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Tgfbeta1-Binding Immunoglobulins And Use Thereof - EP3365368

The patent EP3365368 was granted to Scholar Rock on May 17, 2023. The application was originally filed on Mar 10, 2017 under application number EP17716332A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3365368

SCHOLAR ROCK
Application Number
EP17716332A
Filing Date
Mar 10, 2017
Status
Granted And Under Opposition
Apr 14, 2023
Grant Date
May 17, 2023
External Links
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CHUGAI SEIYAKU KABUSHIKI KAISHAFeb 16, 2024SIMMONS & SIMMONS MUNICHADMISSIBLE

Patent Citations (45) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
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OPPOSITIONWO2014182676
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OPPOSITIONWO2019075090
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Non-Patent Literature (NPL) Citations (32) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- Biolegend, "Ultra-LEAF(TM) Purified anti-mouse/human LAP (TGF-[beta]1) Antibody", (20140827), URL: https://www.biolegend.com/en-us/global-elements/pdf-popup/ultra-leaf-purified-anti-mouse-human-lap-tgf-beta1-antibody-9009?filename=Ultra-LEAF%20Purified%20anti-mousehuman%20LAP%20TGF-beta1%20Antibody.pdf&pdfgen=true, (20180516), XP055475631-
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EXAMINATION- John C. Morris ET AL, "Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGF&bgr;) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma", PLoS ONE, (20140311), vol. 9, no. 3, doi:10.1371/journal.pone.0090353, page e90353, XP055171683
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EXAMINATION- James Voelker ET AL, "Anti-TGF- [beta] 1 Antibody Therapy in Patients with Diabetic Nephropathy", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY., US, (20160919), vol. 28, no. 3, doi:10.1681/ASN.2015111230, ISSN 1046-6673, pages 953 - 962, XP055503719
OPPOSITION- Anonymous, "2012/13 BioLegend Catalog and Reference Manual - General Information", 2012/13 BioLegend Catalog and Reference Manual, BioLegend, (20111218), pages 1 - 22, 2012/13 BioLegend Catalog and Reference Manual, URL: https://www.ida.gen.tr/files/biolegend-immunoloji-genel--1490872348.pdf, XP093165548-
OPPOSITION- Anonymous, "2012/13 BioLegend Catalog and Reference Manual - Human Immunology", 2012/13 BioLegend Catalog and Reference Manual, BioLegend, (20111218), pages 179 - 315, 2012/13 BioLegend Catalog and Reference Manual, URL: https://web.archive.org/web/20130926084025/http://www.biolegend.com/printcatalog, XP093165563-
OPPOSITION- Anonymous, "SRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON)", ClinicalTrials.gov; NCT04291079, (20240710), ClinicalTrials.gov; NCT04291079, URL: https://clinicaltrials.gov/study/NCT04291079 , XP093230880-
OPPOSITION- Biolegend, "Ultra-LEAF™ Purified anti-mouse/human LAP (TGF-β1) Antibody", (20140827), URL: https://www.biolegend.com/en-us/global-elements/pdf-popup/ultra-leaf-purified-anti-mouse-human-lap-tgf-beta1-antibody-9009?filename=Ultra-LEAF%20Purified%20anti-mousehuman%20LAP%20TGF-beta1%20Antibody.pdf&pdfgen=true, (20180516), XP055475631-
OPPOSITION- D20 - CLINICAL TRIAL JRCT2031200407-
OPPOSITION- D21 - Slide characterising SOF10 from Chugai investor meeting, July 2021-
OPPOSITION- Gold Leslie I., Jussila Tommi, Fusenig Norbert E., Stenbäck Frej, "TGF-beta isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis", The Journal of Pathology, Longman, Hoboken, USA, Hoboken, USA, (20000401), vol. 190, no. 5, doi:10.1002/(SICI)1096-9896(200004)190:5<579::AID-PATH548>3.0.CO;2-I, ISSN 0022-3417, pages 579 - 588, XP093230985
OPPOSITION- Ask, K. Bonniaud, P. Maass, K. Eickelberg, O. Margetts, P.J. Warburton, D. Groffen, J. Gauldie, J. Kolb, M., "Progressive pulmonary fibrosis is mediated by TGF-@b isoform 1 but not TGF-@b3", International Journal of Biochemistry and Cell Biology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20080101), vol. 40, no. 3, doi:10.1016/j.biocel.2007.08.016, ISSN 1357-2725, pages 484 - 495, XP022486816
OPPOSITION- Robertson Ian B.; Rifkin Daniel B., "Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activa", Cytokine & Growth Factor Reviews, Elsevier Ltd, GB, GB , (20130712), vol. 24, no. 4, doi:10.1016/j.cytogfr.2013.06.003, ISSN 1359-6101, pages 355 - 372, XP028709264
OPPOSITION- Ian B. Robertson, Masahito Horiguchi, Lior Zilberberg, Branka Dabovic, Krassimira Hadjiolova, Daniel B. Rifkin, "Latent TGF-β-binding proteins", Matrix Biology, Elsevier, NL, NL , (20150901), vol. 47, doi:10.1016/j.matbio.2015.05.005, ISSN 0945-053X, pages 44 - 53, XP055510283
OPPOSITION- Neuzillet Cindy; Tijeras-Raballand Annemilaï; Cohen Romain; Cros Jérôme; Faivre Sandrine; Raymond Eric; de Gramont Armand , "Targeting the TGFβ pathway for cancer the", Pharmacology & Therapeutics, ELSEVIER., GB, GB , (19000101), vol. 147, doi:10.1016/j.pharmthera.2014.11.001, ISSN 0163-7258, pages 22 - 31, XP029196208
OPPOSITION- Minlong Shi, Jianghai Zhu, Rui Wang, Xing Chen, Lizhi Mi, Thomas Walz, Timothy A. Springer, "Latent TGF-&bgr; structure and activation", Nature, vol. 474, no. 7351, doi:10.1038/nature10152, pages 343 - 349, XP055167968
OPPOSITION- Ling Yu, Border Wayne A., Huang Yufeng, Noble Nancy A., "TGF-β isoforms in renal fibrogenesis", Kidney International, Elsevier, United States, United States, (20030901), vol. 64, no. 3, doi:10.1046/j.1523-1755.2003.00162.x, ISSN 0085-2538, pages 844 - 856, XP055508434
OPPOSITION- Daniel Bedinger, Llewelyn Lao, Shireen Khan, Steve Lee, Toshihiko Takeuchi, Amer M. Mirza, "Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms", mAbs, Landes Bioscience, US, US , (20160217), vol. 8, no. 2, doi:10.1080/19420862.2015.1115166, ISSN 1942-0862, pages 389 - 404, XP055710365
OPPOSITION- Berdougo Eli, Joseph R. Couto, Benjamin J. Doranz, "Maximal Humanization of Monoclonal Abs : Integral Molecular Uses Shotgun Mutagenesis to Germline-Humanize Monoclonal Antibodies", GENETIC ENGINEERING & BIOTECHNOLOGY NEWS, Mary Ann Liebert, Inc. Publishers, US, US , (20110801), vol. 31, no. 14, doi:10.1089/gen.31.14.18, ISSN 1935-472X, page 42, XP093230982
OPPOSITION- Mitra Mayur S, Lancaster Karla, Adedeji Adeyemi O, Palanisamy Gopinath S, Dave Rutwij A, Zhong Fiona, Holdren Matthew S, Turley Shannon J, Liang Wei-Ching, Wu Yan, Meng Y Gloria, Vernes Jean-Michel, Schutten Melissa M, "A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys", Toxicological Sciences, Academic Press, US, US, (20200501), vol. 175, no. 1, doi:10.1093/toxsci/kfaa024, ISSN 1096-6080, pages 24 - 34, XP093230975
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OPPOSITION- Michael K. Lichtman, "Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis", WOUND REPAIR AND REGENERATION., MOSBY-YEAR BOOK, ST. LOUIS, MO., US, US , (20160301), vol. 24, no. 2, doi:10.1111/wrr.12398, ISSN 1067-1927, pages 215 - 222, XP093165504
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OPPOSITION- Stephen E. Bottoms, Jane E. Howell, Alistair K. Reinhardt, Iona C. Evans, Robin J. Mcanulty, "TGF-β Isoform Specific Regulation of Airway Inflammation and Remodelling in a Murine Model of Asthma", PLoS ONE, vol. 5, no. 3, doi:10.1371/journal.pone.0009674, page e9674, XP055383009
OPPOSITION- John C. Morris, Tan Antoinette, Olencki Thomas, Shapiro Geoffrey, Dezube Bruce, Reiss Michael, Hsu Frank, Berzofsky Jay, Lawrence Donald, Perez Gracia Jose, "Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGF&bgr;) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma", PLoS ONE, Public Library of Science, (20140311), vol. 9, no. 3, doi:10.1371/journal.pone.0090353, page e90353, XP055171683
OPPOSITION- Diane R. Mould, Bruce Green, "Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies", BIODRUGS, Adis International Ltd., NZ, NZ , (20100201), vol. 24, no. 1, doi:10.2165/11530560-000000000-00000, ISSN 1173-8804, pages 23 - 39, XP009514743
OPPOSITION- Scott Lonning, Mannick Joan, M. Mcpherson John, "Antibody Targeting of TGF-β in Cancer Patients", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, BENTHAM SCIENCE PUBLISHERS,, NL, NL , (20111201), vol. 12, no. 12, doi:10.2174/138920111798808392, ISSN 1389-2010, pages 2176 - 2189, XP055513483
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OPPOSITION- Stevenson James P, Kindler Hedy L, Papasavvas Emmanouil, Sun Jing, Jacobs-Small Mona, Hull Jennifer, Schwed Daniel, Ranganathan Anjana, Newick Kheng, Heitjan Daniel F, Langer Corey J, Mcpherson John M, Montaner Luis J, Albelda Steven M, "Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients", OncoImmunology, (20130801), vol. 2, no. 8, doi:10.4161/onci.26218, ISSN 2162-402X, page e26218, XP093230978

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