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Processes To Produce Brivaracetam - EP3302441

The patent EP3302441 was granted to Esteve Quimica on Dec 13, 2023. The application was originally filed on May 24, 2016 under application number EP16800643A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3302441

ESTEVE QUIMICA
Application Number
EP16800643A
Filing Date
May 24, 2016
Status
Granted And Under Opposition
Nov 10, 2023
Grant Date
Dec 13, 2023
External Links
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Patent Family

Patent Oppositions (3)

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FRY HEATH & SPENCESep 13, 2024RICHARDSADMISSIBLE
KRAUS & LEDERER PARTGMBBSep 13, 2024KRAUS & LEDERER PARTGMBBADMISSIBLE
SOLARA ACTIVE PHARMA SCIENCESep 12, 2024AOMB POLSKA SP ZOOADMISSIBLE

Patent Citations (32) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS6784197
DESCRIPTIONUS7629474
DESCRIPTIONUS8338621
DESCRIPTIONUS8957226
EXAMINATIONKR100915671B
EXAMINATIONUS6784197
EXAMINATIONUS8034958
EXAMINATIONUS8338621
EXAMINATIONWO03014080
INTERNATIONAL-SEARCH-REPORTKR20090017316
INTERNATIONAL-SEARCH-REPORTUS2008009638
INTERNATIONAL-SEARCH-REPORTUS2009318708
INTERNATIONAL-SEARCH-REPORTUS2012021469
INTERNATIONAL-SEARCH-REPORTUS2014031368
INTERNATIONAL-SEARCH-REPORTUS2014228579
INTERNATIONAL-SEARCH-REPORTWO0162726
INTERNATIONAL-SEARCH-REPORTWO2012140504
OPPOSITIONKR100915671B
OPPOSITIONUS6784197
OPPOSITIONUS8034958
OPPOSITIONUS8338621
OPPOSITIONWO0162726
OPPOSITIONWO2009022839
OTHEREP3302441
OTHERUS6784197
OTHERUS8034958
OTHERUS8338621
OTHERUS8957226
OTHERWO0162726
OTHERWO2009022839
SEARCHWO0162726
SEARCHWO2009022839

