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Method For The Reduction Of Host Cell Proteins In Affinity Chromatography - EP3337812

The patent EP3337812 was granted to F Hoffmann LA Roche on Apr 28, 2021. The application was originally filed on Aug 18, 2016 under application number EP16757608A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3337812

F HOFFMANN LA ROCHE
Application Number
EP16757608A
Filing Date
Aug 18, 2016
Status
Granted And Under Opposition
Mar 26, 2021
Grant Date
Apr 28, 2021
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (4)

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ELKINGTON AND FIFEJan 28, 2022ELKINGTON AND FIFE -
WALLINGER RICKER SCHLOTTER TOSTMANNJan 28, 2022WALLINGER RICKER SCHLOTTER TOSTMANN -
WITHERS & ROGERSJan 28, 2022TOMBLING -
MAIWALDJan 27, 2022MAIWALD -

Patent Citations (18) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
EXAMINATIONWO2015038888
INTERNATIONAL-SEARCH-REPORTEP2583973
INTERNATIONAL-SEARCH-REPORTWO2007068429
INTERNATIONAL-SEARCH-REPORTWO2011038894
INTERNATIONAL-SEARCH-REPORTWO2014207763
INTERNATIONAL-SEARCH-REPORTWO2015000886
INTERNATIONAL-SEARCH-REPORTWO2015024896
OPPOSITIONEP2583973
OPPOSITIONEP3337817
OPPOSITIONUS2006142549
OPPOSITIONWO2006072564
OPPOSITIONWO2007109163
OPPOSITIONWO2011038894
OPPOSITIONWO2011073389
OPPOSITIONWO2014186350
OPPOSITIONWO2014207763
OPPOSITIONWO2015038888
OPPOSITIONWO2017032686

Non-Patent Literature (NPL) Citations (32) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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OPPOSITION- Anonymous, "Shell Chemicals. Data Sheet IS 3.2.13A 6th edition", Shell Chemicals, (20010701), pages 1 - 3, Shell Chemicals, URL: https://www.chemical-supermarket.com/files/MSDS/Solvents/MSDS,%20Hexylene%20Glycol.pdf, (20220208), XP055889045-
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OPPOSITION- Martin Vanderlaan, Et Al, "Hamster Phospholipase B-Like 2 (PLBL2): A Host-Cell Protein Impurity in Therapeutic Monoclonal Antibodies Derived from Chinese Hamster Ovary Cells", BioProcess International, (20150414), vol. 13, no. 4, pages 18 - 55, XP055337487-
OPPOSITION- VANDERLAAN et al., "Hamster Phospholipase B-Like 2 (PLBL2): A Host-Cell Protein Impurity in Therapeutic Monoclonal Antibodies Derived from Chinese Hamster Ovary Cells", BioProcess International, vol. 13, no. 4, (20150400), URL: https://bioprocessintl.com/wp-content/uploads/20 15/04/13-4- Vanderlaan-Secured. pdf, XP055337487-
OPPOSITION- VANDERLAAN, "Recent experiences with Host Cell Protein Impurity Analysis", CaSSS Conference Presentation, (20141113), pages 1 - 16, XP055888347-
OPPOSITION- Kristin N. Valente Abraham M. Lenhoff Kelvin H. Lee, "Expression of Difficult-to-Remove Host Cell Protein Impurities During Extended Chinese Hamster Ovary Cell Culture and Their Impact on Continuous Bioprocessing", (20150601), vol. 112, no. 6, doi:10.1002/bit.25515, pages 1232 - 1242, XP002796221
OPPOSITION- Yuk et al., "More similar than different: Host cell protein production using three null CHO cell lines", Biotechnology and Bioengineering, Hoboken, USA, (201505), vol. 112, no. 10, doi:10.1002/bit.25615, ISSN 0006-3592, pages 2068 - 2083, XP071052310
OPPOSITION- ABOULAICH, N. et al., "A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies", Biotechnol Progress, (20140000), vol. 30, doi:10.1002/btpr.1948, pages 1114 - 1124, XP055425286
OPPOSITION- Nabila Aboulaich et al., "A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies", Biotechnology Progress, (20140901), vol. 30, no. 5, doi:10.1002/btpr.1948, ISSN 8756-7938, pages 1114 - 1124, XP055425286
OPPOSITION- SHUKLA, A.A. et al., "Host cell protein clearance during protein A chromatography: Development of an improved column wash step", Biotechnol Progress, (20080000), vol. 24, doi:10.1002/btpr.50, pages 1115 - 1121, XP002562071
OPPOSITION- Wilson, M.R. ; Easterbrook-Smith, S.B., "Clusterin binds by a multivalent mechanism to the Fc and Fab regions of IgG", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM; NL, AMSTERDAM; NL , (19921020), vol. 1159, no. 3, doi:10.1016/0167-4838(92)90062-I, ISSN 0167-4838, pages 319 - 326, XP022906448
OPPOSITION- Tran Benjamin et al, "Investigating interactions between phospholipase B-Like 2 and antibodies during Protein A chromatography", Journal of Chromatography A, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20160122), vol. 1438, doi:10.1016/j.chroma.2016.01.047, ISSN 0021-9673, pages 31 - 38, XP029436225
OPPOSITION- Tran et al., "Investigating interactions between phospholipase B-Like 2 and antibodies during Protein A chromatography", Journal of Chromatography A, AMSTERDAM, NL, (2016), vol. 1438, doi:10.1016/j.chroma.2016.01.047, ISSN 0021-9673, pages 31 - 38, XP029436225
OPPOSITION- TRAN et al., "Investigating Interactions Between Phospholipase B-Like 2 and Antibodies During Protein A Chromatography", Journal of Chromatography A, vol. 1438, doi:10.1016/j.chroma.2016.01.047, (20160122), pages 31 - 38, XP029436225
OPPOSITION- Catherine Em Hogwood, Daniel G Bracewell, C Mark Smales, "Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses", Current Opinion in Biotechnology, LONDON, GB, GB , (20141201), vol. 30, doi:10.1016/j.copbio.2014.06.017, ISSN 0958-1669, pages 153 - 160, XP055378440
OPPOSITION- Ritzen et al., "Endotoxin reduction in monoclonal antibody preparations using arginine", Journal of Chromatography B, NL , (20070827), vol. 856, no. 1-2, doi:10.1016/j.jchromb.2007.06.020, ISSN 1570-0232, pages 343 - 347, XP022215625
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OPPOSITION- Molden Rosalynn, Et Al, "Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development", mAbs, Landes Bioscience, US, US , (20210101), vol. 13, no. 1, doi:10.1080/19420862.2021.1955811, ISSN 1942-0862, XP055888956
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OPPOSITION- Yin Xuefeng, Et Al, "RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response", Clinical Cancer Research, Association for Cancer Research, US, US, (20131015), vol. 19, no. 20, doi:10.1158/1078-0432.CCR-13-0405, ISSN 1078-0432, pages 5686 - 5698, XP055888885
OPPOSITION- Lu et al., "Development of therapeutic antibodies for the treatment of diseases", JOURNAL OF BIOMEDICAL SCIENCE, CH , (2020), vol. 27, no. 1, doi:10.1186/s12929-019-0592-z, ISSN 1021-7770, pages 1 - 30, XP009528498
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OPPOSITION- Zhang et al., "Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry", mAbs, US , (20140501), vol. 6, no. 3, doi:10.4161/mabs.28120, ISSN 1942-0870, pages 659 - 670, XP055888336

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