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The patent EP3389630 was granted to Gritstone BIO on Nov 8, 2023. The application was filed on Dec 16, 2016 under application number EP16876766A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
A method for identifying neoantigens that can be presented by tumor cells for cancer immunotherapy. The method employs a novel approach to neoantigen identification that integrates mass spectrometry data with computational models to predict peptide presentation by tumor MHC alleles. The method trains models on peptide sequences from tumor samples and presents them to MHC alleles, generating likelihoods of peptide presentation. These likelihoods are then used to select the most promising neoantigens for vaccine development. The approach addresses the limitations of current methods by incorporating mass spectrometry data and computational models to improve peptide presentation predictions.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| BIONTECH | Aug 8, 2024 | THOMANN | ADMISSIBLE |
| MARGARET DIXON | Aug 8, 2024 | MEWBURN ELLIS | ADMISSIBLE |
| STRAWMAN | Aug 8, 2024 | HGF | ADMISSIBLE |
| INSPICOS PS | Aug 7, 2024 | INSPICOS PS | ADMISSIBLE |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| INTERNATIONAL-SEARCH-REPORT | US2011293637 |
| INTERNATIONAL-SEARCH-REPORT | WO2015095811 |
| OPPOSITION | CN105524984 |
| OPPOSITION | US2011293637 |
| OPPOSITION | US2015099798 |
| OPPOSITION | WO2011143656 |
| OPPOSITION | WO2014168874 |
| OPPOSITION | WO2016040682 |
| OPPOSITION | WO2017106638 |
| OPPOSITION | WO2017184590 |
| OPPOSITION | WO2018098362 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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Decision to grant a European patent
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(Electronic) Receipt
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Filing of the translations of the claims
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Sep 28, 2023
French translation of claims
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German translation of the claims
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Letter accompanying subsequently filed items
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Intention to grant (signatures)
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Jun 5, 2023
Text intended for grant (clean copy)
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Examination started
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Jul 26, 2021
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Annexes in respect of a client data request
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Letter accompanying subsequently filed items
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(Electronic) Receipt
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Amended claims with annotations
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Jun 25, 2020
Amendments received before examination
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Jun 25, 2020
Letter accompanying subsequently filed items
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European search opinion
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Information on Search Strategy
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Nov 29, 2019
Supplementary European search report
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Submission concerning representation
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Search started
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Mar 11, 2019
Submission concerning representation
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Feb 4, 2019
(Electronic) Receipt
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Amended claims with annotations
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Feb 4, 2019
Amendments received before examination
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Feb 4, 2019
Letter accompanying subsequently filed items
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Oct 15, 2018
Refund of fees
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Sep 26, 2018
Sep 20, 2018
(Electronic) Receipt
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Sep 20, 2018
Converted Sequence Listing
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Sep 20, 2018
Letter accompanying subsequently filed items
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Sep 20, 2018
Matter concerning the application
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Jul 24, 2018
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Communication to designated inventor
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Communication to designated inventor
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Communication to designated inventor
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Communication to designated inventor
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(Electronic) Receipt
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Jul 5, 2018
Request for entry into the European phase
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Submission concerning representation
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Apr 30, 2018
Information on entry into European phase
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Copy of the international search report
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Jun 22, 2017
Published international application - A1
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