Non-Patent Literature (NPL) Citations (32) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- KENDA et al., Journal of Medicinal Chemistry, (20040000), vol. 47, page 530-
OPPOSITION- Ahuja, Satinder , "Selected Applications and Perspectives", Ahuja, Satinder , Satinder Ahuja, CHIRAL SEPARATIONS: APPLICATIONS AND TECHNOLOGY, AMERICAN CHEMICAL SOCIETY, (19970101), pages 294 - 308, ISBN 0-8412-3407-8, XP009562282-
OPPOSITION- Olah George A, Narang S.C. ; Balaram Gupty B.G. ; Malhotra R., "Synthetic Methods and Reactions. 62. Transformations with Chlorotrimethylsilane/Sodium Iodide, a Convenient in Situ Iodotrimethylsilane Reagent", Journal of Organic Chemistry, McGraw-Hill Prentice-Hall Fred-erick Smith Chemical Co, (19790101), vol. 44, no. 8, pages 1247 - 1250, XP093039329-
OPPOSITION- Peterson Emily A., Barry Dillon, Izzat Raheem, Paul Richardson, Daniel Richter, Rachel Schmidt, Helen F. Sneddon, "Sustainable Chromatography (an oxymoron?) ", Green Chemistry, Accepted Manuscript, (20140101), vol. 16, pages 4060 - 4075, XP093230904-
OPPOSITION- Boukouvalas John, "γ-Butyrolactone", e-EROS Encyclopedia of Reagents for Organic Synthesis-Conference, John Wiley & Sons, (20010101), pages 1 - 4, doi:10.1002/047084289X.rb418, XP055930199
OPPOSITION- Satinder Ahuja, "3 Basic Considerations in HPLC Method Development of Chiral Compounds", Satinder Ahuja, Satinder Ahuja, CHIRAL SEPARATION METHODS FOR PHARMACEUTICAL AND BIOTECHNOLOGICAL PRODUCTS, Wiley, (20110101), pages 35 - 56, doi:10.1002/9780470608661.ch3, ISBN 978-0-470-40691-5, XP009562280
OPPOSITION- Takigawa, T. ; Ibata, K. ; Mizuno, M., "Synthesis of mammalian dolichols from plant polyprenols", CHEMISTRY AND PHYSICS OF LIPIDS., LIMERICK, IR, IR , (19891101), vol. 51, no. 3-4, doi:10.1016/0009-3084(89)90004-2, ISSN 0009-3084, pages 171 - 182, XP023388713
OPPOSITION- Mazzini, C. Lebreton, J. Alphand, V. Furstoss, R., "A Chemoenzymatic Strategy for the Synthesis of Enantiopure (R)-(-)-Baclofen", Tetrahedron Letters, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL, (19970217), vol. 38, no. 7, doi:10.1016/S0040-4039(97)00062-2, ISSN 0040-4039, pages 1195 - 1196, XP004034232
OPPOSITION- Pemp, A. Seifert, K., "Enantioselective Total Synthesis of (+)-Labd-8(17)-ene-3@b,15-diol and (@?)-Labd-8(17)-ene-3@b,7@a,15-triol", Tetrahedron Letters, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL, (19970324), vol. 38, no. 12, doi:10.1016/S0040-4039(97)00346-8, ISSN 0040-4039, pages 2081 - 2084, XP004055940
OPPOSITION- KENDA B M, ET AL, "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", Journal of Medicinal Chemistry, American Chemical Society, US, US , (20031225), vol. 47, doi:10.1021/jm030913e, ISSN 0022-2623, pages 530 - 549, XP002383261
OPPOSITION- KENDA B.M. ET AL, "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", Journal of Medicinal Chemistry, American Chemical Society, US, US , (20041225), vol. 47, no. 3, doi:10.1021/jm030913e, ISSN 0022-2623, pages 530 - 549, XP002379289
OPPOSITION- Hanessian Stephen, Gomtsyan Arthur, Malek Nadia, "Asymmetric Conjugate Additions of Chiral Phosphonamide Anions to α,β-Unsaturated Carbonyl Compounds. A Versatile Method for Vicinally Substituted Chirons", The Journal of Organic Chemistry, American Chemical Society, United States, United States, (20000901), vol. 65, no. 18, doi:10.1021/jo000388g, ISSN 0022-3263, pages 5623 - 5631, XP093217679
OPPOSITION- Stacie Koch, A. Richard Chamberlin, "Enantioselective preparation of .beta.-alkyl-.gamma.-butyrolactones from functionalized ketene dithioacetals", The Journal of Organic Chemistry, doi:10.1021/jo00062a013, (19930501), pages 2725 - 2737, The Journal of Organic Chemistry, URL: https://pubs.acs.org/doi/pdf/10.1021/jo00062a013, XP055528300
OPPOSITION- OK TAEDONG, ET AL, "Enantiomerically pure synthesis of beta-substituted gamma-butyrolactones: A key intermediate to concise synthesis of pregabalin", The Journal of Organic Chemistry, American Chemical Society, United States, United States, (20070801), vol. 72, doi:10.1021/JO0709605, ISSN 0022-3263, pages 7390 - 7393, XP002517949
OPPOSITION- Fray M. Jonathan, David J. Bull, Keith James , "A Short Synthesis of the Glycine Antagonist (3R,4R)-3-Amino-1-hydroxy-4-methyl-pyrrolidin-2-one (L-687,414)", SYNLETT, GEORG THIEME VERLAG, DE, DE , (19920901), vol. 1992, no. 9, doi:10.1055/s-1992-21462, ISSN 0936-5214, pages 709 - 710, XP093217676
