Metabolically Optimized Cell Culture - EP3351620

The patent EP3351620 was granted to Regeneron Pharmaceuticals on Sep 2, 2020. The application was originally filed on Oct 10, 2014 under application number EP18161278A. The patent is currently recorded with a legal status of "Revoked".

EP3351620

REGENERON PHARMACEUTICALS
Application Number
EP18161278A
Filing Date
Oct 10, 2014
Status
Revoked
Apr 22, 2022
Publication Date
Sep 2, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BREUERJun 2, 2021BREUER FRIEDRICH HAHNER PATENTANWALTE PARTG MBBADMISSIBLE
NEUEFEINDJun 2, 2021MAIWALDADMISSIBLE

Patent Citations (19) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2009162901
DESCRIPTIONUS2010291626
DESCRIPTIONUS5589466
DESCRIPTIONUS5972650
DESCRIPTIONUS5973972
DESCRIPTIONUS6165741
DESCRIPTIONUS7390660
DESCRIPTIONUS7435553
DESCRIPTIONUS7575890
DESCRIPTIONUS8192951
DESCRIPTIONWO2004104186
DESCRIPTIONWO2007059782
OPPOSITIONEP3351620
OPPOSITIONUS2006160180
OPPOSITIONUS2011010474
OPPOSITIONWO2009023562
OPPOSITIONWO2014073967
OPPOSITIONWO2015054554
SEARCHUS8470552

Non-Patent Literature (NPL) Citations (54) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ARAKI et al., Nuc Acids Res, (20020000), vol. 30, no. 19, page e103
DESCRIPTION- ARAKI et al., PNAS, (19950000), vol. 92, pages 160 - 4
DESCRIPTION- BLECKWENN, NA; SHILOACH, J, "Large-scale cell culture", Curr Protoc Immunol, (20040000), vol. 59
DESCRIPTION- CHOTHIA; LESK, J. Mol. Biol., (19870000), vol. 196, pages 901 - 917
DESCRIPTION- CRUZ et al., Biotechnol Bioeng, (19990000), vol. 66, no. 2, pages 104 - 113
DESCRIPTION- DYMECKI, S., PNAS, (19960000), vol. 93, no. 12, pages 6191 - 6196
DESCRIPTION- "Escherichia coli and Salmonella", Cellular and Molecular Biology, ASM Press, (19960000), vol. 2
DESCRIPTION- EUROPA, A. F. et al., Biotechnol. Bioeng., (20000000), vol. 67, pages 25 - 34
DESCRIPTION- FEIL et al., Biochem. Biophys. Res. Commun., (19970000), vol. 237, pages 752 - 757
DESCRIPTION- GAMBHIR, A. et al., J Bioscience Bioeng, (20030000), vol. 95, no. 4, pages 317 - 327
DESCRIPTION- HOLLIGER et al., PNAS USA, (19930000), vol. 90, no. 14, pages 6444 - 8
DESCRIPTION- HOLT et al., Trends Biotechnol., (20030000), vol. 21, no. 11, pages 484 - 90
DESCRIPTION- JAIN, M. et al., Science, (20120525), vol. 336, no. 6084, pages 1040 - 1044
DESCRIPTION- KIM, BJ et al., Biotechnol Bioeng., (20120100), vol. 109, no. 1, pages 137 - 45
DESCRIPTION- KIM, S.H.; LEE, G.M., Appl. Microbiol. Biotechnol., (20070000), vol. 74, pages 152 - 159
DESCRIPTION- KIM, S.H.; LEE, G.M., Appl. Microbiol. Biotechnol., (20070000), vol. 76, pages 659 - 665
DESCRIPTION- LI, F. et al., mAbs, (20100000), vol. 2, no. 5, pages 466 - 479
DESCRIPTION- NAGY, A. et al., Genesis, (20000000), vol. 26, pages 99 - 109
DESCRIPTION- NEWLAND et al., Biotechnol. Bioeng., (19940000), vol. 43, no. 5, pages 434 - 8
DESCRIPTION- OLIVARI et al., J. Biol. Chem., (20050000), vol. 280, no. 4, pages 2424 - 2428
DESCRIPTION- OMASA et al., Current Pharmaceutical Biotechnology, (20100000), vol. 11, pages 233 - 240
DESCRIPTION- OZTURK, S.S.; RILEY, M.R.; PALSSON, B.O., Biotechnol. and Bioeng., (19920000), vol. 39, pages 418 - 431
DESCRIPTION- QUEK et al., Metab Eng, (20100000), vol. 12, no. 2, pages 161 - 71
DESCRIPTION- REVETS et al., Expert Opin Biol Ther., (20050000), vol. 5, no. 1, pages 111 - 24
DESCRIPTION- RON D; WALTER P, Nat Rev Mol Cell Bio, (20070000), vol. 8, pages 519 - 529
DESCRIPTION- VEMBAR; BRODSKY, Nat. Rev. Mol. Cell. Biol., (20080000), vol. 9, no. 12, pages 944 - 957
DESCRIPTION- WARD et al., Nature, (19890000), vol. 341, pages 544 - 546
DESCRIPTION- WLASCHIN, K.F.; HU, W-S., J. Biotechnol., (20070000), vol. 131, pages 168 - 176
DESCRIPTION- XIE; WANG, Biotechnol. Bioeng., (19940000), vol. 43, no. 11, pages 1175 - 1189
DESCRIPTION- XIE; WANG, Biotechnol Bioeng, (19940000), vol. 43, pages 1174 - 89
DESCRIPTION- ZAGARI et al., New Biotechnol., (20130000), vol. 30, no. 2, pages 238 - 245
DESCRIPTION- ZAGARI et al., New Biotechnol., (20130000), vol. 30, no. 2, pages 238 - 45
DESCRIPTION- ZHOU et al., Cytotechnology, (19970000), vol. 24, pages 99 - 108
OPPOSITION- Jun Luo et al, "Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process", Biotechnology and Bioengineering, (20120101), vol. 109, no. 1, doi:10.1002/bit.23291, ISSN 00063592, pages 146 - 156, XP055135701
OPPOSITION- Jun Luo; Natarajan Vijayasankaran; Jennifer Autsen; Rodell Santuray; Terry Hudson; Ashraf Amanullah; Feng Li, "Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process", Biotechnology and Bioengineering, (20110930), vol. 109, no. 1, pages 146 - 156, XP055135701
OPPOSITION- Templeton Neil; Dean Jason; Reddy Pranhitha; Young Jamey D, "Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture", Biotechnology and Bioengineering, (20130304), vol. 110, no. 7, pages 2013 - 2024, XP055818630
OPPOSITION- Templeton Neil, Dean Jason, Reddy Pranhitha, Young Jamey D., "Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture", BIOTECHNOLOGY AND BIOENGINEERING, Wiley, US, US, (20130701), vol. 110, no. 7, doi:10.1002/bit.24858, ISSN 0006-3592, pages 2013 - 2024, XP055818630
OPPOSITION- Bibila T., Flickinger M. C., "A structured model for monoclonal antibody synthesis in exponentially growing and stationary phase hybridoma cells", BIOTECHNOLOGY AND BIOENGINEERING, Wiley, US, US, (19910205), vol. 37, no. 3, doi:10.1002/bit.260370304, ISSN 0006-3592, pages 210 - 226, XP055818645
OPPOSITION- Ningning Ma et al, "A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism", Biotechnology Progress, American Chemical Society, (20090927), vol. 25, no. 5, doi:10.1002/btpr.238, ISSN 8756-7938, pages 1353 - 1363, XP055287324
OPPOSITION- Abu-Absi; S; Sen Xuhugh Grahamnimish Dalalmarcus Boyerkedar Dave, "Cell culture process operations for recombinant protein production", Advances in Biochemical Engineering and Biotechnology, (20131024), vol. 139, pages 35 - 68, XP055728889
OPPOSITION- Birch; Racher J R; A J, "Antibody production", Advanced Drug Delivery Reviews, (20060522), vol. 58, pages 671 - 685, XP005611421
OPPOSITION- Tsao, Y.S. et al, "Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism", Journal of Biotechnology, Elsevier, Amsterdam NL, Amsterdam NL, (20050822), vol. 118, no. 3, doi:10.1016/j.jbiotec.2005.05.016, ISSN 0168-1656, pages 316 - 327, XP004987759
OPPOSITION- Huong Le; Santosh Kabbur; Luciano Pollastrini; Ziran Sun; Keri Mills; Kevin Johnson; George Karypis; Wei-Shou Hu, "Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator", Journal of Biotechnology, (20120910), vol. 162, pages 210 - 223, XP055287323
OPPOSITION- Francesca Zagari et al, "Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity", New BIOTECHNOLOGY, ELSEVIER BV, NL, NL, (20130101), vol. 30, no. 2, doi:10.1016/j.nbt.2012.05.021, ISSN 1871-6784, pages 238 - 245, XP055295213
OPPOSITION- Bhanu Chandra Mulukutla; Michael Gramer; Wei-Shou Hu, "On metabolic shift to lactate consumption in fed-batch culture of mammalian cells", Metabolic Engineering, (20120108), vol. 14, pages 138 - 149, XP028466094
OPPOSITION- Feng Li et al, "Cell culture processes for monoclonal antibody production", mAbs, (20100901), vol. 2, no. 5, doi:10.4161/mabs.2.5.12720, ISSN 19420862, pages 466 - 479, XP055166177
SEARCH- NINGNING MA ET AL, "A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism", BIOTECHNOLOGY PROGRESS., US, (20090927), vol. 25, no. 5, doi:10.1002/btpr.238, ISSN 8756-7938, pages 1353 - 1363, XP055287324 [A] 1-14 * the whole document *
SEARCH- ZHOU W ET AL, "Fed-batch culture of recombinant NS0 myeloma cells with high monoclonal antibody production", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, (19970101), vol. 55, doi:10.1002/(SICI)1097-0290(19970905)55:5<783::AID-BIT8>3.0.CO;2-7, ISSN 0006-3592, pages 783 - 792, XP002170348 [A] 1-14 * abstract *
SEARCH- SHEIKHOLESLAMI ZAHRA ET AL, "The impact of the timing of induction on the metabolism and productivity of CHO cells in culture", BIOCHEMICAL ENGINEERING JOURNAL, (20130808), vol. 79, doi:10.1016/J.BEJ.2013.07.015, ISSN 1369-703X, pages 162 - 171, XP028733030 [A] 1-14 * the whole document *
SEARCH- JAMEY D YOUNG, "Metabolic flux rewiring in mammalian cell cultures", CURRENT OPINION IN BIOTECHNOLOGY., GB, (20130528), vol. 24, no. 6, doi:10.1016/j.copbio.2013.04.016, ISSN 0958-1669, pages 1108 - 1115, XP055295214 [A] 1-14 * the whole document *
SEARCH- HUONG LE ET AL, "Multivariate analysis of cell culture bioprocess data-Lactate consumption as process indicator", JOURNAL OF BIOTECHNOLOGY, AMSTERDAM, NL, (20121201), vol. 162, no. 2-3, doi:10.1016/j.jbiotec.2012.08.021, ISSN 0168-1656, pages 210 - 223, XP055287323 [A] 1-14 * the whole document *
SEARCH- FRANCESCA ZAGARI ET AL, "Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity", NEW BIOTECHNOLOGY, NL, (20130101), vol. 30, no. 2, doi:10.1016/j.nbt.2012.05.021, ISSN 1871-6784, pages 238 - 245, XP055295213 [A] 1-14 * page 239, column l, paragraph 2 - column r, paragraph last *
SEARCH- BHANU CHANDRA MULUKUTLA ET AL, "On metabolic shift to lactate consumption in fed-batch culture of mammalian cells", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 14, no. 2, doi:10.1016/J.YMBEN.2011.12.006, ISSN 1096-7176, (20111216), pages 138 - 149, (20120108), XP028466094 [A] 1-14 * page 139, column l, lines 2-10 * * page 147, column r, lines 5-8 * * page 148, column l, paragraph last - column r, paragraph 1 *
SEARCH- FENG LI ET AL, "Cell culture processes for monoclonal antibody production", MABS, (20100901), vol. 2, no. 5, doi:10.4161/mabs.2.5.12720, ISSN 1942-0862, pages 466 - 479, XP055166177 [A] 1-14 * figure 5 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents