IP Verse

Methods For Treating Huntington'S Disease - EP3386511

The patent EP3386511 was granted to PTC Therapeutics on Mar 20, 2024. The application was originally filed on Dec 11, 2016 under application number EP16874024A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3386511

PTC THERAPEUTICS
Application Number
EP16874024A
Filing Date
Dec 11, 2016
Status
Patent Maintained As Amended
Feb 16, 2024
Publication Date
Mar 20, 2024
External Links
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JAMES POOLEFeb 11, 2022CARPMAELS & RANSFORDADMISSIBLE

Patent Citations (13) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONWO2014028459
DESCRIPTIONWO2014116845
DESCRIPTIONWO2015017589
INTERNATIONAL-SEARCH-REPORTUS2003004164
INTERNATIONAL-SEARCH-REPORTUS2012083495
INTERNATIONAL-SEARCH-REPORTUS2014051672
INTERNATIONAL-SEARCH-REPORTUS2014329825
SEARCHUS2010267721
SEARCHUS2014051672
SEARCHWO2007003604
SEARCHWO2007130383
SEARCHWO2007133561
SEARCHWO2015017589

Non-Patent Literature (NPL) Citations (15) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
OPPOSITION- "28.3.1 The Ends of the Pre-mRNA Transcript Acquire a 5' Cap 1and a 3' Poly(A) Tail", BERG, J. M. et al., Biochemistry, (20020000), page 798, XP055895853
OPPOSITION- Daguenet Elisabeth, Dujardin Gwendal, Valcárcel Juan, "The pathogenicity of splicing defects: mechanisticinsights into pre-mRNA processing inform novel therapeutic approaches", EMBO REPORTS, NATURE PUBLISHING GROUP, LONDON, GB, GB , (20151201), vol. 16, no. 12, doi:10.15252/embr.201541116, ISSN 1469-221X, pages 1640 - 1655
OPPOSITION- James Palacino, Swalley Susanne E, Song Cheng, Cheung Atwood K, Shu Lei, Zhang Xiaolu, Van Hoosear Mailin, Shin Youngah, Chin Donovan N, Keller Caroline Gubser, Beibel Martin, Renaud Nicole A, Smith Thomas M, Salcius Michael, Shi Xiaoying, Hild Marc, Servais Rebecca, Jain Monish, Deng Lin, Bullock Caroline, Mclellan Michael, Schuierer Sven, Murphy Leo, Blommers Marcel J J, Blaustein Cecile, Berenshteyn Frada, Lacoste Arnaud, Thomas Jason R, Roma Guglielmo, Michaud Gregory A, Tseng Brian S, Porter Jeffery A, Myer Vic E, Tallarico John A, Hamann Lawrence G, Curtis Daniel, Fishman Mark C, Dietrich William F, Dales Natalie A, Sivasankaran Rajeev, "SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice", Nature Chemical Biology, Nature Publishing Group US, New York, New York, (20160101), vol. 11, no. 7, doi:10.1038/nchembio.1837, ISSN 1552-4450, pages 511 - 517
OPPOSITION- Labadorf Adam T., Myers Richard H., "Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing", PLOS ONE, Public Library of Science, (20151023), vol. 10, no. 10, doi:10.1371/journal.pone.0141298, page e0141298
OPPOSITION- Ross, C.A. ; Tabrizi, S.J., "Huntington's disease: from molecular pathogenesis to clinical treatment", The Lancet Neurology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20110101), vol. 10, no. 1, ISSN 1474-4422, pages 83 - 98, XP027557896
OPPOSITION- MACDONALD M.E., ET AL., "A NOVEL GENE CONTAINING A TRINUCLEOTIDE REPEAT THAT IS EXPANDED AND UNSTABLE ON HUNTINGTON'S DISEASE CHROMOSOMES.", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (19930326), vol. 72, doi:10.1016/0092-8674(93)90585-E, ISSN 0092-8674, pages 971 - 983, XP000199501
OPPOSITION- Hughes Alis C.; Mort Matthew; Elliston Lyn; Thomas Rhian M.; Brooks Simon P.; Dunnett Stephen B.; Jones Lesley, "Identification of Novel Alternative Splicing Events in the Huntingtin Gene and Assessment of the Functional Consequences Using Structural Protein Homology Modelling", Journal of Molecular Biology, Academic Press, United Kingdom, United Kingdom , (20140103), vol. 426, no. 7, doi:10.1016/j.jmb.2013.12.028, ISSN 0022-2836, pages 1428 - 1438, XP028627773
OPPOSITION- HollyB. Kordasiewicz; LisaM. Stanek; EdwardV. Wancewicz; Curt Mazur; MelissaM. McAlonis; KimberlyA. Pytel; JonathanW. Artates; Andreas Weiss; SengH. Cheng; LamyaS. Shihabuddin; Gene Hung; C.Frank Bennett; DonW. Cleveland;, "Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis", Neuron, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20120501), vol. 74, no. 6, doi:10.1016/j.neuron.2012.05.009, ISSN 0896-6273, pages 1031 - 1044, XP028496461
OPPOSITION- Daisuke Kaida, Michael G. Berg, Ihab Younis, Mumtaz Kasim, Larry N. Singh, Lili Wan, Gideon Dreyfuss, "U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation", Nature, ¬Macmillan Journals Ltd., etc.|, (20101202), vol. 468, no. 7324, doi:10.1038/nature09479, ISSN 00280836, pages 664 - 668, XP055184745
OPPOSITION- James Palacino, Swalley Susanne E, Song Cheng, Cheung Atwood K, Shu Lei, Zhang Xiaolu, Van Hoosear Mailin, Shin Youngah, Chin Donovan N, Keller Caroline Gubser, Beibel Martin, Renaud Nicole A, Smith Thomas M, Salcius Michael, Shi Xiaoying, Hild Marc, Servais Rebecca, Jain Monish, Deng Lin, Bullock Caroline, Mclellan Michael, Schuierer Sven, Murphy Leo, Blommers Marcel J J, Blaustein Cecile, Berenshteyn Frada, Lacoste Arnaud, Thomas Jason R, Roma Guglielmo, Michaud Gregory A, Tseng Brian S, Porter Jeffery A, Myer Vic E, Tallarico John A, Hamann Lawrence G, Curtis Daniel, Fishman Mark C, Dietrich William F, Dales Natalie A, Sivasankaran Rajeev, "SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice", Nature Chemical Biology, Nature Publishing Group US, New York, New York, (20160101), vol. 11, no. 7, doi:10.1038/nchembio.1837, ISSN 1552-4450, pages 511 - 517, XP055520469
OPPOSITION- Sathasivam K., Neueder A., Gipson T. A., Landles C., Benjamin A. C., Bondulich M. K., Smith D. L., Faull R. L. M., Roos R. A. C., Howland D., Detloff P. J., Housman D. E., Bates G. P., "Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20130205), vol. 110, no. 6, doi:10.1073/pnas.1221891110, ISSN 0027-8424, pages 2366 - 2370, XP055867220
OPPOSITION- Lisa M. Stanek, Sergio P. Sardi, Bryan Mastis, Amy R. Richards, Christopher M. Treleaven, Tatyana Taksir, Kuma Misra, Seng H. Cheng, Lamya S. Shihabuddin, "Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease", HUMAN GENE THERAPY, Mary Ann Liebert, Inc. Publishers, GB, GB , (20140501), vol. 25, no. 5, doi:10.1089/hum.2013.200, ISSN 1043-0342, pages 461 - 474, XP055277689
OPPOSITION- Labadorf Adam T., Myers Richard H., "Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing", PLOS ONE, Public Library of Science, (20151023), vol. 10, no. 10, doi:10.1371/journal.pone.0141298, page e0141298, XP055895845
OPPOSITION- Daguenet Elisabeth, Dujardin Gwendal, Valcárcel Juan, "The pathogenicity of splicing defects: mechanisticinsights into pre-mRNA processing inform novel therapeutic approaches", EMBO REPORTS, NATURE PUBLISHING GROUP, LONDON, GB, GB , (20151201), vol. 16, no. 12, doi:10.15252/embr.201541116, ISSN 1469-221X, pages 1640 - 1655, XP055895843
OPPOSITION- Yan Wang, Jing Liu, Bo Huang, Yan-Mei Xu, Jing Li, Lin-Feng Huang, Jin Lin, Jing Zhang, Qing-Hua Min, Wei-Ming Yang, Xiao-Zhong Wang, "Mechanism of alternative splicing and its regulation", BIOMEDICAL REPORTS MAY 2014 SPANDIDOS PUBLICATIONS GBR, Spandidos Publications, Greece, Greece , (20150301), vol. 3, no. 2, doi:10.3892/br.2014.407, ISSN 2049-9434, pages 152 - 158, XP055729424

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