Novel Crispr Enzymes And Systems - EP3310917

The patent EP3310917 was granted to Massachusetts Institute OF Technology on Sep 3, 2025. The application was originally filed on Jun 17, 2016 under application number EP16734803A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3310917

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Application Number
EP16734803A
Filing Date
Jun 17, 2016
Status
Patent Maintained As Amended
Aug 1, 2025
Grant Date
Sep 3, 2025
External Links
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Patent Family

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BOULT WADE TENNANTNov 12, 2020BOULT WADE TENNANTADMISSIBLE
JAMES POOLENov 11, 2020CARPMAELS & RANSFORDADMISSIBLE
STRAWMANNov 11, 2020POTTER CLARKSONWITHDRAWN
NEUEFEINDSep 25, 2020MAIWALDADMISSIBLE

Patent Citations (108) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONWO1994US05700
DESCRIPTIONEP1519714
DESCRIPTIONEP1664316
DESCRIPTIONEP1766035
DESCRIPTIONEP1781593
DESCRIPTIONUS2004013648
DESCRIPTIONUS2005019923
DESCRIPTIONUS2006281180
DESCRIPTIONUS2007025970
DESCRIPTIONUS2007054961
DESCRIPTIONUS2008267903
DESCRIPTIONUS2009007284
DESCRIPTIONUS2009017543
DESCRIPTIONUS2009029861
DESCRIPTIONUS2009111106
DESCRIPTIONUS2010317109
DESCRIPTIONUS2011117189
DESCRIPTIONUS2011195123
DESCRIPTIONUS2011265198
DESCRIPTIONUS2011293571
DESCRIPTIONUS2011293703
DESCRIPTIONUS2012017290
DESCRIPTIONUS2012164118
DESCRIPTIONUS2012251618
DESCRIPTIONUS2012295960
DESCRIPTIONUS2013185823
DESCRIPTIONUS2013236946
DESCRIPTIONUS2013244279
DESCRIPTIONUS2013245107
DESCRIPTIONUS2013252281
DESCRIPTIONUS2013302401
DESCRIPTIONUS2014342456
DESCRIPTIONUS2014356959
DESCRIPTIONUS2015031132
DESCRIPTIONUS4186183
DESCRIPTIONUS4217344
DESCRIPTIONUS4235871
DESCRIPTIONUS4261975
DESCRIPTIONUS4485054
DESCRIPTIONUS4501728
DESCRIPTIONUS4774085
DESCRIPTIONUS4797368
DESCRIPTIONUS4837028
DESCRIPTIONUS4897355
DESCRIPTIONUS4946787
DESCRIPTIONUS5049386
DESCRIPTIONUS5173414
DESCRIPTIONUS5210015
DESCRIPTIONUS5445934
DESCRIPTIONUS5543158
DESCRIPTIONUS5563055
DESCRIPTIONUS5789156
DESCRIPTIONUS5814618
DESCRIPTIONUS5846946
DESCRIPTIONUS5855913
DESCRIPTIONUS5985309
DESCRIPTIONUS6007845
DESCRIPTIONUS7022896
DESCRIPTIONUS7259015
DESCRIPTIONUS7303910
DESCRIPTIONUS7351585
DESCRIPTIONUS7745651
DESCRIPTIONUS7799565
DESCRIPTIONUS7803397
DESCRIPTIONUS7838658
DESCRIPTIONUS7901708
DESCRIPTIONUS7915399
DESCRIPTIONUS7982027
DESCRIPTIONUS8044019
DESCRIPTIONUS8058069
DESCRIPTIONUS8101741
DESCRIPTIONUS8106022
DESCRIPTIONUS8188263
DESCRIPTIONUS8236943
DESCRIPTIONUS8283333
DESCRIPTIONUS8313772
DESCRIPTIONUS8372951
DESCRIPTIONUS8404658
DESCRIPTIONUS8454972
DESCRIPTIONUS8575305
DESCRIPTIONUS8614194
DESCRIPTIONUS8709843
DESCRIPTIONUS8945839
DESCRIPTIONUS9301923
DESCRIPTIONWO2008042156
DESCRIPTIONWO2010061186
DESCRIPTIONWO2014093622
DESCRIPTIONWO2015086795
DESCRIPTIONWO2015089351
DESCRIPTIONWO2015089419
DESCRIPTIONWO9116024
DESCRIPTIONWO9117424
DESCRIPTIONWO9301294
DESCRIPTIONWO9324641
DESCRIPTIONWO9639154
DESCRIPTIONWO9703211
DESCRIPTIONWO9741228
INTERNATIONAL-SEARCH-REPORTWO2015089419
OPPOSITIONGB1506509
OPPOSITIONUS2010076057
OPPOSITIONWO2014093622
OPPOSITIONWO2014093712
OPPOSITIONWO2014118272
OPPOSITIONWO2015089419
OPPOSITIONWO2016166340
OPPOSITIONWO2016205711
OPPOSITIONWO2017064546
OPPOSITIONWO2017189308

Non-Patent Literature (NPL) Citations (344) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ADVANCED DRUG DELIVERY REVIEWS, (2012), vol. 64, pages 1730 - 1737
DESCRIPTION- AHMAD ET AL., CANCER RES., (1992), vol. 52, pages 4817 - 4820
DESCRIPTION- AHMAD, S. ET AL., J ROYAL SOC INTERFACE, (2010), vol. 7, pages S423 - S433
DESCRIPTION- AKINC A ET AL., MOLECULAR THERAPY, (2010), vol. 18, no. 7, pages 1357 - 1364
DESCRIPTION- AKINC ET AL., NAT. BIOTECH., (2010), vol. 26, pages 561 - 569
DESCRIPTION- ALABI ET AL., PROC NATL ACAD SCI U S A., (20130806), vol. 110, no. 32, pages 12881 - 12886
DESCRIPTION- ALTSCHUL ET AL., J. MOL. BIOL., (1990), pages 403 - 410
DESCRIPTION- ALVAREZ-ERVITI ET AL., NAT BIOTECHNOL, (2011), vol. 29, page 341
DESCRIPTION- AMRANN ET AL., GENE, (1988), vol. 69, pages 301 - 315
DESCRIPTION- ANDERSON, SCIENCE, (1992), vol. 256, pages 808 - 813
DESCRIPTION- A.R. GRUBER ET AL., CELL, (2008), vol. 106, no. 1, pages 23 - 24
DESCRIPTION- ATSCHUL ET AL., J. MOL. BIOL., (1990), pages 403 - 410
DESCRIPTION- AUSUBEL ET AL., SHORT PROTOCOLS IN MOLECULAR BIOLOGY, (1999), pages 7 - 58,7-60
DESCRIPTION- BABU M ET AL., "A dual function of the CRISPR-Cassystem in bacterial antivirus immunity and DNA repair", MOL MICROBIOL, (2011), vol. 79, pages 484 - 502
DESCRIPTION- BALAGAAN, J GENE MED, (2006), vol. 8, pages 275 - 285
DESCRIPTION- BALDARI ET AL., EMBO J., (1987), vol. 6, pages 229 - 234
DESCRIPTION- BANASZYNSKI LA; CHEN LC; MAYNARD-SMITH LA; OOI AG; WANDLESS TJ, "A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules", CELL, (2006), vol. 126, pages 995 - 1004
DESCRIPTION- BANASZYNSKI LA; ELLMYER MA; CONTAG CH; WANDLESS TJ; THOME SH, "Chemical control of protein stability and function in living mice", NAT MED., (2008), vol. 14, pages 1123 - 1127
DESCRIPTION- BANEIJI ET AL., CELL, (1983), vol. 33, pages 729 - 740
DESCRIPTION- BARTLETT ET AL., PNAS, (20070925), vol. 104, no. 39
DESCRIPTION- BEHR ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 382 - 389
DESCRIPTION- BENNETZEN; HALL, J BIOL CHEM., (19820325), vol. 257, no. 6, pages 3026 - 3031
DESCRIPTION- BINLEY ET AL., HUMAN GENE THERAPY, (201209), vol. 23, pages 980 - 991
DESCRIPTION- BLAESE ET AL., CANCER GENE THER., (1995), vol. 2, pages 291 - 297
DESCRIPTION- BLUNDELL ET AL., EUR J BIOCHEM, (1988), vol. 172, page 513
DESCRIPTION- BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530
DESCRIPTION- BOSHARTET, CELL, (1985), vol. 41, pages 521 - 530
DESCRIPTION- BRINSTER RL ET AL., NATURE (LONDON, (1982), vol. 296, pages 39 - 42
DESCRIPTION- BROOKS, "Efficient gene editing in tomato in the first generation using the CRISPR-Cas9 system", PLANT PHYSIOLOGY, (201409), page 114,247577
DESCRIPTION- BUCHSCHER ET AL., J. VIROL., (1992), vol. 66, pages 2731 - 2739
DESCRIPTION- BUCKHOLZ, R.G.; GLEESON, M.A., BIOTECHNOLOGY (NY, (1991), vol. 9, no. 11, pages 1067 - 1072
DESCRIPTION- BYRNE; RUDDLE, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 5473 - 5477
DESCRIPTION- CALAME; EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275
DESCRIPTION- CALIANDO ET AL., "Targeted DNA degradation using a CRISPR device stably carried in the host genome", NATURE COMMUNICATIONS, vol. 6, page 6989, URL: www.naure.com/naturecommunications
DESCRIPTION- CALICETI; VERONESE, ADVANCED DRUG DELIVERY REVIEWS, (2003), vol. 55, pages 1261 - 1277
DESCRIPTION- CAMPBELL; GOWRI, PLANT PHYSIOL., (199001), vol. 92, no. 1, pages 11 - 11
DESCRIPTION- CAMPES; TILGHMAN, GENES DEV., (1989), vol. 3, pages 537 - 546
DESCRIPTION- CAPANA ET AL., PLANT MOL BIOL, (1994), vol. 25, pages 681 - 691
DESCRIPTION- CHAN-HUI ET AL., CLINICAL IMMUNOLOGY, (2003), vol. 111, pages 162 - 174
DESCRIPTION- CHEN B; GILBERT LA; CIMINI BA; SCHNITZBAUER J; ZHANG W; LI GW; PARK J; BLACKBURN EH; WEISSMAN JS; QI LS, "Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system", CELL, (2013), vol. 155, no. 7, pages 1479 - 1491
DESCRIPTION- CHEN, PLOS COMPUT BIOL, (2015), vol. 11, no. 5, page E1004248
DESCRIPTION- CHOI ET AL., PROC. NATL. ACAD. SCI. USA., (2013), vol. 110, no. 19, pages 7625 - 7630
DESCRIPTION- CHO, S.; GOLDBERG, M.; SON, S.; XU, Q.; YANG, F.; MEI, Y.; BOGATYREV, S.; LANGER, R.; ANDERSON, D., "Lipid-like nanoparticles for small interfering RNA delivery to endothelial cells", ADVANCED FUNCTIONAL MATERIALS, (2010), vol. 19, pages 3112 - 3118
DESCRIPTION- COELHO ET AL., N ENGL J MED, (2013), vol. 369, pages 819 - 829
DESCRIPTION- CRABTREE ET AL., CHEMISTRY & BIOLOGY, (200601), vol. 13, pages 99 - 107
DESCRIPTION- CRONICAN ET AL., ACS CHEMICAL BIOLOGY, (2010), vol. 5, pages 747 - 752
DESCRIPTION- CRONICAN ET AL., CHEMISTRY & BIOLOGY, (2011), vol. 18, pages 833 - 838
DESCRIPTION- CRYSTAL, SCIENCE, (1995), vol. 270, pages 404 - 410
DESCRIPTION- CUTLER ET AL., J. AM. CHEM. SOC., (2011), vol. 133, pages 9254 - 9257
DESCRIPTION- CUTLER ET AL., J. AM. CHEM. SOC., (2012), vol. 134, pages 1376 - 1391
DESCRIPTION- DAHLMAN, NAT BIOTECHNOL., (20151005), vol. 33, no. 11, pages 1159 - 1161
DESCRIPTION- DAVEY ET AL., PLANT MOL BIOL., (198909), vol. 13, no. 3, pages 273 - 285
DESCRIPTION- DAVIS ET AL., NATURE, (20100415), vol. 464
DESCRIPTION- DELEAVEY, GLEN F. ET AL., CHEMISTRY & BIOLOGY, (2012), vol. 19, no. 8, pages 937 - 954
DESCRIPTION- DEVEREUX ET AL., NUC. ACIDS RESEARCH, (1984), vol. 1 2, page 387
DESCRIPTION- DEVEREUX ET AL., NUCLEIC ACIDS RESEARCH, (1984), vol. 12, page 387
DESCRIPTION- DE VEYLDER ET AL., PLANT CELL PHYSIOL, (1997), vol. 38, pages 568 - 577
DESCRIPTION- DEY ET AL., PROT SCI, (2013), vol. 22, pages 359 - 366
DESCRIPTION- DEY F; CLIFF ZHANG Q; PETREY D; HONIG B., "Toward a ''structural BLAST'': using structural relationships to infer function", PROTEIN SCI., (201304), vol. 22, no. 4, pages 359 - 366
DESCRIPTION- DIGIUSTO ET AL., SCI TRANSL MED, (2010), vol. 2, page 36RA43
DESCRIPTION- DILLON, TIB TECH, (1993), vol. 11, pages 167 - 175
DESCRIPTION- DILLON, TIBTECH, (1993), vol. 11, pages 167 - 175
DESCRIPTION- DUMITRACHE ET AL., GENETICS, (201108), vol. 188, no. 4, pages 787 - 797
DESCRIPTION- EDGAR, R.C., "PILER-CR: fast and accurate identification of CRISPR repeats", BMC BIOINFORMATICS, (200701), vol. 20, no. 8, page 18
DESCRIPTION- EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916
DESCRIPTION- EI-ANDALOUSSI ET AL., NATURE PROTOCOLS, (2012), vol. 7, pages 2112 - 2126
DESCRIPTION- EL-ANDALOUSSI S ET AL., "Exosome-mediated delivery of siRNA in vitro and in vivo", NATPROTOC., (20121115), vol. 7, no. 12, pages 2112 - 2126
DESCRIPTION- FEMS MICROBIOL LETT., (1999), vol. 174, no. 2, pages 247 - 250
DESCRIPTION- FEMS MICROBIOL LETT., (1999), vol. 177, no. 1, pages 187 - 188
DESCRIPTION- FENG, "Efficient genome editing in plants using a CRISPR/Cas system", CELL, (20130820), vol. 23, pages 1229 - 1232
DESCRIPTION- FU ET AL., "Improving CRISPR-Cas nuclease specificity using truncated guide RNAs", NATURE BIOTECHNOLOGY, (20131117), vol. 32, pages 279 - 284
DESCRIPTION- FU ET AL., TRANSGENIC RES., (200002), vol. 9, no. 1, pages 11 - 9
DESCRIPTION- FUSSENEGGER M, BIOTECHNOL PROG, (2001), vol. 17, pages 1 - 51
DESCRIPTION- GALLIE, PLANT CELL REPORTS, (1993), vol. 13, pages 119 - 122
DESCRIPTION- GAO ET AL., GENE THERAPY, (1995), vol. 2, pages 710 - 722
DESCRIPTION- GARRETT, N.L. ET AL., J BIOPHOTONICS, (2012), vol. 5, no. 5-6, pages 458 - 468
DESCRIPTION- GARRETT, N.L. ET AL., J RAMAN SPECT, (2012), vol. 43, no. 5, pages 681 - 688
DESCRIPTION- GASIUNAS, PNAS, (20120904), URL: www.pnas.org/cgi/doi/10.1073/pnas.1208507109
DESCRIPTION- GATZ ET AL., MOL GEN GENET, (1991), vol. 227, pages 229 - 237
DESCRIPTION- GEISBERT ET AL., LANCET, (2010), vol. 375, pages 1896 - 1905
DESCRIPTION- GILLERON J. ET AL., NUCL. ACIDS RES., (2015), vol. 43, no. 16, pages 7984 - 8001
DESCRIPTION- GOEDDEL, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185
DESCRIPTION- GREER, SCIENCE, (1985), vol. 228, page 1055
DESCRIPTION- GRIMM, D. ET AL., J. VIROL., (2008), vol. 82, pages 5887 - 5911
DESCRIPTION- GROENEN ET AL., MOL. MICROBIOL., (1993), vol. 10, pages 1057 - 1065
DESCRIPTION- HAO ET AL., SMALL, (2011), vol. 7, pages 3158 - 3162
DESCRIPTION- HENDEL, NAT BIOTECHNOL., (20150629), vol. 33, no. 9, pages 985 - 989
DESCRIPTION- HERMONAT; MUZYCZKA, PNAS, (1984), vol. 81, pages 6466 - 6470
DESCRIPTION- HIGGINS DG; SHARP PM, GENE, (1988), vol. 73, no. 1, pages 237 - 244
DESCRIPTION- HIRE ET AL., PLANT MOL BIOL, (1992), vol. 20, pages 207 - 218
DESCRIPTION- HOE ET AL., EMERG. INFECT. DIS., (1999), vol. 5, pages 254 - 263
DESCRIPTION- HORWELL DC, TRENDS BIOTECHNOL., (1995), vol. 13, no. 4, pages 132 - 134
DESCRIPTION- HYNES, PROC NATL ACAD SCI, (1981), vol. 78, pages 2038 - 2042
DESCRIPTION- ISHINO ET AL., J. BACTERIOL, (1987), vol. 169, pages 5429 - 5433
DESCRIPTION- JANSEN ET AL., MOL. MICROBIOL, (2002), vol. 43, pages 1565 - 1575
DESCRIPTION- JANSSEN ET AL., OMICS J. INTEG. BIOL., (2002), vol. 6, pages 23 - 33
DESCRIPTION- JAYARAMAN, ANGEW. CHEM. INT. ED., (2012), vol. 51, pages 8529 - 8533
DESCRIPTION- JENSEN ET AL., SCI. TRANSL. MED., (2013), vol. 5, page 209RAL52
DESCRIPTION- JIANG ET AL., NANO LETT., (20130313), vol. 13, no. 3, pages 1059 - 1064
DESCRIPTION- JOHANN ET AL., J. VIROL., (1992), vol. 66, pages 1635 - 1640
DESCRIPTION- JOHN BESEMER; ALEXANDRE LOMSADZE; MARK BORODOVSKY, "GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions", NUCLEIC ACIDS RESEARCH, (2001), vol. 29, pages 2607 - 2618
DESCRIPTION- JONKERS ET AL., AM. J. VET. RES., (1964), vol. 25, pages 236 - 242
DESCRIPTION- JUDGE, J. CLIN. INVEST., (2009), vol. 119, pages 661 - 673
DESCRIPTION- KARAGIANNIS ET AL., ACS NANO, (20121023), vol. 6, no. 10, pages 8484 - 8487
DESCRIPTION- KAUFFMAN, W. BERKELEY ET AL., TRENDS IN BIOCHEMICAL SCIENCES, (2015), vol. 40, no. 12, pages 749 - 764
DESCRIPTION- KAUFMAN ET AL., EMBO J., (1987), vol. 6, pages 187 - 195
DESCRIPTION- KAWAI ET AL., BIOENG BUGS, (201011), vol. 1, no. 6, pages 395 - 403
DESCRIPTION- KAWAMATA ET AL., PLANT CELL PHYSIOL, (1997), vol. 38, pages 792 - 803
DESCRIPTION- KESSEL; GRUSS, SCIENCE, (1990), vol. 249, pages 374 - 379
DESCRIPTION- KLEINSTIVER BP ET AL., "Engineered CRLSPR-Cas9 nucleases with altered PAM specificities", NATURE, (20150723), vol. 523, no. 7561, pages 481 - 485
DESCRIPTION- KLOCK G ET AL., NATURE (LONDON, (1987), vol. 329, pages 734 - 736
DESCRIPTION- KONNERMAN ET AL., NATURE, (20150129), vol. 517, pages 583 - 588
DESCRIPTION- KOREN; TORCHILIN, TRENDS IN MOLECULAR MEDICINE, (2012), vol. 18, no. 7
DESCRIPTION- KOTIN, HUMAN GENE THERAPY, (1994), vol. 5, pages 793 - 801
DESCRIPTION- KREMER; PERRICAUDET, BRITISH MEDICAL BULLETIN, (1995), vol. 51, no. 1, pages 31 - 44
DESCRIPTION- KUIJAN; HERSKOWITZ, CELL, (1982), vol. 30, pages 933 - 943
DESCRIPTION- KUSTER ET AL., PLANT MOL BIOL, (1995), vol. 29, pages 759 - 772
DESCRIPTION- LALATSA, A. ET AL., J CONTR REL, (2012), vol. 161, no. 2, pages 523 - 536
DESCRIPTION- LALATSA, A. ET AL., MOL PHARM, (2012), vol. 9, no. 6, pages 1665 - 1680
DESCRIPTION- LALATSA, A. ET AL., MOL PHARM, (2012), vol. 9, no. 6, pages 1764 - 1774
DESCRIPTION- LALATSA ET AL., J CONTROL RELEASE, (20120720), vol. 161, no. 2, pages 523 - 536
DESCRIPTION- LAWRENCE ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2007), vol. 129, pages 10110 - 10112
DESCRIPTION- LEE ET AL., NAT NANOTECHNOL., (20120603), vol. 7, no. 6, pages 389 - 393
DESCRIPTION- LEE F ET AL., NATURE (LONDON, (1981), vol. 294, pages 228 - 232
DESCRIPTION- LEWIS ET AL., NAT. GEN., (2002), vol. 32, pages 107 - 108
DESCRIPTION- LI, GENE THERAPY, (2012), vol. 19, pages 775 - 780
DESCRIPTION- LIVINGSTONE C.D.; BARTON G.J., "Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation", COMPUT. APPL. BIOSCI., (1993), vol. 9, pages 745 - 756
DESCRIPTION- LUCKLOW; SUMMERS, VIROLOGY, (1989), vol. 170, pages 31 - 39
DESCRIPTION- MAGALHAES M. ET AL., MOLECULAR THERAPY, (2012), vol. 20, no. 3, pages 616 - 624
DESCRIPTION- MAKAROVA KS; KOONIN EV, "Annotation and Classification of CRISPR-Cas Systems", METHODS MOL BIOL., (2015), vol. 1311, pages 47 - 75
DESCRIPTION- MALI, P. ET AL., SCIENCE, (20130103), vol. 339, no. 6121, pages 823 - 826
DESCRIPTION- MASEPOHL ET AL., BIOCHIM. BIOPHYS. ACTA, (1996), vol. 1307, pages 26 - 30
DESCRIPTION- MAYNARD-SMITH LA; CHEN LC; BANASZYNSKI LA; OOI AG; WANDLESS TJ, "A directed approach for engineering conditional protein stability using biologically silent small molecules", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2007), vol. 282, pages 24866 - 24872
DESCRIPTION- MAYO KE ET AL., CELL, (1982), vol. 29, pages 99 - 108
DESCRIPTION- MAZZA ET AL., ACS NANO, (20130226), vol. 7, no. 2, pages 1016 - 1026
DESCRIPTION- MAZZA, M. ET AL., ACSNANO, (2013), vol. 7, no. 2, pages 1016 - 1026
DESCRIPTION- MCNAUGHTON ET AL., PROC. NATL. ACAD. SCI. USA, (2009), vol. 106, pages 6111 - 6116
DESCRIPTION- MEADE BR ET AL., NATURE BIOTECHNOLOGY, (2014), vol. 32, pages 1256 - 1261
DESCRIPTION- MILLER ET AL., J, VIROL., (1991), vol. 65, pages 2220 - 2224
DESCRIPTION- MILLER ET AL., J. VIROL., (1991), vol. 65, pages 2220 - 2224
DESCRIPTION- MILLER, NATURE, (1992), vol. 357, pages 455 - 460
DESCRIPTION- MIRKIN ET AL., SMALL, vol. 10, pages 186 - 192
DESCRIPTION- MIRKIN, NANOMEDICINE, (2012), vol. 7, pages 635 - 638
DESCRIPTION- MITANI; CASKE, TIB TECH, (1993), vol. 11, pages 162 - 166
DESCRIPTION- MITANI; CASKEY, TIBTECH, (1993), vol. 11, pages 162 - 166
DESCRIPTION- MIYAZAKI, J AM CHEM SOC., (20120307), vol. 134, no. 9, pages 3942 - 3945
DESCRIPTION- MOJICA ET AL., MOL. MICROBIOL., (1995), vol. 17, pages 85 - 93
DESCRIPTION- MOJICA ET AL., MOL. MICROBIOL., (2000), vol. 36, pages 244 - 246
DESCRIPTION- MOL. CELL. BIOL., (1988), vol. 8, no. 1, pages 466 - 472
DESCRIPTION- MORRELL ET AL., "Crop genomics: advances and applications", NAT REV GENET., (20111229), vol. 13, no. 2, pages 85 - 96
DESCRIPTION- MORRISSEY ET AL., NATURE BIOTECHNOLOGY, (200508), vol. 23, no. 8
DESCRIPTION- MORTON BR, J MOL EVOL., (199804), vol. 46, no. 4, pages 449 - 459
DESCRIPTION- MURRAY ET AL., NUCLEIC ACIDS RES., (19890125), vol. 17, no. 2, pages 477 - 498
DESCRIPTION- MUZYCZKA, J. CLIN. INVEST., (1994), vol. 94, page 1351
DESCRIPTION- NABEL; FEIGNER, TIBTECH, (1993), vol. 11, pages 211 - 217
DESCRIPTION- NAIR, JK ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2014), vol. 136, no. 49, pages 16958 - 16961
DESCRIPTION- NAKAMURA, Y. ET AL., "Codon usage tabulated from the international DNA sequence databases: status for the year 2000", NUCL. ACIDS RES., (2000), vol. 28, page 292
DESCRIPTION- NAKATA ET AL., J. BACTERIOL., (1989), vol. 171, pages 3553 - 3556
DESCRIPTION- NATURE METHODS, (2008), page 5
DESCRIPTION- NEKRASOV, "Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR-Cas system", PLANT METHODS, (2013), vol. 9, page 39
DESCRIPTION- NIHONGAKI ET AL., NAT. BIOTECHNOL., (2015), vol. 33, pages 755 - 790
DESCRIPTION- NIKIC I. ET AL., NATURE PROTOCOLS, (2015), vol. 10, pages 780 - 791
DESCRIPTION- NO D ET AL., PROC NATL ACAD SCI USA, (1996), vol. 93, pages 3346 - 3351
DESCRIPTION- NOVOBRANTSEVA, MOLECULAR THERAPY-NUCLEIC ACIDS, (2002), vol. 1, page E4
DESCRIPTION- ONO ET AL., BIOSCI BIOTECHNOL BIOCHEM, (2004), vol. 68, pages 803 - 807
DESCRIPTION- ØSTERGAARD ET AL., BIOCONJUGATE CHEM., (2015), vol. 26, no. 8, pages 1451 - 1455
DESCRIPTION- PA CARR; GM CHURCH, NATURE BIOTECHNOLOGY, (2009), vol. 27, no. 12, pages 1151 - 1162
DESCRIPTION- PAULMURUGAN; GAMBHIR, CANCER RES, (20050815), vol. 65, page 7413
DESCRIPTION- PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277
DESCRIPTION- PLATT, CELL, (2014), vol. 159, no. 2, pages 440 - 455
DESCRIPTION- PLATT ET AL., CELL, (2014), vol. 159, no. 2, pages 440 - 455
DESCRIPTION- PROC. NATL. ACAD. SCI. USA., (1981), vol. 78, no. 3, pages 1527 - 1531
DESCRIPTION- "Protein Transport into Chloroplasts", ANNUAL REVIEW OF PLANT BIOLOGY, (2010), vol. 61, pages 157 - 180
DESCRIPTION- QUEEN; BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748
DESCRIPTION- QU, X., BIOMACROMOLECULES, (2006), vol. 7, no. 12, pages 3452 - 3459
DESCRIPTION- RAMAKRISHNA, GENOME RES., (201406), vol. 24, no. 6, pages 1020 - 1027
DESCRIPTION- REICH ET AL., MOL. VISION., (2003), vol. 9, pages 210 - 216
DESCRIPTION- REMY ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 647 - 654
DESCRIPTION- RIVERA VM ET AL., NAT MED, (1996), vol. 2, pages 1028 - 1032
DESCRIPTION- RODRIGUEZ, CHEM BIOL., (20120323), vol. 19, no. 3, pages 391 - 398
DESCRIPTION- ROSIN ET AL., MOLECULAR THERAPY, (201112), vol. 19, no. 1 2, pages 1286 - 2200
DESCRIPTION- ROSIN ET AL., MOLECULAR THERAPY, (201112), vol. 19, no. 12, pages 1286 - 2200
DESCRIPTION- SAEZ E ET AL., PROC NATL ACAD SCI USA, (2000), vol. 97, pages 14512 - 14517
DESCRIPTION- SAHAY G. ET AL., NATURE BIOTECHNOLOGY, (2013), vol. 31, pages 653 - 658
DESCRIPTION- SAINSBURY F. ET AL., PLANT BIOTECHNOL J., (200909), vol. 7, no. 7, pages 682 - 693
DESCRIPTION- SAMULSKI ET AL., J. VIROL., (198909), vol. 63, no. 9, pages 3822 - 3828
DESCRIPTION- SAPRANAUSKAS, R. ET AL., NUCLEIC ACIDS RES, (2011), vol. 39, pages 9275 - 9282
DESCRIPTION- SCHIFFELERS ET AL., NUCLEIC ACIDS RESEARCH, (2004), vol. 32, no. 19
DESCRIPTION- SCHOLTHOF ET AL., ANNU REV PHYTOPATHOL., (1996), vol. 34, pages 299 - 323
DESCRIPTION- SCHROEDER, A.; LEVINS, C.; CORTEZ, C.; LANGER, R.; ANDERSON, D., "Lipid-based nanotherapeutics for siRNA delivery", JOURNAL OF INTERNAL MEDICINE, (2010), vol. 267, pages 9 - 21
DESCRIPTION- SCHULTZ ET AL., GENE, (1987), vol. 54, pages 113 - 123
DESCRIPTION- SCIENCE, (20140103), vol. 343, no. 6166, pages 84 - 87
DESCRIPTION- S D KORMANN ET AL., "Expression of therapeutic proteins after delivery of chemically modified mRNA in mice", NATURE BIOTECHNOLOGY, (2011), vol. 29, pages 154 - 157
DESCRIPTION- SEARLE PF ET AL., MOL CELL BIOL, (1985), vol. 5, pages 1480 - 1489
DESCRIPTION- SEED, NATURE, (1987), vol. 329, page 840
DESCRIPTION- SEMPLE ET AL., NATURE NIOTECHNOLOGY, (201002), vol. 28, no. 2, pages 172 - 177
DESCRIPTION- SHAN, "Targeted genome modification of crop plants using a CRISPR-Cas system", NATURE BIOTECHNOLOGY, (2013), vol. 31, pages 686 - 688
DESCRIPTION- SHEN ET AL., FEBS LET., (2003), vol. 539, pages 111 - 114
DESCRIPTION- SHENGDAR Q; TSAI; NICOLAS WYVEKENS; CYD KHAYTER; JENNIFER A. FODEN; VISHAL THAPAR; DEEPAK REYON; MATHEW J. GOODWIN; MARTIN J. ARYE, "Dimeric CRISPR RNA-guided Fold nucleases for highly specific genome editing", NATURE BIOTECHNOLOGY, (2014), vol. 32, no. 6, pages 569 - 577
DESCRIPTION- SIEW, A. ET AL., MOL PHARM, (2012), vol. 9, no. 1, pages 14 - 28
DESCRIPTION- SIMEONI ET AL., NAR, (2003), vol. 31, no. 11, pages 2717 - 2724
DESCRIPTION- SIMON RJ ET AL., PNAS, (1992), vol. 89, no. 20, pages 9367 - 9371
DESCRIPTION- SLAYMAKER ET AL., SCIENCE, (20151201), vol. 351, no. 6268, pages 84 - 88
DESCRIPTION- SMITH ET AL., MOL. CELL. BIOL., (1983), vol. 3, pages 2156 - 2165
DESCRIPTION- SMITH; JOHNSON, GENE, (1988), vol. 67, pages 31 - 40
DESCRIPTION- SOMMNERFELT ET AL., VIROL., (1990), vol. 176, pages 58 - 59
DESCRIPTION- SORENSEN ET AL., J. MOL. BIOL., (2003), vol. 327, pages 761 - 766
DESCRIPTION- SPUCH; NAVARRO, JOURNAL OF DRUG DELIVERY, (2011), page 12
DESCRIPTION- STERNBERG ET AL., NATURE, (20151028), vol. 527, no. 7576, pages 110 - 113
DESCRIPTION- STUDIER ET AL., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185, pages 60 - 89
DESCRIPTION- SUN W ET AL., "Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery", J AM CHEM SOC., (20141013), vol. 136, no. 42, pages 14722 - 14725
DESCRIPTION- SUN W ET AL., "Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing", ANGEW CHEM INT ED ENGL., (20150827), vol. 54, no. 41, pages 12029 - 12033
DESCRIPTION- SU X; FRICKE J; KAVANAGH DG; IRVINE DJ, "In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles", MOL PHARM., (20110401), vol. 8, no. 3, pages 774 - 787
DESCRIPTION- SVENSEN ET AL., TRENDS IN PHARMACOLOGICAL SCIENCES, (2012), vol. 33, no. 4
DESCRIPTION- TABERNERO ET AL., CANCER DISCOVERY, (201304), vol. 3, no. 4, pages 363 - 470
DESCRIPTION- TAN W. ET AL., TRENDS IN BIOTECHNOLOGY, (201112), vol. 29, no. 12
DESCRIPTION- TAYLOR W.R., "The classification of amino acid conservation", J. THEOR. BIOI., (1986), vol. 119, pages 205 - 218
DESCRIPTION- THOMPSON, D.B. ET AL., CHEMISTRY & BIOLOGY, (2012), vol. 19, no. 7, pages 831 - 843
DESCRIPTION- THOMPSON ET AL., METHODS IN ENZYMOLOGY, (2012), vol. 503, pages 293 - 319
DESCRIPTION- "Transcription, translation and the control of gene expression", MULLICK A; MASSIE B, Encyclopedia of Cell Technology, WILEY, (2000), pages 1140 - 1164
DESCRIPTION- TRATSCHIN ET AL., MOL. CELL, BIOL., (1984), vol. 4, pages 2072 - 2081
DESCRIPTION- TRATSCHIN ET AL., MOL. CELL. BIOL., (1985), vol. 5, pages 3251 - 3260
DESCRIPTION- TRAVASSOS DA ROSA ET AL., AM. J. TROPICAL MED. & HYGIENE, (1984), vol. 33, pages 999 - 1006
DESCRIPTION- TSAI ET AL., NATURE BIOTECHNOLOGY, (201406), vol. 32, no. 6
DESCRIPTION- UCHEGBU, I.F. ET AL., INT J PHARM, (2001), vol. 224, pages 185 - 199
DESCRIPTION- UCHEGBU, I.F., EXPERT OPIN DRUG DELIV, (2006), vol. 3, no. 5, pages 629 - 640
DESCRIPTION- UCHEGBU; SIEW, J PHARM SCI., (2013), vol. 102, no. 2, pages 305 - 310
DESCRIPTION- UNO ET AL., HUMAN GENE THERAPY, (201106), vol. 22, pages 711 - 719
DESCRIPTION- VAN BRUNT, BIOTECHNOLOGY, (1988), vol. 6, no. 10, pages 1149 - 1154
DESCRIPTION- VAN EMBDEN ET AL., J. BACTERIOL., (2000), vol. 182, pages 2393 - 2401
DESCRIPTION- VIGNE, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, (1995), vol. 8, pages 35 - 36
DESCRIPTION- WAHLGREN ET AL., NUCLEIC ACIDS RESEARCH, (2012), vol. 40, no. 17, page E130
DESCRIPTION- WEINTRAUB, NATURE, (2013), vol. 495, pages S14 - S16
DESCRIPTION- WEST ET AL., VIROLOGY, (1987), vol. 160, pages 38 - 47
DESCRIPTION- WHITEHEAD ET AL., ACS NANO, (20120828), vol. 6, no. 8, pages 6922 - 6929
DESCRIPTION- WILSON ET AL., J. VIROL., (1989), vol. 63, pages 2374 - 2378
DESCRIPTION- WINOTO; BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733
DESCRIPTION- XIA ET AL., NAT. BIOTECH., (2002), vol. 20, pages 1006 - 1010
DESCRIPTION- XIE, "RNA-guided genome editing in plants using a CRISPR-Cas system", MOL PLANT., (2013), vol. 6, no. 6, pages 1975 - 83
DESCRIPTION- XU, "Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice", RICE, (2014), vol. 7, page 5
DESCRIPTION- YAMAMOTO ET AL., PLANT J, (1997), vol. 12, pages 255 - 265
DESCRIPTION- YOUNG ET AL., NANO LETT., (2012), vol. 12, pages 3867 - 3871
DESCRIPTION- YU ET AL., GENE THERAPY, (1994), vol. 1, pages 13 - 26
DESCRIPTION- ZALIPSKY, ADVANCED DRUG DELIVERY REVIEWS, (1995), vol. 16, pages 157 - 182
DESCRIPTION- ZHANG ET AL., ACS NANO, (2011), vol. 5, pages 6962 - 6970
DESCRIPTION- ZHANG ET AL., ADV MATER., (20130906), vol. 25, no. 33, pages 4641 - 4645
DESCRIPTION- ZHANG ET AL., J. AM. CHEM. SOC., (2012), vol. 134, pages 16488 - 16491
DESCRIPTION- ZHANG ET AL., NATURE, (2012), vol. 490, no. 7421, pages 556 - 560
DESCRIPTION- ZHAO ET AL., NAT GENET, (2006), vol. 38, pages 1341 - 1347
DESCRIPTION- ZHENG ET AL., PROC. NATL. ACAD. SCI. USA., (2012), vol. 109, pages 11975 - 11980
DESCRIPTION- ZHOU ET AL., "Exploiting SNPs for bialllic CRISPR mutations in the outcrossing woody perennial Populus reveals 4-coumarate: CoA ligase specificity and Redundancy", NEW PHYTOLOGIST, (2015), pages 1 - 4, URL: www.newphytologist.com
DESCRIPTION- ZIMMERMAN ET AL., NATURE LETTERS, (20060504), vol. 441
DESCRIPTION- ZOU ET AL., HUMAN GENE THERAPY, (201104), vol. 22, pages 465 - 475
DESCRIPTION- ZUKER; STIEGLER, NUCLEIC ACIDS RES., (1981), vol. 9, pages 133 - 148
INTERNATIONAL-SEARCH-REPORT- Haft, D.H., "HMM Summary Page: TIGR04330", (20120517), URL: http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR04330, XP002757584 [A] 1-55 * the whole document *
INTERNATIONAL-SEARCH-REPORT- BERND ZETSCHE ET AL, "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", CELL, US, (20150925), vol. 163, no. 3, doi:10.1016/j.cell.2015.09.038, ISSN 0092-8674, pages 759 - 771, XP055267511 [XP] 1-55 * the whole document *
INTERNATIONAL-SEARCH-REPORT- EVA SCHUNDER ET AL, "First indication for a functional CRISPR/Cas system in Francisella tularensis", INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, DE, (20130301), vol. 303, no. 2, doi:10.1016/j.ijmm.2012.11.004, ISSN 1438-4221, pages 51 - 60, XP055271835 [A] 1-55 * the whole document *
INTERNATIONAL-SEARCH-REPORT- KIRA S. MAKAROVA ET AL, "An updated evolutionary classification of CRISPR-Cas systems", NATURE REVIEWS. MICROBIOLOGY, GB, (20150928), vol. 13, no. 11, doi:10.1038/nrmicro3569, ISSN 1740-1526, pages 722 - 736, XP055271841 [AP] 1-55 * the whole document *
INTERNATIONAL-SEARCH-REPORT- GISLE VESTERGAARD ET AL, "CRISPR adaptive immune systems of Archaea", RNA BIOLOGY, US, (20140214), vol. 11, no. 2, doi:10.4161/rna.27990, ISSN 1547-6286, pages 156 - 167, XP055271855 [A] 1-55 * page 161, column r, paragraph 3 *
OPPOSITION- anonymous, "CRISPR Conference 2015 Event", CRISPR Conference 2015, (20150708), URL: https://www.crispr2015.com, XP055752960
OPPOSITION- anonymous, "CRISPR Conference 2015 Program", CRISPR Conference 2015, New York, NY, USA, (20150618), XP055752964
OPPOSITION- Burmistrz Michal, Bartosz Dudek , Dominika Staniec, Jose Ignacio Rodriguez Martinez, Matthias Bochtler, Jan Potempa, Krzysztof Pyrc, "Functional analysis of Porphyromonas gingivalis W83 CRISPR- Cas systems", J. Bacteriol., (20150526), pages 1 - 33, XP055756419
OPPOSITION- CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130201), vol. 339, no. 6121, pages 819 - 823, XP002779503
OPPOSITION- Fagerlund R. D. , Raymond H. J. Staals and Peter C. Fineran, "The Cpf1 CRISPR- Cas protein expands genome editing tools", GENOME BIOLOGY, (20151117), vol. 16, no. 251, pages 1 - 3, XP055838967
OPPOSITION- "FnCpfl Francisella tularensis subsp. novicida U112, complete genome"
OPPOSITION- "Francisella tularensis subsp. novicida U112, complete genome", Locus CP000439
OPPOSITION- "Francisella tularensis subsp. novicida U112, complete genome", NUCLEOTIDE, (20140207), Database accession no. CP000439, XP055741415
OPPOSITION- Haft Daniel H., Selengut Jeremy D., Richter Roland A., Harkins Derek, Basu Malay K., Beck Erin, "TIGRFAMs and Genome Properties in 2013", Nucleic Acids Research, (20130000), vol. 41, pages D387 - D395, XP055838952
OPPOSITION- HAFT, D.H., "HMM Summary Page: TIGR04330", (20120517), URL: http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR04330
OPPOSITION- HAFT D. H., "HMM Summary page : TIGR04330", (20120517), URL: http://www.jcvi.org/cgibin/tigrfams/HmmReportPage.cgi?ace=TIGR04330
OPPOSITION- HAFT D H, "HMM Summary Page: TIGR04330"", HMM Summary Page: TIGR04330, (20120517), XP002757584
OPPOSITION- Haft D H, "HMM Summary Page: TIGR04330", J. Craig Venter - jcvi, (20120517), URL: https://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR04330, XP002757584
OPPOSITION- Heidrich et al., "Chapters 1 and 4", Heidrich et al., Lundgren et al., CRISPR Methods and Protocols, Methods in Molecular Biology, (20150520), vol. 1311, pages 1-21, 47 - 75, XP055738628
OPPOSITION- HEIDRICH et al., "Investigating CRISPR RNA Biogenesis and Function Using RNA-seq", CRISPR. Methods and Protocols, Methods in Molecular Biology, New York, NY, (20150000), vol. 1311, pages 1 - 21
OPPOSITION- LUNDGREN et al., "CRISPR: Methods and Protocols", Methods in Molecular Biology, (20150000), vol. 1311, no. Chapters 1 and 4, XP055476456
OPPOSITION- Lundgren Et Al, "CRISPR: Methods and Protocols,", Methods in Molecular Biology, (20150500), vol. 1311, pages 1 - 21, 47-75, XP055476456
OPPOSITION- LUNDGREN M. et al., "CRISPR : Methods and protocols", Methods in Molecular Biology, (20150520), vol. 1311, pages 1-21 - 47-75, XP055476456
OPPOSITION- RAN et al., "CRISPR-Cas: Development and Applications for Mammalian Genome Editing", PhD Thesis, (20140424), XP055754930
OPPOSITION- RAN Fei Ann, "CRISPR-Cas: development and applications for mammalian genome editing", THESIS, (20140424), pages 1 - 156, XP055754930
OPPOSITION- STELLA. S. et al., "Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage", Nature, (20170622), vol. 546, pages 559 - 563, XP055467377
OPPOSITION- Vestergaard G., Roger A Garrett, Shiraz A Shah, "CRISPR adapive immune systems of Archea", RNA BIOLOGY, (20140207), vol. 11, no. 2, pages 156 - 167, XP055838987
OPPOSITION- Zetsche B. , Jonathan S. Gootenberg, Omar O. Abudayyeh Aviv Regev, Eugene V. Koonin, Feng Zhang, "Cpf is a single RNA- guided endonuclease of a class 2 CRISPR- Cas system", CELL, (20150925), vol. 163, no. 3, pages 759 - 771, XP055838963
OPPOSITION- ZETSCHE, B. et al., "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", CELL, (20150925), vol. 163, no. 3, doi:10.1016/j.cell.2015.09.038, pages 759 - 771, XP055267511
OPPOSITION- ZETSCHE et al., "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", Cell, (20150000), vol. 163, no. 3, pages 759 - 771, XP055267511
OPPOSITION- ZETSCHE et al., "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", Cell, (20150925), vol. 163, no. 3, pages 759 - 771, XP055267511
OPPOSITION- ZETSCHE et al., "Cpf1 is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", Cell, (20151022), vol. 163, doi:10.1016/j.cell.2015.09.038, pages 759 - 771, XP055267511
OPPOSITION- HIRANO, H et al., "Structure and Engineering of Francisella novicida Cas9", Cell, (20160225), vol. 164, no. 5, pages 950 - 961, XP029433860
OPPOSITION- Eva Schunder; Kerstin Rydzewski; Roland Grunow; Klaus Heuner, "First indication for a functional CRISPR/ Cas system in Francisella tularensis", INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, (20130301), vol. 303, no. 2, pages 51 - 60, XP055271835
OPPOSITION- SCHUNDER, E. et al., "First indication for a functional CRISPR/Cas system in Francisella tularensis", INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, (20130118), vol. 303, no. 2, doi:10.1016/j.ijmm.2012.11.004, pages 51 - 60, XP055271835
OPPOSITION- SCHUNDER et al., "First indication for a functional CRISPR/Cas system in Francisella tularensis", Int J Med Micro, (20130118), vol. 303, no. 2, pages 51 - 60, XP055271835
OPPOSITION- SCHUNDER et al., "First indication for a functional CRISPR/Cas system in Francisella tularensis", Int. J. Med. Microbiol., (20130118), vol. 303, no. 2, pages 51 - 60, XP055271835
OPPOSITION- SCHUNDER et al., "First indication for a functional CRISPR/Cas system in Francisella tularensis", Int. J of Medical Microbiology, (20130000), vol. 303, doi:10.1016/j.ijmm.2012.11.004, pages 51 - 60, XP055271835
OPPOSITION- BARRANGOU et al., "CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity", Molecular Cell, (20140400), vol. 54, doi:10.1016/j.molcel.2014.03.011, pages 234 - 244, XP055190330
OPPOSITION- LEENAY, R.T. et al., "Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems", Mol Cell, (20160407), vol. 62, no. 1, doi:10.1016/j.molcel.2016.02.031, pages 137 - 147, XP029496719
OPPOSITION- DELTCHEVA, E. et al., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110331), vol. 471, pages 602 - 607, XP055619637
OPPOSITION- KLEINSTIVER, B.P. et al., "Engineered CRISPR-Cas9 nucleases with altered PAM specificities", Nature, (20150723), vol. 523, doi:10.1038/nature14592, pages 481 - 485, XP055293257
OPPOSITION- KLEINSTIVER et al., "Engineered CRISPR-Cas9 nucleases with altered PAM specificities", Nature, (20150723), vol. 523, no. 7561, pages 481 - 485, XP055293257
OPPOSITION- HWANG et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nat. Biotechnol., (20130129), vol. 31, no. 3, pages 227 - 229, XP055086625
OPPOSITION- CHO et al., "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nat. Biotechnol., (20130129), vol. 31, no. 3, pages 230 - 232, XP002699850
OPPOSITION- JIANG et al., "RNA-guided editing of bacterial genomes using CRISPR-Cas systems(includes Online Methods and Supplementary Information)", Nat. Biotechnol., (20130301), vol. 31, no. 3, pages 233 - 239, XP002699849
OPPOSITION- SANDER, J.D. et al., "CRISPR-Cas systems for genome editing, regulation and targeting", Nature Biotechnology, (20141001), vol. 32, pages 347 - 355, XP055481941
OPPOSITION- GAO et al., "Engineered Cpf1 variants with altered PAM specificities", Nat. Biotechnol., (20170605), vol. 35, no. 8, pages 789 - 792, XP055553021
OPPOSITION- GAO, L. et al., "Engineered Cpf1 variants with altered PAM specificities", Nature Biotechnology, (20170605), pages 789 - 792, XP055553021
OPPOSITION- CHEN, F. et al., "Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting", Nature Communications, (20170407), vol. 8, no. Article number 14958, doi:10.1038/ncomms14958, XP002776524
OPPOSITION- MAKAROVA, K.S. et al., "Evolution and classification of the CRISPR-Cas systems", Nature Reviews Microbiology, (20110509), vol. 9, no. 6, doi:10.1038/nrmicro2577, pages 467 - 77, XP009155547
OPPOSITION- VAN DER OOST et al., "Unravelling the structural and mechanistic basis of CRISPR-Cas systems", Nat Rev Microbiol, (20140609), vol. 12, no. 7, pages 479 - 492, XP055619310
OPPOSITION- VAN DER OOS T et al., "Unravelling the structural and mechanistic basis of CRISPR-Cas systems", Nat Rev Microbiol, (20140700), vol. 12, no. 7, doi:10.1038/nrmicro3279, pages 479 - 492, XP055619310
OPPOSITION- Van Der Oost J., Edze R. Westra, Ryan N. Jackson, Blake Wiedenheft, "Unravelling the structural and mechanistic basis of CRISPR-Cassystems", MICROBIOLOGY, (20140609), vol. 12, no. 7, pages 479 - 492, XP055619310
OPPOSITION- MAKAROVA, K.S. et al., "An updated evolutionary classification of CRISPR-Cas systems", NATURE REVIEWS MICROBIOLOGY, (20150928), vol. 13, no. 11, doi:10.1038/nrmicro3569, pages 722 - 736, XP055271841
OPPOSITION- HOCHSTRASSER et al., "CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference", PNAS, (20140506), vol. 111, no. 18, pages 6618 - 6623, XP055752880
OPPOSITION- GRISSA et al., "CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats", Nucleic Acids Research, (20070000), vol. 35, doi:10.1093/nar/gkm360, pages W52 - W57, XP002490217
OPPOSITION- Grissa I., Vergnaud G., Pourcel C., "CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats", Nucleic Acids Research, (20070531), vol. 35, pages W52 - W57, XP002490217
OPPOSITION- SAPRANAUSKAS, R. et al., "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", Nucleic Acids Research, (20110803), vol. 39, no. 21, doi:10.1093/nar/gkr606, pages 9275 - 82, XP055265024
OPPOSITION- ZHANG et al., "Expanding the catalog of cas genes with metagenomes", Nucleic Acids Research, (20140000), vol. 42, no. 4, doi:10.1093/nar/gkt1262, pages 2448 - 2459, XP055181273
OPPOSITION- JIANG et al., "Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice", Nucleic Acids Res., (20130902), vol. 41, no. 20, page e188, XP055219328
OPPOSITION- JIANG et al., "Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice", Nucleic Acids Research, (20130000), pages 41 , 20, e188, 1 - 12, XP055219328
OPPOSITION- JIANG, W. et al., "Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice", Nucleic Acids Research, (20130902), vol. 41, no. 20, pages 1 - 12, XP055219328
OPPOSITION- Jiang W., Huanbin Zhou, Honghao Bi, Michael Fromm, Bing Yang, Donald P. Weeks, "Demonstration of CRISPR/Cas9/sgRNA-mediatedtargeted gene modification in Arabidopsis, tobacco, sorghum and rice", Nucleic Acids Research, (20130902), vol. 41, no. 20, page e188, XP055219328
OPPOSITION- PRAKASH et al., "Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10- fold in mice", Nucleic Acids Research, (20140000), vol. 42, no. 13, doi:10.1093/nar/gku531, pages 8796 - 8807, XP055148318
OPPOSITION- PRAKASH, T.P. et al., "Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice", Nucl. Acids Res., (20140703), vol. 42, no. 13, doi:10.1093/nar/gku531, pages 8796 - 8807, XP055148318
OPPOSITION- Prakash T P; Graham M J; Yu J; Carty R; Low A; Chappell A; Schmidt K; Zhao C; Aghajan M; Murray H F; Riney S; Booten S L; Murray S F; Gaus H; Crosby J; Lima W F; Guo S; Monia B P; Swayze E E; Seth P P, "Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N- acetyl galactosamine improves potency 10-fold in mice", Nucleic Acids Research, (20140703), vol. 42, no. 13, pages 8796 - 8807, XP055148318
OPPOSITION- F. J. M Mojicas., C. Diez-Villasenor, J. Garcia-Martinez , C. Almendros, "Short motif sequences determine the targets of the prokaryotic CRISPR defence system", Society for General Microbiology, (20090301), vol. 155, no. 3, pages 733 - 740, XP055118633
OPPOSITION- MOJICA et al., "Short motif sequences determine the targets of the prokaryotic CRISPR defence system", Microbiology, (20090000), vol. 155, doi:10.1099/mic.0.023960-0, pages 733 - 740, XP055118633
OPPOSITION- ZETSCHE, B. et al., "A Survey of Genome Editing Activity for 16 Cpf1 orthologs", BioRxiv, (20170504), URL: http://dx.doi.org/10.1101/134015, XP055467379
OPPOSITION- ZETSCHE et al., "A Survey of Genome Editing Activity for 16 Cpf1 orthologs", BioRxiv, (20170504), URL: http://dx.doi.org/10.1101/134015, XP055467379
OPPOSITION- JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120000), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055549487
OPPOSITION- JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120817), vol. 337, pages 816 - 821, XP055067740
OPPOSITION- Jinek M; Chylinski K; Fonfara I; Hauer M; Doudna J A; Charpentier E, "A Programmable Dual-RNA-GuidedDNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, pages 816 - 821, XP055549487
OPPOSITION- MALI et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130103), vol. 339, no. 6121, pages 823 - 826, XP055111247
OPPOSITION- BURMISTRZ et al., "Functional analysis of Porphyromonas gingivalis W83 CRISPR-Cas systems", J. Bacteriol., (20150500), XP055755640
OPPOSITION- ROHMER et al., "Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains", Genome Biol., (20070605), vol. 8, no. 6, page R102, XP021031234
OPPOSITION- ROHMER, L. et al., "Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains", Genome Biology, (20070605), vol. 8, doi:10.1186/gb-2007-8-6-r102, page R102, XP021031234
OPPOSITION- KARVELIS, T. et al., "Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements", Genome Biology, (20151119), vol. 16, XP055551291
OPPOSITION- GRAHAM, D.B. et al., "Resources for the design of CRISPR gene editing experiments", Genome Biology, (20151127), vol. 16, XP055377553
OPPOSITION- GRAHAM et al., "Resources for the design of CRISPR gene editing experiments", Genome Biol., (20151127), vol. 16, no. 1, page 260, XP055377553
OPPOSITION- FAGERLUND et al., "The Cpf1 CRISPR-Cas protein expands genome-editing tools", Genome Biology, (20151100), vol. 16, doi:10.1186/s13059-015-0824-9, page 251, XP002757560
OPPOSITION- FAGERLUND, R.D. et al., "The Cpf1 CRISPR-Cas protein expands genome-editing tools", GENOME BIOLOGY, (20151117), vol. 16, doi:10.1186/s13059-015-0824-9, page 251, XP002757560
OPPOSITION- TENG et al., "Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds", Genome Biol., (20190205), vol. 20, page 15, XP055697389
OPPOSITION- TENG, F. et al., "Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds", Genome Biology, (20190205), vol. 20, XP055697389
OPPOSITION- ZETSCHE, B. et al., "A Survey of Genome Editing Activity for 16 Cas12a Orthologs", The Keio Journal of Medicine, (20191114), XP055738661
OPPOSITION- ZETSCHE et al., "A Survey of Genome Editing Activity for 16 Cas12a Orthologs", Keio J. Med., (20190000), vol. 69, no. 3, pages 59 - 65, XP055738652
OPPOSITION- VESTERGAARD et al., "CRISPR adaptive immune systems of Archaea", RNA Biol., (20140207), vol. 11, no. 2, pages 156 - 167, XP055271855
OPPOSITION- VESTERGAARD et al., "CRISPR adaptive immune systems of Archaea", RNA Biology, (20140200), vol. 11, no. 2, doi:10.4161/rna.27990, pages 156 - 167, XP055271855
OPPOSITION- VESTERGAARD, G. et al., "CRISPR adaptive immune systems of Archaea", RNA BIOLOGY, (20140207), vol. 11, no. 2, doi:10.4161/rna.27990, pages 156 - 167, XP055271855

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