The patent EP3325669 was granted to The Johns Hopkins University on Jul 5, 2023. The application was originally filed on Jul 22, 2016 under application number EP16831111A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | US19940285385 |
| DESCRIPTION | WO2008US76717 |
| DESCRIPTION | WO2008US76723 |
| DESCRIPTION | US1975 |
| INTERNATIONAL-SEARCH-REPORT | US2008241831 |
| INTERNATIONAL-SEARCH-REPORT | US2010256017 |
| INTERNATIONAL-SEARCH-REPORT | US2013157269 |
| OPPOSITION | US2016068886 |
| OPPOSITION | USRE38442E |
| SEARCH | US2014171338 |
| SEARCH | US8008010 |
| SEARCH | USRE38442E |
NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.
| Citation Phase | Reference Text |
|---|---|
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| INTERNATIONAL-SEARCH-REPORT | - WANG et al., "RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues", The Journal of Molecular Diagnostics, (20120100), vol. 14, no. 1, pages 22 - 29, XP055191966 [A] 1-41 * See abstract; p.23, left column, line 42 - p.24, left column, line 3; p.27, left column, line 28 - right column, line 9. * |
| INTERNATIONAL-SEARCH-REPORT | - LARMAN et al., "Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay", Nucleic Acids Research, (20140000), vol. 42, no. 14, pages 9146 - 9157, XP055351343 [X] 1-32 * See abstract; p.9146, right column, lines 13-24; p.9147, left column, lines 27-37 and right column, lines 19-23; p.9149, left column, lines 1-4 and right column, lines 22-25; p.9151, left column, lines 52-61; and p.9156, right column, lines 1-30. * [Y] 33-41 |
| INTERNATIONAL-SEARCH-REPORT | - GREYTAK et al., "Accuracy of molecular data generated with FFPE biospecimens: lessons from the literature", Cancer Research, (20150415), vol. 75, no. 8, pages 1541 - 5147, XP055351345 [A] 1-41 * See abstract; Table 1. * |
| OPPOSITION | - Jayakrishnan Nandakumar, "How an RNA Ligase Discriminates RNA versus DNA Damage", Molecular Cell, (20041022), vol. 16, no. 2, pages 211 - 221, XP093165031 |
| OPPOSITION | - Stougaard Magnus; Lohmann Jakob S; Zajac Magdalena; Hamilton-Dutoit Stephen; Koch Jørn, "In situ detection of non-polyadenylated RNA molecules using Turtle Probes and target primed rolling circle PRINS", BMC Biotechnology, BioMed Central Ltd, (20071018), vol. 7, no. 1, ISSN 1472-6750, page 69, XP021035652 |
| OPPOSITION | - CHRISTIAN A T,ET AL, "Detection of DNA point mutations and mRNA expression levels by rolling circle amplification in individual cells.", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20011204), vol. 98, no. 25, doi:10.1073/pnas.251383598, ISSN 0027-8424, pages 14238 - 14243, XP002226709 |
| OPPOSITION | - H. Benjamin Larman, Erick R. Scott, Megan Wogan, Glenn Oliveira, Ali Torkamani, Peter G. Schultz, "Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay", Nucleic Acids Research, Oxford University Press, GB, GB , (20140818), vol. 42, no. 14, doi:10.1093/nar/gku636, ISSN 0305-1048, pages 9146 - 9157, XP055351343 |
| OPPOSITION | - Joel J. Credle, Christopher Y. Itoh, Tiezheng Yuan, Rajni Sharma, Erick R. Scott, Rachael E. Workman, Yunfan Fan, Franck Housseau, Nicolas J. Llosa, W. Robert. Bell, Heather Miller, Sean X. Zhang, Winston Timp, H. Benjamin Larman, "Multiplexed analysis of fixed tissue RNA using Ligation in situ Hybridization", Nucleic Acids Research, Oxford University Press, GB, GB , (20170821), vol. 45, no. 14, doi:10.1093/nar/gkx471, ISSN 0305-1048, pages e128 - e128, XP055525254 |
| OPPOSITION | - E. Merkiene, Gaidamaviciute E., Riauba L., Janulaitis A., Lagunavicius A., "Direct detection of RNA in vitro and in situ by target-primed RCA: The impact of E. coli RNase III on the detection efficiency of RNA sequences distanced far from the 3'-end", RNA, Cambridge University Press on behalf of the RNA Society, (20100801), vol. 16, no. 8, doi:10.1261/rna.2068510, ISSN 13558382, pages 1508 - 1515, XP055035267 |
| SEARCH | [ ] - JOEL J. CREDLE ET AL, "Multiplexed analysis of fixed tissue RNA using Ligation in situ Hybridization", NUCLEIC ACIDS RESEARCH, (20170619), vol. 45, no. 14, doi:10.1093/nar/gkx471, ISSN 0305-1048, pages e128 - e128, XP055525254 [ ] * the whole document * |
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