IP Verse

Delivery Of Mrna For The Augmentation Of Proteins And Enzymes In Human Genetic Diseases - EP3318248

The patent EP3318248 was granted to Translate BIO on Apr 10, 2019. The application was originally filed on Nov 30, 2010 under application number EP17207662A. The patent is currently recorded with a legal status of "Revoked".

EP3318248

TRANSLATE BIO
Application Number
EP17207662A
Filing Date
Nov 30, 2010
Status
Revoked
May 24, 2024
Grant Date
Apr 10, 2019
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BRADYJan 10, 2020EIPADMISSIBLE
WITHERS & ROGERSJan 10, 2020GRAF VON STOSCH PATENTANWALTSGESELLSCHAFTADMISSIBLE

Patent Citations (29) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS19970835281-
DESCRIPTIONUS19980083294-
DESCRIPTIONUS4737323
DESCRIPTIONUS4897355
DESCRIPTIONUS4920016
DESCRIPTIONUS4946683
DESCRIPTIONUS5171678
DESCRIPTIONUS5194654
DESCRIPTIONUS5223263
DESCRIPTIONUS5334761
DESCRIPTIONUS5677124
DESCRIPTIONUS5744335
DESCRIPTIONUS5885613
DESCRIPTIONWO2005121348
OPPOSITIONEP1026253
OPPOSITIONUS5580859
OPPOSITIONUS5912159
OPPOSITIONUS6077835
OPPOSITIONUS6734171
OPPOSITIONWO2004002453
OPPOSITIONWO2005120152
OPPOSITIONWO2007024708
OPPOSITIONWO2008052770
OPPOSITIONWO2009086558
OPPOSITIONWO9011092
OPPOSITIONWO9851278
OPPOSITIONWO9918933
SEARCHWO2005120152
SEARCHWO9011092

Non-Patent Literature (NPL) Citations (71) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BEHR et al., Proc. Nat.'l Acad. Sci., (19890000), vol. 86, page 6982-
DESCRIPTION- Bloomfield, Ann. Rev. Biophys. Bioeng., (19810000), vol. 10, pages 421 - 450-
DESCRIPTION- DRUMMOND et al., Pharmacol. Rev., (19990000), vol. 51, pages 691 - 743-
DESCRIPTION- FECHTER, P. et al., J. Gen. Virology, (20050000), vol. 86, pages 1239 - 1249-
DESCRIPTION- FEIGNER et al., Proc. Nat'l Acad. Sci., (19870000), vol. 84, page 7413-
DESCRIPTION- GAO et al., Biochem. Biophys. Res. Comm., (19910000), vol. 179, page 280-
DESCRIPTION- GORDON N, Eur J Paediatr Neurol, (20030000), vol. 7, pages 115 - 121-
DESCRIPTION- GORDON, N., Eur J Paediatr Neurol, (20030000), vol. 7, pages 115 - 121-
DESCRIPTION- HATA, A. et al., J. Biochem., (19860000), vol. 100, pages 717 - 725-
DESCRIPTION- HEIDENREICH et al., J Biol Chem, (19940000), vol. 269, pages 2131 - 2138-
DESCRIPTION- HEYES, J. et al., J Controlled Release, (20050000), vol. 107, pages 276 - 287-
DESCRIPTION- HORWICH AL et al., Cell, (19860000), vol. 44, pages 451 - 459-
DESCRIPTION- HORWICH, AL et al., Cell, (19860000), vol. 44, pages 451 - 459-
DESCRIPTION- HORWICH, AL et al., Science, (19840000), vol. 224, pages 1068 - 1074-
DESCRIPTION- Hum. Gene Ther., (20080900), vol. 19, no. 9, pages 887 - 895-
DESCRIPTION- KARIKO, K. et al., Molecular Therapy, (20080000), vol. 16, no. 11, pages 1833 - 1840-
DESCRIPTION- KLIBANOV et al., FEBS Letters, (19900000), vol. 268, no. 1, pages 235 - 237-
DESCRIPTION- KOZAK, M., Nucleic Acids Res, (19870000), vol. 15, no. 20, pages 8125 - 8148-
DESCRIPTION- KRIEG et al., Melton. Methods in Enzymology, (19870000), vol. 155, pages 397 - 415-
DESCRIPTION- LASIC et al., FEBS Lett., (19920000), vol. 312, pages 255 - 258-
DESCRIPTION- LASIC, Trends Biotechnol., (19980000), vol. 16, pages 307 - 321-
DESCRIPTION- LIEBHABER, J. Mol. Biol., (19920000), vol. 226, pages 2 - 13-
DESCRIPTION- LINDGREN V. et al., Science, (19841100), vol. 226, pages 698 - 700-
DESCRIPTION- MONIA et al., J Biol Chem., (19930000), vol. 268, pages 14514 - 14522-
DESCRIPTION- MORRISSEY, DV. et al., Nat. Biotechnol., (20050000), vol. 23, no. 8, pages 1003 - 1007-
DESCRIPTION- NG et al., Nature Genetics, (20100000), vol. 42, pages 1035 - 1036-
DESCRIPTION- N.J. CAPLEN et al., Gene Ther., (19950000), vol. 2, page 603-
DESCRIPTION- PONSA, M. et al., Int. J. Pharm., (19930000), vol. 95, pages 51 - 56-
DESCRIPTION- "Reduction of Liposome Size and Preparation of Unilamellar Vesicles by Extrusion Techniques", HOPE, M J et al., Liposome Technology, (19930000), vol. 1, page 123-
DESCRIPTION- Remington's Pharmaceutical Sciences, Mack Publishing Co.-
DESCRIPTION- S. LI et al., Gene Ther., (19970000), vol. 4, page 891-
DESCRIPTION- WILCOX, J.N., J. Histochem. Cytochem., (19930000), vol. 41, pages 1725 - 1733-
DESCRIPTION- WOLF et al., BioTechniques, (19970000), vol. 23, page 139-
DESCRIPTION- YOKOE et al., Nature Biotechnology, (19960000), vol. 14, pages 1252 - 1256-
OPPOSITION- Anonymous, "A Phase 1/2 Randomized Double-Blind Placebo-Controlled Combined Single and Multiple Ascending Dose Study Evaluating the Safety Tolerability and Biological Activity of MRT5005 (COhCFTR mRNA/ICE LNP) Administered by Nebulization to Adult Subjects with Cystic Fibrosis", Study Overview 829530-
OPPOSITION- Anonymous, "Recent Advances in the Lipid Nanoparticle-Mediated Delivery of Messenger RNA", AsiaTIDES Conference, Tokyo, Japan, (20140225), pages 1, 11 - 13-
OPPOSITION- Anonymous, "Translate Bio Continues Trial of Inhaled Cystic Fibrosis mRNA Despite Setback", Genetic Engineering & Biotechnolgy News, (20210319), pages 1 - 4, Genetic Engineering & Biotechnolgy News, URL: https://www.genengnews.com/news/translate-bio-continues-trial-of-inhaled-cystic-fibrosis-mrna-despite-setback/, (20220513), XP055920874-
OPPOSITION- Atul Pathak, Et Al, "Nano-vectors for efficient liver specific gene transfer", International Journal of Nanomedicine, (20080301), vol. 3, no. 1, pages 31 - 49, XP055422063-
OPPOSITION- Honek Jennifer, "Preclinicalresearch in drug development", Medical Writing, (20171201), vol. 26, no. 4, pages 5 - 8, XP055920909-
OPPOSITION- Michele Schlich, Roberto Palomba1 Gabriella Costabile1 Shoshy Mizrahy1,3,4’5’6 Martina Pannuzzo1 Dan Peer3,4,5,6 Paolo Decuzzi1, "Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles", Bioeng Transl Med., (20210101), vol. 6, no. 2, XP055899429-
OPPOSITION- MONCK et al., "Stabilized Plasmid-Lipid Particles: Pharmacokinetics and Plasmid Delivery to Distal Tumors following Intravenous Injection", Journal of Drug Targeting, (20000000), vol. 7, no. 6, pages 439 - 452, XP055671518-
OPPOSITION- Nathan-Kazis Josh, "Translate Bio Drops Liver-Disease Program. The Stock Is Falling", Barrons Health, (20190910), pages 1 - 2, Barrons Health , URL: https://www.barrons.com/articles/big-tech-stocks-amazon-apple-meta-alphabet-nvidia-51652197183, (20220513), XP055920906-
OPPOSITION- Nick Paul Taylor, "Translate Bio's mRNA fails to improve lung function in cystic fibrosis patients | Fierce Biotech", Fierce Biotech, (20210318), pages 1 - 5, Fierce Biotech , URL: https://www.fiercebiotech.com/biotech/translate-bio-s-mrna-fails-to-improve-lung-function-cystic-fibrosis-patients, (20220513), XP055920889-
OPPOSITION- SCHERPHOF et al., "Uptake of Liposomes by Rat and Mouse Hepatocytes and Kupffer Cells", Biol Cell, (19830000), vol. 47, pages 47 - 58, XP055530819-
OPPOSITION- Teri Dahlman, Maura Gavaghan, "Translate Bio Announces Pipeline Program Update", Translate Bio Press Release, (20190909), pages 1 - 2, Translate Bio Press Release, URL: https://investors.translate.bio/node/7121/pdf, (20220513), XP055920893-
OPPOSITION- Wilson J.M., Et Al, "Ex Vivo Gene Therapy of Familial Hypercholesterolemia", Hum Gene Ther, (19920401), vol. 3, no. 2, pages 179 - 222, XP055422061-
OPPOSITION- Shayne Cox, Steve Pascolo, "Chapter 7.2. Plasmid DNA and Messenger RNA for Therapy", Handbook of Pharmaceutical Biotechnology, John Wiley & Sons , (20070601), pages 971 - 1011, doi:10.1002/9780470117118.ch07b, ISBN 978-0-471-21386-4, XP055626043
OPPOSITION- OKUMURA et al., The Journal of Gene Medicine, (20080000), vol. 10, pages 910 - 917, XP055101210
OPPOSITION- WOODLE et al., "Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes", Biochimica et Biophysica Acta, (19920000), vol. 1105, no. 2, pages 193 - 200, XP023574846
OPPOSITION- Litzinger, D.C. ; Buiting, A.M.J. ; van Rooijen, N. ; Huang, L., "Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes", Biochimica et Biophysica Acta, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (19940223), vol. 1190, no. 1, doi:10.1016/0005-2736(94)90038-8, ISSN 0005-2736, pages 99 - 107, XP023139752
OPPOSITION- Li, S.D. ; Huang, L., "Nanoparticles evading the reticuloendothelial system: Role of the supported bilayer", Biochimica et Biophysica Acta (BBA) - Biomembranes, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL, (20091001), vol. 1788, no. 10, doi:10.1016/j.bbamem.2009.06.022, ISSN 0005-2736, pages 2259 - 2266, XP026669957
OPPOSITION- Yan, X. Kuipers, F. Havekes, L.M. Havinga, R. Dontje, B. Poelstra, K. Scherphof, G.L. Kamps, J.A.A.M., "The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse", Biochemical and Biophysical Research Communications, Elsevier, Amsterdam NL, Amsterdam NL , (20050304), vol. 328, no. 1, doi:10.1016/j.bbrc.2004.12.137, ISSN 0006-291X, pages 57 - 62, XP004723739
OPPOSITION- Yamamoto, A. et al, "Current prospects for mRNA gene delivery", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS., ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, NL, (20090301), vol. 71, no. 3, doi:10.1016/j.ejpb.2008.09.016, ISSN 0939-6411, pages 484 - 489, XP025992169
OPPOSITION- Zou S., Scarfo K., Nantz M.H., Hecker J.G., "Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells /NIH Author Manuscript/", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, NL , (20100401), vol. 389, no. 1-2, doi:10.1016/j.ijpharm.2010.01.019, ISSN 0378-5173, pages 232 - 243, XP055920916
OPPOSITION- James Heyes et al, "'Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM., NL, NL, (20050101), vol. 107, no. 2, doi:10.1016/j.jconrel.2005.06.014, ISSN 0168-3659, pages 276 - 287, XP008157522
OPPOSITION- Hassett Kimberly J., Benenato Kerry E., Jacquinet Eric, Lee Aisha, Woods Angela, Yuzhakov Olga, Himansu Sunny, Deterling Jessica, Geilich Benjamin M., Ketova Tatiana, Mihai Cosmin, Lynn Andy, Mcfadyen Iain, Moore Melissa J., Senn Joseph J., Stanton Matthew G., Almarsson Örn, Ciaramella Giuseppe, Brito Luis A., "Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", Molecular Therapy-Nucleic Acids, Cell Press, US, US , (20190415), vol. 15, doi:10.1016/j.omtn.2019.01.013, ISSN 2162-2531, pages 1 - 11, XP055815007
OPPOSITION- Son, K.K. Patel, D.H. Tkach, D. Park, A., "Cationic liposome and plasmid DNA complexes formed in serum-free medium under optimum transfection condition are negatively charged", Biochimica et Biophysica Acta, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20000601), vol. 1466, no. 1-2, doi:10.1016/S0005-2736(00)00176-0, ISSN 0005-2736, pages 11 - 15, XP004273221
OPPOSITION- E Wisse, Jacobs F, Topal B, Frederik P, De Geest B, "The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer", Gene Therapy, Nature Publishing Group, London, GB, GB , (20080410), vol. 15, no. 17, doi:10.1038/gt.2008.60, ISSN 0969-7128, pages 1193 - 1199, XP055534609
OPPOSITION- Karikó Katalin, Muramatsu Hiromi, Welsh Frank A, Ludwig János, Kato Hiroki, Akira Shizuo, Weissman Drew, "Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability /NIH Author Manuscript/", Molecular Therapy, Elsevier Inc., US, US , (20081101), vol. 16, no. 11, doi:10.1038/mt.2008.200, ISSN 1525-0016, pages 1833 - 1840, XP055920956
OPPOSITION- Akinc A., ET AL, "Development of Lipidoid-siRNA Formulations for Systemic Delivery to the Liver", Molecular Therapy, Elsevier Inc., US, US , (20090501), vol. 17, no. 5, doi:10.1038/MT.2009.36, ISSN 1525-0016, pages 872 - 879, XP008105983
OPPOSITION- Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. Narayanannair Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G Rajeev, William L Cantley, J Robert Dorkin, James S Butler, Liuliang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J Hope, Marino Zerial, Dinah Wy Sah, Kevin Fitzgerald, Mark A Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin De Fougerolles, Martin A Maier, "Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms", Molecular Therapy, No longer published by Elsevier, (20100701), vol. 18, no. 7, doi:10.1038/mt.2010.85, ISSN 15250016, pages 1357 - 1364, XP055016290
OPPOSITION- FANG J, et al, "Stable antibody expression at therapeutic levels using the 2A peptide.", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20050417), vol. 23, no. 5, doi:10.1038/nbt1087, ISSN 1087-0156, pages 584 - 590, XP002369310
OPPOSITION- Akinc Akin; Maier Martin A.; Manoharan Muthiah; Fitzgerald Kevin; Jayaraman Muthusamy; Barros Scott; Ansell Steven; Du Xinyao; Hope Michael J.; Madden Thomas D.; Mui Barbara L.; Semple Sean C.; Tam Ying K.; Ciufolini Marco; Witzigmann Dominik; Kulkarni Jayesh A.; van der Meel Roy; Cullis Pieter R., "The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs", Nature Nanotechnology, Nature Pub. Group, Inc., London, London , (20191201), vol. 14, no. 12, doi:10.1038/s41565-019-0591-y, ISSN 1748-3387, pages 1084 - 1087, XP036953174
OPPOSITION- Dong Y, Love K T, Dorkin J R, Sirirungruang S, Zhang Y, Chen D, Bogorad R L, Yin H, Chen Y, Vegas A J, Alabi C A, Sahay G, Olejnik K T, Wang W, Schroeder A, Lytton-Jean A K, Siegwart D J, Akinc A, Barnes C, Barros S A, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva T I, Qin J, Querbes W, Koteliansky V, Langer R, Anderson D G, "Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20140318), vol. 111, no. 11, doi:10.1073/pnas.1322937111, ISSN 0027-8424, pages 3955 - 3960, XP002758392
OPPOSITION- FELGNER et al., "LIPOFECTON: A HIGHLY EFFICIENT, LIPID-MEDIATED DNA-TRANSFECTION PROCEDURE", Proc Natl Acad Sci USA, (19871100), vol. 84, pages 7413 - 7417, XP000602252
OPPOSITION- MALONE et al., "CATIONIC LIPOSOME-MEDIATED RNA TRANSFECTION", Proc Natl Acad Sci USA, (19890000), vol. 86, pages 6077 - 6081, XP000604642
OPPOSITION- Sameersingh G Raney et al, "The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN", Journal of Drug Targeting, Taylor & Francis, GB, GB, (20080801), vol. 16, no. 7-8, doi:10.1080/10611860802228756, ISSN 1061-186X, pages 564 - 577, XP055534629
OPPOSITION- Jayesh A. Kulkarni, Pieter R. Cullis, Roy Van Der Meel, "Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility", Nucleic Acid Therapeutics, Mary Ann Liebert, Inc. Publishers, US, US , (20180601), vol. 28, no. 3, doi:10.1089/nat.2018.0721, ISSN 2159-3337, pages 146 - 157, XP055551908
OPPOSITION- BETTINGER T, et al, "Peptide-mediated RNA delivery: A novel approach for enhanced transfection of primary and post-mitotic cells", Nucleic Acids Research, Oxford University Press, GB, GB , (20010915), vol. 29, no. 18, doi:10.1093/nar/29.18.3882, ISSN 0305-1048, pages 3882 - 3891, XP002374430
OPPOSITION- Ian MacLachlan, "Liposomal Formulations for Nucleic Acid Delivery (Chapter 9)", Ian MacLachlan, Stanley T. Crooke, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition, CRC Press, (20070725), pages 237 - 270, XP055591157
SEARCH- JIAN WU ET AL, "Modification of liposomes for liver targeting", JOURNAL OF HEPATOLOGY, (19960601), vol. 24, no. 6, doi:10.1016/S0168-8278(96)80274-1, ISSN 0168-8278, pages 757 - 763, XP055101270 [A] 1-20 * page 757, column l, paragraph l - column r, paragraph 1 * * page 758, column r, paragraph 2 - page 759, column l, paragraph 1 * * page 760, column l, paragraph l - page 761, column l, paragraph 1 * * page 761, column r, paragraph 3 * * page 761, column r, paragraph l - page 762 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents