IP Verse

Method For Predicting The Off-Target Biding Of A Peptide Which Binds To A Target Peptide Presented By A Major Histocompatibility Complex - EP3373013

The patent EP3373013 was granted to Adaptimmune on Jul 19, 2023. The application was originally filed on Dec 17, 2013 under application number EP18162980A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3373013

ADAPTIMMUNE
Application Number
EP18162980A
Filing Date
Dec 17, 2013
Status
Granted And Under Opposition
Jun 16, 2023
Grant Date
Jul 19, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (3)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

STRAWMANApr 19, 2024ARENDSWITHDRAWN
PAGEApr 18, 2024PAGEADMISSIBLE
GRAF VON STOSCH PATENTANWALTSGESELLSCHAFTApr 18, 2024-WITHDRAWN

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO1992US09965-
DESCRIPTIONEP0120694
DESCRIPTIONEP0125023
DESCRIPTIONEP0184187
DESCRIPTIONEP0239400
DESCRIPTIONGB2188638
DESCRIPTIONUS5225539
DESCRIPTIONWO03020763
DESCRIPTIONWO2004033685
DESCRIPTIONWO2010133828
DESCRIPTIONWO2012013913
DESCRIPTIONWO9413804
DESCRIPTIONWO9960120
EXAMINATIONWO03020763
EXAMINATIONWO2004044004
SEARCHWO2011161127

Non-Patent Literature (NPL) Citations (81) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALTSCHUL et al., Nucleic Acids Res., vol. 25, (19970000), pages 3389 - 3402, URL: http://blast.ncbi.nlm. nih.gov/Blast.cgi?CM D=Web&PAGE TYPE=BlastHome-
DESCRIPTION- AMOS et al., Blood, (20110000), vol. 118, no. 3, pages 499 - 509-
DESCRIPTION- BAEUERLE et al., Curr Opin Mol Ther, (20090000), vol. 11, no. 1, pages 22 - 30-
DESCRIPTION- BIRD et al., Science, (19880000), vol. 242, pages 423 - 426-
DESCRIPTION- BOULTER et al., Protein Eng, (20030000), vol. 16, pages 707 - 711-
DESCRIPTION- DAHAN, R.; Y. REITER, Expert Rev Mol Med., (20120000), vol. 14, page e6-
DESCRIPTION- DANIEL-MESHULAM et al., Front Immunol, (20120000), vol. 3, page 186-
DESCRIPTION- DE CASTRO et al., Nucleic Acids Res., (20060701), vol. 34, pages 362 - 5-
DESCRIPTION- GARBOCZI et al., Proc Natl Acad Sci USA, (19920000), vol. 89, pages 3429 - 3433-
DESCRIPTION- GEBAUER, M.; A. SKERRA, Curr Opin Chem Biol, (20090000), vol. 13, no. 3, pages 245 - 55-
DESCRIPTION- HOLLINGER et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 6444 - 6448-
DESCRIPTION- HOLLINGER; WINTER, Current Opinion Biotechnol., (19930000), vol. 4, pages 446 - 449-
DESCRIPTION- HUSTON et al., PNAS USA, (19880000), vol. 85, pages 5879 - 5883-
DESCRIPTION- LIDDY et al., Nat Med, (20120000), vol. 18, pages 980 - 987-
DESCRIPTION- LIDDY et al., Nat Med, (20120000), vol. 8, pages 980 - 987-
DESCRIPTION- MCCORMACK et al., Cancer Immunol Immunother, (20130000), vol. 62, no. 4, pages 773 - 85-
DESCRIPTION- NYGREN, P. A., FEBS J, (20080000), vol. 275, no. 11, pages 2668 - 76-
DESCRIPTION- O'CALLAGHAN et al., Anal Biochem, (19990000), vol. 266, pages 9 - 15-
DESCRIPTION- RESTIFO et al., Nat Rev Immunol, (20120000), vol. 12, no. 4, pages 269 - 81-
DESCRIPTION- SERGEEVA, A., G. et al., Blood, (20110000), vol. 117, no. 16, pages 4262 - 72-
DESCRIPTION- SKERRA, A., FEBS J, (20080000), vol. 275, no. 11, pages 2677 - 83-
DESCRIPTION- TRAUNECKER et al., EMBO Journal, (19910000), vol. 10, pages 3655 - 3659-
DESCRIPTION- UDYAVAR et al., J Immunol, (20090000), vol. 182, no. 7, pages 4439 - 47-
DESCRIPTION- VAN DER LOOP et al., J Muscle Res Cell Motil., (19960000), vol. 17, pages 23 - 36-
DESCRIPTION- WARD, E.S. et al., Nature, (19890000), vol. 341, pages 544 - 546-
DESCRIPTION- WATT, P. M., Nat Biotechnol, (20060000), vol. 24, no. 2, pages 177 - 83-
DESCRIPTION- WELLS, Methods Enzymol, (19910000), vol. 202, pages 390 - 411-
EXAMINATION- DAHAN RONY ET AL, "T-cell-receptor-like antibodies - generation, function and applications.", EXPERT REVIEWS IN MOLECULAR MEDICINE 24 FEB 2012, (20120224), vol. 14, ISSN 1462-3994, page e6-
EXAMINATION- H�YDAHL LENE ST�KKEN ET AL, "Targeting the MHC Ligandome by Use of TCR-Like Antibodies.", ANTIBODIES (BASEL, SWITZERLAND) 09 MAY 2019, (20190509), vol. 8, no. 2, ISSN 2073-4468-
EXAMINATION- Jane L Grogan ET AL, "Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice", The Journal of Immunology, United States, (19991001), pages 3764 - 3770, URL: https://www.jimmunol.org/content/jimmunol/163/7/3764.full.pdf, (20191220), XP055654579-
EXAMINATION- MAIER B ET AL, "MULTIPLE CROSS-REACTIVE SELF-LIGANDS FOR BORRELIA BURGDORFERI-SPECIFIC HLA-DR4-RESTRICTED T CELLS", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY VCH, WEINHEIM, (20000101), vol. 30, no. 2, doi:10.1002/1521-4141(200002)30:2<448::AID-IMMU448>3.3.CO;2-0, ISSN 0014-2980, pages 448 - 457, XP001029420
EXAMINATION- THOMAS LINNEMANN ET AL, "Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-VCH, HOBOKEN, USA, (20001214), vol. 31, no. 1, doi:10.1002/1521-4141(200101)31:1<156::AID-IMMU156>3.0.CO;2-P, ISSN 0014-2980, pages 156 - 165, XP071221366
EXAMINATION- Tuure Kinnunen ET AL, "The immunodominant epitope of lipocalin allergen Bos?d?2 is suboptimal for human T cells", European Journal of Immunology, Weinheim, doi:https://doi.org/10.1002/eji.200322952, (20030601), pages 1717 - 1726, URL: https://onlinelibrary.wiley.com/doi/full/10.1002/eji.200322952, (20211103), XP055654595
EXAMINATION- RYAN L. HARD ET AL, "HDAC6 and Ubp-M BUZ Domains Recognize Specific C-Terminal Sequences of Proteins", NIH PUBLIC ACCESS AUTHOR MANUSCRIPT, (20101221), vol. 49, no. 50, doi:10.1021/bi101014s, pages 1 - 19, XP055654582
EXAMINATION- J. K. LEE, "T Cell Cross-Reactivity and Conformational Changes during TCR Engagement", JOURNAL OF EXPERIMENTAL MEDICINE, (20041206), vol. 200, no. 11, doi:10.1084/jem.20041251, ISSN 0022-1007, pages 1455 - 1466, XP055108653
EXAMINATION- Y. UEMURA ET AL, "Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs", THE JOURNAL OF IMMUNOLOGY, US, (20030115), vol. 170, no. 2, doi:10.4049/jimmunol.170.2.947, ISSN 0022-1767, pages 947 - 960, XP055578553
OPPOSITION- Hausmann Stefan, Biddison William E, Smith Kathrine J, Ding Yuan-Hua, Garboczi David N, Utz Ursula, Wiley Don C, Wucherpfennig2 Kai W, "Peptide Recognition by Two HLA-A2/TaXii_i9~Specific T Cell Clones in Relationship to Their MHC/Peptide/TCR Crystal Structures", The Journal of Immunology, Williams & Wilkins Co., US, US , (19990501), vol. 162, no. 9, ISSN 0022-1767, pages 5389 - 5397, XP093189567-
