system (RAS) ", European Medicines Agency; EMA/554928/2014, (20140909), European Medicines Agency; EMA/554928/2014, URL: https://www.ema.europa.eu/en/medicines/human/referrals/renin-angiotensin-system-ras-acting-agents, (20240405), XP093148362 | - |
| OPPOSITION | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients - Full Text View - ClinicalTrials.gov", URL: https://clinicaltrials.gov/ct2/show/NCT01922089?term=NCT01922089&rank=1, (20160616), XP055281080 | - |
| OPPOSITION | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients (TITRATION)", ClinicalTrials.gov ID NCT01922089, (20151015), ClinicalTrials.gov ID NCT01922089, URL: https://classic.clinicaltrials.gov/ct2/show/NCT01922089, (20240404), XP093147861 | - |
| OPPOSITION | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients (TITRATION)", ClinicalTrials.gov; NCT01922089, (20090101), ClinicalTrials.gov; NCT01922089, URL: https://www.clinicaltrials.gov/study/NCT01922089, (20240326), XP093145909 | - |
| OPPOSITION | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients (TITRATION) - History of Changes for Study: NCT01922089", (20150916), pages 1 - 28, ClinicalTrials.gov; NCT01922089, (20240322), XP093144505 | - |
| OPPOSITION | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients (TITRATION) - History of Changes for Study: NCT01922089", ClinicalTrials.gov; NCT01922089, (20140924), ClinicalTrials.gov; NCT01922089, URL: https://classic.clinicaltrials.gov/ct2/history/NCT01922089?A=6&B=6&C=merged#StudyPageTop, XP093170340 | - |
| OPPOSITION | - Anonymous, "Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients (TITRATION) - History of Changes for Study: NCT01922089", ClinicalTrials.gov; NCT01922089, (20150916), ClinicalTrials.gov; NCT01922089, (20240322), XP093144505 | - |
| OPPOSITION | - Anonymous, "Therapie der Herzinsuffizienz", Mutschler Arzneimittelwirkungen Pharmakologie - Klinische Pharmakologie - Toxikologie, (20200101), pages 435 - 435, ISBN 978-3-8047-3663-4, XP093148941 | - |
| OPPOSITION | - Anonymous, "TITRATION study confirms LCZ696 safe and tolerated in clinical practice", European Society of Cadiology, (20150523), European Society of Cadiology, URL: https://www.escardio.org/The-ESC/Press-Office/Press-releases/TITRATION-study-confirms-LCZ696-safe-and-tolerated-in-clinical-practice, (20240405), XP093148477 | - |
| OPPOSITION | - Anonymous, "VASOTEC tablets", (20141201), (20240404), XP093148142 | - |
| OPPOSITION | - Basile Jan N., "Titration of beta-blockers in heart failure. How to maximize benefit while minimizing adverse events", Postgraduate Medicine, (20030301), vol. 113, no. 3, pages 63 - 70, XP055980347 | - |
| OPPOSITION | - Chen Fabian, Alan Charney , Jim Gong , Victor Shi , Michele Senni, "086 Comparison of the Baseline Demographics of the LCZ696 PARADIGM-HF and TITRATION Studies", Clinical Trials, (20150801), pages S45 - S45, XP093148447 | - |
| OPPOSITION | - Colledge, Nicki R. ; Walker, Brian R. ; Ralston, Stuart H. ; Davidson, Sir Stanley, "2 - Good prescribing - Practical prescribing", Colledge, Nicki R. ; Walker, Brian R. ; Ralston, Stuart H. ; Davidson, Sir Stanley, Nicholas A. Boon, Nicki R. Colledge, Brian R. Walker, John A.A. Hunter, DAVIDSON'S PRINCIPLE & PRACTICE OF MEDICINE (20th Edition), Churchill Livingstone Elsevier, (20060101), pages 17 - 35, ISBN 978-0-443-10057-4, XP009555067 | - |
| OPPOSITION | - D75 - ES003_CR1 - Prof. Iain Squire Declaration | - |
| OPPOSITION | - D76 - ES003_CR2 - BNF Entresto guidelines | - |
| OPPOSITION | - Davila Carine, Elisabeth Askin, "02. ACE Inhibitor Conversion Table", Outpatient Handbook, (20230101), Outpatient Handbook, URL: https://hospitalhandbook.ucsf.edu/02-ace-inhibitor-conversion-table/02-ace-inhibitor-conversion-table, (20240404), XP093147873 | - |
| OPPOSITION | - Delagarza Vincent W, "Pharmacologic Treatment of Alzheimer's Disease: An Update", American family physician, (20031001), vol. 68, no. 7, ISSN 0002-838x, pages 1365 - 1372, XP008091098 | - |
| OPPOSITION | - Jackowski Leslie, Roshmeen Azam, "Beta blockers in systolic heart failure", Australian family physician, Mosby, (20080301), vol. 37, no. 3, pages 137 - 139, XP093148766 | - |
| OPPOSITION | - Kao-Chang Lin, Hsi-Ming Chen, Wei-Hung Chen, Wei-Ta Chen, Yen-Yu Chen, Jong-Ling Fuh, Sung-Tsang Hsieh, Li-Chi Hsu, Kai-Dih Juang, Ryh-Huei Lin, Chung-Hsiang Liu, Shiang-Ru Lu, Jing-Jane Tsai, Po-Jen Wang, Shuu-Jiun Wang, Zin-An Wu, "Treatment Guidelines for preventive treatment of migraine", Acta neurologica Taiwanica, (20080101), vol. 17, no. 2, ISSN 1019-6099, pages 132 - 148, XP009553248 | - |
| OPPOSITION | - Kobalava Zhanna, Pavlikova Elena, Averkov Oleg, Moiseev Valentin, Albrecht Diego, Feng Aimen, Chandra Priyamvada, Jordaan Pierre J, "Abstract 19378: First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure", Circulation, (20180323), vol. 122, no. Suppl. 21, XP093147856 | - |
| OPPOSITION | - Kobalava Zhanna, Pavlikova Elena, Averkov Oleg, Moiseev Valentin, Albrecht Diego, Feng Aimen, Chandra Priyamvada, Jordaan Pierre J, "bstract 19378: First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure", Circulation, (20180323), vol. 122, no. Suppl. 21, page A19378, XP093147856 | - |
| OPPOSITION | - Kobalava Zhanna, Pavlikova Elena, Averkov Oleg, Moiseev Valentin, Albrecht Diego, Feng Aimen, Chandra Priyamvada, Jordaan Pierre J, "bstract 19378: First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure", Circulation, (20180323), vol. 122, no. Suppl. 21, XP093147856 | - |
| OPPOSITION | - Kobalava Zhanna; Pavlikova Elena; Averkov Oleg; Moiseev Valentin; Albrecht Diego; Feng Aimen; Chandra Priyamvada; Jordaan Pierre J, "First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure", Circulation, American Heart Association, US, US , (20101101), vol. 122, no. 21, Suppl., ISSN 0009-7322, XP009190562 | - |
| OPPOSITION | - Koch D., "Vergleichstabelle Angiotensin II -Rezeptor Antagonisten (Sartane)", Kantonsspital Aarau, (20200115), Kantonsspital Aarau, URL: https://www.ksa.ch/sites/default/files/cms/spitalpharmazie/docs/sartane_vergleichstabelle-spitalpharmazie-ksa.pdf, (20240404), XP093147896 | - |
| OPPOSITION | - Lang Chim C, Struthers Allan D., "Targeting the renin-angiotensin-aldosterone system in heart failure", Nature Reviews Cardiology, (20130301), vol. 10, pages 125 - 134, XP055788520 | - |
| OPPOSITION | - McMurray, J. Cohen-Solal, A. Dietz, R. Eichhorn, E. Erhardt, L. Hobbs, F.D.R. Krum, H. Maggioni, A. McKelvie, R.S. Pina, I.L. Soler-Soler, J. Swedberg, K., "Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice", EUROPEAN JOURNAL OF HEART FAILURE, ELSEVIER, AMSTERDAM, NL, NL , (20050801), vol. 7, no. 5, ISSN 1388-9842, pages 710 - 721, XP005011092 | - |
| OPPOSITION | - McMurray, J. ; Cohen-Solal, A. ; Dietz, R. ; Eichhorn, E. ; Erhardt, L. ; Hobbs, F.D.R. ; Krum, H. ; Maggioni, A. ; McKelvie, R.S. ; Pina, I.L. ; Soler-Soler, J. ; Swedberg, K., "Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice", EUROPEAN JOURNAL OF HEART FAILURE, ELSEVIER, AMSTERDAM, NL, NL , (20050801), vol. 7, no. 5, ISSN 1388-9842, pages 710 - 721, XP027706770 | - |
| OPPOSITION | - Rph Angevine, "THE DOSE. An estimation of equivalent doses between ARBs andACEIs", Thames Valley Family Health Team Drug Resource, (20200101), Thames Valley Family Health Team Drug Resource, URL: https://thamesvalleyfht.ca/wp-content/uploads/2020/05/TheDoseACEIsARBs-drina.pdf, (20240404), XP093147884 | - |
| OPPOSITION | - Shammas F V, K. Dickstein, "Clinical Pharmacokinetics in Heart Failure", Shammas F V, K. Dickstein, Amitabh Prakash , Anton van Rensburg, Clinical Pharmacokinetics, Adis Press Limited, (19880801), pages 94 - 113, XP093148776 | - |
| OPPOSITION | - Valsartan, "Prescribing information for Diovan", VALSARTAN, (20120101), pages 1 - 20, XP093093489 | - |
| OPPOSITION | - Voors Adriaan A., Gori Mauro, Liu Licette C.Y., Claggett Brian, Zile Michael R., Pieske Burkert, Mcmurray John J.V., Packer Milton, Shi Victor, Lefkowitz Martin P., Solomon Scott D., "in patients with heart failure and preserved ejection fraction", European journal of heart failure, NL , (20150501), vol. 17, no. 5, doi:10.1002/ejhf.232, ISSN 1388-9842, pages 510 - 517, XP093148787 | |
| OPPOSITION | - Ferrari Roberto, Böhm Michael, Cleland John G.F., Paulus Walter J.S., Pieske Burkert, Rapezzi Claudio, Tavazzi Luigi, "Heart failure with preserved ejection fraction: uncertainties and dilemmas", EUROPEAN JOURNAL OF HEART FAILURE, ELSEVIER, AMSTERDAM, NL, NL , (20150701), vol. 17, no. 7, doi:10.1002/ejhf.304, ISSN 1388-9842, pages 665 - 671, XP093194467 | |
| OPPOSITION | - Senni Michele, Mcmurray John J.V., Wachter Rolf, Mcintyre Hugh F., Reyes Antonio, Majercak Ivan, Andreka Peter, Shehova‐yankova Nina, Anand Inder, Yilmaz Mehmet B., Gogia Harinder, Martinez‐selles Manuel, Fischer Steffen, Zilahi Zsolt, Cosmi Franco, Gelev Valeri, Galve Enrique, Gómez‐doblas Juanjo J., Nociar Jan, Radomska Maria, Sokolova Beata, Volterrani Maurizio, Sarkar Arnab, Reimund Bernard, Chen Fabian, Charney Alan, "Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double‐blind, randomized comparison of two uptitration regimens", EUROPEAN JOURNAL OF HEART FAILURE, ELSEVIER, AMSTERDAM, NL, NL , (20160901), vol. 18, no. 9, doi:10.1002/ejhf.548, ISSN 1388-9842, pages 1193 - 1202, XP093147870 | |
| OPPOSITION | - U. C. Hoppe, E. Erdmann, "Passage; 5.6 Medikamentöse Therapie der chronischen systolischen Herzinsuffizienz", U. C. Hoppe, E. Erdmann, Erland Erdmann, Klinische Kardiologie Krankheiten des Herzens, des Kreislaufs und der herznahen GefaBe, Berlin, Springer, (20110611), pages 150 - 161, doi:10.1007/978-3-642-16481-1_5, ISBN 978-3-642-16480-4, XP093148944 | |
| OPPOSITION | - Frank P. Brouwers; Hans L. Hillege; Wiek H. van Gilst; Dirk J. van Veldhuisen, "Comparing New Onset Heart Failure with Reduced Ejection Fraction and New Onset Heart Failure with Preserved Ejection Fraction: An Epidemiologic Perspective", Current Heart Failure Reports, Current Science Inc., New York, New York , (20120912), vol. 9, no. 4, doi:10.1007/s11897-012-0115-7, ISSN 1546-9549, pages 363 - 368, XP035134729 | |
| OPPOSITION | - Borer Jeffrey S, Komajda Michel, Ford Ian, Tavazzi Luigi, Dominjon Fabienne, Maya Juan, Wu Yuna, Depre Christophe, Böhm Michael, "085 Effects of Heart Rate Reduction in Black Patients from the SHIFT (Systolic Heart Failure treatment with the If Inhibitor Ivabradine Trial) Study - Clinical Trials I ", The 19th Annual Scientific Meeting, (20150801), vol. 21, no. 8, doi:10.1016/j.cardfail.2015.06.156, XP093148481 | |
| OPPOSITION | - O'meara Eileen, Thibodeau-Jarry Nicolas, Ducharme Anique, Rouleau Jean Lucien, "The Epidemic of Heart Failure: A Lucid Approach to Stemming the Rising Tide", Canadian journal of cardiology, PULSUS GROUP, INC., CANADA, CANADA , (20141201), vol. 30, no. 12, doi:10.1016/j.cjca.2014.09.032, ISSN 0828-282X, pages S442 - S454, XP093194468 | |
| OPPOSITION | - L. FENG et al., "LCZ696: a dual-acting sodium supramolecular complex", Tetrahe- dron Letters, (20120000), vol. 53, doi:10.1016/j.tetlet.2011.11.029, pages 275 - 276, XP028393477 | |
| OPPOSITION | - Lili Feng; Piotr H. Karpinski; Paul Sutton; Yugang Liu; David F. Hook; Bin Hu; Thomas J. Blacklock; Philip E. Fanwick; Mahavir Prashad; Sven Godtfredsen; Christoph Ziltener;, "LCZ696: a dual-acting sodium supramolecular complex", Tetrahedron Letters, Elsevier, Amsterdam , NL, Amsterdam , NL , (20111105), vol. 53, no. 3, doi:10.1016/j.tetlet.2011.11.029, ISSN 0040-4039, pages 275 - 276, XP028393477 | |
| OPPOSITION | - RUILOPE et al., "Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study", Lancet, (20100410), vol. 375, no. 9722, doi:10.1016/S0140-6736(09)61966-8, pages 1255 - 66, XP027490781 | |
| OPPOSITION | - Ruilope, L.M. ; Dukat, A. ; Bohm, M. ; Lacourciere, Y. ; Gong, J. ; Lefkowitz, M.P., "Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20100410), vol. 375, no. 9722, doi:10.1016/S0140-6736(09)61966-8, ISSN 0140-6736, pages 1255 - 1266, XP027490781 | |
| OPPOSITION | - Scott D Solomon, Michael Zile, Burkert Pieske, Adriaan Voors, Amil Shah, Elisabeth Kraigher-Krainer, Victor Shi, Toni Bransford, Madoka Takeuchi, Jianjian Gong, Martin Lefkowitz, Milton Packer, John Jv Mcmurray, "The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial", The Lancet, ¬J.B. Flint|, (20121001), vol. 380, no. 9851, doi:10.1016/S0140-6736(12)61227-6, ISSN 01406736, pages 1387 - 1395, XP055083562 | |
| OPPOSITION | - SOLOMON et al., "The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with reserved ejection fraction: a phase 2 double-blind randomised controlled trial", Lancet, (20121020), vol. 380, no. 9851, doi:10.1016/S0140-6736(12)61227-6, pages 1387 - 95, XP055083562 | |
| OPPOSITION | - SOLOMON, SCOTT D et al., "The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial", The Lancet., (20120826), vol. 380, no. 9851, doi:10.1016/S0140-6736(12)61227-6, pages 1387 - 1395, XP055083562 | |
| OPPOSITION | - Just H, "Medikamentöse Therapie bei Herzinsuffizienz", Therapeutische umschau, CH , (20000501), vol. 57, no. 5, doi:10.1024/0040-5930.57.5.313, ISSN 0040-5930, pages 313 - 320, XP093148807 | |
| OPPOSITION | - I. SADAYOSHI et al., "Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction", Hypertension Research, (20150000), vol. 38, doi:10.1038/hr.2015.1, pages 269 - 275, XP093148349 | |
| OPPOSITION | - Ito Sadayoshi, Satoh Minoru, Tamaki Yuko, Gotou Hiromi, Charney Alan, Okino Naoko, Akahori Mizuki, Zhang Jack, "Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction", HYPERTENSION RESEARCH. CLINICAL AND EXPERIMENTAL., OSAKA., JP, JP , (20150401), vol. 38, no. 4, doi:10.1038/hr.2015.1, ISSN 0916-9636, pages 269 - 275, XP093148349 | |
| OPPOSITION | - Lim Gregory B., "LCZ696—a PARADIGM shift in treatment for heart failure", Nature Reviews Cardiology, Nature Publishing Group, GB, GB , (20141101), vol. 11, no. 11, doi:10.1038/nrcardio.2014.139, ISSN 1759-5002, pages 618 - 618, XP093144488 | |
| OPPOSITION | - COHN J N, TOGNONI G, "A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure", New England Journal of Medicine, The - NEJM, Massachusetts Medical Society, US, US , (20011206), vol. 345, no. 23, doi:10.1056/NEJMoa010713, ISSN 1533-4406, pages 1667 - 1675, XP009033568 | |
| OPPOSITION | - COHN J N, TOGNONI G, "A RANDOMIZED TRIAL OF THE ANGIOTENSIN-RECEPTOR BLOCKER VALSARTAN IN CHRONIC HEART FAILURE", New England Journal of Medicine, The - NEJM, Massachusetts Medical Society, US, US , (20011206), vol. 345, no. 23, doi:10.1056/NEJMoa010713, ISSN 1533-4406, pages 1667 - 1675, XP009033568 | |
| OPPOSITION | - Theophilus E Owan, M D, Hodge David O, M S, Herges Regina M, B S, Jacobsen Steven J, M D, Ph D, Roger Veronique L, M D, M P H, Redfield Margaret M, M D, Background, " Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction", The new england journal of medicine, (20060101), vol. 355, doi:10.1056/NEJMoa052256, pages 251 - 259, XP055393398 | |
| OPPOSITION | - J. J. V. MCMURRAY et al., "Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure", N Engl J Med, (20140000), vol. 371, doi:10.1056/NEJMoa1409077, pages 993 - 1004, XP055175908 | |
| OPPOSITION | - John J.V. Mcmurray, Milton Packer, Akshay S. Desai, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, "Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure", New England Journal of Medicine, New England Journal of Medicine, (20140911), vol. 371, no. 11, doi:10.1056/NEJMoa1409077, ISSN 00284793, pages 993 - 1004, XP055175908 | |
| OPPOSITION | - Dickstein K., Cohen-Solal A., Filippatos G., Mcmurray J. J.V., Ponikowski P., Poole-Wilson P. A., Stromberg A., Van Veldhuisen D. J., Atar D., Hoes A. W., Keren A., Mebazaa A., Nieminen M., Priori S. G., Swedberg K., Vahanian A., Camm J., De Caterina R., Dean V., Funck-Brentano C., Hellemans I., Kristensen S. D., Mcgregor K., Sechtem U., Silber S., Tendera M., Widimsky P., Zamorano J. L., Auricchio A., Bax J., Bohm M., Corra U., Della Bella P., Elliott P. M., Follath F., Gheorghiade M., Hasin Y., Hernborg A., Jaarsma T., Komajda M., Kornowski R., Piepoli M., Prendergast B., Tavazzi L., Vachiery J.-L., Verheugt F. W. A., Zannad F., "ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)", European Heart Journal, Oxford University Press, GB, GB , (20081001), vol. 29, no. 19, doi:10.1093/eurheartj/ehn309, ISSN 0195-668X, pages 2388 - 2442, XP093145908 | |
| OPPOSITION | - Piotr Ponikowski, Adriaan A. Voors, Stefan D. Anker, Héctor Bueno, John G. F. Cleland, Andrew J. S. Coats, Volkmar Falk, José Ramón González-Juanatey, Veli-Pekka Harjola, Ewa A. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Parissis, Burkert Pieske, Jillian P. Riley, Giuseppe M. C. Rosano, Luis M. Ruilope, Frank Ruschitzka, Frans H. Rutten, Peter Van Der Meer, "2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure", European Heart Journal, Oxford University Press, GB, GB , (20160714), vol. 37, no. 27, doi:10.1093/eurheartj/ehw128, ISSN 0195-668X, pages 2129 - 2200, XP055360432 | |
| OPPOSITION | - Düngen Hans-Dirk, Apostolović Svetlana, Inkrot Simone, Tahirović Elvis, Töpper Agnieszka, Mehrhof Felix, Prettin Christiane, Putniković Biljana, Nešković Aleksandar N., Krotin Mirjana, Sakač Dejan, Lainščak Mitja, Edelmann Frank, Wachter Rolf, Rau Thomas, Eschenhagen Thomas, Doehner Wolfram, Anker Stefan D., Waagstein Finn, Herrmann-Lingen Christoph, Gelbrich Goetz, Dietz Rainer, "Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial", EUROPEAN JOURNAL OF HEART FAILURE, ELSEVIER, AMSTERDAM, NL, NL , (20110601), vol. 13, no. 6, doi:10.1093/eurjhf/hfr020, ISSN 1388-9842, pages 670 - 680, XP093145904 | |
| OPPOSITION | - John J. V. Mcmurray, Milton Packer, Akshay S. Desai, Jim Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, "Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact", European journal of haert failure, NL , (20130901), vol. 15, no. 9, doi:10.1093/eurjhf/hft052, ISSN 1388-9842, pages 1062 - 1073, XP055161544 | |
| OPPOSITION | - John J. V. Mcmurray, Milton Packer, Akshay S. Desai, Jim Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, "Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact", EUROPEAN JOURNAL OF HEART FAILURE, ELSEVIER, AMSTERDAM, NL, NL , (20130901), vol. 15, no. 9, doi:10.1093/eurjhf/hft052, ISSN 1388-9842, pages 1062 - 1073, XP055161544 | |
| OPPOSITION | - Steckler Anne E, Bishu Kalkidan, Wassif Heba, Sigurdsson Gardar, Wagner Judy, Jaenicke Connie, Vats Shashank, Rector Thomas, Anand Inder S, "Telephone Titration of Heart Failure Medications", JOURNAL OF CARDIOVASCULAR NURSING, ASPEN PUBLISHERS, FREDERICK, MD, US, US , (20110101), vol. 26, no. 1, doi:10.1097/JCN.0b013e3181ec1223, ISSN 0889-4655, pages 29 - 36, XP009556418 | |
| OPPOSITION | - Pergolizzi Joseph, Böger Rainer H, Budd Keith, Dahan Albert, Erdine Serdar, Hans Guy, Kress Hans‐georg, Langford Richard, Likar Rudolf, Raffa Robert B., Sacerdote Paola, "Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)", Pain practice, US , (20080701), vol. 8, no. 4, doi:10.1111/j.1533-2500.2008.00204.x, ISSN 1530-7085, pages 287 - 313, XP093148817 | |
| OPPOSITION | - J. Nielsen; P. Damkier; H. Lublin; D. Taylor, "Optimizing clozapine treatment", ACTA psychiatrica scandinavica, DE , (20110428), vol. 123, no. 6, doi:10.1111/j.1600-0447.2011.01710.x, ISSN 0001-690X, pages 411 - 422, XP071044011 | |
| OPPOSITION | - Kazuomi Kario, Yuko Tamaki, Naoko Okino, Hiromi Gotou, Min Zhu, Jack Zhang, "LCZ696, a First-in-Class Angiotensin Receptor-Neprilysin Inhibitor: The First Clinical Experience in Patients With Severe Hypertension", The journal of clinical hypertension, Le Jacq Communications, US, US , (20160401), vol. 18, no. 4, doi:10.1111/jch.12667, ISSN 1524-6175, pages 308 - 314, XP055280953 | |
| OPPOSITION | - Yancy Clyde W., Jessup Mariell, Bozkurt Biykem, Butler Javed, Casey Donald E., Colvin Monica M., Drazner Mark H., Filippatos Gerasimos, Fonarow Gregg C., Givertz Michael M., Hollenberg Steven M., Lindenfeld Joann, Masoudi Frederick A., Mcbride Patrick E., Peterson Pamela N., Stevenson Lynne Warner, Westlake Cheryl, "2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America", Circulation, American Heart Association, US, US , (20160927), vol. 134, no. 13, doi:10.1161/CIR.0000000000000435, ISSN 0009-7322, XP093194466 | |
| OPPOSITION | - Yancy Clyde W., Jessup Mariell, Bozkurt Biykem, Butler Javed, Casey Donald E., Drazner Mark H., Fonarow Gregg C., Geraci Stephen A., Horwich Tamara, Januzzi James L., Johnson Maryl R., Kasper Edward K., Levy Wayne C., Masoudi Frederick A., Mcbride Patrick E., Mcmurray John J.V., Mitchell Judith E., Peterson Pamela N., Riegel Barbara, Sam Flora, Stevenson Lynne W., Tang W.H. Wilson, Tsai Emily J., Wilkoff Bruce L., "2013 ACCF/AHA Guideline for the Management of Heart Failure : A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines", Circulation, American Heart Association, US, US , (20131015), vol. 128, no. 16, doi:10.1161/CIR.0b013e31829e8776, ISSN 0009-7322, pages e240 - e327, XP055889103 | |
| OPPOSITION | - Bozkurt Biykem, "Response to Ryan and Parwani: Heart Failure Patients With Low Blood Pressure: How Should We Manage Neurohormonal Blocking Drugs?", Circulation. Heart Failure, US , (20121101), vol. 5, no. 6, doi:10.1161/CIRCHEARTFAILURE.112.972240, ISSN 1941-3289, pages 820 - 821, XP093148781 | |
| OPPOSITION | - GOTTLIEB et al., "Tolerability of beta-Blocker Initiation and Titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF", Circulation, (20020312), vol. 105, no. 10, doi:10.1161/hc1002.105180, pages 1182 - 8, XP093148346 | |
| OPPOSITION | - GU et al., "Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi", J. Clin. Pharmacol., (20100400), vol. 50, no. 4, doi:10.1177/0091270009343932, pages 401 - 14, XP002718352 | |
| OPPOSITION | - Gu J, Noe A, Chandra P, Al-Fayoumi S, Ligueros-Saylan M, Sarangapani R, Maahs S, Ksander G, Rigel D F, Jeng A Y, Lin T H, Zheng W, Dole W P, "Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).", Journal of clinical pharmacology, Wiley-Blackwell Publishing, Inc., US, US , (20100401), vol. 50, no. 4, doi:10.1177/0091270009343932, ISSN 1552-4604, pages 401 - 414, XP002718352 | |
| OPPOSITION | - Cada Dennis J., Baker Danial E., Leonard James, "Sacubitril/Valsartan - Formulary Drug Reviews", HOSPITAL PHARMACY., LIPPINCOTT, PHILADELPHIA., US, US , (20151201), vol. 50, no. 11, doi:10.1310/hpj5011-1025, ISSN 0018-5787, pages 1025 - 1036, XP093148348 | |
| OPPOSITION | - Ripley Toni L, "Valsartan in Chronic Heart Failure", ANNALS OF PHARMACOTHERAPY, Harvey Whitney Books Company, US, US , (20050301), vol. 39, no. 3, doi:10.1345/aph.1E327, ISSN 1060-0280, pages 460 - 469, XP093148962 | |
| OPPOSITION | - Minguet Joan, Sutton Gemma, Ferrero Carmen, Gomez Timothy, Bramlage Peter, "LCZ696: a new paradigm for the treatment of heart failure?", Expert Opin Pharmacother, Ashley Publications LTD, London, UK, London, UK , (20150211), vol. 16, no. 3, doi:10.1517/14656566.2015.1000300, ISSN 1465-6566, pages 435 - 446, XP093148128 | |
| OPPOSITION | - Zaccara Gaetano, Tramacere Luciana, Cincotta Massimo, "Drug safety evaluation of zonisamide for the treatment of epilepsy", Expert opinion on drug safety, GB , (20110701), vol. 10, no. 4, doi:10.1517/14740338.2011.571201, ISSN 1474-0338, pages 623 - 631, XP093148825 | |
| OPPOSITION | - Mohammed Asim A, Ianuzzi James L, "Natriuretic Peptide Guided Heart Failure Management", Current Clinical Pharmacology, Bentham Science Publishers Ltd., NL, NL , (20090101), vol. 4, no. 2, doi:10.2174/157488409788184945, ISSN 1574-8847, pages 87 - 94, XP093148953 | |
| OPPOSITION | - Krum Henry, Andrea Driscoll , "Management of heart failure", The medical journal of Australia, (20130902), vol. 199, no. 5, doi:10.5694/mjal2.10993, pages 334 - 339, XP093148794 | |
| OTHER | - Anonymous, "Diovan (Valsartan) Tablets. FDA label. Reference ID: 3199353", Novartis Pharmaceuticals Corp., (20121001), pages 1 - 20, XP055780468 | - |
| OTHER | - McMurray, J. ; Cohen-Solal, A. ; Dietz, R. ; Eichhorn, E. ; Erhardt, L. ; Hobbs, F.D.R. ; Krum, H. ; Maggioni, A. ; McKelvie, R.S. ; Pina, I.L. ; Soler-Soler, J. ; Swedberg, K., "Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice", EUROPEAN JOURNAL OF HEART FAILURE, NL , (20050801), vol. 7, no. 5, ISSN 1388-9842, pages 710 - 721, XP027706770 | - |
| OTHER | - COHN J N, TOGNONI G, "A RANDOMIZED TRIAL OF THE ANGIOTENSIN-RECEPTOR BLOCKER VALSARTAN IN CHRONIC HEART FAILURE", New England Journal of Medicine, US , (20011206), vol. 345, no. 23, doi:10.1056/NEJMoa010713, ISSN 1533-4406, pages 1667 - 1675, XP009033568 | |
| OTHER | - John J.V. Mcmurray, Milton Packer, Akshay S. Desai, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, "Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure", New England Journal of Medicine, (20140911), vol. 371, no. 11, doi:10.1056/NEJMoa1409077, ISSN 00284793, pages 993 - 1004, XP055175908 | |
