Process For Cultivation Of Cho Cells - EP3330370

The patent EP3330370 was granted to Novartis on Feb 24, 2021. The application was originally filed on Apr 25, 2011 under application number EP17199357A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3330370

NOVARTIS
Application Number
EP17199357A
Filing Date
Apr 25, 2011
Status
Granted And Under Opposition
Jan 22, 2021
Grant Date
Feb 24, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (6)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BOULT WADE TENNANTNov 24, 2021BOULT WADE TENNANTADMISSIBLE
MAIWALDNov 24, 2021MAIWALDADMISSIBLE
POHLMANNov 24, 2021POHLMANADMISSIBLE
DEHNSNov 23, 2021DEHNSADMISSIBLE
WEINZIERLNov 23, 2021SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBADMISSIBLE
STRAWMANNov 22, 2021VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE

Patent Citations (25) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONEP0481791
OPPOSITIONEP1757700
OPPOSITIONEP3330370
OPPOSITIONUS2005019859
OPPOSITIONUS2008081356
OPPOSITIONUS2008108553
OPPOSITIONUS2008182297
OPPOSITIONUS2008269132
OPPOSITIONUS2009123975
OPPOSITIONUS5122469
OPPOSITIONUS5672502
OPPOSITIONUS5871999
OPPOSITIONUS6924124
OPPOSITIONWO02101019
OPPOSITIONWO2006026408
OPPOSITIONWO2006026445
OPPOSITIONWO2006026447
OPPOSITIONWO2008055260
OPPOSITIONWO2008131374
OPPOSITIONWO2008141207
OPPOSITIONWO2011134919
OPPOSITIONWO9512664
OPPOSITIONWO9808934
SEARCHEP1757700
SEARCHUS2005019859

Non-Patent Literature (NPL) Citations (52) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Cell culture bioreactors 9 controls measurements and Scale-Down Model", Manual of Industrial Microbiology and Biotechnology, (20100325), pages 565 - 573, XP055873300-
OPPOSITION- Anonymous, "Dulbecco's Modified Eagle Medium/Nutrient Mixture F-12 Ham (DMEM/ F12, 1:1 Mixture) ", cell culture, (20110101), pages 1 - 2, XP055873304-
OPPOSITION- Anonymous, "EX-CELL® 302 Serum-Free Medium for CHO Cells without L-glutamine, liquid, sterile-filtered, suitable for cell culture product number 14324C", Sigma Aldrich, (20100101), pages 1 - 1, Sigma Aldrich, URL: https://www.sigmaaldrich.com/specification-sheets/137/571/14324C-500ML.pdf, (20211215), XP055873322-
OPPOSITION- Anonymous, "phosphate buffer", cold spring harbor protocols, (20060101), pages 1 - 1, cold spring harbor protocols, URL: http://cshprotocols.cshlp.org/content/2006/1/pdb.rec8543.full, (20211210), XP055871597-
OPPOSITION- Anonymous, "physiologic pH - Wiktionary", Wiktionary, (20190103), pages 1 - 1, Wiktionary, URL: https://en.wiktionary.org/wiki/physiologic_pH, (20211215), XP055873364-
OPPOSITION- BECK et al., "5Tth European antibody Congress 2009, November 30-december 2, 2009, Geneva, Switzerland", mAbs, (20100301), vol. 2, no. 2, pages 108 - 128, XP055874862-
OPPOSITION- Frahm Bjorn, "Seed train optimization for cell culture", Animal Cell Biotechnology. Methods in Molecular Biology, (20140101), vol. 1104, pages 355 - 367, XP055873353-
OPPOSITION- Hopkins Erin, "Physiology, Acid Base Balance", NCBI Bookshelf, (20210914), pages 1 - 7, NCBI Bookshelf, URL: https://www.ncbi.nlm.nih.gov/books/NBK507807/, (20211216), XP055873680-
OPPOSITION- Jason J Osman; John Birch; Julie Varley, "The Response of GS-NSO Myeloma Cells to pH Shifts and pH Perturbations", Biotechnology and Bioengineering, (20011005), vol. 75, no. 1, pages 63 - 73, XP055510846-
OPPOSITION- Maurer Daniela, "The Significance of pH Stability for Cell Cultures | American Laboratory", American Laboratory, (20050901), pages 1 - 3, American Laboratory, URL: https://www.americanlaboratory.com/914-Application-Notes/30798-The-Significance-of-pH-Stability-for-Cell-Cultures/, (20211216), XP055873683-