OPPOSITION- Liang Xiaoling, "Functional characterization of allorestricted T cell receptors (TCRs)with specificity for HER2/neu and FMNL1 in vitro and in vivo for potential clinical application", Dissertation, Technische Universität München, Technische Universität München, (20110101), Dissertation, URL: https://mediatum.ub.tum.de/doc/1079457/1079457.pdf, XP093189587-
OPPOSITION- Sewell Andrew K., "Why must T cells be cross-reactive? ", NATURE REVIEWS | IMMUNOLOGY, (20120901), vol. 12, pages 669 - 677, XP093189831-
OPPOSITION- Bert Maier; Marc Molinger; Andrew P. Cope; Lars Fugger; Jens Schneider‐Mergener; Grete Sønderstrup; Thomas Kamradt; Achim Kramer, "Multiple cross‐reactive self‐ligands for Borrelia burgdorferi‐specific HLA‐DR4‐restricted T cells", European Journal of Immunology, Wiley-VCH, Hoboken, USA, Hoboken, USA, (20000831), vol. 30, no. 2, doi:10.1002/1521-4141(200002)30:2<448::AID-IMMU448>3.0.CO;2-9, ISSN 0014-2980, pages 448 - 457, XP071220911
OPPOSITION- MAIER B, ET AL., "MULTIPLE CROSS-REACTIVE SELF-LIGANDS FOR BORRELIA BURGDORFERI-SPECIFIC HLA-DR4-RESTRICTED T CELLS", European Journal of Immunology, Wiley-VCH, Hoboken, USA, Hoboken, USA, (20000101), vol. 30, no. 02, doi:10.1002/1521-4141(200002)30:2<448::AID-IMMU448>3.3.CO;2-0, ISSN 0014-2980, pages 448 - 457, XP001029420
OPPOSITION- Tuure Kinnunen et al, "The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells", European Journal of Immunology, WILEY‐VCH Verlag, Weinheim, Weinheim , doi:10.1002/eji.200322952, (20030601), pages 1717 - 1726, European Journal of Immunology, XP055654595
OPPOSITION- Martin Roland et al, "Molecular Mimicry and Antigen-Specific T Cell Responses in Multiple Sclerosis and Chronic CNS Lyme Disease", JOURNAL OF AUTOIMMUNITY, LONDON, GB, GB , (20010501), vol. 16, no. 3, doi:10.1006/jaut.2000.0501, ISSN 0896-8411, pages 187 - 192, XP093189824
OPPOSITION- Michael Haack, Beck-Sickinger A.G., "Multiple Peptide Synthesis to Identify Bioactive Hormone Structures", Combinatorial Chemistry on Solid Supports. Topics in Current Chemistry, vol 278., Berlin, Heidelberg , Springer , (20070202), pages 243 - 288, doi:10.1007/128_2006_106, ISBN 978-3-540-72509-1, XP055705484
OPPOSITION- WUCHERPFENNIG K. W., STROMINGER J. L., "MOLECULAR MIMICRY IN T CELL-MEDIATED AUTOIMMUNITY: VIRAL PEPTIDES ACTIVATE HUMAN T CELL CLONES SPECIFIC FOR MYELIN BASIC PROTEIN.", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (19950310), vol. 80., no. 05., doi:10.1016/0092-8674(95)90348-8, ISSN 0092-8674, pages 695 - 705., XP000652360
OPPOSITION- Maynard Jennifer, Petersson Karin, Wilson Dianne H., Adams Erin J., Blondelle Sylvie E., Boulanger Marty J., Wilson Darcy B., Garcia K.Christopher, "Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC", Immunity, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (20050101), vol. 22, no. 1, doi:10.1016/j.immuni.2004.11.015, ISSN 1074-7613, pages 81 - 92, XP093189597
OPPOSITION- Wilson D. et al, "Specificity and degeneracy of T cells", Molecular Immunology, PERGAMON, GB, GB , (20040201), vol. 40, doi:10.1016/j.molimm.2003.11.022, ISSN 0161-5890, pages 1047 - 1055, XP093189820
OPPOSITION- Helena M. Bijen, Dirk M. Van Der Steen, Renate S. Hagedoorn, Anne K. Wouters, Linda Wooldridge, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk, "Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs", Molecular Therapy, Elsevier Inc., US, US , (20180501), vol. 26, no. 5, doi:10.1016/j.ymthe.2018.02.017, ISSN 1525-0016, pages 1206 - 1214, XP055654816
OPPOSITION- Walden Peter, "T-cell epitope determination", Current Opinion in Immunology, ELSEVIER, OXFORD., GB, GB , (19960201), vol. 8, no. 1, doi:10.1016/S0952-7915(96)80107-5, ISSN 0952-7915, pages 68 - 74, XP093189856
OPPOSITION- Pinilla C. et al, "Exploring immunological specificity using synthetic peptide combinatorial libraries", Current Opinion in Immunology, ELSEVIER, OXFORD., GB, GB , (19990401), vol. 11, no. 2, doi:10.1016/S0952-7915(99)80033-8, ISSN 0952-7915, pages 193 - 202, XP004257523
OPPOSITION- Nicholas P. Restifo et al, "Adoptive immunotherapy for cancer: harnessing the T cell response", Nature Reviews Immunology, Nature Pub. Group, (20120401), vol. 12, no. 4, doi:10.1038/nri3191, ISSN 14741733, pages 269 - 281, XP055034896
OPPOSITION- J. K. Lee, "T Cell Cross-Reactivity and Conformational Changes during TCR Engagement", Journal of Experimental Medicine, Rockefeller University Press, (20041206), vol. 200, no. 11, doi:10.1084/jem.20041251, ISSN 00221007, pages 1455 - 1466, XP055108653
OPPOSITION- Isabel K. Macdonald et al, "MHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell Receptors", PLoS Pathogens, (20101014), vol. 6, no. 10, doi:10.1371/journal.ppat.1001149, pages 1 - 11, XP055578560
OPPOSITION- Galina Petrova et al, "Cross-Reactivity of T Cells and Its Role in the Immune System", NIH Public Access Author Manuscript, (20120101), vol. 32, no. 4, doi:10.1615/CritRevImmunol.v32.i4.50, pages 349 - 372, XP055578532
OPPOSITION- Akshata Udyavar, Alli Rajshekhar, Nguyen Phuong, Baker Lesley, Geiger Terrence L., "Subtle Affinity-Enhancing Mutations in a Myelin Oligodendrocyte Glycoprotein-Specific TCR Alter Specificity and Generate New Self-Reactivity", NIH Public Access Author Manuscript, (20090401), vol. 182, no. 7, doi:10.4049/jimmunol.0804377, pages 1 - 19, XP055654495
OPPOSITION- X. Liang, L. U. Weigand, I. G. Schuster, E. Eppinger, J. C. Van Der Griendt, A. Schub, M. Leisegang, D. Sommermeyer, F. Anderl, Y. Han, J. Ellwart, A. Moosmann, D. H. Busch, W. Uckert, C. Peschel, A. M. Krackhardt, "A Single TCR -Chain with Dominant Peptide Recognition in the Allorestricted HER2/neu-Specific T Cell Repertoire", The Journal of Immunology, American Association of Immunologists, (20100201), vol. 184, no. 3, doi:10.4049/jimmunol.0902155, ISSN 00221767, pages 1617 - 1629, XP055065447
OPPOSITION- Levitsky Victor, De Campos-Lima Pedro-Otavio, Frisan Teresa, Masucci Maria G., "The Clonal Composition of a Peptide-Specific Oligoclonal CTL Repertoire Selected in Response to Persistent EBV Infection Is Stable Over Time", The Journal of Immunology, Williams & Wilkins Co., US, US , (19980715), vol. 161, no. 2, doi:10.4049/jimmunol.161.2.594, ISSN 0022-1767, pages 594 - 601, XP093189560
