Method For Treating Multiple Sclerosis - EP3359572

The patent EP3359572 was granted to F Hoffmann LA Roche on Nov 27, 2024. The application was originally filed on Oct 6, 2016 under application number EP16790464A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3359572

F HOFFMANN LA ROCHE
Application Number
EP16790464A
Filing Date
Oct 6, 2016
Status
Granted And Under Opposition
Oct 25, 2024
Grant Date
Nov 27, 2024
External Links
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Patent Family

Patent Oppositions (6)

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ABEL & IMRAYAug 27, 2025ABEL & IMRAYADMISSIBLE
ELKINGTON AND FIFEAug 27, 2025ELKINGTON AND FIFEADMISSIBLE
GRUNECKER PATENT UND RECHTSANWALTE PARTG MBBAug 27, 2025GRUNECKER PATENTADMISSIBLE
HEXALAug 27, 2025HOFFMANN EITLEADMISSIBLE
STRAWMANAug 27, 2025HOFFMANN EITLEADMISSIBLE
POLPHARMA BIOLOGICSAug 26, 2025WICHMANNADMISSIBLE

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Non-Patent Literature (NPL) Citations (75) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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OPPOSITION- Anonymous, "Genentech’s Ocrelizumab First Investigational Medicine to Show Efficacy in People with Primary Progressive Multiple Sclerosis in Large Phase III Study", Genentech: Press Releases, Genentech, Inc., pages 1 - 4, Genentech: Press Releases, URL: https://www.gene.com/media/press-releases/14608/2015-09-27/genentechs-ocrelizumab-first-investigati, XP093311060-
OPPOSITION- Anonymous, "Genentech’s Ocrelizumab First Investigational Medicine to Show Positive Pivotal Study Results in Both Relapsing and Primary Progressive Forms of Multiple Sclerosis", Genentech: Press Releases, Genentech, Inc., pages 1 - 6, Genentech: Press Releases, URL: https://www.gene.com/media/press-releases/14609/2015-10-08/genentechs-ocrelizumab-first-investigati, XP093311079-
OPPOSITION- Anonymous, "Genentech's Ocrelizumab First lnvestigational Medicine to Show Efficacy in People with Primary Progressive Multiple Sclerosis in Large Phase Ill Study", Pipeline Review, La Merie Publishing, DE, DE, pages 1 - 6, Pipeline Review, URL: https://pipelinereview.com/genentech-s-ocrelizumab-first-investigation-Medicine-to-Show-Efficacy-in-People-with-Primary-Progressive-Multiple-Sclerosis-in-Large-Phase-Ill-Study.htm, XP093311519-
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OPPOSITION- Anonymous, "Roche's ocrelizumab first investigational medicine to show efficacy in people with primary progressive multiple sclerosis in large Phase III study", Press Release, Fierce Pharma, pages 1 - 3, Press Release, URL: https://www.fiercepharma.com/marketing/roche-s-ocrelizumab-first-investigational-medicine-to-show-efficacy-people-primary, XP093309801-
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OPPOSITION- D40c - Roic AI, Roche Holdings Inc. Q2 2015 Earnings Conference Call on 23 July 2015. Available at: https://www.roic.ai/quote/RHHBY/transcripts/2015-year/2-quarter-
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OPPOSITION- Genentech, Inc., "Genentech: Press Releases | Phase II Study Showed Ocrelizumab Maintained Significant Reduction in Disease Activity for Multiple Sclerosis Patients for Almost Two Years", URL: http://www.gene.com/media/press-releases/13627/2011-10-19/phase-ii-study-showed-ocrelizumab-mainta, (20150717), XP055203108-
OPPOSITION- Hauser, S L, Gc Comi, H-P Hartung, K Selmaj, A Traboulsee, A Bar-Or, Dl Arnold, G Klingelschmitt, F Lublin, H Garren, L Kappos, "Efficacy and Safety of Ocrelizumab in Relapsing Multiple Sclerosis - Results of the Phase III Double-blind, Interferon beta-1a-controlled OPERA I and II Studies", 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis 2015; 7 - 10 October 2015 - Barcelona - Spain, (20151019), pages 1 - 22, XP093311077-
OPPOSITION- Hawker Kathleen; O'Connor Paul; Freedman Mark; Calabresi Peter; Antel Jack; Simon Jack; Hauser Stephen; Waubant Emmanuelle; Vollmer Timothy; Paniteh Hillel; Zhang Jia-meng; Chin Peter; Smith Craig H, "Efficacy and Safety of Rituximab in Patients with Primary Progressive Multiple Sclerosis (PPMS): Results of a Randomized Double-Blind Placebo-Controlled Multicenter Trial", Neurology, Lippincott Williams & Wilkins, (20090301), vol. 72, no. 11, Suppl. 3, ISSN 0028-3878, page A254, XP009128823-
OPPOSITION- Helwick Caroline, "Ocrelizumab benefit in PPMS consistent in subgroups - Consortium of Multiple Sclerosis Centers", MSCare.org, pages 1 - 7, MSCare.org, URL: https://www.mscare.org/ocrelizumab-benefit-in-ppms-consistent-in-subgroups/, XP093311709-
OPPOSITION- Helwick Caroline, "Ocrelizumab Benefit in Primary Progressive MS Consistent in Subgroups", MedScape, pages 1 - 2, MedScape, URL: https://www.medscape.com/viewarticle/859222, XP093311706-
OPPOSITION- Hoffmann-La Roche, "NCT01194570 | A Study of Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis ", ClinicalTrials.gov, NLM, pages 1 - 26, ClinicalTrials.gov, URL: https://clinicaltrials.gov/study/NCT01194570?tab=history&a=96#version-content-panel, XP093311160-
OPPOSITION- Kurtzke J. F., Ludwig Kappos, "Neurostatus Scoring: Definitions for a standardised, quantified neurological examination and assessment of Kurtzke's Functional Systems and Expanded Disability Status Scale in Multiple Sclerosis Slightly modified from", Neurostatus Scoring, Neurostatus.Net, pages 1 - 11, Neurostatus Scoring, URL: https://www.neurostatus.net/media/specimen/Definitions_0410-2_s.pdf, XP093311059-
OPPOSITION- Maia, Margarida, "Disability progression in PPMS Anti-CD20 therapies appear to be ineffective in real-world study", Multiple Sclerosis, News Today, pages 1 - 4, Multiple Sclerosis, News Today, URL: https://multiplesclerosisnewstoday.com/news-posts/2024/10/02/ocrevus-rituximab-ineffective-disability-progression-ppms/, XP093269112-
OPPOSITION- Montalban X, B Hemmer, K Rammohan, G Giovannoni, J De Seze, A Bar-Or, Dl Arnold, A Sauter, D Masterman, P Chin, H Garren, J Wolinsky, "Efficacy and Safety of Ocrelizumab in Primary Progressive Multiple Sclerosis - Results of the Phase III, Double-blind, Placebo-controlled ORATORIO Study", 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis 2015; 7 - 10 October 2015 - Barcelona - Spain, (20151019), pages 1 - 19, XP093311078-
OPPOSITION- Palkhivala Alison, "Rituximab Effective Only in Selected Patients With Primary Progressive Multiple Sclerosis", MedScape, pages 1 - 2, MedScape, URL: https://www.medscape.com/viewarticle/580869_print, XP093269108-
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OPPOSITION- Roche Products Limited, "OCREVUS 300 mg concentrate for solution for infusion", Summary of Product Characteristics (SmPC), Medicines.org.uk, pages 1 - 17, Summary of Product Characteristics (SmPC), URL: https://www.medicines.org.uk/emc/product/8898/smpc/print, XP093311466-
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OPPOSITION- Sa Transcripts, "Roche Holding's (RHHBY) CEO Severin Schwan on Q2 2015 Results - Earnings Call Transcript", Seeking Alpha, (20150907), pages 1 - 23, Seeking Alpha, URL: https://web.archive.org/web/20150907011207/http://seekingalpha.com/article/3353505-roche-holdings-rhhby-ceo-severin-schwan-on-q2-2015-results-earnings-call-transcript, XP093311157-
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OPPOSITION- Simon Jack H, Li D, Traboulsee A, Coyle P K, Arnold D L, Barkhof F, Frank J A, Grossman R, Paty D W, Radue E W, Wolinsky J S, "Standardized MR Imaging Protocol for Multiple Sclerosis: Consortium of MS Centers Consensus Guidelines", American Journal of Neuroradiology, US , (20060201), vol. 27, no. 2, ISSN 0195-6108, pages 455 - 461, XP093268740-
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OPPOSITION- Wolinsky Jerry, Dl Arnold, A Bar-Or, J De Seze, G Giovannoni, B Hemmer, K Rammohan,P Chin, P Fontoura, H Garren, D Masterman, A Sauter, "Abstract: Ocrelizumab Efficacy in PPMS Patients in the Presence/Absence of T1 Gadolinium-Enhancing Lesions at Baseline in a Phase III, Placebo-Controlled Trial (2016 CMSC Annual Meeting)", THE 2016 ANNUAL MEETING OF THE CONSORTIUM OF MULTIPLE SCLEROSIS CENTERS NATIONAL HARBOR, MD, USA, JUNE 1-4, 2016, (20160603), pages 1 - 2, XP093311130-
OPPOSITION- Chris H. Polman; Stephen C. Reingold; Gilles Edan; Massimo Filippi; Hans‐Peter Hartung; Ludwig Kappos; Fred D. Lublin; Luanne M. Metz; Henry F. McFarland; Paul W. O'Connor; Magnhild Sandberg‐Wollheim; Alan J. Thompson; Brian G. Weinshenker; Jerry S. Wolinsky, "Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”", Annals of Neurology, John Wiley and Sons, Boston , US, Boston , US , (20051110), vol. 58, no. 6, doi:10.1002/ana.20703, ISSN 0364-5134, pages 840 - 846, XP071637904
OPPOSITION- Amit Bar‐Or; Peter A. J. Calabresi; Douglas Arnold; Clyde Markowitz; Stuart Shafer; Lloyd H. Kasper; Emmanuelle Waubant; Suzanne Gazda; Robert J. Fox; Michael Panzara; Neena Sarkar; Sunil Agarwal; Craig H. Smith, "Rituximab in relapsing‐remitting multiple sclerosis: A 72‐week, open‐label, phase I trial", Annals of Neurology, John Wiley and Sons, Boston , US, Boston , US , (20080326), vol. 63, no. 3, doi:10.1002/ana.21363, ISSN 0364-5134, pages 395 - 400, XP071638579
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OPPOSITION- Hans‐Peter Hartung; Orhan Aktas, "Bleak prospects for primary progressive multiple sclerosis therapy: Downs and downs, but a glimmer of hope", Annals of Neurology, John Wiley and Sons, Boston , US, Boston , US , (20090925), vol. 66, no. 4, doi:10.1002/ana.21880, ISSN 0364-5134, pages 429 - 432, XP071639195
OPPOSITION- Mark C. Genovese, Jeffrey L. Kaine, Mitchell B. Lowenstein, José Del Giudice, Andrew Baldassare, Joy Schechtman, Edward Fudman, Michael Kohen, Sheila Gujrathi, Robert G. Trapp, Nadera J. Sweiss, Greg Spaniolo, Wolfgang Dummer, "Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study", Arthritis & Rheumatism, Wiley InterScience, US, US , (20080901), vol. 58, no. 9, doi:10.1002/art.23732, ISSN 0004-3591, pages 2652 - 2661, XP055190940
OPPOSITION- Rigby W., Tony H.‐p., Oelke K., Combe B., Laster A., Von Muhlen C. A., Fisheleva E., Martin C., Travers H., Dummer W., "Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a forty‐eight-week randomized, double‐blind, placebo‐controlled, parallel‐group phase III trial", Arthritis & Rheumatism, Wiley InterScience, US, US , (20120201), vol. 64, no. 2, doi:10.1002/art.33317, ISSN 0004-3591, pages 350 - 359, XP093311134
OPPOSITION- Mysler Eduardo F., Spindler Alberto J., Guzman Renato, Bijl Marc, Jayne David, Furie Richard A., Houssiau Frédéric A., Drappa Jorn, Close David, Maciuca Romeo, Rao Kajal, Shahdad Saba, Brunetta Paul, "Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results From a Randomized, Double‐Blind, Phase III Study", Arthritis & Rheumatism, Wiley InterScience, US, US , (20130901), vol. 65, no. 9, doi:10.1002/art.38037, ISSN 0004-3591, pages 2368 - 2379, XP093311141
OPPOSITION- Sabeen Lulu, Emmanuelle Waubant, "Humoral-Targeted Immunotherapies in Multiple Sclerosis", Neurotherapeutics, Springer International Publishing, Cham, Cham, (20130101), vol. 10, no. 1, doi:10.1007/s13311-012-0164-3, ISSN 1933-7213, pages 34 - 43, XP055333733
OPPOSITION- M Yin, Hoff F, Roche Ltd Mann-La, Basel Switzerland ( D, Leppert R, Glanzman J, Tinbergen, Kappos Prof Ludwig, "Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20111119), vol. 378, no. 9805, doi:10.1016/S0140-6736(11)61649-8, pages 1779 - 1787, XP055333854
OPPOSITION- Wolinsky Jerry S; Arnold Douglas L; Brochet Bruno; Hartung Hans-Peter; Montalban Xavier; Naismith Robert T; Manfrini Marianna; Overell James; Koendgen Harold; Sauter Annette; Bennett Iain; Hubeaux Stanislas; Kappos Ludwig; Hauser Stephen L, "Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial", The Lancet Neurology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20201029), vol. 19, no. 12, doi:10.1016/S1474-4422(20)30342-2, ISSN 1474-4422, pages 998 - 1009, XP086349456
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OPPOSITION- Ciccarelli Olga, Miller David, "Magnetic Resonance Imaging in Multiple Sclerosis", Practical neurology, BMJ publishing, London, UK, London, UK , (20020401), vol. 2, no. 2, doi:10.1046/j.1474-7766.2002.00405.x, ISSN 1474-7758, pages 103 - 112, XP009562790
OPPOSITION- Stephen L Hauser, Emmanuelle Waubant, Douglas L Arnold, Timothy Vollmer, Jack Antel, Robert J Fox, Amit Bar-Or, Michael Panzara, Neena Sarkar, Sunil Agarwal, Annette Langer-Gould, Craig H Smith, "B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis", New England Journal of Medicine, United States, (20080214), vol. 358, no. 7, doi:10.1056/NEJMoa0706383, ISSN 0028-4793, pages 676 - 688, XP002567454
OPPOSITION- Xavier Montalban, "Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis", New England Journal of Medicine, Massachusetts Medical Society, United States, United States, (20170119), vol. 376, no. 3, doi:10.1056/NEJMoa1606468, ISSN 0028-4793, pages 209 - 220, XP093166692
OPPOSITION- J. L. Jones, J. M. Anderson, C.-L. Phuah, E. J. Fox, K. Selmaj, D. Margolin, S. L. Lake, J. Palmer, S. J. Thompson, A. Wilkins, D. J. Webber, D. A. Compston, A. J. Coles, "Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity", Brain, Oxford University Press, GB, GB , (20100801), vol. 133, no. 8, doi:10.1093/brain/awq176, ISSN 0006-8950, pages 2232 - 2247, XP055334857
OPPOSITION- Siddharama Pawate, Bagnato Francesca, "Newer Agents in the Treatment of Multiple Sclerosis", NEUROLOGIST, WLLIAMS AND WILKINS, BALTIMORE, MD, US, US , (20150401), vol. 19, no. 4, doi:10.1097/NRL.0000000000000020, ISSN 1074-7931, pages 104 - 117, XP055333727
OPPOSITION- Ontaneda Daniel; Fox Robert J, "Progressive multiple sclerosis", CURRENT OPINION IN NEUROLOGY, GB , (20150601), vol. 28, no. 3, doi:10.1097/WCO.0000000000000195, ISSN 1350-7540, pages 237 - 243, XP009192987
OPPOSITION- Von Büdingen H.-Christian, Palanichamy Arumugam, Lehmann-Horn Klaus, Michel Brady A., Zamvil Scott S., "Author manuscript Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets: ", European Neurology, S. Karger AG, Switzerland, Switzerland , (20150401), vol. 73, no. 3-4, doi:10.1159/000377675, ISSN 0014-3022, pages 1 - 17, XP093311064
OPPOSITION- Kieseier Bernd C., Pozzilli Carlo, "Assessing walking disability in multiple sclerosis", Multiple Sclerosis Journal, Sage, US, US , (20120701), vol. 18, no. 7, doi:10.1177/1352458512444498, ISSN 1352-4585, pages 914 - 924, XP093311125
OPPOSITION- Zhang Jiameng, Waubant Emmanuelle, Cutter Gary, Wolinsky Jerry S, Glanzman Robert, "EDSS variability before randomization may limit treatment discovery in primary progressive MS", Multiple Sclerosis Journal, Sage, US, US , (20130501), vol. 19, no. 6, doi:10.1177/1352458512459685, ISSN 1352-4585, pages 775 - 781, XP055841737
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