OTHER- M. JONATHAN FRAY, "A Short Synthesis of the Glycine Antagonist (3R,4R)-3-Amino-l-hydroxy-4-methyl-pyrrolidin-2-one (L-687,414", Synlett, (19920000), vol. 1992, no. 9, pages 709 - 710, XP93018366-
OTHER- Olah George A, Narang S.C. ; Balaram Gupty B.G. ; Malhotra R., "Synthetic Methods and Reactions. 62. Transformations with Chlorotrimethylsilane/Sodium Iodide, a Convenient in Situ Iodotrimethylsilane Reagent", Journal of Organic Chemistry, McGraw-Hill Prentice-Hall Fred-erick Smith Chemical Co, (19790101), vol. 44, no. 8, pages 1247 - 1250, XP093039329-
OTHER- Anonymous, "y-Butyrolactone", e-EROS Encyclopedia of Reagents for Organic Synthesis, Conference General Review; Online Computer File, (20010101), pages 1 - 4, XP093018373
OTHER- Boukouvalas John, "γ-Butyrolactone", e-EROS Encyclopedia of Reagents for Organic Synthesis-Conference, John Wiley & Sons, (20010101), pages 1 - 4, XP055930199
OTHER- Takigawa, T. ; Ibata, K. ; Mizuno, M., "Synthesis of mammalian dolichols from plant polyprenols", CHEMISTRY AND PHYSICS OF LIPIDS., LIMERICK, IR, IR , (19891101), vol. 51, no. 3-4, doi:10.1016/0009-3084(89)90004-2, ISSN 0009-3084, pages 171 - 182, XP023388713
OTHER- TETSUO TAKIGAWA, "Synthesis of mammalian dolichols from plant polyprenols", Chemistry and Physics of Lipids, (19891100), vol. 51, doi:10.1016/0009-3084(89)90004-2, pages 171 - 182, XP023388713
OTHER- Pinard, E. ; Burner, S. ; Cueni, P. ; Montavon, F. ; Zimmerli, D., "A short and efficient synthesis of the NMDA glycine site antagonist: (3R,4R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)", Tetrahedron Letters, Elsevier, Amsterdam , NL, Amsterdam , NL , (20081013), vol. 49, no. 42, doi:10.1016/j.tetlet.2008.07.172, ISSN 0040-4039, pages 6079 - 6080, XP024528684
OTHER- Mazzini, C. Lebreton, J. Alphand, V. Furstoss, R., "A Chemoenzymatic Strategy for the Synthesis of Enantiopure (R)-(-)-Baclofen", Tetrahedron Letters, Elsevier, Amsterdam , NL, Amsterdam , NL , (19970217), vol. 38, no. 7, doi:10.1016/S0040-4039(97)00062-2, ISSN 0040-4039, pages 1195 - 1196, XP004034232
OTHER- ALEXANDER PEMP, "Enantioselective total synthesis of (+)-labd-8(17)-ene-3β,15-diol and (-)-labd-8(17)-ene-3p,7cc,15-triol", Tetrahedron Letters, vol. 38, doi:10.1016/S0040-4039(97)00346-8, pages 2081 - 2084, XP004055940
OTHER- Arnaud Schule, Alain Merschaert, Christophe Szczepaniak, Christophe Marechai, Nicolas Carly, John O’Rourke, and Celal Ates, "A Biocatalytic Route to the Novel Antiepileptic Drug Brivaracetam", Organic Process Research & Development, (20160000), vol. 20, no. 9, pages 1566 - 1575, XP055525783
OTHER- B.M. KENDA et al., "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", Journal of Medicinal Chemistry, (20041225), vol. 47, no. 3, pages 530 - 549, XP002379289
OTHER- KENDA B M, ET AL, "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", Journal of Medicinal Chemistry, American Chemical Society, US, US , (20041225), vol. 47, no. 3, doi:10.1021/jm030913e, ISSN 0022-2623, pages 530 - 549, XP002379289
OTHER- KENDA et al., "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", Journal of Medicinal Chemistry, US , (20041225), vol. 47, no. 3, doi:10.1021/jm030913e, ISSN 0022-2623, pages 530 - 549, XP002379289
OTHER- OK TAEDONG, ET AL, "Enantiomerically pure synthesis of beta-substituted gamma-butyrolactones: A key intermediate to concise synthesis of pregabalin", The Journal of Organic Chemistry, American Chemical Society, (20070801), vol. 72, no. 19, doi:10.1021/JO0709605, ISSN 0022-3263, pages 7390 - 7393, XP002517949
OTHER- TAEDONG OK, "Enantiomerically Pure Synthesis of β-Substituted γ-Butyrolactones: A Key Intermediate to Concise Synthesis of Pregabalin", J. Org. Chem., (20070000), vol. 72, doi:10.1021/JO0709605, pages 7390 - 7393, XP002517949
SEARCH- KENDA B M ET AL, "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, (20041225), vol. 47, no. 3, doi:10.1021/JM030913E, ISSN 0022-2623, pages 530 - 549, XP002379289 [Y] 1-21 * Scheme 7; page 545, column rh, paragraph last - page 546, column lh, paragraph 1 *
SEARCH- Stacie Koch ET AL, "Enantioselective preparation of .beta.-alkyl-.gamma.-butyrolactones from functionalized ketene dithioacetals", The Journal of Organic Chemistry, doi:10.1021/jo00062a013, (19930501), pages 2725 - 2737, URL: https://pubs.acs.org/doi/pdf/10.1021/jo00062a013, XP055528300 [Y] 1-21 * table I; compound 33a *

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