Compositions And Methods For Modulation Of Smn2 Splicing In A Subject - EP3305302

The patent EP3305302 was granted to Biogen MA on Sep 19, 2018. The application was originally filed on Jun 17, 2010 under application number EP17203913A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3305302

BIOGEN MA
Application Number
EP17203913A
Filing Date
Jun 17, 2010
Status
Granted And Under Opposition
Aug 17, 2018
Grant Date
Sep 19, 2018
External Links
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TAYLOR WESSINGJun 19, 2019ROYLEWITHDRAWN

Patent Citations (111) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS19990334130-
DESCRIPTIONUS20090168885-
DESCRIPTIONWO2006US24469-
DESCRIPTIONWO2008US64591-
DESCRIPTIONWO2008US66154-
DESCRIPTIONWO2008US68922-
DESCRIPTIONUS2004171570
DESCRIPTIONUS2005020525
DESCRIPTIONUS2005054836
DESCRIPTIONUS2005074801
DESCRIPTIONUS2005130923
DESCRIPTIONUS2006172962
DESCRIPTIONUS2007002390
DESCRIPTIONUS2007105807
DESCRIPTIONUS4587044
DESCRIPTIONUS4605735
DESCRIPTIONUS4667025
DESCRIPTIONUS4762779
DESCRIPTIONUS4789737
DESCRIPTIONUS4824941
DESCRIPTIONUS4828979
DESCRIPTIONUS4835263
DESCRIPTIONUS4876335
DESCRIPTIONUS4904582
DESCRIPTIONUS4948882
DESCRIPTIONUS4958013
DESCRIPTIONUS4981957
DESCRIPTIONUS5082830
DESCRIPTIONUS5109124
DESCRIPTIONUS5112963
DESCRIPTIONUS5118800
DESCRIPTIONUS5118802
DESCRIPTIONUS5138045
DESCRIPTIONUS5214136
DESCRIPTIONUS5218105
DESCRIPTIONUS5245022
DESCRIPTIONUS5254469
DESCRIPTIONUS5258506
DESCRIPTIONUS5262536
DESCRIPTIONUS5272250
DESCRIPTIONUS5292873
DESCRIPTIONUS5317098
DESCRIPTIONUS5319080
DESCRIPTIONUS5359044
DESCRIPTIONUS5371241
DESCRIPTIONUS5391723
DESCRIPTIONUS5393878
DESCRIPTIONUS5414077
DESCRIPTIONUS5416203
DESCRIPTIONUS5446137
DESCRIPTIONUS5451463
DESCRIPTIONUS5466786
DESCRIPTIONUS5486603
DESCRIPTIONUS5510475
DESCRIPTIONUS5512439
DESCRIPTIONUS5512667
DESCRIPTIONUS5514785
DESCRIPTIONUS5519134
DESCRIPTIONUS5525465
DESCRIPTIONUS5541313
DESCRIPTIONUS5545730
DESCRIPTIONUS5552538
DESCRIPTIONUS5565552
DESCRIPTIONUS5567810
DESCRIPTIONUS5567811
DESCRIPTIONUS5574142
DESCRIPTIONUS5576427
DESCRIPTIONUS5578717
DESCRIPTIONUS5578718
DESCRIPTIONUS5580731
DESCRIPTIONUS5585481
DESCRIPTIONUS5587371
DESCRIPTIONUS5591584
DESCRIPTIONUS5591722
DESCRIPTIONUS5595726
DESCRIPTIONUS5597696
DESCRIPTIONUS5597909
DESCRIPTIONUS5599923
DESCRIPTIONUS5599928
DESCRIPTIONUS5608046
DESCRIPTIONUS5610300
DESCRIPTIONUS5627053
DESCRIPTIONUS5627274
DESCRIPTIONUS5639873
DESCRIPTIONUS5646265
DESCRIPTIONUS5658873
DESCRIPTIONUS5665593
DESCRIPTIONUS5670633
DESCRIPTIONUS5688941
DESCRIPTIONUS5700920
DESCRIPTIONUS5792747
DESCRIPTIONUS5916808
DESCRIPTIONUS5976879
DESCRIPTIONUS6172216
DESCRIPTIONUS6210892
DESCRIPTIONUS6214986
DESCRIPTIONUS7399845
DESCRIPTIONUS7427672
DESCRIPTIONWO0238738
DESCRIPTIONWO03004602
DESCRIPTIONWO2007002390
DESCRIPTIONWO2007047913
DESCRIPTIONWO2007090073
DESCRIPTIONWO2007134181
DESCRIPTIONWO2008101157
DESCRIPTIONWO2010148249
DESCRIPTIONWO9426887
DESCRIPTIONWO9726270
SEARCHUS2007292408
SEARCHWO2007002390
SEARCHWO2010091308

Non-Patent Literature (NPL) Citations (53) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AKINC et al., Nature Biotechnology, (20080501), vol. 26, pages 561 - 569-
DESCRIPTION- ALTMANN et al., Biochem. Soc. Trans., (19960000), vol. 24, pages 630 - 637-
DESCRIPTION- ALTMANN et al., Chimia, (19960000), vol. 50, pages 168 - 176-
DESCRIPTION- ALTMANN et al., Nucleosides Nucleotides, (19970000), vol. 16, pages 917 - 926-
DESCRIPTION- BAKER et al., J. Biol. Chem., (19970000), vol. 272, pages 11944 - 12000-
DESCRIPTION- BEAUCAGE; TYER, Tetrahedron, (19930000), vol. 49, page 1925-
DESCRIPTION- CARTEGNI et al., Nat. Rev. Genet., (20020000), vol. 3, pages 285 - 298-
DESCRIPTION- CARTEGNI; KRAINER, Nat. Genet., (20020000), vol. 30, pages 377 - 384-
DESCRIPTION- CARTEGNI; KRAINER, Nat. Struct. Biol., (20030000), vol. 10, pages 120 - 125-
DESCRIPTION- COADY et al., PLoS ONE, (20080000), vol. 3, no. 10, page e3468-
DESCRIPTION- CROOKE et al., J. Pharmacol. Exp. Ther., (19960000), vol. 277, pages 923 - 937-
DESCRIPTION- DRAWCZAK et al., Hum. Genet., (19920000), vol. 90, pages 41 - 54-
DESCRIPTION- FREIER et al., Nucleic Acids Research, (19970000), vol. 25, no. 22, pages 4429 - 4443-
DESCRIPTION- GRAVRILINA et al., Hum Mol Genet, (20080000), vol. 17, no. 8, pages 1063 - 1075-
DESCRIPTION- HOVHANNISYAN; CARSTENS, Mol. Cell. Biol., (20050000), vol. 25, no. 1, pages 250 - 263-
DESCRIPTION- HSIEH-LI et al., Nat. Genet., (20000000), vol. 24, pages 66 - 70-
DESCRIPTION- HSIEH-LI HM et al., Nature Genet, (20000000), vol. 24, pages 66 - 70-
DESCRIPTION- HUA et al., American J. of Human Genetics, (20080400), vol. 82, pages 1 - 15-
DESCRIPTION- HUA et al., PLoS Biol, vol. 5, no. 4, page e73-
DESCRIPTION- KABANOV et al., FEBS Lett., (19900000), vol. 259, pages 327 - 330-
DESCRIPTION- KOLE, Acta Biochimica Polonica, (19970000), vol. 44, pages 231 - 238-
DESCRIPTION- LE et al., Hum. Mol. Genet., (20050000), vol. 14, pages 845 - 857-
DESCRIPTION- LEFEBVRE et al., Hum. Mol. Genet., (19980000), vol. 7, pages 1531 - 1536-
DESCRIPTION- LETSINGER et al., Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 6553 - 6556-
DESCRIPTION- MANOHARAN et al., Ann. N.Y. Acad. Sci., (19920000), vol. 660, pages 306 - 309-
DESCRIPTION- MANOHARAN et al., Bioorg. Med. Chem. Let., (19930000), vol. 3, pages 2765 - 2770-
DESCRIPTION- MANOHARAN et al., Bioorg. Med. Chem. Let., (19940000), vol. 4, pages 1053 - 1060-
DESCRIPTION- MANOHARAN et al., Nucleosides & Nucleotides, (19950000), vol. 14, pages 969 - 973-
DESCRIPTION- MANOHARAN et al., Tetrahedron Lett., (19950000), vol. 36, pages 3651 - 3654-
DESCRIPTION- MARTIN, P., Helv. Chim. Acta, (19950000), vol. 78, pages 486 - 504-
DESCRIPTION- MINOVITSKY et al., Nucleic Acids Res., (20050000), vol. 33, no. 2, pages 714 - 724-
DESCRIPTION- MISHRA et al., Biochim. Biophys. Acta, (19950000), vol. 1264, pages 229 - 237-
DESCRIPTION- MONANI et al., Hum. Mol. Genet., (20000000), vol. 9, pages 333 - 339-
DESCRIPTION- OBERHAUSER et al., Nucl. Acids Res., (19920000), vol. 20, pages 533 - 538-
DESCRIPTION- PASSINI et al., J Clin Invest, (20100401), vol. 120, no. 4, pages 1253 - 64-
DESCRIPTION- PASSINI et al., J. Virol., (20010000), vol. 75, pages 12382 - 12392-
DESCRIPTION- SAISON-BEHMOARAS et al., EMBO J., (19910000), vol. 10, pages 1111 - 1118-
DESCRIPTION- SCAMBOROVA et al., Mol. Cell. Bioi., (20040000), vol. 24, no. 5, pages 1855 - 1869-
DESCRIPTION- SHEA et al., Nucl. Acids Res., (19900000), vol. 18, pages 3777 - 3783-
DESCRIPTION- SINGH et al., RNA Bio., (20090000), vol. 6, no. 3, pages 1 - 10-
DESCRIPTION- Stanley T. Crooke,, Antisense Drug Technology, Principles, Strategies, and Applications, CRC Press-
DESCRIPTION- SVINARCHUK et al., Biochimie, (19930000), vol. 75, pages 49 - 54-
DESCRIPTION- TAYLOR et al., Nat. Biotechnol., (19990000), vol. 17, pages 1097 - 1100-
DESCRIPTION- THURMOND et al., J. Med Chem., (20080000), vol. 51, pages 449 - 469-
DESCRIPTION- VICKERS et al., J. Immunol., (20060315), vol. 176, no. 6, pages 3652 - 61-
DESCRIPTION- WILTON et al., Neuromuscul. Disord., (19990000), vol. 9, pages 330 - 338-
DESCRIPTION- YEO et al., Proc. Natl. Acad. Sci. U.S.A., (20040000), vol. 101, no. 44, pages 15700 - 15705-
SEARCH- SINGH NIRMAL K ET AL, "Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, (20060201), vol. 26, no. 4, ISSN 0270-7306, pages 1333 - 1346, XP002596112 [A] 1-17 * the whole document *-
SEARCH- HUA Y ET AL, "Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 82, no. 4, doi:10.1016/J.AJHG.2008.01.014, ISSN 0002-9297, (20080401), pages 834 - 848, (20080327), XP002692598 [A] 1-17 * the whole document *
SEARCH- LE THANH T. ET AL., "SMNdelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, (20050101), vol. 14, no. 6, doi:10.1093/HMG/DDI078, ISSN 0964-6906, pages 845 - 857, XP008073633 [A] 1-17 * the whole document *
SEARCH- T. D. BAUGHAN ET AL, "Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy", HUMAN MOLECULAR GENETICS, (20090219), vol. 18, no. 9, doi:10.1093/hmg/ddp076, ISSN 0964-6906, pages 1600 - 1611, XP055051447 [A] 1-17 * page 1603, column r - page 1604 *
SEARCH- SCHMID ALOICIA ET AL, "Animal models of spinal muscular atrophy", JOURNAL OF CHILD NEUROLOGY, DECKER PERIODICALS, HAMILTON, CA, (20070801), vol. 22, no. 8, doi:10.1177/0883073807305667, ISSN 0883-0738, pages 1004 - 1012, XP002550020 [A] 1-17 * the whole document *
SEARCH- J. H. WILLIAMS ET AL., "Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of Spinal Muscular Atrophy", JOURNAL OF NEUROSCIENCE, (20090617), vol. 29, no. 24, doi:10.1523/JNEUROSCI.0950-09.2009, ISSN 0270-6474, pages 7633 - 7638, XP055044377 [AP] 1-17 * the whole document *

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