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Heterodimers Of Glutamic Acid - EP3335736

The patent EP3335736 was granted to Molecular Insight Pharmaceuticals on Dec 30, 2020. The application was originally filed on Nov 7, 2007 under application number EP18150494A. The patent is currently recorded with a legal status of "Revoked".

EP3335736

MOLECULAR INSIGHT PHARMACEUTICALS
Application Number
EP18150494A
Filing Date
Nov 7, 2007
Status
Revoked
Jun 24, 2022
Grant Date
Dec 30, 2020
External Links
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Patent Summary

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Patent Family

Patent Oppositions (3)

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DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS UNIVERSITAT HEIDELBERGSep 30, 2021KILGERADMISSIBLE
POLSERVICE KANCELARIA RZECZNIKOW PATENTOWYCH SP Z OOSep 30, 2021KAWCZYNSKAADMISSIBLE
LEWIS SILKINSep 23, 2021GAUNTWITHDRAWN

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2004002478
DESCRIPTIONUS2004054190
DESCRIPTIONWO0222627
DESCRIPTIONWO03060523
OPPOSITIONUS2004054190
OPPOSITIONWO0222627
OTHEREP2097111
OTHEREP2942065
OTHERWO2008058192

Non-Patent Literature (NPL) Citations (33) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- LUTHI-CARTER et al., J Pharm Exp Therap, (19980000), vol. 286, no. 2-
DESCRIPTION- TANG, H.; BROWN, M.; YE, Y.; HUANG, G.; ZHANG, Y.; WANG, Y.; ZHAI, H.; CHEN, X.; SHEN, T.Y.; TENNISWOOD, M., "Prostate targeting ligands based on N-acetylated alpha-linked acidic dipeptidase", Biochem. Biophys. Res. Commun., (20030000), vol. 307, doi:doi:10.1016/S0006-291X(03)01119-7, pages 8 - 14, XP002327104
EXAMINATION- ALAN P. KOZOKOWSKI ET AL., "Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)", J. MED. CHEM., (2001), vol. 44, pages 289 - 301-
EXAMINATION- CATHERINE FOSS, "Following are the abstracts from the Fourth Annual Meeting of the Society for Molecular Imaging Plenary I: Advances in Biological Molecular Imaging", MOLECULAR IMAGING, (20050701), vol. 4, no. 3, pages 210 - 397, XP055590449-
EXAMINATION- YONG-QIAN WU ET AL., "A mild deprotection procedure for tert-butyl esters and tert-butyl ethers using ZnBr2 in methylene chloride", TETRAHEDRON LETT., (2000), vol. 41, pages 2847 - 2849-
OPPOSITION- Anonymous, "Cleavage deprotection and isolation of peptides after fmoc synthesis.", Applied Biosystems, (19980501), pages 1 - 12, Applied Biosystems, URL: http://docplayer.net/5655729-Cleavage-deprotection-and-isolation-of-peptides-after-fmoc-synthesis.html, XP002783250-
OPPOSITION- Catherine Foss, "Abstracts from the Fourth Annual Meeting of the Society for Molecular Imaging Plenary I: Advances in Biological Molecular Imaging", Molecular Imaging, (20150701), vol. 4, no. 3, page 210, 321, XP055590449-
OPPOSITION- Catherine Foss, Crystal Dusich, Ronnie Mease, Anirban Maitra, Martin Romper., "Abstract ID: 362 Synthesis and Validation of a Novel Small-Molecule Fluorescent Probe for PSMA Expression in Human Tumor Neovasculature", Molecular Imaging, (20050701), vol. 4, no. 3, pages 209 - 210, XP055762960-
OPPOSITION- Catherine Foss et al, "Abstract ID: 362 Synthesis and Validation of a Novel Small-Molecule Fluorescent Probe for PSMA Expression in Human Tumor Neovasculature", Molecular Imaging, (20050701), vol. 4, no. 3, pages 209 - 210, XP055762960-
OPPOSITION- CATHERINE FOSS, "Fourth Annual Meeting of the Society for Molecular Imaging Plenary I : Advances in Biological Molecular Imaging", Molecular Imaging, (20050701), vol. 4, no. 3, pages 210 - 397-
OPPOSITION- Clayden, Et Al, "peptide synthesis: carbonyl chemistry in action", Organic Chemistry, (20010101), pages 651 - 658, XP055853603-
OPPOSITION- Clayden, Greeves, Warren, "Organic Chemistry. Passage", Oxford University Press, (20010101), page 657, XP055848473-
OPPOSITION- FIELDS GREGG B, "Introduction to peptide synthesis.", Current Protocols in Protein Science, John Wiley & Sons, Inc., US, US, (20011226), no. SUPPLEMENT 26, ISSN 1934-3655, pages 18.1.1 - 18.1.10, XP002522466-
OPPOSITION- SARVA JAYAPRAKASH ET AL., "Design and Synthesis of a PSMA Inhibitor-Doxorubicin Conjugate for Targeted Prostate Cancer Therapy", (20060101), vol. 1, pages 299 - 302, XP002390389-
OPPOSITION- Seneci, "Solid-phase synthesis oligomeric molecules", Solid-phase synthesis and combinatorial technologies, (20000101), pages 48 - 48, XP055853609-
OPPOSITION- Sewald, "Peptides Synthesis", Peptides: Chemistry and Biology, (20020626), pages 1 - 7, XP055853615-
OPPOSITION- TANG H, ET AL, "Prostate targeting ligands based on N-acetylated alpha-linked acidic dipeptidase.", Biochemical and Biophysical Research Communications, Elsevier, Amsterdam NL, Amsterdam NL, (20030718), vol. 307, no. 1, doi:10.1016/S0006-291X(03)01119-7, ISSN 0006-291X, pages 8 - 14, XP002327104
OPPOSITION- WU et al., "A mild deprotection procedure for tert-butyl esters and ethers using ZnBr2 in methylene chloride", Tetrahedron Letters, (20000000), vol. 41, doi:10.1016/S0040-4039(00)00300-2, pages 2847 - 2849, XP004195685
OPPOSITION- Wu, Y.-q et al, "A mild deprotection procedure for tert-butyl esters and tert-butyl ethers using ZnBr"2 in methylene chloride", Tetrahedron Letters, Elsevier, Amsterdam , NL, Amsterdam , NL, (20000401), vol. 41, no. 16, doi:10.1016/S0040-4039(00)00300-2, ISSN 0040-4039, pages 2847 - 2849, XP004195685
OPPOSITION- ANDERSON et al., "t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis", Journal of the American Chemical Society, (19600701), vol. 82, doi:10.1021/ja01498a032, pages 3359 - 3363, XP055656908
OPPOSITION- KOZIKOWSKI A.P. ET AL., "Design of remarkably simple, yet potent urea-based inhibitors of Glutamate carboxypeptidase II (NAALADase)", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY., AMERICAN CHEMICAL SOCIETY. EASTON., US, US, (20010201), vol. 44, no. 3, doi:10.1021/jm000406m, pages 298 - 301, XP002196918
OPPOSITION- KOZIKOWSKI et al., "Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Caboxypeptidase (NAALADase", Journal of Medicinal Chemistry, vol. 44, doi:10.1021/jm000406m, (20010103), pages 298 - 301, XP002196918
OPPOSITION- KOZIKOWSKI A P, ET AL, "Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents", Journal of Medicinal Chemistry, American Chemical Society, US, US, (20040302), vol. 47, doi:10.1021/jm0306226, ISSN 0022-2623, pages 1729 - 1738, XP002390387
OPPOSITION- KOZIKOWSKI et al., "Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents", Journal of Medicinal Chemistry, vol. 47, doi:10.1021/jm0306226, (20040302), pages 1729 - 1738, XP002390387
OPPOSITION- Catherine A. Foss et al, "Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: in Vivo Imaging in Experimental Models of Prostate Cancer", Clinical Cancer Research, Association for Cancer Research, (20050601), vol. 11, no. 11, doi:10.1158/1078-0432.CCR-04-2690, ISSN 1078-0432, pages 4022 - 4028, XP008109807
OTHER- GREENE et al., Protective Groups in Organic Synthesis, John Wiley & Sons Inc., (19990000), pages 65 - 67-
OTHER- WU Y-Q et al, "A mild deprotection procedure for tert-butyl esters and tert-butyl ethers using ZnBr"2 in methylene chloride", Tetrahedron Lett, (20000400), vol. 41, no. 16, pages 2847 - 2849, XP004195685
OTHER- KOZIKOWSKI et al., "Design of remarkably simple, yet potent urea-based inhibitors of Glutamate carboxypeptidase II (NAALADase)", J. Med. Chem., (20010200), vol. 44, no. 3, pages 298 - 301, XP002196918
OTHER- KOZIKOWSKI et al., "Design of remarkably simple, yet potent urea-based inhibitors of Glutamate carboxypeptidase II (NAALADase)", J. Med. Chem., (20010201), vol. 44, no. 3, pages 298 - 301, XP002196918
OTHER- KOZIKOWSKI et al., "Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents", J. Med. Chem., (20040301), vol. 47, no. 7, pages 1729 - 1738, XP002390387
OTHER- KOZIKOWSKI et al., "Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents"", J. Med. Chem., (20040302), vol. 47, pages 1729 - 1738, XP002390387
SEARCH- KOZIKOWSKI A P ET AL, "Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20040302), vol. 47, doi:10.1021/JM0306226, ISSN 0022-2623, pages 1729 - 1738, XP002390387 [A] 1-5 * compounds 8b,8d *
SEARCH- CATHERINE A FOSS ET AL, "Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: in Vivo Imaging in Experimental Models of Prostate Cancer", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20050601), vol. 11, no. 11, doi:10.1158/1078-0432.CCR-04-2690, ISSN 1078-0432, pages 4022 - 4028, XP008109807 [A] 1-5 * [125I]DCIT *

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