OPPOSITION- Mizrahi A, Et Al, "media for cultivation of animal cells: an overview", Animal Cell Culture and Production of Biologicals, (19910101), pages 159 - 180, XP055873702-
OPPOSITION- NAM et al., "The effects of microcarrier culture on recombinant CHO cells under biphasic hypothermic culture conditions", Cytotechnology, (20090000), vol. 59, pages 81 - 91, XP019673346-
OPPOSITION- Ozturk S., Et Al., "3 Medium Development", Cell Culture Technology For Pharmaceutical And Cell-Based Therapies - Biotechnology and bioprocessing series, 20050000, CRC PRESS, pages 41 - 79, XP055874847-
OPPOSITION- Richard Mirro, "Introduction to CHO Culture in a Stirred-Tank Bioreactor", (20111001), URL: https://online-shop.eppendorf.us/US-en/eshopdownload/downloadbykey/160731_Application_186, (20180208), XP055449636-
OPPOSITION- Stein, "basic cell culture growth conditions Chapter 4", Human Stem Cell Technology and Biology, (20100101), pages 34 - 34, XP055873372-
OPPOSITION- Stephen F. Gorfien et al, "Optimized Nutrient Additives for Fed-Batch Cultures", BIOPHARM INTERNATIONAL, ADVANSTAR COMMUNICATIONS, DULUTH, MN, US, US , (20030401), ISSN 1542-166X, pages 34 - 40, XP007920843-
OPPOSITION- Sung Hyun Kim; Gyun Min Lee, "Differences in Optimal pH and Temperature for Cell Growth and Antibody Production Between Two Chinese Hamster Ovary Clones Derived from the Same Parental Clone", J. Microbiol. Biotechnol., (20070101), vol. 17, no. 5, pages 712 - 720, XP055414758-
OPPOSITION- Evelyn Trummer et al, "Process parameter shifting: Part II. Biphasic cultivation - A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20060820), vol. 94, no. 6, doi:10.1002/BIT.20958, ISSN 0006-3592, pages 1045 - 1052, XP002651719
OPPOSITION- Evelyn Trummer; Katharina Fauland; Silke Seidinger; Kornelia Schriebl; Christine Lattenmayer; Renate Kunert; Karola Vorauer-Uhl; Robert Weik; Nicole Borth; Hermann Katinger; Dethardt Müller, "Process parameter shifting: Part II. Biphasic cultivation - A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells", Biotechnology and Bioengineering, (20060000), vol. 94, no. 6, pages 1045 - 1052, XP002651719
OPPOSITION- Evelyn Trummer; Katharina Fauland; Silke Seidinger; Kornelia Schriebl; Christine Lattenmayer; Renate Kunert; Karola Vorauer-Uhl; Robert Weik; Nicole Borth; Hermann Katinger; Dethardt Müller, "Process parameter shifting: Part II. Biphasic cultivation - A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells", Biotechnology and Bioengineering, (20060820), vol. 94, no. 6, pages 1045 - 1052, XP002651719
OPPOSITION- TRUMMER EVELYN; ET AL, "Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors", Biotechnology and Bioengineering, (20060000), vol. 94, no. 6, pages 1033 - 1044, XP002486305
OPPOSITION- TRUMMER EVELYN; ET AL, "Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors", Biotechnology and Bioengineering, (20060820), vol. 94, no. 6, pages 1033 - 1044, XP002486305
OPPOSITION- TRUMMER EVELYN ET AL, "Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20060820), vol. 94, no. 6, doi:10.1002/bit.21013, ISSN 0006-3592, pages 1033 - 1044, XP002486305
OPPOSITION- Woo Suk Ahn; Jae-Jin Jeon; Yeong-Ran Jeong; Seung Joo Lee; Sung Kwan Yoon, "Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells", Biotechnology and Bioengineering, (20081215), vol. 101, no. 6, pages 1234 - 1244, XP055510834
OPPOSITION- Michael C. Borys et al, "Effects of culture conditions on N‐glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20091228), vol. 105, no. 6, doi:10.1002/bit.22644, ISSN 0006-3592, pages 1048 - 1057, XP071033267
OPPOSITION- Michael C Borys; Nimish G Dalal; Nicholas R Abu‐Absi; Sarwat F Khattak; Ying Jing; Zizhuo Xing; Zheng Jian Li, "Effects of culture conditions on N‐glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells", Biotechnology and Bioengineering, (20091228), vol. 105, no. 6, pages 1048 - 1057, XP071033267
OPPOSITION- Matthew Gagnon et al, "High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures", Biotechnology and Bioengineering, Wiley ¬etc.|, (20110624), vol. 108, no. 6, doi:10.1002/bit.23072, ISSN 00063592, pages 1328 - 1337, XP055187906
OPPOSITION- Maria Elisa Rodrigues; Costa Ana Rita; Henriques Mariana; Azeredo Joana; Oliveira Rosã¡rio, "Technological progresses in monoclonal antibody production systems", Biotechnol. Prog., (20091230), vol. 26, no. 2, pages 332 - 351, XP055117107
OPPOSITION- Maria Elisa Rodrigues et al, "Technological progresses in monoclonal antibody production systems", Biotechnology Progress, American Chemical Society, (20091230), vol. 26, doi:10.1002/btpr.348, ISSN 87567938, pages 332 - 351, XP055117107
OPPOSITION- RODRIGUES et al., "Technological progress in monoclonal antibody production systems", Biotechnol. Prog., (20100000), vol. 26, doi:10.1002/btpr.348, pages 332 - 351, XP055117107
OPPOSITION- Natalia Gomez et al, "Effect of Temperature, pH, Dissolved Oxygen, and Hydrolysate on the Formation of Triple Light Chain Antibodies in Cell Culture", Biotechnology Progress, American Chemical Society, (20100901), vol. 26, no. 5, doi:10.1002/btpr.465, ISSN 8756-7938, pages 1438 - 1445, XP002638898
OPPOSITION- Sung Kwan Yoon et al, "Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor", Applied Microbiology and Biotechnology, Springer, Berlin, DE, Berlin, DE , (20070503), vol. 76, no. 1, doi:10.1007/s00253-007-0985-x, ISSN 1432-0614, pages 83 - 89, XP019538802
OPPOSITION- OGUCHI et al., "pH conditions in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture", Cytotechnology, (20060000), vol. 52, doi:10.1007/s10616-007-9059-2, pages 199 - 207, XP019499827
OPPOSITION- Satoshi Oguchi; Hiroyuki Saito; Masayoshi Tsukahara; Haruhiko Tsumura, "pH Condition in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture", Cytotechnology, (20070308), vol. 52, no. 3, pages 199 - 207, XP019499827
OPPOSITION- Tian-Ci Kou et al, "Increasing the productivity of TNFR-Fc in GS-CHO cells at reduced culture temperatures", Biotechnology and Bioprocess Engineering, The Korean Society for Biotechnology and Bioengineering, Heidelberg, Heidelberg , (20110413), vol. 16, no. 1, doi:10.1007/s12257-010-0157-1, ISSN 1976-3816, pages 136 - 143, XP019895890
OPPOSITION- Birch, J.R. Racher, A.J., "Antibody production", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (20060807), vol. 58, no. 5-6, doi:10.1016/j.addr.2005.12.006, ISSN 0169-409X, pages 671 - 685, XP005611421
OPPOSITION- Birch; Racher J R; A J, "Antibody production", Advanced Drug Delivery Review s, (20060522), vol. 56, no. 5-6, pages 671 - 685, XP005611421
OPPOSITION- Yoon; Kim S K; Song S H; Lee J Y; G M, "Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells", Enzyme and Microbial Technology, (20060000), vol. 39, no. 3, pages 362 - 365, XP005459366
OPPOSITION- Yoon; Kim S K; Song S H; Lee J Y; G M, "Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells", Enzyme and Microbial Technology, (20060000), vol. 39, pages 362 - 365, XP005459366
OPPOSITION- Yoon, S.K. et al, "Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, US , (20060703), vol. 39, no. 3, doi:10.1016/j.enzmictec.2005.11.029, ISSN 0141-0229, pages 362 - 365, XP005459366
OPPOSITION- Rodriguez, J. et al, "High productivity of human recombinant beta-interferon from a low-temperature perfusion culture", Journal of Biotechnology, Elsevier, Amsterdam NL, Amsterdam NL , (20101201), vol. 150, no. 4, doi:10.1016/j.jbiotec.2010.09.959, ISSN 0168-1656, pages 509 - 518, XP027516641
OPPOSITION- Hong Jong Kwang; Nargund Shilpa; Lakshmanan Meiyappan; Kyriakopoulos Sarantos; Kim Do Yun; Ang Kok Siong; Leong Dawn; Yang Yuansheng; Lee Dong-Yup, "Comparative phenotypic analysis of CHO clones and culture media for lactate shift", J. Biotechnol., (20180000), vol. 283, pages 97 - 104, XP085462274
OPPOSITION- KAUFMAN RANDAL J; SWAROOP M; MURTHA-RIEL P, "Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells", Biochemistry, (19940823), vol. 33, no. 33, pages 9813 - 9819, XP002454613
OPPOSITION- Michl Johanna, Park Kyung Chan, Swietach Pawel, "Evidence-based guidelines for controlling pH in mammalian live-cell culture systems", Communications Biology, (20191201), vol. 2, no. 1, doi:10.1038/s42003-019-0393-7, XP055873676
OPPOSITION- Hossler P; Khattak S F; Li Z J, "Optimal and consistent protein glycosylation in mammalian cell culture", Glycobiology, (20090603), vol. 19, no. 9, pages 936 - 949, XP055112498
OPPOSITION- FENG LI et al, "Current therapeutic antibody production and process optimization", BIOPROCESSING: ADVANCES AND TRENDS IN BIOLOGICAL PRODUCTDEVELOPMENT, US , (20050901), ISSN 1538-8786, pages 1 - 8, XP002519952
OPPOSITION- FENG LI et al, "Current therapeutic antibody production and process optimization", BIOPROCESSING: ADVANCES AND TRENDS IN BIOLOGICAL PRODUCTDEVELOPMENT, WILLIAMSBURG BIOPROCESSING FOUNDATION, US, US , (20050901), ISSN 1538-8786, pages 1 - 8, XP002519952
OPPOSITION- Feng Li; Joe X Zhou; Xiaoming Yang; Tim Tressel And Brian Lee, "Current therapeutic antibody production and process optimisation", BioProcess J, (20050900), pages 1 - 8, XP002519952
SEARCH- YOON S K ET AL, "Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 39, no. 3, ISSN 0141-0229, (20060703), pages 362 - 365, (20060703), XP027948954 [X] 1,4-7,17 * Page 363, left hand column, second paragraph; page 364, left hand column; Table 2 and Figure2 * [I] 12-16-
SEARCH- EVELYN TRUMMER ET AL, "Process parameter shifting: Part II. Biphasic cultivation - A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells", BIOTECHNOLOGY AND BIOENGINEERING, WILEY ETC, vol. 94, no. 6, doi:10.1002/BIT.20958, ISSN 0006-3592, (20060820), pages 1045 - 1052, (20060530), XP002651719 [X] 1,4-7,17,18 * page 1046 (paragrapha bridging left and right columns), Figure 1 and Table 1 * [I] 12-16
SEARCH- GOMEZ NATALIA ET AL, "Effect of Temperature, pH, Dissolved Oxygen, and Hydrolysate on the Formation of Triple Light Chain Antibodies in Cell Culture", BIOTECHNOLOGY PROGRESS, (201009), vol. 26, no. 5, ISSN 8756-7938(print), pages 1438 - 1445, XP002638898 [AP] 1-18
SEARCH- SATOSHI OGUCHI ET AL, "pH Condition in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, (20070308), vol. 52, no. 3, doi:10.1007/S10616-007-9059-2, ISSN 1573-0778, pages 199 - 207, XP019499827 [A] 1-18 * Page 200, Materil and methods: Cell culture. Pages 201-22, Results: effect of the pH..., Fig. 1 and Discussion. *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents