IP Verse

Compositions And Methods For Synthesizing 5'-Capped Rnas - EP3352584

The patent EP3352584 was granted to Trilink Biotechnologies on May 12, 2021. The application was originally filed on Sep 20, 2016 under application number EP16849423A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3352584

TRILINK BIOTECHNOLOGIES
Application Number
EP16849423A
Filing Date
Sep 20, 2016
Status
Granted And Under Opposition
Apr 9, 2021
Publication Date
May 12, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

COHAUSZ & FLORACK PATENT UND RECHTSANWALTE PARTNERSCHAFTSGESELLSCHAFT MBBFeb 11, 2022COHAUSZ & FLORACKADMISSIBLE
EISENFUHR SPEISERFeb 11, 2022EISENFUHR SPEISERADMISSIBLE

Patent Citations (13) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS1997
DESCRIPTIONUS2007281308
DESCRIPTIONUS6762298
DESCRIPTIONUS7074596
DESCRIPTIONUS8344118
DESCRIPTIONUS9409573
DESCRIPTIONWO2008016473
DESCRIPTIONWO2009058911
INTERNATIONAL-SEARCH-REPORTEP0081089
OPPOSITIONWO2008016473
OPPOSITIONWO2009058911
SEARCHWO2008016473
SEARCHWO2009058911

Non-Patent Literature (NPL) Citations (45) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
OPPOSITION- Alberts et al., Molecular Biology of The Cell, 5th ed., (20080101), pages 331 - 339, XP055896354
OPPOSITION- ambion®, "mMESSAGE mMACHINE® T7 Ultra Kit - Synthesis of Translation Enhanced Capped Transcripts", User Guide, (20140221), no. AM1345, pages 1 - 36, XP055897133
OPPOSITION- Anonymous, "CleanCap AG", (20220101), pages 1 - 4, Trilinkbiotech, URL: https://www.trilinkbiotech.com/media/folio3/productattachments/product_insert/n7113_insert_v4.pdf, (20231120), XP093103214
OPPOSITION- CANAANI, ET AL., "SEQUENCE HETEROGENEITY AT THE 5' TERMINI OF LATE SIMIAN VIRUS 40 19S AND 16S MRNAS.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, US , (19790701), vol. 76, no. 7, pages 3078 - 3082, XP000607076
OPPOSITION- Gruegelsiepe et al., "Chapter 1 - Enzymatic RNA Synthesis, Ligation and Modification", Gruegelsiepe et al., Hartmann et al., Handbook of RNA Biochemistry, Part I - RNA Synthesis, Wiley-VCH, (20050101), pages 3 - 21, XP055896409
OPPOSITION- Liau Brian, "mRNA Capping Analysis Report - dinucleotide vs. trinuc/eotide cap analogs", Genetic Design & Manufacturing, (20210101), pages 1 - 34, XP093098425
OPPOSITION- Promega, "pGEM®-4Z Vector - instructions for use of product P2161", Technical Bulletin, (20090501), pages 1 - 7, XP055896367
OPPOSITION- Ed Dudley, "Mass spectrometry analysis of nucleosides and nucleotides", MASS SPECTROMETRY REVIEWS., JOHN WILEY AND SONS, NEW YORK, NY., US, US , (20140701), vol. 33, no. 4, doi:10.1002/mas.21388, ISSN 0277-7037, pages 302 - 331, XP093165178
OPPOSITION- BECKERT et al., "Chapter 3 - Synthesis of RNA by In Vitro Transcription", BECKERT et al., Nielsen, RNA, Methods and Protocols, (2011), pages 29 - 41, XP009186069
OPPOSITION- Krupp, G., "RNA synthesis: strategies for the use of bacteriophage RNA polymerases", Gene, Elsevier Amsterdam, NL, NL , (19881210), vol. 72, no. 1-2, doi:10.1016/0378-1119(88)90129-1, ISSN 0378-1119, pages 75 - 89, XP025722560
OPPOSITION- Pitulle, C. ; Kleineidam, R.G. ; Sproat, B. ; Krupp, G., "Initiator oligonucleotides for the combination of chemical and enzymatic RNA synthesis", Gene, NL , (19920301), vol. 112, no. 1, doi:10.1016/0378-1119(92)90309-D, ISSN 0378-1119, pages 101 - 105, XP023542230
OPPOSITION- Durairaj, A. ; Limbach, P.A., "Mass spectrometry of the fifth nucleoside: A review of the identification of pseudouridine in nucleic acids", Analytica Chimica Acta, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20080815), vol. 623, no. 2, doi:10.1016/j.aca.2008.06.027, ISSN 0003-2670, pages 117 - 125, XP022833260
OPPOSITION- Tuytten Robin; Lemière Filip; Dongen Walter Van; Esmans Eddy L.; Witters Erwin; Herrebout Wouter; Veken Benjamin Van Der; Dudley Ed; Newton Russell P., "Intriguing Mass Spectrometric Behavior of Guanosine Under Low Energy Collision-Induced Dissociation: H2O Adduct Formation and Gas-Phase Reactions in the Collision Cell", Journal of the American society for mass spectrometry, Elsevier science INC, US, US , (20050801), vol. 16, no. 8, doi:10.1016/j.jasms.2005.03.026, ISSN 1044-0305, pages 1291 - 1304, XP036031627
OPPOSITION- KENNEDY et al., "Mechanism for De Novo RNA Synthesis and Initiating Nucleotide Specificity by T7 RNA Polymerase", J. Mol. Biol., (20070000), vol. 370, pages 256 - 268, XP022103110
OPPOSITION- FECHTER et al., "RIBOZYME PROCESSED TRNA TRANSCRIPTS WITH UNFRIENDLY INTERNAL PROMOTER FOR T7 RNA POLYMERASE: PRODUCTION AND ACTIVITY", FEBS letters, (19980000), vol. 436, pages 99 - 103, XP002938228
OPPOSITION- NAM et al., "Transcription Initiation Site Selection and Abortive Initiation Cycling of Phage SP6 RNA Polymerase", Journal of Biological Chemistry, (19880000), vol. 263, no. 34, pages 18123 - 18127, XP055896394
OPPOSITION- NYGAARD et al., "Formation and properties of RNA-DNA complexes", Journal of Molecular Biology, (19640700), vol. 9, no. 1, doi:10.1016/S0022-2836(64)80095-4, XP026055373
OPPOSITION- FUKUOKA et al., "ONE-POT REACTION FOR THE SYNTHESIS OF M7G5'PPPG AND M7G5'PPPA BY USING AN ACTIVATABLE BIFUNCTIONAL PHOSPHORYLATING REAGENT", Tetrahedron Letters, (19940000), vol. 35, no. 7, pages 1063 - 1066, XP000608145
OPPOSITION- STEPINSKI et al., "Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl(3'-deoxy)GpppG", RNA, (20010000), vol. 7, pages 1486 - 1495, XP002466762
OPPOSITION- Hiroshi Nakayama, "Method for Direct Mass-Spectrometry-Based Identification of Monomethylated RNA Nucleoside Positional Isomers and Its Application to the Analysis of Leishmania rRNA", Analytical Chemistry, American Chemical Society, US, US , (20191217), vol. 91, no. 24, doi:10.1021/acs.analchem.9b03735, ISSN 0003-2700, pages 15634 - 15643, XP093165179
OPPOSITION- IMBURGIO et al., "Studies of Promoter Recognition and Start Site Selection by T7 RNA Polymerase Using a Comprehensive Collection of Promoter Variants", Biochemistry, (20000000), vol. 39, no. 34, pages 10419 - 10430, XP055125483
OPPOSITION- MORONEY et al., "Abortive Products as Initiating Nucleotides during Transcription by T7 RNA Polymerase", Biochemistry, (19910000), vol. 30, no. 42, doi:10.1021/bi00106a036, XP002168056
OPPOSITION- AXELROD et al., "TRANSCRIPTION FROM BACTERIOPHAGE T7 AND SP6 RNA POLYMERASE PROMOTERS IN PRESENCE OF 3'-DEOXYRIBONUCLEOSIDE 5'-TRIPHOSPHATE CHAIN TERMINATORS", Biochemistry, (19850000), vol. 24, no. 21, pages 5716 - 5723, XP000674402
OPPOSITION- Owczarzy et al., "Stability and Mismatch Discrimination of Locked Nucleic Acid-DNA Duplexes", Biochemistry, (20111101), vol. 50, no. 43, doi:10.1021/bi200904e, ISSN 00062960, pages 9352 - 9367, XP055012733
OPPOSITION- FREIER et al., "IMPROVED FREE-ENERGY PARAMETERS FOR PREDICTIONS OF RNA DUPLEX STABILITY", Proceedings of the National Academy of Sciences, (19861201), vol. 83, no. 24, doi:10.1073/pnas.83.24.9373, ISSN 0027-8424, pages 9373 - 9377, XP002471127
OPPOSITION- CAZENAVE et al., "RNA template-directed RNA synthesis by T7 RNA polymerase", Proc. Natl. Acad. Sci. USA, (19940700), vol. 91, doi:10.1073/pnas.91.15.6972, pages 6972 - 6976, XP002049779
OPPOSITION- MCGINNESS et al., "Substitution of Ribonucleotides in the T7 RNA Polymerase Promoter Element", Journal of Biological Chemistry, (20020000), vol. 277, no. 4, pages 2987 - 2991, XP055736077
OPPOSITION- MCGINNESS et al., "Substitution of Ribonucleotides in the T7 RNA Polymerase Promoter Element", The Journal of Biological Chemistry, (20020125), vol. 277, no. 4, doi:10.1074/jbc.M108820200, pages 2987 - 2991, XP055736077
OPPOSITION- Iaroslav Kuzmine, Philip A. Gottlieb, Craig T. Martin, "Binding of the Priming Nucleotide in the Initiation of Transcription by T7 RNA Polymerase", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20030131), vol. 278, no. 5, doi:10.1074/jbc.M208405200, ISSN 0021-9258, pages 2819 - 2823, XP055693453
OPPOSITION- KUZMINE et al., "Binding of the Priming Nucleotide in the Initiation of Transcription by T7 RNA Polymerase", Journal of Biological Chemistry, (20030000), vol. 278, no. 5, pages 2819 - 2823, XP055693453
OPPOSITION- Koukhareva et al., "Chemical Route to the Capped RNAs", Nucleosides, Nucleotides & Nucleic Acids, US , (20040101), vol. 23, no. 10, doi:10.1081/NCN-200031492, ISSN 1525-7770, pages 1667 - 1680, XP055553747
OPPOSITION- Yutaka Suzuki; Hirotoshi Taira; Tatsuhiko Tsunoda; Junko Mizushima‐Sugano; Jun Sese; Hiroko Hata; Toshio Ota; Takao Isogai; Toshihiro Tanaka; Shinichi Morishita; Kousaku Okubo; Yoshiyuki Sakaki; Yusuke Nakamura; Akira Suyama; Sumio Sugano, "Diverse transcriptional initiation revealed by fine, large‐scale mapping of mRNA start sites", EMBO Reports, GB , (20010501), vol. 2, no. 5, doi:10.1093/embo-reports/kve085, ISSN 1469-221X, pages 388 - 393, XP072228544
OPPOSITION- ARNAUD-BARBE N ET AL, "Transcription of RNA templates by T7 RNA polymerase.", Nucleic Acids Research, Oxford University Press, GB, GB , (19980801), vol. 26, no. 15, doi:10.1093/nar/26.15.3550, ISSN 0305-1048, pages 3550 - 3554, XP002305270
OPPOSITION- PEYRANE et al., "High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions", Nucleic acids research, (20070000), vol. 35, no. 4, pages 1 - 11, XP002631670
OPPOSITION- COLEMAN et al., "Superior 5' homogeneity of RNA from ATP-initiated transcription under the T7 2.5 promoter", Nucleic acids research, (20040000), vol. 32, no. 1, pages 1 - 4, XP055718310
OPPOSITION- COLEMAN et al., "Superior 5' homogeneity of RNA from ATP-initiated transcription under the T7 PHI2.5 promoter", Nucleic Acids Research, (20040000), vol. 32, no. 1, doi:10.1093/nar/gnh007, XP055718310
OPPOSITION- ISHIKAWA et al., "Preparation of eukaryotic mRNA having differently methylated adenosine at the 5'-terminus and the effect of the methyl group in translation", Nucleic Acids Symposium Series, (20090000), no. 53, pages 129 - 130, XP055331388
OPPOSITION- Ishikawa et al., "Preparation of eukaryotic mRNA having differently methylated adenosine at the 5'-terminus and the effect of the methyl group in translation", Nucleic Acids Symposium Series, (200909), vol. 53, no. 1, doi:10.1093/nass/nrp065, ISSN 0261-3166, pages 129 - 130, XP055331388
OPPOSITION- Ray et al., "West Nile Virus 5′-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2′-O Methylations by Nonstructural Protein 5", Journal of Virology, (2006), vol. 80, no. 17, pages 8362 - 8370, XP055897121
OPPOSITION- BANERJEE AK, "5'-Terminal Cap Structure in Eucaryotic Messenger Ribonucleic Acids", Microbiological Reviews, (19800000), vol. 44, no. 2, pages 175 - 205, XP055897139
OPPOSITION- JEMIELITY et al., "Novel "anti-reverse" cap analogs with superior translational properties", RNA, (20030000), vol. 9, pages 1108 - 1122, XP002378472
OPPOSITION- KHANDELWAL G et al., "A Phenomenological Model for Predicting Melting Temperatures of DNA Sequences", PLoS ONE, (20100000), vol. 5, no. 8, page e12433, XP055897354
SEARCH- HIROAKI SAWAI ET AL, "Synthesis and Reactions of Nucleoside 5'-Diphosphate Imidazolide. A Nonenzymatic Capping Agent for 5'-Monophosphorylated Oligoribonucleotides in Aqueous Solution", JOURNAL OF ORGANIC CHEMISTRY, (19990801), vol. 64, no. 16, doi:10.1021/jo990286u, ISSN 0022-3263, pages 5836 - 5840, XP055331109 [X] 1-17 * the whole document * * Materials and methods * * Scheme 2 * [Y] 1-17
SEARCH- I. I. KOUKHAREVA ET AL, "Chemical Route to the Capped RNAs", NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS., US, (20040101), vol. 23, no. 10, doi:10.1081/NCN-200031492, ISSN 1525-7770, pages 1667 - 1680, XP055553747 [Y] 1-17 * the whole document * * table 1 * * Results *
SEARCH- Y. THILLIER ET AL, "Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N7)-methyl transferase", RNA, US, (20120214), vol. 18, no. 4, doi:10.1261/rna.030932.111, ISSN 1355-8382, pages 856 - 868, XP055553150 [X] 1-17 * the whole document * * figure 1 * * Results and Discussion * [Y] 1-17

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents