IP Verse

Non-Human Animal Having Human Cd3 Gene Substituted For Endogenous Cd3 Gene - EP3320773

The patent EP3320773 was granted to Chugai Seiyaku Kabushiki Kaisha on Oct 11, 2023. The application was originally filed on Jul 8, 2016 under application number EP16824403A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3320773

CHUGAI SEIYAKU KABUSHIKI KAISHA
Application Number
EP16824403A
Filing Date
Jul 8, 2016
Status
Granted And Under Opposition
Apr 7, 2023
Grant Date
Oct 11, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

STRAWMANFeb 8, 2024HOFFMANN EITLEADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONUS2007209083
OPPOSITIONWO03006639
OPPOSITIONWO2012143524
OPPOSITIONWO2015095392
OPPOSITIONWO2016085889
SEARCHWO03006639
SEARCHWO2012143524
SEARCHWO2015095392
SEARCHWO2016085889

Non-Patent Literature (NPL) Citations (20) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "CD4+/CD8+ ratio", Wikipedia, (20230915), pages 1 - 4, Wikipedia, URL: https://en.wikipedia.org/w/index.php?title=CD4+/CD8+%20ratio&oldid=1175496365, XP093163660-
OPPOSITION- Charles A. Janeway Jr.; Paul Travers; Mark Walport, "7-6: The activation of some receptors generates small-molecule second messenger", Janeway's Immunobiology, 8th ed., Garland Science, Taylor & Francis Group, LLC, (20120101), pages 246 - 247, ISBN 978-0-8153-4243-4, XP009554156-
OPPOSITION- Pan, Q. ; Brodeur, J.F. ; Drbal, K. ; Dave, V.P., "Different role for mouse and human CD3@d/@? heterodimer in preT cell receptor (preTCR) function: Human CD3@d/@? heterodimer restores the defective preTCR function in CD3@c- and CD3@c@d-deficient mice", Molecular Immunology, PERGAMON, GB, GB , (20060401), vol. 43, no. 11, ISSN 0161-5890, pages 1741 - 1750, XP027899392-
OPPOSITION- Atkinson, T. ; Dai, Y. ; Schoeb, T.R., "Transgenic Human CD3 Zeta Reconstitutes T Cell Development in CD3 Zeta Knockout Mice", Journal of Allergy and Clinical Immunology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20100201), vol. 125, no. 2, doi:10.1016/j.jaci.2009.12.560, ISSN 0091-6749, page AB143, XP026901963
OPPOSITION- Heather J. Bax, "Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes", British Journal of Cancer, Nature Publishing Group UK, London, London, (20230119), vol. 128, no. 2, doi:10.1038/s41416-022-02031-x, ISSN 0007-0920, pages 342 - 353, XP093163611
OPPOSITION- Julie A. Zorn, "Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model", Scientific Reports, Nature Publishing Group, US, US , (20220303), vol. 12, no. 1, doi:10.1038/s41598-022-06953-7, ISSN 2045-2322, pages 3530 - 13, XP093163637
OPPOSITION- Otoya Ueda, Et Al., "Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics", Scientific Reports, (20170403), vol. 7, no. 45839, doi:10.1038/srep45839, pages 1 - 15, XP055617393
OPPOSITION- Ulrich H. Weidle, Roland E. Kontermann, Ulrich Brinkmann, "Tumor-Antigen–Binding Bispecific Antibodies for Cancer Treatment", Seminars in Oncology, W.B. Saunders, (20141001), vol. 41, no. 5, doi:10.1053/j.seminoncol.2014.08.004, ISSN 0093-7754, pages 653 - 660, XP055250095
OPPOSITION- B. Wang, C. Biron, J. She, K. Higgins, M. J. Sunshine, E. Lacy, N. Lonberg, C. Terhorst, "A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.", Proceedings of the National Academy of Sciences, National Academy of Sciences, (19940927), vol. 91, no. 20, doi:10.1073/pnas.91.20.9402, ISSN 0027-8424, pages 9402 - 9406, XP055345530
OPPOSITION- A De La Hera, "Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex.", Journal of Experimental Medicine, Rockefeller University Press, US, US , (19910101), vol. 173, no. 1, doi:10.1084/jem.173.1.7, ISSN 0022-1007, pages 7 - 17, XP093163617
OPPOSITION- Vibhuti P Dave, "CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage Thus the lack of CD3ε or ζ invariably leads to the absence", The EMBO journal / European Molecular Biology Organization, IRL Press, Oxford, Oxford , (19970317), vol. 16, no. 6, doi:10.1093/emboj/16.6.1360, ISSN 0261-4189, pages 1360 - 1377, XP093163631
OPPOSITION- N Wang, B Wang, M Salio, D Allen, J She, C Terhorst, "Expression of a CD3epsilon transgene in CD3epsilon-null mice does not restore CD3gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes", International Immunology, Oxford University Press, GB, GB , (19981201), vol. 10, no. 12, doi:10.1093/intimm/10.12.1777, ISSN 0953-8178, pages 1777 - 1788, XP002483379
OPPOSITION- Tunnacliffe A; Olsson C; de la Hera A, "The majority of human CD3 epitopes are conferred by the epsilon chain.", International Immunology, Oxford University Press, GB, GB , (19890101), vol. 1, no. 5, doi:10.1093/intimm/1.5.546, ISSN 0953-8178, pages 546 - 550, XP009179788
OPPOSITION- C. Kuhn, You S., Valette F., Hale G., Van Endert P., Bach J.-F., Waldmann H., Chatenoud L., "Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance", SCIENCE TRANSLATIONAL MEDICINE, American Association for the Advancement of Science, (20110202), vol. 3, no. 68, doi:10.1126/scitranslmed.3001830, ISSN 1946-6234, pages 68ra10 - 68ra10, XP055249939
OPPOSITION- T. T. Junttila, J. Li, J. Johnston, M. Hristopoulos, R. Clark, D. Ellerman, B.-E. Wang, Y. Li, M. Mathieu, G. Li, J. Young, E. Luis, G. Lewis Phillips, E. Stefanich, C. Spiess, A. Polson, B. Irving, J. M. Scheer, M. R. Junttila, M. S. Dennis, R. Kelley, K. Totpal, A. Ebens, "Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells", Cancer research, American Association for Cancer Research, (20141001), vol. 74, no. 19, doi:10.1158/0008-5472.CAN-13-3622-T, ISSN 00085472, pages 5561 - 5571, XP055216350
OPPOSITION- Fernández-Malavé Edgar; Wang Ninghai; Pulgar Manuel; Schamel Wolfgang W.A.; Alarcón Balbino; Terhorst Cox, "Overlapping functions of human CD3δ and mouse CD3γ in αβ T-cell development revealed in a humanized CD3γ-deficient mouse", Blood, American Society of Hematology, US, US , (20061115), vol. 108, no. 10, doi:10.1182/blood-2006-03-010850, ISSN 0006-4971, pages 3420 - 3427, XP086510639
OPPOSITION- T. W. F. Gobel, J.-P. Dangy, "Evidence for a Stepwise Evolution of the CD3 Family", The Journal of Immunology, Williams & Wilkins Co., US, US , (20000115), vol. 164, no. 2, doi:10.4049/jimmunol.164.2.879, ISSN 0022-1767, pages 879 - 883, XP055536717
SEARCH- ULRICH H. WEIDLE ET AL, "Tumor-Antigen-Binding Bispecific Antibodies for Cancer Treatment", SEMINARS IN ONCOLOGY, US, (201410), vol. 41, no. 5, doi:10.1053/j.seminoncol.2014.08.004, ISSN 0093-7754, pages 653 - 660, XP055250095 [A] 1-16 * the whole document *
SEARCH- C. KUHN ET AL, "Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance", SCIENCE TRANSLATIONAL MEDICINE, US, (20110202), vol. 3, no. 68, doi:10.1126/scitranslmed.3001830, ISSN 1946-6234, pages 68ra10 - 68ra10, XP055249939 [Y] 8-10,13-16 * page 4 - page 6 *
SEARCH- T. W. F. GOBEL ET AL, "Evidence for a Stepwise Evolution of the CD3 Family", THE JOURNAL OF IMMUNOLOGY, US, (20000115), vol. 164, no. 2, doi:10.4049/jimmunol.164.2.879, ISSN 0022-1767, pages 879 - 883, XP055536717 [A] 1 * figure 1 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents