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Nicotinamide Mononucleotide Derivatives And Their Uses - EP3331894

The patent EP3331894 was granted to Metro Biotech on Feb 17, 2021. The application was originally filed on Aug 5, 2016 under application number EP16833957A. The patent is currently recorded with a legal status of "Opposition Rejected".

EP3331894

METRO BIOTECH
Application Number
EP16833957A
Filing Date
Aug 5, 2016
Status
Opposition Rejected
Jun 9, 2023
Grant Date
Feb 17, 2021
External Links
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Patent Citations (23) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS20080745419-
DESCRIPTIONUS20090396359-
DESCRIPTIONCN101497638
DESCRIPTIONUS2006229265
DESCRIPTIONUS2012328526
DESCRIPTIONUS2013143835
DESCRIPTIONUS5318508
DESCRIPTIONUS8063025
DESCRIPTIONUS8106184
DESCRIPTIONUS8318682
DESCRIPTIONUS8415308
DESCRIPTIONWO2007022073
DESCRIPTIONWO2007061798
DESCRIPTIONWO2012094343
DESCRIPTIONWO2013177219
DESCRIPTIONWO2017079195
INTERNATIONAL-SEARCH-REPORTCN101497638
INTERNATIONAL-SEARCH-REPORTUS2012328526
OPPOSITIONWO2017024255
OPPOSITIONWO2017161165
SEARCHCN101497638
SEARCHWO2012094343
SEARCHWO2017079195

Non-Patent Literature (NPL) Citations (23) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Nicotinamide riboside", Wikipedia, (20150622), pages 1 - 4, XP093004977-
OPPOSITION- Anonymous, "Nicotinamide riboside", Wikipedia, (20160821), pages 1 - 5, XP093004998-
OPPOSITION- McGuigan, C. ; Bellevergue, P. ; Sheeka, H. ; Mahmood, N. ; Hay, A.J., "Certain phosphoramidate derivatives of dideoxy uridine (ddU) are active against HIV and successfully by-pass thymidine kinase", FEBS Letters, ELSEVIER, AMSTERDAM., NL, NL , (19940829), vol. 351, no. 1, doi:10.1016/0014-5793(94)00776-4, ISSN 0014-5793, pages 11 - 14, XP025652830
OPPOSITION- Jun Yoshino; KathrynF. Mills; MyeongJin Yoon; Shin-ichiro Imai;, "Nicotinamide Mononucleotide, a Key NADIntermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice", Cell Metabolism, Cell Press, United States, United States , (20110831), vol. 14, no. 4, doi:10.1016/j.cmet.2011.08.014, ISSN 1550-4131, pages 528 - 536, XP028308487
OPPOSITION- J.H.CHO et al., "Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection", Tetrahedron, (20110729), vol. 67, no. 30, doi:10.1016/j.tet.2011.05.046, pages 5487 - 5493, XP055092851
OPPOSITION- P. BIEGANOWSKI et al., "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans", Cell, (20040000), vol. 117, doi:10.1016/S0092-8674(04)00416-7, pages 495 - 502, XP002410220
OPPOSITION- ERION et al., "Design, Synthesis and Characterization of a series of cytochrome P450 3A-Activated prodrugs (HepDirect Prodrugs", J. AM. CHEM. SOC., (20040000), vol. 126, doi:10.1021/JA031818Y, pages 5154 - 5163, XP002628532
OPPOSITION- MACGUIGUAN et al., "Phosphorodiamidates as a Promising New Phosphate Prodrug Motif for Antiviral Drug Discovery: Application to Anti-HCV Agents", J. Med. Chem., (20110000), vol. 54, doi:10.1021/jm2011673, pages 8632 - 8645, XP055058426
OPPOSITION- SCOTT J.H et al., "Prodrugs of Phosphates and Phosphonates", Journal of Medicinal Chemistry, (20080424), vol. 51, doi:10.1021/jm701260b, pages 2328 - 2345, XP008148502
OPPOSITION- Nikiforov Andrey, Dölle Christian, Niere Marc, Ziegler Mathias, "Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20110601), vol. 286, no. 24, doi:10.1074/jbc.M110.213298, ISSN 0021-9258, pages 21767 - 21778, XP055878840
OPPOSITION- Long Aaron N, Owens Katrina, Schlappal Anna E, Kristian Tibor, Fishman Paul S, Schuh Rosemary A, "Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model", BMC Neurol, (20150000), vol. 15, no. 1, pages 1 - 14, XP021219119
OPPOSITION- Yamamoto Takanobu, Byun Jaemin, Zhai Peiyong, Ikeda Yoshiyuki, Oka Shinichi, Sadoshima Junichi, "Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion", PLoS ONE, (20140000), vol. 9, no. 6, pages 1 - 14, XP055769555
OPPOSITION- NORTH et al., "SIRT2 induces the checkpoint kinase BubR1 to increase lifespan", EMBO Journal, (20140000), vol. 33, doi:10.15252/embj.201386907, pages 1438 - 1453, XP055320196
OPPOSITION- Poddar Saikat Kumar, Sifat Ali Ehsan, Haque Sanjana, Nahid Noor Ahmed, Chowdhury Sabiha, Mehedi Imtias, "Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule", Biomolecules, (20190000), vol. 9, no. 34, pages 1 - 15, XP093005003
SEARCH- GERHARD PFLEIDERER ET AL, "Zum Wirkungsmechanismus von Dehydrogenasen. Das Reaktionsverhalten von Pyridinnucleotiden (PN) und PN-Modellen mit Sulfit als nucleophilem Agens", CHEMISCHE BERICHTE, DE, (19601201), vol. 93, no. 12, doi:10.1002/cber.19600931240, ISSN 0009-2940, pages 3083 - 3099, XP055533445 [X] 1-4 * page 3093; table 3; compounds 8-10 *
SEARCH- CHRISTOPH W. WOENCKHAUS, "Synthesen und biochemische Eigenschaften wasserstoffübertragender Coenzymmodelle", CHEMISCHE BERICHTE, DE, (19640901), vol. 97, no. 9, doi:10.1002/cber.19640970906, ISSN 0009-2940, pages 2439 - 2446, XP055533514 [X] 1-3 * page 2440; compounds XII,XIII,XIV *
SEARCH- PARK I ET AL, "Nicotinamide Ribose 5'-O-[S-(3-Bromo-2-oxopropyl)]thiophosphate: A New Affinity Label for NMN Sites in Enzymes", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 303, no. 2, doi:10.1006/ABBI.1993.1312, ISSN 0003-9861, (19930601), pages 483 - 488, (19930601), XP024753264 [X] 1 * page 484; compound III *
SEARCH- Andrew J. Wiemer ET AL, "Prodrugs of Phosphonates and Phosphates: Crossing the Membrane Barrier", TOPICS IN CURRENT CHEMISTRY., DE, SPRINGER, BERLIN., (20140101), vol. 360, pages 115 - 160, doi:10.1007/128_2014_561, ISSN 0340-1022, XP055533434 [Y] 1-20 * the whole document *
SEARCH- LIU W ET AL, "Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 65, no. 40, doi:10.1016/J.TET.2009.08.007, ISSN 0040-4020, (20091003), pages 8378 - 8383, (20090809), XP026546562 [X] 1 * scheme 2; page 8379 *
SEARCH- SCOTT J HECKER AND MARK D ERION, "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 51, no. 8, doi:10.1021/JM701260B, ISSN 0022-2623, (20080424), pages 2328 - 2345, (20080201), XP008148502 [Y] 1-20 * the whole document *
SEARCH- A. GÖCKEL ET AL, "Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices", ORGANIC & BIOMOLECULAR CHEMISTRY, (20150101), vol. 13, no. 41, doi:10.1039/C5OB01714A, ISSN 1477-0520, pages 10303 - 10309, XP055533609 [X] 1 * compound 1 *
SEARCH- JAMES DOWDEN ET AL, "CHEMICAL SYNTHESIS OF THE NOVEL CA 2+ MESSENGER NAADP", NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS., US, (20050401), vol. 24, no. 5-7, doi:10.1081/NCN-200061786, ISSN 1525-7770, pages 513 - 518, XP055533527 [X] 1-3 * compounds 6,14 *
SEARCH- DREW R BOBECK ET AL, "Advances in nucleoside monophosphate prodrugs as anti-HCV agents", ANTIVIRAL THERAPY- AN OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR ANTIVIRAL RESEARCH, GB, (20100101), vol. 15, no. 7, doi:10.3851/IMP1667, ISSN 1359-6535, pages 935 - 950, XP055338263 [Y] 1-20 * the whole document *

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