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The patent EP3331894 was granted to Metro Biotech on Feb 17, 2021. The application was filed on Aug 5, 2016 under application number EP16833957A. The patent is currently recorded with a legal status of "Opposition Rejected".
Using nicotinamide mononucleotide (NMN) derivatives to boost NAD+ levels for treating diseases and improving cell survival. The derivatives are compounds that mimic NMN, a precursor to NAD+, and can increase NAD+ levels more than NMN alone. The derivatives have structures represented by formulas II and III. Administering these derivatives promotes intracellular NAD+ elevation for treating diseases associated with NAD+ biosynthesis deficiency. Applications include neurodegenerative diseases, stroke prevention, diabetes, lipid disorders, cardiovascular disease, aging, stress, drug toxicity, and retinal disorders.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent citations refer to prior patents cited during different phases such as opposition or international search.
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