OPPOSITION- Grogan Jane L., Kramer Achim, Nogai Axel, Dong Liying, Ohde Manuela, Schneider-Mergener Jens, Kamradt Thomas, "Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice", The Journal of Immunology, Williams & Wilkins Co., US, US , (19991001), vol. 163, no. 7, doi:10.4049/jimmunol.163.7.3764, ISSN 0022-1767, pages 3764 - 3770, XP093189570
OPPOSITION- Y. Uemura, S. Senju, K. Maenaka, L. K. Iwai, S. Fujii, H. Tabata, H. Tsukamoto, S. Hirata, Y.-Z. Chen, Y. Nishimura, "Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs", The Journal of Immunology, Williams & Wilkins Co., US, US , (20030115), vol. 170, no. 2, doi:10.4049/jimmunol.170.2.947, ISSN 0022-1767, pages 947 - 960, XP055578553
OTHER- GROGAN et al., "Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice", Journal of Immunology, (19990000), vol. 163, pages 3764 - 3770, XP055654579-
OTHER- "In vitro", Wikipedia, (20201202), URL: https://en.wikipedia.org/w/index.php?title=in_vitro&oldid=991819389, XP055783075-
OTHER- Piepenbrink et al., "Methods for Quantifying T cell Receptor Binding Affinities and Thermodynamics", NIH Public Access Author Manuscript, Methods Enzymol. - Elsevier, (20130619), pages 1 - 18, XP055783086-
OTHER- Maier et al., "MULTIPLE CROSS-REACTIVE SELF-LIGANDS FOR BORRELIA BURGDORFERI-SPECIFIC HLA-DR4-RESTRICTED T CELLS", European Journal of Immunology, (2000), vol. 30, pages 448 - 457, XP001029420
OTHER- LINNEMANN et al., "Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries", Eur. J. Immunol., (20010000), vol. 31, pages 156 - 165, XP002241433
OTHER- KINNUNEN et al., "The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells", Eur. J. Immunol., (20030000), vol. 33, pages 1717 - 1726, XP055654595
OTHER- Kinnunen et al., "The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells", European Journal of Immunology, (2003), vol. 33, pages 1717 - 1726, XP055654595
OTHER- Margulies et al., "Studying interactions involving the T-cell antigen receptor by surface plasmon resonance", CURRENT OPINION IN IMMUNOLOGY, (1996), vol. 8, pages 262 - 270, XP055783077
OTHER- GLUSMAN et al., "Comparative genomics of the human and mouse T cell receptor loci", Immunity, (20010900), vol. 15, pages 337 - 349, XP002322411
OTHER- HARD et al., "HDAC6 and Ubp-M BUZ Domains Recognize Specific C-Terminal Sequences of Proteins", Biochemistry, (20101221), vol. 49, pages 10737 - 10746, XP055178545
OTHER- Matsui et al., "KINETICS OF T-CELL RECEPTOR BINDING TO PEPTIDE/I-EK COMPLEXES CORRELATION OF THE DISSOCIATION RATE WITH T-CELL RESPONSIVENESS", PNAS, (199412), vol. 91, pages 12862 - 12866, XP002008363
OTHER- LEE et al., "T Cell Cross-Reactivity and Conformational Changes during TCR Engagement", J Exp Med., (20041206), vol. 200, no. 11, pages 1455 - 1466, XP055108653
OTHER- UEMURA et al., "Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs", J Immunol, (20030115), vol. 170, pages 947 - 960, XP055578553
SEARCH- HAUSMANN S ET AL, "Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19990501), vol. 162, no. 9, ISSN 0022-1767, pages 5389 - 5397, XP002287146 [X] 1-10,13-14 * Table I-II ; pg 5395, col 1, para 1; figure - * [I] 12-
SEARCH- HEMMER B ET AL, "CONTRIBUTION OF ONDIVIDUAL AMINO ACIDS WITHIN MHC MOLECULE OR ANTIGENIC PEPTIDE TO TCR LIGAND POTENCY", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (20000101), vol. 164, no. 2, ISSN 0022-1767, pages 861 - 871, XP001084041 [A] 1-14 * page 862, column 2, paragraph l; table I * * page 868, column 1, paragraph 1 * * page 869, column 1, paragraphs 1-2 *-
SEARCH- AGGELIKI KOSMOPOULOU ET AL, "T-cell epitopes of the La/SSB autoantigen: Prediction based on the homology modeling of HLA-DQ2/DQ7 with the insulin-B peptide/HLA-DQ8 complex", JOURNAL OF COMPUTATIONAL CHEMISTRY, (20060715), vol. 27, no. 9, doi:10.1002/jcc.20422, ISSN 0192-8651, pages 1033 - 1044, XP055108846 [A] 1-14 * abstract; figure 4 *
SEARCH- Carsten Linnemann ET AL, "T-Cell Receptor Gene Therapy: Critical Parameters for Clinical Success", Journal of Investigative Dermatology, (20110616), pages 1806 - 1816, URL: http://www.nature.com/jid/journal/v131/n9/pdf/jid2011160a.pdf?WT.ec_id=JID-201109, (20140318), XP055108738 [A] 1-14 * page 1809, column 1, paragraph l - page 1810, column 2, paragraph 2 * * page 1811, column 2, paragraph 1 - page 1812, column 1, paragraph 1 *
SEARCH- HIROTO KITA ET AL, "Analysis of TCR antagonism and molecular mimicry of an HLA-A*0201-restricted CTL epitope in primary biliary cirrhosis", HEPATOLOGY, US, (20021001), vol. 36, no. 4, doi:10.1053/jhep.2002.35616, ISSN 0270-9139, pages 918 - 926, XP055437640 [X] 1-11,13-14 * abstract ; Fig 2 ; Table 2 *
SEARCH- MISHRA S ET AL, "Immunoinformatics and modeling perspective of T cell epitope-based cancer immunotherapy: a holistic picture", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 27, no. 3, doi:10.1080/07391102.2009.10507317, ISSN 0739-1102, (20091201), pages 293 - 306, (20120515), XP008168174 [A] 1-14 * abstract; figure 1 *
SEARCH[ ] - BRIAN J CAMERON1 ET AL, "Immunotherapy Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells", SCIENCE TRANSLATION MEDICINE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, (20130801), vol. 5, no. 197-200, doi:10.1126/SCITRANSLMED.3006034, ISSN 1946-6234, pages 48 - 58, XP008168202 [ ] * page 6, column 2, paragraph 3 * * page 2, column 1, paragraph 1 *
SEARCH- SUNE FRANKILD ET AL, "Amino Acid Similarity Accounts for T Cell Cross-Reactivity and for "Holes" in the T Cell Repertoire", PLOS ONE, (20080319), vol. 3, no. 3, doi:10.1371/journal.pone.0001831, ISSN 1932-6203, page e1831, XP055107157 [X] 1-2,5-9,11,13-14 * pg 6, col 2, para 3 ; pg 2, col 2, para bridging pg 3 ;; figure 1 * [I] 3-4,10
SEARCH- CHINNASAMY N ET AL, "A TCR Targeting the HLA-A*0201-Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 186, no. 2, doi:10.4049/JIMMUNOL.1001775, ISSN 0022-1767, (20110115), pages 685 - 696, (20101213), XP002712845 [X] 1,5-10,13-14 * page 693, column 1, paragraph l - column 2 * * page 691, column 1, paragraph 1; figures 6, 8 * * page 688, column 2, paragraph l; tables I-III * * page 693, column 1, paragraph 1 * * abstract * [I] 2-4,11-12

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents