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Nuclease-Independent Targeted Gene Editing Platform And Uses Thereof - EP3322804

The patent EP3322804 was granted to Rutgers on Sep 1, 2021. The application was originally filed on Jul 15, 2016 under application number EP16825229A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3322804

RUTGERS
Application Number
EP16825229A
Filing Date
Jul 15, 2016
Status
Granted And Under Opposition
Jul 30, 2021
Grant Date
Sep 1, 2021
External Links
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Patent Oppositions (2)

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BEAM THERAPEUTICSMay 31, 2022HGFADMISSIBLE
STRAWMANMay 31, 2022FINNEGAN EUROPEADMISSIBLE

Patent Citations (27) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2010063258
DESCRIPTIONUS2014179006
DESCRIPTIONUS2014273226
DESCRIPTIONUS2014273233
DESCRIPTIONUS2015182596
DESCRIPTIONUS4625014
DESCRIPTIONUS5057301
DESCRIPTIONUS5514363
DESCRIPTIONUS5856456
DESCRIPTIONUS6165476
DESCRIPTIONUS63258
DESCRIPTIONUS8202983
DESCRIPTIONWO2012142515
DESCRIPTIONWO2013176772
DESCRIPTIONWO2014099750
DESCRIPTIONWO2014144592
DESCRIPTIONWO2014144761
INTERNATIONAL-SEARCH-REPORTUS2014273226
INTERNATIONAL-SEARCH-REPORTUS2014295556
OPPOSITIONEP3115457
OPPOSITIONUS2011104787
OPPOSITIONWO2015089406
OPPOSITIONWO2016054106
OPPOSITIONWO2017011721
OPPOSITIONWO2023015307
SEARCHEP3115457
SEARCHWO2015089406

Non-Patent Literature (NPL) Citations (47) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Genome Engineering CRISPR Frontiers ", Abstracts of papers, (20220801), pages 1 - 222, XP093109691-
OPPOSITION- Carlos Collantes Juan, Tan Victor M, Xu Huiting, Ruiz-Urigüen Melany, Alasadi Amer, Guo Jingjing, Tao Hanlin, Su Chi, Tyc Katarzyna M, Selmi Tommaso, Lambourne John J, Harbottle Jennifer A, Stombaugh Jesse, Xing Jinchuan, Wiggins Ceri M, Jin Shengkan, Ugi, "Development and Characterization of a Modular CRISPR-RNA Aptamer-Mediated Base /SUPPLEMENTARY SEQUENCES/", The CRISPR Journal, (20210101), pages 35 - 43, XP055931274-
OPPOSITION- Collantes Juan Carlos, "A Novel CRISPR/RNA-Aptamer-Mediated Base Editing System with Potential Therapeutic Value", Dissertation, (20190101), pages ii-vii, 1 - 165, XP055932757-
OPPOSITION- David Cyranoski, Reardon, Sara, "Chinese scientists genetically modify human embryos : Nature News & Comment", nature, URL: http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378, (20150423), XP055185319-
OPPOSITION- Kefei Yu, Feng-Ting Huang, Michael R.Lieber, "DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine", Journal of Biological Chemistry, (20040220), vol. 279, no. 8, pages 6496 - 6500, XP055932741-
OPPOSITION- "pCMV-BE3 (Plasmid #73021)", ADDGENE, URL: https://www.addgene.org/73021/-
OPPOSITION- STAFFORST THORSTEN ET AL., "An RNA-deaminase conjugate selectively repairs point mutations", Angewandte Chemie (International Edition), Wiley - VCH Verlag GmbH & Co., DE, DE , (20121029), vol. 51, no. 44, ISSN 1521-3773, pages 11166 - 11169, XP002765253-
OPPOSITION- Makarova Kira S., Koonin Eugene V., "Annotation and Classification of CRISPR-Cas Systems /HHS Author Manuscript/", Methods in molecular biology, Springer New York, New York, NY, New York, NY, (20150101), vol. 1311, doi:10.1007/978-1-4939-2687-9_4, ISSN 1064-3745, pages 47 - 75, XP055932748
OPPOSITION- Lei s. Qi, Larson Matthew h., Gilbert Luke a., Doudna Jennifer a., Weissman Jonathan s., Arkin Adam p., Lim Wendell a., "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20130228), vol. 152, no. 5, doi:10.1016/j.cell.2013.02.022, ISSN 0092-8674, pages 1173 - 1183, XP055346792
OPPOSITION- Luke a. Gilbert, Matthew h. Larson, Leonardo Morsut, Zairan Liu, Gloria a. Brar, Sandra e. Torres, Noam Stern-Ginossar, Onn Brandman, Evan h. Whitehead, Jennifer a. Doudna, Wendell a. Lim, Jonathan s. Weissman, Lei s. Qi, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20130718), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843
OPPOSITION- Patrick d. Hsu, Eric s. Lander, Feng Zhang, "Development and Applications of CRISPR-Cas9 for Genome Engineering", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20140601), vol. 157, no. 6, doi:10.1016/j.cell.2014.05.010, ISSN 0092-8674, pages 1262 - 1278, XP055694974
OPPOSITION- Jesse g. Zalatan, Michael e. Lee, Ricardo Almeida, Luke a. Gilbert, Evan h. Whitehead, Marie La russa, Jordan c. Tsai, Jonathan s. Weissman, John e. Dueber, Lei s. Qi, Wendell a. Lim, "Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20150101), vol. 160, no. 1-2, doi:10.1016/j.cell.2014.11.052, ISSN 0092-8674, pages 339 - 350, XP055278878
OPPOSITION- Koonin Eugene V; Makarova Kira S; Zhang Feng, "Diversity, classification and evolution of CRISPR-Cas systems", CURRENT OPINION IN MICROBIOLOGY, CURRENT BIOLOGY LTD, GB, GB , (20170000), vol. 37, doi:10.1016/j.mib.2017.05.008, ISSN 1369-5274, pages 67 - 78, XP085276922
OPPOSITION- Jackson Ryan N; van Erp Paul BG; Sternberg Samuel H; Wiedenheft Blake, "Conformational regulation of CRISPR-associated nucleases", CURRENT OPINION IN MICROBIOLOGY, CURRENT BIOLOGY LTD, GB, GB , (19000101), vol. 37, doi:10.1016/j.mib.2017.05.010, ISSN 1369-5274, pages 110 - 119, XP085276926
OPPOSITION- Heckl Dirk; Charpentier Emmanuelle, "Toward Whole-Transcriptome Editing with CRISPR-Cas9", Molecular Cell, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (19000101), vol. 58, no. 4, doi:10.1016/j.molcel.2015.05.016, ISSN 1097-2765, pages 560 - 562, XP029129116
OPPOSITION- Gilbertson, L., "Cre-lox recombination: Cre-ative tools for plant biotechnology", TRENDS IN BIOTECHNOLOGY., ELSEVIER PUBLICATIONS, CAMBRIDGE., GB, GB , (20031201), vol. 21, no. 12, doi:10.1016/j.tibtech.2003.09.011, ISSN 0167-7799, pages 550 - 555, XP004473520
OPPOSITION- Cyranoski David; Ledford Heidi, "Genome-edited baby claim provokes international outcry", Nature, Nature Publishing Group UK, London, London, (20181126), vol. 563, no. 7733, doi:10.1038/d41586-018-07545-0, ISSN 0028-0836, pages 607 - 608, XP036647928
OPPOSITION- Cyranoski David, "The CRISPR-baby scandal: what’s next for human gene-editing", Nature, Nature Publishing Group UK, London, London, (20190226), vol. 566, no. 7745, doi:10.1038/d41586-019-00673-1, ISSN 0028-0836, pages 440 - 442, XP036723170
OPPOSITION- Jayanta Chaudhuri, Ming Tian, Chan Khuong, Katrin Chua, Eric Pinaud & Frederick W. Alt, "Amino-acid cycling drives nitrogen fixation in the legume-Rhizobium symbiosis", Nature, Nature Publishing Group UK, London, London, (20030417), vol. 422, doi:10.1038/nature01527, ISSN 0028-0836, pages 726 - 730, XP055932735
OPPOSITION- Konermann Silvana; Brigham Mark D.; Trevino Alexandro E.; Joung Julia; Abudayyeh Omar O.; Barcena Clea; Hsu Patrick D.; Habib Naomi; Gootenberg Jonathan S.; Nishimasu Hiroshi; Nureki Osamu; Zhang Feng, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", Nature, Nature Publishing Group UK, London, London, (20141210), vol. 517, no. 7536, doi:10.1038/nature14136, ISSN 0028-0836, pages 583 - 588, XP037474522
OPPOSITION- Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris, David R. Liu, "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage", Nature, Nature Publishing Group UK, London, London, (20160501), vol. 533, no. 7603, doi:10.1038/nature17946, ISSN 0028-0836, pages 420 - 424, XP055551781
OPPOSITION- Patrick D Hsu, David A Scott, Joshua A Weinstein, F Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J Fine, Xuebing Wu, Ophir Shalem, Thomas J Cradick, Luciano A Marraffini, Gang Bao & Feng Zhang, "DNA targeting specificity of RNA-guided Cas9 nucleases.", Nature Biotechnology, (20130901), vol. 31, no. 9, doi:10.1038/nbt.2647 , ISSN 1546-1696, pages 827 - 832, XP002718604
OPPOSITION- Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, Sriram Kosuri, Luhan Yang, George M Church, "CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20130901), vol. 31, no. 9, doi:10.1038/nbt.2675, ISSN 1087-0156, pages 833 - 838, XP055693153
OPPOSITION- Maeder Morgan L; Angstman James F; Richardson Marcy E; Linder Samantha J; Cascio Vincent M; Tsai Shengdar Q; Ho Quan H; Sander Jeffry D; Reyon Deepak; Bernstein Bradley E; Costello Joseph F; Wilkinson Miles F; Joung J Keith, "Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20131201), vol. 31, no. 12, doi:10.1038/nbt.2726, ISSN 1087-0156, pages 1137 - 1142, XP037163685
OPPOSITION- Isaac B Hilton, Anthony M D'ippolito, Christopher M Vockley, Pratiksha I Thakore, Gregory E Crawford, Timothy E Reddy, Charles A Gersbach, "Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers", Nature Biotechnology, Nature Publishing Group US, New York, New York, vol. 33, no. 5, doi:10.1038/nbt.3199, ISSN 1087-0156, pages 510 - 517, XP055327077
OPPOSITION- Morgan L Maeder, Samantha J Linder, Vincent M Cascio, Yanfang Fu, Quan H Ho, J Keith Joung, "CRISPR RNA–guided activation of endogenous human genes", Nature Methods, Nature Publishing Group US, New York, New York, vol. 10, no. 10, doi:10.1038/nmeth.2598, ISSN 1548-7091, pages 977 - 979, XP055291599
OPPOSITION- Pablo Perez-Pinera, Kocak D Dewran, Vockley Christopher M, Adler Andrew F, Kabadi Ami M, Polstein Lauren R, Thakore Pratiksha I, Glass Katherine A, Ousterout David G, Leong Kam W, Guilak Farshid, Crawford Gregory E, Reddy Timothy E, Gersbach Charles A, "RNA-guided gene activation by CRISPR-Cas9–based transcription factors", Nature Methods, Nature Pub. Group, (20131001), vol. 10, no. 10, doi:10.1038/nmeth.2600, ISSN 15487091, pages 973 - 976, XP055181249
OPPOSITION- Pablo Perez-Pinera, Kocak D Dewran, Vockley Christopher M, Adler Andrew F, Kabadi Ami M, Polstein Lauren R, Thakore Pratiksha I, Glass Katherine A, Ousterout David G, Leong Kam W, Guilak Farshid, Crawford Gregory E, Reddy Timothy E, Gersbach Charles A, "RNA-guided gene activation by CRISPR-Cas9–based transcription factors (Supplementary Information)", Nature Methods, Nature Publishing Group US, New York, New York, (20130101), vol. 10, no. 10, doi:10.1038/nmeth.2600, ISSN 1548-7091, pages 1 - 15, XP055344343
OPPOSITION- Prashant Mali, Kevin M Esvelt & George M Church, "Cas9 as a versatile tool for engineering biology.", NATURE METHODS, Nature Publishing Group, GB, GB , (20131001), vol. 10, no. 10, doi:10.1038/nmeth.2649 , ISSN 1548-7105, pages 957 - 963, XP002718606
OPPOSITION- Kearns Nicola A, Pham Hannah, Tabak Barbara, Genga Ryan M, Silverstein Noah J, Garber Manuel, Maehr René, "Functional annotation of native enhancers with a Cas9-histone demethylase fusion /HHS AUTHOR MANUSCRIPT/", Nature Methods, Nature Publishing Group US, New York, New York, (20150501), vol. 12, no. 5, doi:10.1038/nmeth.3325, ISSN 1548-7091, pages 401 - 403, XP055931429
OPPOSITION- David M Shechner, Ezgi Hacisuleyman, Scott T Younger, John L Rinn, "Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display", Nature Methods, Nature Publishing Group US, New York, New York, (20150701), vol. 12, no. 7, doi:10.1038/nmeth.3433, ISSN 1548-7091, pages 664 - 670, XP055456041
OPPOSITION- Matthew H Larson, Et Al., "CRISPR interference (CRISPRi) for sequence-specific control of gene expression", Nature Protocols, Nature Publishing Group, GB, GB , (20131101), vol. 8, no. 11, doi:10.1038/nprot.2013.132, ISSN 1754-2189, pages 2180 - 2196, XP055572363
OPPOSITION- Makarova Kira S., Haft Daniel H., Barrangou Rodolphe, Brouns Stan J. J., Charpentier Emmanuelle, Horvath Philippe, Moineau Sylvain, Mojica Francisco J. M., Wolf Yuri I., Yakunin Alexander F., Van Der Oost John, Koonin Eugene V., "Evolution and classification of the CRISPR-Cas systems /NIH Author Manuscript/", Nature Reviews Microbiology, NATURE PUBLISHING GROUP, GB, GB , (20110601), vol. 9, no. 6, doi:10.1038/nrmicro2577, ISSN 1740-1526, pages 467 - 477, XP055932744
OPPOSITION- Collantes Juan Carlos, Tan Victor M., Xu Huiting, Ruiz-Urigüen Melany, Alasadi Amer, Guo Jingjing, Tao Hanlin, Su Chi, Tyc Katarzyna M., Selmi Tommaso, Lambourne John J., Harbottle Jennifer A., Stombaugh Jesse, Xing Jinchuan, Wiggins Ceri M., Jin Shengkan, "Development and Characterization of a Modular CRISPR and RNA Aptamer Mediated Base Editing System", The CRISPR Journal, (20210201), vol. 4, no. 1, doi:10.1089/crispr.2020.0035, ISSN 2573-1599, pages 58 - 68, XP055847136
OPPOSITION- Yang Lu, Wang Huijun, Luo Xin, Mao Pengliang, Tian Weidong, Shi Yujiang, Huang Guoying, Zhang Jin, Ma Duan, "Virion protein 16 induces demethylation of DNA integrated within chromatin in a novel mammalian cell model", Acta Biochimica Biophysica Sinica, BLACKWELL PUBLISHING, INC., MALDEN, MA, US, US , (20120201), vol. 44, no. 2, doi:10.1093/abbs/gmr104, ISSN 1672-9145, pages 154 - 161, XP055932770
OPPOSITION- Ying Yue, Yang Xingyu, Zhao Kai, Mao Jifang, Kuang Ying, Wang Zhugang, Sun Ruilin, Fei Jian, "The Krüppel-associated box repressor domain induces reversible and irreversible regulation of endogenous mouse genes by mediating different chromatin states", Nucleic Acids Research, Oxford University Press, GB, GB , (20150218), vol. 43, no. 3, doi:10.1093/nar/gkv016, ISSN 0305-1048, pages 1549 - 1561, XP055932775
OPPOSITION- Chemello F., Chai A. C., Li H., Rodriguez-Caycedo C., Sanchez-Ortiz E., Atmanli A., Mireault A. A., Liu N., Bassel-Duby R., Olson E. N., "Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing", SCIENCE ADVANCES Science, US , (20210430), vol. 7, no. 18, doi:10.1126/sciadv.abg4910, ISSN 2375-2548, pages 1 - 12, XP093109681
OPPOSITION- M. Jinek, Chylinski K, Fonfara I, Hauer M, Doudna J. A, Charpentier E., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, American Association for the Advancement of Science, US, US , (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 1 - 37, XP055067747
OPPOSITION- M. Jinek, K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna, E. Charpentier, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, American Association for the Advancement of Science, US, US , (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055229606
OPPOSITION- L. Cong, F. A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib, P. D. Hsu, X. Wu, W. Jiang, L. A. Marraffini, F. Zhang, "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, American Association for the Advancement of Science, US, US , (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055400719
OPPOSITION- S. Cong Et Al, "Multiplex genome engineering using CRISPR/Cas systems", Science, American Association for the Advancement of Science, US, US , (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055300065
OPPOSITION- Mali Et Al., "RNA-guided human genome engineering via Cas9", Science, American Association for the Advancement of Science, US, US , (20130101), vol. 339, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055362871
OPPOSITION- PRASHANT MALI, LUHAN YANG, KEVIN M. ESVELT, JOHN AACH, MARC GUELL, JAMES E. DICARLO, JULIE E. NORVILLE, GEORGE M. CHURCH, "Supplementary Materials for RNA-Guided Human Genome Engineering via Cas9", Science, American Association for the Advancement of Science, US, US , vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, (20130215), pages 1 - 36, Science, URL: http://www.sciencemag.org/content/suppl/2013/01/03/science.1232033.DC1, XP002723674
OPPOSITION- J. A. Doudna, E. Charpentier, "The new frontier of genome engineering with CRISPR-Cas9", Science, American Association for the Advancement of Science, (20141128), vol. 346, no. 6213, doi:10.1126/science.1258096, ISSN 00368075, pages 1258096 - 1258096, XP055162699
OPPOSITION- Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann, Julia Joung, Ian M. Slaymaker, David B. T. Cox, Sergey Shmakov, Kira S. Makarova, Ekaterina Semenova, Leonid Minakhin, Konstantin Severinov, Aviv Regev, Eric S. Lander, Eugene V. Koonin, Feng Zhang, "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector", Science, American Association for the Advancement of Science, US, US , (20160805), vol. 353, no. 6299, doi:10.1126/science.aaf5573, ISSN 0036-8075, page aaf5573, XP055407071
OPPOSITION- CONTICELLO SILVESTRO G, "The AID/APOBEC family of nucleic acid mutators.", GENOME BIOLOGY (ONLINE), BioMed Central Ltd., GB, GB , (20080617), vol. 9, no. 6, doi:10.1186/GB-2008-9-6-229, ISSN 1465-6914, pages 229.1 - 229.10, XP002667006
SEARCH- JESSE G. ZALATAN ET AL, "Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds", CELL, AMSTERDAM, NL, (20150101), vol. 160, no. 1-2, doi:10.1016/j.cell.2014.11.052, ISSN 0092-8674, pages 339 - 350, XP055278878 [X] 1-4,6,15 * figure 1B * * page 341, column r, paragraph 4 - paragraph 6; figure 2C * [Y] 1-15

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