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Manipulation Of Immunoglobulin Gene Diversity And Multi-Antibody Therapeutics - EP3311661

The patent EP3311661 was granted to Kymab on Apr 20, 2022. The application was originally filed on Sep 18, 2012 under application number EP17196235A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3311661

KYMAB
Application Number
EP17196235A
Filing Date
Sep 18, 2012
Status
Granted And Under Opposition
Mar 18, 2022
Grant Date
Apr 20, 2022
External Links
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JAMES POOLEJan 20, 2023MAIWALDWITHDRAWN

Patent Citations (35) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONEP2757875
OPPOSITIONUS2012204278
OPPOSITIONUS5545806
OPPOSITIONUS6596541
OPPOSITIONWO02053596
OPPOSITIONWO02066630
OPPOSITIONWO2004009618
OPPOSITIONWO2007117410
OPPOSITIONWO2008054606
OPPOSITIONWO2009018411
OPPOSITIONWO2009157771
OPPOSITIONWO2010039900
OPPOSITIONWO2010077854
OPPOSITIONWO2011004192
OPPOSITIONWO2011097603
OPPOSITIONWO2011158009
OPPOSITIONWO2011163311
OPPOSITIONWO2011163314
OPPOSITIONWO2012018764
OPPOSITIONWO2013059230
OPPOSITIONWO2013130981
OPPOSITIONWO9824893
OTHEREP2758535
OTHERUS2012204278
OTHERUS5545806
OTHERUS6596541
OTHERWO02066630
OTHERWO2007117410
OTHERWO2008054606
OTHERWO2009018411
OTHERWO2010077854
OTHERWO2011158009
OTHERWO2013130981
SEARCHWO02053596
SEARCHWO2011004192

Non-Patent Literature (NPL) Citations (72) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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OPPOSITION- Zhiqiang An, "Therapeutic Monoclonal Antibodies: from bench to Clinic /Passage/", Therapeutic Monoclonal Antibodies: from bench to Clinic, John Wiley & Sons, Inc. , (20090101), page 4pp, XP055535891-
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OPPOSITION- Marianne Brüggemann et al, "Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus", European Journal of Immunology, Wiley-VCH, Hoboken, USA, Hoboken, USA, (19910501), vol. 21, doi:10.1002/eji.1830210535, ISSN 0014-2980, pages 1323 - 1326, XP000944561
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OPPOSITION- Zemlin, M. et al, "Expressed Murine and Human CDR-H3 Intervals of Equal Length Exhibit Distinct Repertoires that Differ in their Amino Acid Composition and Predicted Range of Structures", Journal of Molecular Biology, Academic Press, United Kingdom, United Kingdom , (20031205), vol. 334, no. 4, doi:10.1016/j.jmb.2003.10.007, ISSN 0022-2836, pages 733 - 749, XP004473368
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OPPOSITION- Green, L.L., "Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies", Journal of Immunological Methods, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM., NL, NL , (19991210), vol. 231, no. 1-2, doi:10.1016/S0022-1759(99)00137-4, ISSN 0022-1759, pages 11 - 23, XP004186071
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OPPOSITION- E-Chiang Lee et al, "Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20140401), vol. 32, no. 4, doi:10.1038/nbt.2825, ISSN 1087-0156, pages 356 - 363, XP055131583
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OPPOSITION- Huang C C. et al, "Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20040302), vol. 101, no. 9, doi:10.1073/pnas.0308527100, ISSN 0027-8424, pages 2706 - 2711, XP002689790
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OPPOSITION- A. J. Murphy, L. E. Macdonald, S. Stevens, M. Karow, A. T. Dore, K. Pobursky, T. T. Huang, W. T. Poueymirou, L. Esau, M. Meola, W. Mikulka, P. Krueger, J. Fairhurst, D. M. Valenzuela, N. Papadopoulos, G. D. Yancopoulos, "Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20140408), vol. 111, no. 14, doi:10.1073/pnas.1324022111, ISSN 00278424, pages 5153 - 5158, XP055162338
OPPOSITION- Schroeder H W , Wang J Y, "Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life", Proceedings of the National Academy of Sciences, National Academy of Sciences, (19900801), vol. 87, no. 16, doi:10.1073/pnas.87.16.6146, ISSN 0027-8424, pages 6146 - 6150, XP002689791
OPPOSITION- P. A. Barthelemy et al, "Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, (20080201), vol. 283, no. 6, doi:10.1074/jbc.M708536200, ISSN 00219258, pages 3639 - 3654, XP055040419
OPPOSITION- ROCK E.P., ET AL., "CDR3 LENGTH IN ANTIGEN-SPECIFIC IMMUNE RECEPTORS.", Journal of Experimental Medicine, Rockefeller University Press, US, US , (19940101), vol. 179., no. 01., doi:10.1084/jem.179.1.323, ISSN 0022-1007, pages 323 - 328., XP000647839
OPPOSITION- Nadel B. et al, "Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo", Journal of Experimental Medicine, Rockefeller University Press, US, US , (19980504), vol. 187, no. 9, doi:10.1084/jem.187.9.1495, ISSN 0022-1007, pages 1495 - 1503, XP002697040
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OPPOSITION- Bryan S. Briney et al, "Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes", PLoS ONE, Public Library of Science, (20120101), vol. 7, no. 5, doi:10.1371/journal.pone.0036750, ISSN 19326203, page e36750, XP055048579
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OPPOSITION- Andrew Murphy, "VelocImmune: Immunoglobulin Variable Region Humanized Mice", Recombinant Antibodies for Immunotherapy, GB , Cambridge University Press , (20090101), pages 100 - 107, doi:http://dx.doi.org/10.1017/CBO9780511596773.011, ISBN 978-0-521-88732-8, XP008160379
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OTHER- ICHIHARA Y; MATSUOKA H; KUROSAWA Y, "ORGANIZATION OF HUMAN IMMUNOGLOBULIN HEAVY CHAIN DIVERSITY GENE LOCI", EMBO Journal, (19880000), vol. 7, no. 13, pages 4141 - 4150, XP000004234-
OTHER- Marianne BRUGGEMANN, "Human Antibody Expression in Transgenic Mice", Archivum Immunologiae et Therapiae Experimentalis, (20010000), vol. 49, pages 203 - 208, XP055535899-
OTHER- Mike NAGLE, "Regeneron helps make Sanofi Velocimmune to its 'weak' pipeline", Outsourcing-Pharma.Com, (20071203), URL: http://www.outsourcing-pharma.com/Preclinical-Research/Regeneron-helps-make-Sanofi-VelocImmune-to-its-weak-pipeline, XP055304507-
OTHER- ROSNER et al., "Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes", Immunology, (20010000), vol. 103, pages 179 - 187, XP055516887-
OTHER- "Therapeutic Monoclonal Antibodies: from bench to Clinic /Passage/", Zhiqiang An, Therapeutic Monoclonal Antibodies: from bench to Clinic, John Wiley & Sons, Inc, (2009), page 4pp, XP055535891-
OTHER- Zhiqiang An, Therapeutic Monoclonal Antibodies: from bench to Clinic, John Wiley & Sons, Inc., (20090000), page 4pp, XP055535891-
OTHER- Zhiqiang An, "Therapeutic Monoclonal Antibodies: from bench to Clinic /Passage/", Therapeutic Monoclonal Antibodies: from bench to Clinic, John Wiley & Sons, Inc. , (20090101), page 4pp, XP055535891-
OTHER- GALLO et al., "The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans", European Journal of Immunology,, (20000000), vol. 30, pages 534 - 540, XP003035688
OTHER- ZEMLIN et al., "Expressed Murine and Human CDR-H3 Intervals of Equal Length Exhibit Distinct Repertoires that Differ in their Amino Acid Composition and Predicted Range of Structures", J. Mol. Biol., (20031205), vol. 334, pages 733 - 749, XP004473368
OTHER- GREEN L L, "Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies", J. Immunol. Methods, (19991211), vol. 231, no. 1-2, pages 11 - 23, XP004186071
OTHER- Andrew MURPHY, "VelocImmune: Immunoglobulin Variable Region Humanised Mice", Andrew MURPHY, Melvyn Little, Recombinant Antibodies for Immunotherapy, Cambridge University Press, (20090000), pages 2pp, 100 - 107, XP055304492
OTHER- Jim Kling, "Big Pharma vies for mice", Nature Biotechnology, (20070600), vol. 25, no. 6, pages 613 - 614, XP055304499
OTHER- Christopher Thomas Scott, "Mice with a human touch", Nature Biotechnology, (20070000), vol. 25, no. 10, pages 1075 - 1077, XP055098497
OTHER- ROCK E P; ET AL, "CDR3 LENGTH IN ANTIGEN-SPECIFIC IMMUNE RECEPTORS", The Journal of Experimental Medicine,, (19940000), vol. 179, no. 1, pages 323 - 328, XP000647839
OTHER- RAAPHORST et al., "Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences", International Immunology,, (19970000), vol. 9, no. 10, pages 1503 - 1515, XP055409001
SEARCH- FEENEY ANN J, "Genetic and epigenetic control of V gene rearrangement frequency.", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2009, (2009), vol. 650, ISSN 0065-2598, pages 73 - 81, XP009169605 [A] 1-22 * abstract * * page 74 - page 75 *-
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SEARCH- YU C C K ET AL, "Differential usage of V(H) gene segments is mediated by cis elements", JOURNAL OF IMMUNOLOGY 19981001 US, (19981001), vol. 161, no. 7, ISSN 0022-1767, pages 3444 - 3454, XP002697039 [A] 1-22 * abstract *-
SEARCH- BRUEGGEMANN M ET AL, "HUMAN ANTIBODY PRODUCTION IN TRANSGENIC MICE: EXPRESSION FROM 100 KB OF THE HUMAN IGH LOCUS", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, (19910501), vol. 21, doi:10.1002/EJI.1830210535, ISSN 0014-2980, pages 1323 - 1326, XP000944561 [A] 1-22 * abstract * * paragraph [0002] - paragraph [0003] *
SEARCH- GREEN L L, "Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, (19991210), vol. 231, no. 1-2, doi:10.1016/S0022-1759(99)00137-4, ISSN 0022-1759, pages 11 - 23, XP004187631 [A] 1-22 * abstract * * figure 2 *
SEARCH- MENDEZ M J ET AL, "FUNCTIONAL TRANSPLANT OF MEGABASE HUMAN IMMUNOGLOBULIN LOCI RECAPITULATES HUMAN ANTIBODY RESPONSE IN MICE", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, (19970201), vol. 15, no. 2, doi:10.1038/NG0297-146, ISSN 1061-4036, pages 146 - 156, XP002067603 [A] 1-22 * abstract * * page 148 ff. * * figure 1 *
SEARCH- HUANG CHIH-CHIN ET AL, "Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20040302), vol. 101, no. 9, ISSN 0027-8424, pages 2706 - 2711, XP002689790 [A] 1-22 * abstract * * page 2708 * * page 2710 *
SEARCH- SCHROEDER H W JR ET AL, "PREFERENTIAL UTILIZATION OF CONSERVED IMMUNOGLOBULIN HEAVY CHAIN VARIABLE GENE SEGMENTS DURING HUMAN FETAL LIFE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1990), vol. 87, no. 16, ISSN 0027-8424, pages 6146 - 6150, XP002689791 [A] 1-22 * abstract *
SEARCH- NADEL BERTRAND ET AL, "Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo", JOURNAL OF EXPERIMENTAL MEDICINE, (19980504), vol. 187, no. 9, ISSN 0022-1007, pages 1495 - 1503, XP002697040 [A] 1-22 * abstract *
SEARCH- LIU LIHONG ET AL, "Potent and Broad Anti-HIV-1 Activity Exhibited by a Glycosyl-Phosphatidylinositol-Anchored Peptide Derived from the CDR H3 of Broadly Neutralizing Antibody PG16", JOURNAL OF VIROLOGY, (20110629), vol. 85, no. 17, pages 8467 - 8476, XP002689792 [DA] 1-22 * abstract *
SEARCH- JUNG D ET AL, "Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus", ANNUAL REVIEW OF IMMUNOLOGY, ANNUAL REVIEWS INC, US, vol. 24, doi:10.1146/ANNUREV.IMMUNOL.23.021704.115830, ISSN 0732-0582, (20060116), pages 541 - 570, (20060116), XP002473551 [A] 1-22 * the whole document *
SEARCH- BRYAN S. BRINEY ET AL, "Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes", PLOS ONE, (20120101), vol. 7, no. 5, doi:10.1371/journal.pone.0036750, ISSN 1932-6203, pages 1 - 13, XP055048579 [DPA] 1-22 * abstract * * page 2 - page 4 * * page 7 - page 10 *

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